CN102308989A - Health care composition of formica rufa, grape and propolis extracts - Google Patents
Health care composition of formica rufa, grape and propolis extracts Download PDFInfo
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Abstract
The invention discloses a health care composition of formica rufa, grape and propolis extracts. The composition contains a formica rufa extract, grape polyphenol and an propolis extract. The invention enables shortcomings of a single sided curative effect and poor action resulting from individual utilization of the formica rufa extract, grape polyphenol or the propolis extract to be overcome, and health care and treatment effects to be optimized.
Description
Technical field the present invention relates to field of health care products, more particularly, the present invention relates to the composition of a kind of Formica rufa with health care, grape, propolis extract, and the purposes of said composition in preparation food and health products.
Background technology
(1) health ministry formally is decided to be the health products new resources with red ant
Just begin one's study as far back as the beginning of this century pharmacological action of red ant of U.S. scientist.Through analysis and research in earnest, they process injection to the body fluid that in the ant body, extracts, be expelled on 200 Itai-itai diseases person, and the result, all patients' symptom all obviously alleviates.
China classifies ant as medicine and the existing history in 3000 of health food." Zhou Li " " Book of Rites " " elegant ", Shennong's Herbal all have the argumentation as medicine and food of pair ant and ant ovum until bright Li Shizhen (1518-1593 A.D.) Compendium of Material Medica.In recent years advocate the exploitation insect food abroad, ant is one of important kind wherein.Traditional Chinese medicine thinks, red ant is warm in nature, flavor is sweet, have strengthen the body resistance to consolidate the constitution, tonifying kidney and strengthening yang, the flourish muscle that nourishes blood, the effect of the vein relaxing that eliminates the phlegm, and the record that has many treatment diseases and health to lengthen the life.
For the first time ant is used as medicine in the supplement to the Herbal of the Tang Dynasty Chen Cangqi.Arrived the Ming Dynasty, had in the period of eternally happy the villager that red ant is pulverized and mix Chinese herbal medicine and process " the strong strong longevity ball of power ", lived at the age of one hundred years old.There is an old man often to eat red ant in Jilin and lives, also can do farm work with descending by 140 years old.
Claim that at Compendium of Material Medica the 40 volume " worm portion ant " Li Shizhen (1518-1593 A.D.) ant is " a profound coltfoal ", and carry: " the ant oviparity of living in caves, its residence have etc.; its row has team, can know that rain waits, and the spring goes out the winter and bites; its ovum name, recluse dig it; have to bucket stone person, and ancients eat it, have fish or meat paste also so " then interior ", " all officials " present the beans of food.Ordinary person eats it, beneficial gas pool face, the person's of dying food and heal also.
Liu Xun " mountain range table record is different " says: hand over the chief of a tribe between the cave of Guangxi, get the ant ovum more, washing in a pan only is sauce, says flavor like meat pulp, and non-honorable non-availability also.Add: the many ants in the south of the Five Ridges, its nest is like thin wadding capsule.Connect branch band leaf, that person stores it with cloth bag, is sold to support the mandarin orange person, to ward off worm ...This shows that ancients have grasped the nutritive value of red ant and the medical value of ant poison already.Traditional Chinese medicine is thought; Red ant is a kind of tonic medicine of gentleness, has and strengthens the body resistance to consolidate the constitution, and tonifying kidney and strengthening yang, flourish muscle nourishes blood; The effect of dispelling wind and removing obstruction in the meridians; Wherein the most remarkable with kidney tonifying, be used for control aging, rheumatoid arthritis, rheumatic arthritis, diseases such as alopecia, impotence, neurasthenia there is better therapeutic effect.In addition, red ant goods can become female hormone in the female body internal conversion, raise libido, and increase secretion, effects such as expansion breast lactagogue.
The human record that edible red ant is just arranged a long time ago just records people and gathers ant and supply emperor and noble to eat with the ant ovum in ancient books in the pre-Qin days " all gift heavenly officials fish or meat paste people ", " in the Book of Rites then ", be referred to as " fish or meat paste " (ant egg sauce).
Some local people of the northeast and the Inner Mongol, red ant commonly used is stewed bean curd, or wears into powder with red ant and make a ball together with minced meat, supplies the puerpera edible, to reach the effect of lactagogue.
The modern science analytical proof, the micro-element nutrition of Changbai Mountain wild red ant is worth high.And compare with other regional red ants, original low temperature tolerance is arranged.Formica rufa through science is extracted is smart, and composition is purer, and nutrition content is more concentrated, more remarkable effect:
1, Formica rufa protamine matter content accounts for 42%-67%;
2, the Formica rufa essence contains 26 seed amino acids such as threonine, lysine, wherein contains necessary 8 seed amino acids of human body (threonine, phenylalanine, valine, leucine, isoleucine, lysine, methionine, tryptophan);
3, the Formica rufa essence contains 28 kinds of trace elements.Like tin, zinc, calcium, manganese, iron, cobalt, copper, iodine, molybdenum, chromium, nickel, selenium, silicon, fluorine, vanadium etc.Micronutrient levels is 4 times of egg, 6 times of milk.The red ant of per kilogram contains about zinc 180mg, and is higher 8 times than soybean, can be rated as various animals and plants zinc contents.
4, the Formica rufa essence contains high energy phosphate compound (ATP) and contains formic acid, cursive script formaldehyde (HCHO) chest formaldehyde (G11H14O), citral special compounds such as (C10H16O);
5, the Formica rufa essence contains multivitamin (B1, B2, B12, VE) etc.;
6, the Formica rufa essence also contains plurality of enzymes and coenzyme, alkaloid, bioactivators such as histamine, and also having special " ant antibiotic " in addition is extraordinary antibiotic such as metathorax side pole parathyrine.
Major function:
1, bone and joint diseases: rheumatoid disease, rheumatic arthritis, scapulohumeral periarthritis, pain in waist and lower extremities.
2, cardiovascular and cerebrovascular disease: coronary heart disease, cerebral embolism sequela, angina pectoris, myocarditis.
3, disease in the urological system: ephritis, impotence, premature ejaculation, frigidity.
4, disease of digestive system: gastritis, indigestion, cholecystitis, hepatitis, liver ascites, cirrhosis.
5, the nervous system disease: neurasthenia, vegetative nerve functional disturbance, insomnia, headache.
6, other disease: diabetes, lupus erythematosus, chorionitis, young person with greying hair, loss of tooth, cancer postoperative.
(2), anti-disease, anti-aging plant---vine polyphenol
Vine polyphenol is that what from grape pip, to extract is main polyphenol compound with the OPC.Basic research shows that vine polyphenol has multiple pharmacological effect, can through suppress oxygen production, directly capturing free radicals, influence enzyme biologically active, influence that DNA synthesizes and gene expression etc. plays a role; Can suppress non-glycosylation, through regulating blood fat, stabilize plaque and impelling patch to disappear, bring high blood pressure down, prevent thrombosis, anti-arrhythmia, protection cardiovascular and cerebrovascular; Have antitumor, prevention gene mutation, radioresistance, antiulcer, antiallergy, anti-inflammatory, pharmacologically active such as antiviral, antibiotic.Clinical research shows; Vine polyphenol can reduce with human body in oxidative stress and non-glycosylation, thereby prevent and treat cardiovascular and cerebrovascular disease, prevent senile dementia, prevent and treat malignant tumour, prevention diabetes and complication, prevent and treat cataract and glaucoma, control allergic inflammation, the beauty treatment of protection beautifying skin, take care of one's teeth, prevent and treat gastrointestinal disease, to prevent and treat effect such as prostatic disorders remarkable.
The fruit of grape, root, rattan all can be used as medicine, fruit promoting eruption, the diuresis detoxifcation of can inducing sweat, and that root and rattan can be dispeled the wind is wet, stop blooding, help digestion, detoxifcation, antiabortive, and external application can be treated fracture.OPC in the grape distributes in seed (60%～70%) at most, is the material that causes the grape wine bitter taste, also is one of main nutrient composition.The main chemical compositions of grape pip mainly contains catechin, OPC class (being the condensed tannin class).
Exceed tens of times with regard to verified its antioxidant effect than VC, VE and green tea as far back as French researcher in 1993.Vine polyphenol wherein (polyphenols) then is distributed widely in seed, pulp, pericarp and the carpopodium of each kind of plant.Wherein the highest with grape pip, be about 65%-70%.
Vine polyphenol is not single a kind of composition in fact, wherein comprises flavones (flavones), tannin (tannins), coumaric acid (coumarque), catechin, the preceding anthocyanidin compositions such as (OPC) of few six benzene.Have strengthen and promote the sanguimotor effect of health capilary, it can protect the collagen and the elastomer of skin, prevents the injury of ultraviolet ray to skin.The resistance function of protection and enhancing skin histology.
The seventies in 20th century; French chemist, biologist's Maas chief rein in and in grape pip, have found vine polyphenol (OTC); And done a series of experiments, like bioavilability test, toxicity test, " three cause " experiment (teratogenesis, carcinogenic, mutagenesis) etc., be used to develop American market.From then on, vine polyphenol is widely used in the health food.
It has mainly acted on:
1, it is active to strengthen the basis: mainly comprise anti-oxidant, free radical capture, metal ion huge legendary turtle close, with protein combination etc., this is the basis of its pharmacological action of performance by its structures shape;
2, reduce low-density lipoprotein, increase choleresis, promote triglycerides to descend;
3, strengthen cytoprotection, improve liver detoxification function;
4, dissolve cytotoxin and prophylaxis of cancer targetedly and take place, grape seed extract (GSPE) has prevention and therapeutic action to the enteric adenoma of adenoma polyp gene mutation;
5, vascular protection effect;
6, organ protection;
7, radiation resistance;
8, other effects: in skin healing and other relevant disease of skin, therapeutic action is arranged.Its treatment potentiality in inflammation and other relevant diseases of inhibitory action indication that GSPE expresses VCAM-1.GSPE and micro-Combined application have long-term health-care effect.The extract that contains OPC can suppress the colibacillary adhesion of P-type through combining with bacterium, prevents bacterial infection.
(3), massive planting thing animal secretions elite is in the active material of one---the Changbai Mountain natural propolis
Bee product can be divided into four big types of honey, royal jelly, pollen, propolis, and propolis is one of higher bee product of medical value wherein.Propolis is the honeybee natural gum that the newborn twig of plant or bark are gathered from the glue source, through adding the compound that the bee secretion modulation forms.It is massive planting thing and animal secretions elite in one, contain abundant physiological activator, like flavonoids, phenols, terpenes, organic acid and several amino acids, enzyme, vitamin, mineral matter etc.
In recent years, the effect of propolis causes people's attention day by day.Experiment showed, that through scientists years of researches propolis contains more than 300 kind of composition, the good result of propolis has been brought up in complementary effect between the composition.Because propolis is a kind of natural materials, make propolis have drug action widely, can not have side effects yet, Here it is, and they are different from the place of the medicine that chemical synthesis process processes.
Topmost composition flavone compound reaches kind more than 40 in the propolis, and its kind and content are very abundant.If everybody notes seeing our more daily treatment hypertension of taking, coronary heart disease, the traditional Chinese medicine ingredients that activates blood circulation and disperses blood clots, just can find wherein to contain flavone compound, it has multiple pharmacological effect.Along with progress of research, find that also the compositions such as terpene compound, lipoid substance in the propolis have the effect that suppresses tumour.Also has synergistic function between the propolis composition.Summary is got up, and the effect of propolis has following several types:
1, antibacterial action: the flavone compound in the propolis, aromatic acid, aliphatic acid, terpene compound etc. all have inhibitory action to bacterium, fungi, pathogenic bacteria, mould etc.It only needs just many microorganisms are had inhibitory action on a small quantity, but only single microorganism is produced effect unlike antibiotic, and also has side effect.In daily life, if wound is arranged, burn, ulcer etc., we are used for protecting health not encroached on by germ by this of propolis capable of using, reach the effect of anti-inflammation and sterilization.
2, antivirus action: compositions such as the flavonols in the propolis, flavones, flavanones, caffeic acid derivative all have antiviral effect.Evidence, propolis all has good effect to influenza virus, vaccinia virus, hepatitis B, herpesviral, bone marrow poliomyelitis virus, vesicle property stomatitis virus etc.Now, our living environment degenerates, and is seriously polluted, and some new viruses occur under our unwitting situation, and are diseases induced.Therefore, we can come prophylaxis of viral diseases with propolis, reach the purpose that improves the health.
3, antioxidation: compositions such as the flavone compound in the propolis, glucoside, phenols, terpene compound all have antioxidation.When organism when carrying out oxygen metabolism, can constantly produce refuse---active oxygen and free radical.It can act on the lipid material in cell membrane and the blood; Form MDA, be deposited on the cell membrane, histocyte is wrecked; Thereby chromogenesis, color spot, whelk, pachylosis etc.; These MDAs also can be deposited on the vascular wall, form thrombus etc., also possibly cause atherosclerotic and cataract.In addition, it also can resist gamma-radiation irradiation, alleviate put, the side effect of chemotherapy.Bad habit in our daily life all can produce refuses such as superfluous active oxygen and free radical like smoking, obesity, pressure, overworked, excessive diet, environmental pollution etc.Because of propolis can effectively stop the generation of MDA, have good antioxidation, be called as anti-oxidant and free radical scavenger.
4, antitumor action: contain abundant antitumorigenic substance in the propolis, like the Quercetin in the flavone compound, kaempferia galamga element, Galangin, apiolin etc.; Multiple times of terpene in the terpene compound, Diterpenes, triterpenes etc.; Glucoside material in the polysaccharide material; Lignanoid in the naphthoquinone compound; Compositions such as the CAPE in the lipoid substance etc., isoprene ester all have antitumor action.Particularly CAPE, Quercetin, methaform diterpene, Artepilin C composition.The experiment proof; The synergy of these compositions can not only suppress cancer of the stomach, liver cancer, the isocellular development of lung cancer; Can also alleviate the side effect that radiotherapy, chemotherapy bring; This effect has improved result of treatment, and propolis do not kill healthy cell when killing cancer cell, and this is the Gospel of tumor patient.Therefore, propolis has prophylaxis of tumours, suppresses canceration, kills cancer cell, prevents effects such as transfer, and do not have the side effect of cancer therapy drug.
5, regulate blood fat, adjusting blood pressure, the effect of adjusting blood sugar: the synergy of propolis composition; Can suppress the rising of triglycerides, cholesterolemia; Can remove interior free yl; Effectively purify the blood, platelet aggregation and thrombosis are had the good restraining effect, thereby reach the purpose of regulating blood fat, regulating blood pressure.Propolis can also promote to utilize exogenous glucose to synthesize hepatic glycogen, to regulating blood sugar good effect is arranged.Particularly to because of the various complication that diabetes caused, as utilize the anti-inflammation and sterilization effect of propolis, prevent and treat various infection; Utilize propolis to remove the effect of free radical, lipopenicillinase and reduction blood stickiness, can prevent the generation of vascular system disease; The raising immunity of propolis can make people's resistance against diseases strengthen or the like.In daily life, utilizing propolis to improve health and prophylactic generation, is very safe, and the side effect that does not have medicine to bring.Now, along with growth in the living standard, the change of dietary structure makes the disease of this respect become younger, and a middle-aged person's the ratio of falling ill should cause our enough attention increasing.
6, suppress the effect of analgesia and local anaesthesia: the inhibition analgesia of propolis and the effect of local anaesthesia, on the books very early both at home and abroad.The scientific worker can match in excellence or beauty with other anaesthetics through the local anaesthesia effect that experiment showed, propolis.Use if mix, can make anesthetic effect synergy, also do not have side effect.In life, can be placed on toothache position pain relieving to propolis; Available propolis spreads upon on the wound, plays the effect of anti-inflammatory and analgesic.
7, anti-inflammatory and antiulcer action: propolis has film forming, in antibiotic, antiviral, analgesic activity, has brought into play the effect of anti-inflammatory.It all has good antiinflammation to ENT diseases such as canker sore, periodontitis, bronchitis, pharyngitis, tonsillitis, rhinitis, nasosinusitis, otitis externas.In addition, propolis can form diaphragm on ulcer surfaces such as gastric ulcer, duodenal ulcer, brings into play the effect of sterilization, promotion regeneration simultaneously, can reach effective antiulcer purpose.Equally, propolis also has good effect to enteritis.In environment now, various pressure, excess ingestion stimulate food, heavy drinking etc. all can cause ulcer to take place, so we should notice that the oneself releases the pressure, and are careful in one's diet, and form good habits and customs.
8, beautification function:,, reach cosmetic purpose through regulating endocrine, improving blood circulation state because propolis has the effect of anti-inflammatory, promotion regeneration.But propolis cosmetics bactericidal antiphlogistic, anti-bursting by freezing, anti-infect etc., respond well to acne.Propolis also has good effect to alopecia.The effect of propolis also more than these, along with development of science and technology, the effect of propolis also can constantly come to light.On the whole, propolis is through the adjusting to the whole body function to people's benefit, enhance metabolism, thereby reach improve the health, the purpose of across-the-board regulation.
9, immunological enhancement: human body self has immune system, in order to infringements such as opposing germs.If immunity is low, with regard to susceptible disease.And the synergy of the composition in the propolis can increase antibody activity, and total serum protein and gamma globulin are increased, and strengthens the phagocytic activity of leucocyte and macrophage, improves body specificity and non-specific immune function.Under the huge environment of current life, operating pressure, sub-health status such as tired, deficient in energy, insomnia appear easily, cause immunity degradation, and propolis can improve immunity, the enhancing resistance against diseases is improved sub-health status.
Above-mentioned red ant, vine polyphenol and propolis all has single health product on market; But all there is function singleness in they, and the shortcoming of poor effect is taken wherein one or more health products for a long time; The ratio that health products are taken because very difficult assurance is respectively distinguished the flavor of; Can consume a large amount of money on the one hand, cause the unbalance situation of endotrophic state on the other hand probably, produce certain side effect.
Summary of the invention the purpose of this invention is to provide the composition of a kind of Formica rufa with health care, grape, propolis extract; It makes full use of the interaction between red ant, vine polyphenol and the propolis; Curative effect is single unilateral when overcoming their independent uses; The shortcoming of poor effect has realized the optimization of care treatment effect.
Composition of the present invention contains red extract from ants, vine polyphenol and propolis extract; The weight of described red extract from ants is the 20%-50% of composition weight; The weight of described vine polyphenol is the 20%-40% of composition weight, and the weight of described propolis extract is the 20%-40% of composition weight.
Preferably, the weight of described red extract from ants is 40% of composition weight, and the weight of described vine polyphenol is 30% of composition weight, and the weight of described propolis extract is 30% of composition weight.
Described red extract from ants is that red ant get the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 3-4.8 times of red ant weight during lixiviate, and extraction time is 40-48 hour, and extraction temperature is 5-30 ℃.Concrete processing technology does, catches the wild red ant and carries out cleaning and sterilizing, soaks with acetone solution, centrifugalizes out the acetone leaching liquor, the acetone leaching liquor reclaimed oven dry obtain red extract from ants.
Described vine polyphenol is after the lixiviate of grape pip process ethanol the alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 40-50 ℃.Concrete processing technology does, collects grape pip and carries out cleaning and sterilizing, the grape pip after the sterilization is pulverized, and the alcohol immersion with 95%, the isolated by filtration alcohol extract reclaims to dry to alcohol extract and obtains vine polyphenol.
Described propolis extract is after the lixiviate of propolis process ethanol the alcohol extract oven dry to be got; Ethanol employing volume fraction is 75% ethanol during lixiviate; Its weight is 2-4 times of propolis weight; Extraction time is 24 hours, and extraction temperature is 40-50 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is 0-5 ℃ after the lixiviate.Concrete processing technology does, collects propolis and carries out fragmentation, and with 75% alcohol immersion, low-temperature centrifugation deleading paraffin removal reclaims to dry to alcohol extract and obtains propolis extract with the propolis after the fragmentation.
The formulation of the present composition is capsule, tablet, electuary, granule, pill, powder.Wherein preferred capsule.
The application of the present composition in preparation food or health products.
Compared with prior art; The organic compatibility of optimal proportion that the present invention draws red ant, vine polyphenol and propolis according to test of many times together; The tonic effect of each herbal medicine is mutually promoted; Guarantee simultaneously the balance picked-up of nutrition on the whole, thereby realized the optimization of care treatment effect, reached the purpose of the ill no disease and health of curing the disease.Composition of the present invention is contained human body eight big system desired nutritionals, realizes real comprehensive health care, whole body conditioning.
Its comprehensive effect is:
1, repair impaired gene, activating cell improves the cell metabolism level.Fundamentally realize removing beverage, beauty treatment, beauty treatment;
2, reconcile the endocrine level from root, effectively treat diabetes, complication prevention.Elimination comprises all diseases that produce because of endocrinopathy climacteric.Let people skip climacteric.
3, improve body immunity, the treatment lupus erythematosus strengthens vivo antitumor factor quantity, suppresses growth of tumour cell, dissolves the side effect that produces because of radiotherapy chemotherapy;
4, remove interior free yl; Improve cardiac and cerebral blood-supply, effectively solve diseases such as hypertension, coronary heart disease, myocardial hypertrophy, tachycardia, bradycardia, premature beat, atrial fibrillation, valve incompetence, uncomfortable in chest, angina pectoris, miocardial infarction, cerebral thrombus, cerebral hemorrhage, encephalatrophy, high cholesterol, high fat of blood, artery sclerosis, cardiac insufficiency, cerebral blood supply insufficiency, anaemia;
5, block and kill virus, dissolve the liver nephrotoxin, protect the liver and protect kidney, eliminate cholecystitis, pancreatitis, eliminating liver and gall kidney stone;
6, improve physiology (property) function, prolong physiological longevity, eliminate diseases such as ephritis, impotence, premature ejaculation, frigidity;
7, promote the growth of intestines and stomach profitable strain, improve digestive function, eradicate gastritis, gastric ulcer, colitis, constipation and other diseases, promote nutrient absorption;
Diseases such as 8, treatment dizziness, insomnia, forgetful, Parkinson, senile dementia, arthritis, rheumatoid disease, osteoproliferation, prostate;
9, strengthen all organ dysfunctions of health, delay senility life-saving.
The specific embodiment
Composition of the present invention contains red extract from ants, vine polyphenol and propolis extract; The weight of described red extract from ants is the 20%-50% of composition weight; The weight of described vine polyphenol is the 20%-40% of composition weight, and the weight of described propolis extract is the 20%-40% of composition weight.
Preferably, the weight of described red extract from ants is 40% of composition weight, and the weight of described vine polyphenol is 30% of composition weight, and the weight of described propolis extract is 30% of composition weight.
Described red extract from ants is that red ant get the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 3-4.8 times of red ant weight during lixiviate, and extraction time is 40-48 hour, and extraction temperature is 5-30 ℃.Concrete processing technology does, catches the wild red ant and carries out cleaning and sterilizing, soaks with acetone solution, centrifugalizes out the acetone leaching liquor, the acetone leaching liquor reclaimed oven dry obtain red extract from ants.
Described vine polyphenol is after the lixiviate of grape pip process ethanol the alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 40-50 ℃.Concrete processing technology does, collects grape pip and carries out cleaning and sterilizing, the grape pip after the sterilization is pulverized, and the alcohol immersion with 95%, the isolated by filtration alcohol extract reclaims to dry to alcohol extract and obtains vine polyphenol.
Described propolis extract is after the lixiviate of propolis process ethanol the alcohol extract oven dry to be got; Ethanol employing volume fraction is 75% ethanol during lixiviate; Its weight is 2-4 times of propolis weight; Extraction time is 24 hours, and extraction temperature is 40-50 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is 0-5 ℃ after the lixiviate.Concrete processing technology does, collects propolis and carries out fragmentation, and with 75% alcohol immersion, low-temperature centrifugation deleading paraffin removal reclaims to dry to alcohol extract and obtains propolis extract with the propolis after the fragmentation.
The formulation of the present composition is capsule, tablet, electuary, granule, pill, powder.Wherein preferred capsule.
Lixiviate of the present invention, low-temperature centrifugation, formulation preparation method all can adopt correlation technique of the prior art, equipment and parameter except that specified otherwise is arranged.
The application of the present composition in preparation food or health products.
A kind of mode of taking of the present invention becomes capsule, tablet, electuary, granule, pill, the powder of 0.5mg/ grain with preparation of compositions, takes three or three parts every day.
Further specify below in conjunction with specific embodiment:
Embodiment 1: composition of the present invention contains red extract from ants, vine polyphenol and propolis extract; The weight of described red extract from ants is 20% of composition weight; The weight of described vine polyphenol is 40% of composition weight, and the weight of described propolis extract is 40% of composition weight.
Described red extract from ants is that red ant gets the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 3 times of red ant weight during lixiviate, and extraction time is 40 hours, and extraction temperature is 30 ℃.
Described vine polyphenol is after the lixiviate of grape pip process ethanol the alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 40 ℃.
Described propolis extract is after the lixiviate of propolis process ethanol the alcohol extract oven dry to be got; Ethanol employing volume fraction is 75% ethanol during lixiviate; Its weight is 2 times of propolis weight; Extraction time is 24 hours, and extraction temperature is 50 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is 0 ℃ after the lixiviate.
Embodiment 2: composition of the present invention contains red extract from ants, vine polyphenol and propolis extract; The weight of described red extract from ants is 50% of composition weight; The weight of described vine polyphenol is 20% of composition weight, and the weight of described propolis extract is 30% of composition weight.
Described red extract from ants is that red ant gets the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 4.8 times of red ant weight during lixiviate, and extraction time is 48 hours, and extraction temperature is 5 ℃.
Described vine polyphenol is after the lixiviate of grape pip process ethanol the alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 50 ℃.
Described propolis extract is after the lixiviate of propolis process ethanol the alcohol extract oven dry to be got; Ethanol employing volume fraction is 75% ethanol during lixiviate; Its weight is 2-4 times of propolis weight; Extraction time is 24 hours, and extraction temperature is 40 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is-5 ℃ after the lixiviate.
Embodiment 3: composition of the present invention contains red extract from ants, vine polyphenol and propolis extract; The weight of described red extract from ants is 40% of composition weight; The weight of described vine polyphenol is 40% of composition weight, and the weight of described propolis extract is 20% of composition weight.
Described red extract from ants is that red ant gets the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 4 times of red ant weight during lixiviate, and extraction time is 44 hours, and extraction temperature is 25 ℃.
Described vine polyphenol is after the lixiviate of grape pip process ethanol the alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 45 ℃.
Described propolis extract is after the lixiviate of propolis process ethanol the alcohol extract oven dry to be got; Ethanol employing volume fraction is 75% ethanol during lixiviate; Its weight is 2-4 times of propolis weight; Extraction time is 24 hours, and extraction temperature is 45 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is-3 ℃ after the lixiviate.
Embodiment 4: composition of the present invention contains red extract from ants, vine polyphenol and propolis extract; The weight of described red extract from ants is 40% of composition weight; The weight of described vine polyphenol is 30% of composition weight, and the weight of described propolis extract is 30% of composition weight.
Described red extract from ants is that red ant gets the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 3 times of red ant weight during lixiviate, and extraction time is 40 hours, and extraction temperature is 28 ℃.
Described vine polyphenol is after the lixiviate of grape pip process ethanol the alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 48 ℃.
Described propolis extract is after the lixiviate of propolis process ethanol the alcohol extract oven dry to be got; Ethanol employing volume fraction is 75% ethanol during lixiviate; Its weight is 3 times of propolis weight; Extraction time is 24 hours, and extraction temperature is 43 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is-4 ℃ after the lixiviate.
Embodiment 5: composition of the present invention contains red extract from ants, vine polyphenol and propolis extract; The weight of described red extract from ants is 35% of composition weight; The weight of described vine polyphenol is 38% of composition weight, and the weight of described propolis extract is 27% of composition weight.
Described red extract from ants is that red ant gets the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 4.3 times of red ant weight during lixiviate, and extraction time is 42 hours, and extraction temperature is 15 ℃.
Described vine polyphenol is after the lixiviate of grape pip process ethanol the alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 47 ℃.
Described propolis extract is after the lixiviate of propolis process ethanol the alcohol extract oven dry to be got; Ethanol employing volume fraction is 75% ethanol during lixiviate; Its weight is 2.5 times of propolis weight; Extraction time is 24 hours, and extraction temperature is 43 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is-2 ℃ after the lixiviate.
Embodiment 6: composition of the present invention contains red extract from ants, vine polyphenol and propolis extract; The weight of described red extract from ants is 28% of composition weight; The weight of described vine polyphenol is 37% of composition weight, and the weight of described propolis extract is 35% of composition weight.
Described red extract from ants is that red ant gets the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 4.5 times of red ant weight during lixiviate, and extraction time is 46 hours, and extraction temperature is 10 ℃.
Described vine polyphenol is after the lixiviate of grape pip process ethanol the alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 43 ℃.
Described propolis extract is after the lixiviate of propolis process ethanol the alcohol extract oven dry to be got; Ethanol employing volume fraction is 75% ethanol during lixiviate; Its weight is 3.3 times of propolis weight; Extraction time is 24 hours, and extraction temperature is 49 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is-1 ℃ after the lixiviate.
Experimental example 1: the married male sex crowd with the 35-45 age in year is an experimental subjects, and 124 of picked at random are carried out clinical testing, to being divided into experimental group and control group; Each 62; Experimental group member takes one of capsule of the present invention (three on the one) morning, noon and afternoon every day, presses embodiment 4 preparations, 3 months courses of treatment; The control group morning, noon and afternoon are taken the placebo (food starch) identical with weight outward appearance of the present invention, 3 months courses of treatment.
Employing experiment front and back check UP respectively (comprising routine blood test, liver function, myocardial function etc.) and the method for (comprising diet, sleep, the state of mind, sense of fatigue, life quality) of inquiring is added up:
Blood each item index all has the variation (comprising blood sugar, blood fat, immunocyte quantity) of trend normal value in the experimental group, myocardium each item index trend normal value, liver function each item index trend normal value; Through inquiry, experimental group 62 philtrums have 55 people to represent that diet, sleep, the state of mind, sense of fatigue, life quality have clear improvement, and remain 7 people and represent to have slight improvement.
Each item index among the control group crowd does not have significant change, inquiry control group member, and all expression does not have significant change.
Experimental example 2: being experimental subjects often near housewife 60 people in the 40-50 of oil smoke year; To being divided into experimental group and control group, every group of each 30 people, experimental group member take 1 of capsule of the present invention (3 on the one) morning, noon and afternoon every day; Press embodiment 1 preparation; Be 3 months the course of treatment, and control group morning, noon and afternoon every day are taken the placebo (food starch) identical with weight outward appearance of the present invention, 3 months courses of treatment.
Experimental group member's facial glossiness all has clear improvement, and wherein, has 22 people's skin age testing result to show than the rejuvenation that 5-8 is arranged before the experiment in the experimental group.The control group skin of face does not obviously improve.
Learn that through inquiry experimental group member representes not occur menopause symptom or menopause symptom is obviously improved or disappearance.Tangible menopause symptom appears in 50% above crowd among the control group member.
Experimental example 3: the married male sex crowd with the 35-45 age in year is an experimental subjects, and 70 of picked at random are carried out clinical testing, and per 10 people divide one group, totally 7 groups, comprise 6 experimental group and 1 control group.Experimental group 1-6 takes the composition of embodiment 1-6 preparation respectively, and control group is taken the placebo (food starch) identical with weight outward appearance of the present invention, and morning, noon and afternoon every day are taken 1 of capsule of the present invention (3 on the one), 3 months courses of treatment.
Employing experiment front and back check UP respectively (comprising routine blood test, liver function, myocardial function etc.) and the method for (comprising diet, sleep, the state of mind, sense of fatigue, life quality) of inquiring is added up:
Blood each item index all has the variation (comprising blood sugar, blood fat, immunocyte quantity) of trend normal value in the experimental group, myocardium each item index trend normal value, liver function each item index trend normal value; Through inquiry; The number that each item condition in the experimental group (comprising diet, sleep, the state of mind, sense of fatigue, life quality) obviously improves is: experimental group 1 is 8 people, and experimental group 2 is 9 people, and experimental group 3 is 9 people; Experimental group 4 is 10 people; Experimental group 5 is 8 people, and experimental group 6 is 9 people, and remaining expression per capita makes moderate progress in each group.
Each item index among the control group crowd does not have significant change, inquiry control group member, and all expression does not have significant change.
Experimental example 4: to be experimental subjects near housewife 70 people in the 40-50 of oil smoke year often, per 10 people divide one group, totally 7 groups, comprise 6 experimental group and 1 control group.Experimental group 1-6 takes the composition of embodiment 1-6 preparation respectively, and control group is taken the placebo (food starch) identical with weight outward appearance of the present invention, and morning, noon and afternoon every day are taken 1 of capsule of the present invention (3 on the one), 3 months courses of treatment.
Experimental group member's facial glossiness all has clear improvement; Wherein, skin age testing result shows have the number of the rejuvenation of 5-8 to be before the experiment in each experimental group: experimental group 1 is 9 people, and experimental group 2 is 9 people; Experimental group 3 is 9 people; Experimental group 4 is 10 people, and experimental group 5 is 8 people, and experimental group 6 is 9 people.The control group skin of face does not obviously improve.
Learn that through inquiry experimental group member representes not occur menopause symptom or menopause symptom is obviously improved or disappearance.Tangible menopause symptom appears in 8 people among the control group member.
Can prove that thus composition of the present invention has following health care:
1, repair impaired gene, activating cell improves the cell metabolism level.Fundamentally realize removing beverage, beauty treatment, beauty treatment;
2, reconcile the endocrine level from root, effectively treat diabetes, complication prevention.Elimination comprises all diseases that produce because of endocrinopathy climacteric.Let people skip climacteric.
3, improve body immunity, the treatment lupus erythematosus strengthens vivo antitumor factor quantity, suppresses growth of tumour cell, dissolves the side effect that produces because of radiotherapy chemotherapy;
4, remove interior free yl; Improve cardiac and cerebral blood-supply, effectively solve diseases such as hypertension, coronary heart disease, myocardial hypertrophy, tachycardia, bradycardia, premature beat, atrial fibrillation, valve incompetence, uncomfortable in chest, angina pectoris, miocardial infarction, cerebral thrombus, cerebral hemorrhage, encephalatrophy, high cholesterol, high fat of blood, artery sclerosis, cardiac insufficiency, cerebral blood supply insufficiency, anaemia;
5, block and kill virus, dissolve the liver nephrotoxin, protect the liver and protect kidney, eliminate cholecystitis, pancreatitis, eliminating liver and gall kidney stone;
6, improve physiology (property) function, prolong physiological longevity, eliminate diseases such as ephritis, impotence, premature ejaculation, frigidity;
7, promote the growth of intestines and stomach profitable strain, improve digestive function, eradicate gastritis, gastric ulcer, colitis, constipation and other diseases, promote nutrient absorption;
Diseases such as 8, treatment dizziness, insomnia, forgetful, Parkinson, senile dementia, arthritis, rheumatoid disease, osteoproliferation, prostate;
9, strengthen all organ dysfunctions of health, delay senility life-saving.
Claims (10)
1. the composition of the Formica rufa with health care, grape, propolis extract; It is characterized in that: described composition contains red extract from ants, vine polyphenol and propolis extract; The weight of described red extract from ants is the 20%-50% of composition weight; The weight of described vine polyphenol is the 20%-40% of composition weight, and the weight of described propolis extract is the 20%-40% of composition weight.
2. composition according to claim 1; It is characterized in that: the weight of described red extract from ants is 40% of composition weight; The weight of described vine polyphenol is 30% of composition weight, and the weight of described propolis extract is 30% of composition weight.
3. composition according to claim 1 and 2 is characterized in that: described red extract from ants is after the lixiviate of red ant process acetone the oven dry of acetone leaching liquor to be got.
4. composition according to claim 3 is characterized in that: during lixiviate the weight of acetone be red ant weight 3-4.8 doubly, extraction time is 40-48 hour, extraction temperature is 5-30 ℃.
5. composition according to claim 1 and 2 is characterized in that: described vine polyphenol is after the lixiviate of grape pip process ethanol the alcohol extract oven dry to be got.
6. composition according to claim 5 is characterized in that: ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 40-50 ℃.
7. composition according to claim 1 and 2 is characterized in that: described propolis extract is after the lixiviate of propolis process ethanol the alcohol extract oven dry to be got.
8. composition according to claim 7; It is characterized in that: ethanol employing volume fraction is 75% ethanol during lixiviate, and its weight is 2-4 times of propolis weight, and extraction time is 24 hours; Extraction temperature is 40-50 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is 0-5 ℃ after the lixiviate.
9. composition according to claim 1 and 2 is characterized in that: the formulation of said composition is capsule, tablet, electuary, granule, pill, powder.
10. the application of composition according to claim 1 and 2 in preparation food or health products.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107455539A (en) * | 2017-06-12 | 2017-12-12 | 安徽真心食品有限公司 | A kind of honey green tea taste raisins processing method |
| CN111012772A (en) * | 2020-01-06 | 2020-04-17 | 华中科技大学同济医学院附属协和医院 | Application of caffeic acid phenethyl ester in treating aortic valve calcification disease |
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| CN1537622A (en) * | 2003-10-22 | 2004-10-20 | 吕国安 | Health-care food used for relaxing bowel, anti-senility and beautifying face |
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| CN1078143A (en) * | 1993-05-15 | 1993-11-10 | 中国人民解放军空军第四研究所 | XUANJU oral liquid and preparation technology thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107455539A (en) * | 2017-06-12 | 2017-12-12 | 安徽真心食品有限公司 | A kind of honey green tea taste raisins processing method |
| CN111012772A (en) * | 2020-01-06 | 2020-04-17 | 华中科技大学同济医学院附属协和医院 | Application of caffeic acid phenethyl ester in treating aortic valve calcification disease |
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| CN102308989B (en) | 2013-03-27 |
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