CN102302584A - Chinese medicinal preparation for treating rhinitis - Google Patents
Chinese medicinal preparation for treating rhinitis Download PDFInfo
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- CN102302584A CN102302584A CN201110287482A CN201110287482A CN102302584A CN 102302584 A CN102302584 A CN 102302584A CN 201110287482 A CN201110287482 A CN 201110287482A CN 201110287482 A CN201110287482 A CN 201110287482A CN 102302584 A CN102302584 A CN 102302584A
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- rhinitis
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Abstract
The invention discloses a Chinese medicinal preparation for treating rhinitis. The effective components for preparing the medicament comprise the following raw materials by weight: 6 to 12g of tree peony bark root, 3 to 10g of biond magnolia flower, 6 to 12g of smoked plum, and 2 to 10g of liquorice. According to the preparation, the symptom of rhinitis can be improved and can be regulated from the perspective of immunology to achieve anti-inflammation and anti-anaphylaxis effects; the preparation can be used for treating both the symptoms and root causes and controlling asthma of patients with rhinitis and asthma, and the adverse reaction is slight; and the preparation process is simple, the administration is convenient, and the price is low.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation of treating rhinitis.
Background technology
Along with the variation of industrialized development and biochemical environment, the sickness rate of allergic rhinitis benefit day increases, and has become a global health problem.At present, medical circle is generally acknowledged the in close relations of rhinitis and asthma, is considered to an air flue, a kind of disease.Calendar year 2001 World Health Organization (WHO) to have write " processing of allergic rhinitis and to the influence of asthma " be famous ARIA plan.Wherein, the treatment of rhinitis has been proposed serial scheme, institute's medicament is to be master's western medicine scheme with topical application hormone and antihistamine drug, exists the effect of taking stopgap measures not rapid, the shortcoming that permanent curing action is very little; Moreover need uninterrupted prolonged application, because drug price is expensive, patient's compliance is poor.In addition, because topical application, medicine is difficult to arrive nasal sinuses hole chamber, can not treat sinusitis, causes a lot of patients to have to select operative treatment.Therefore, be necessary to develop a kind of Chinese medicine preparation of treating rhinitis.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine preparation of treating rhinitis.
In order to realize the foregoing invention purpose, characteristics of the present invention are that raw material composition and the weight proportion thereof of processing this effective ingredient are: Cortex Moutan 6-12g, Flos Magnoliae 3-10g, Fructus Mume 6-12g, Radix Glycyrrhizae 2-10g.
Preferred prescription of the present invention is that raw material composition and the weight proportion thereof of processing this effective ingredient are: Cortex Moutan 8-10g, Flos Magnoliae 5-8g, Fructus Mume 8-10g, Radix Glycyrrhizae 5-8g.
In the drug prescription: Cortex Moutan, bitter in the mouth, suffering, cold nature, GUIXIN, liver, kidney channel, but clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; Modern medicine study thinks that Cortex Moutan has the effect of antiinflammatory, antiallergic action and desensitization, so be monarch drug.Flos Magnoliae, acrid in the mouth, warm in nature, attach to the lung and stomach meridians, the ability dispersing wind and cold, clearing the nasal passage is ministerial drug.Fructus Mume, sour in the mouth, puckery, property is flat, returns liver, spleen, lung, large intestine channel, can astringe the lung and promote the production of body fluid, and can be used for chronic cough of deficiency lung, is adjuvant drug.Radix Glycyrrhizae, sweet in the mouth property is flat, goes into the heart, lung, spleen, stomach warp, the QI invigorating invigorating middle warmer, the mediation property of medicine is messenger drug.All medicines are shared, gather nourishing YIN and clearing away heat, the sensible merit of circulation of qi promoting altogether.
The present invention has nourishing YIN and clearing away heat, and the effect that circulation of qi promoting is sensible cures mainly that allergic rhinitis, sinusitis, waste gas are weak, wind heat is taken advantage of lung disease.Disease is seen: rhinocnesmus, nasal cavity are stopped up match, and sneeze is done frequently, and meeting cold, steam etc. stimulates then thin nasal discharge ripples ripples, and time ends when doing.Pale complexion, breathe hard nasal mucosa swelling, pale, the clear rare or thickness of secretions.Body of the tongue is slightly red, thin lingual fur or BOHUANG, floating and rapid pulse.
Through clinical experiment curative effect of the present invention is verified below.
1 case history source
This group case all derives from the inpatient of Weifang City asthma hospital, totally 134 examples.Wherein male 69 examples, women 65 examples; Age between 15 years old~65 years old, 37.4 years old mean age; Course of disease 3-35, average 8.7 years.
2 diagnostic criterias
(1) diagnostic criteria of allergia nose-sinusitis, with reference to Society of Ophthalmology of China, Chinese hals,Nasen und Ohrenheilkunde magazine editorial board. diagnosis of allergic rhinitis standard and efficacy assessment standard;
(2) said preparation traditional Chinese medical science disease diagnostic criteria: " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " according to State Administration of Traditional Chinese Medicine's promulgation cures mainly formulation in conjunction with the said preparation function.
3 include standard in
1. meet the diagnostic criteria of doctor trained in Western medicine allergia nose-sinusitis, with reference to Society of Ophthalmology of China, Chinese hals,Nasen und Ohrenheilkunde magazine editorial board. diagnosis of allergic rhinitis standard and efficacy assessment standard;
2. meet this sick traditional Chinese medical science disease diagnostic criteria: insufficiency of lung-QI, wind heat are taken advantage of lung disease;
3. the age is in 18~65 one full year of life;
4. sign Informed Consent Form.
4 exclusion standards
1. gestation or women breast-feeding their children;
2. to this drug allergy person;
3. be associated with serious diseases such as cardiovascular, liver, kidney and hemopoietic system, the psychotic;
4. merge nose chronic tumor.
5 Therapeutic Method
Adopt the granule of the embodiment of the invention 3 preparations, oral every day 2 times, each 6-12g, 2 weeks of the course of treatment.
All cases are stopped using treatments such as nasal cavity cleaning, physical therapy, immunity at part or the whole body antiallergic class medicine of stopping using in last week of treatment by Chinese herbs during the treatment, set up the clinical observation archives and follow up a case by regular visits to March.
6 observational techniques
(1) safety observation
1. general health check-up project;
2. blood, urine, just routine examination;
3. electrocardiogram, liver function, kidney function test;
4. write down untoward reaction.
(2) symptom and sign scoring: combine this requirement of experiment to formulate according to the study of tcm new drug guideline, see table 1 for details.
Table 1 allergia nose-sinusitis symptom and sign classification score standard
(3) curative effect judging standard is formulated with reference to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " of " the anxious nasal sinusitis clinical research of new Chinese medicine guideline is formulated " and State Administration of Traditional Chinese Medicine's promulgation.
(1) clinical recovery clinical symptoms, sign disappear or basic the disappearance, and symptom integral reduces >=95%.
(2) produce effects individual event clinical symptoms, sign are obviously sent, and symptom integral reduces >=70%.
(3) effectively individual event clinical symptoms, sign all take a favorable turn, and symptom integral reduces >=30%.
(4) invalid individual event clinical symptoms, sign all do not have obvious transmission, even increase the weight of, the syndrome integration reduces less than 30%.
Annotate: symptom integral reduces computing formula (nimodipine method) and is: [ integration before (integration before the treatment-treatment back integration) ÷ treatment ] * 100%.
4 statistical procedures:
5 results
(1) safety detects
Treatment bleeding from anus, urine, just routine examination and electrocardiogram, liver function, kidney function test no abnormality seen.According to the untoward reaction record, 5 routine patients are only arranged when first week, feel slight gastrointestinal upset, do not do special handling, its uncomfortable anesthesia in the time of second week, not influence treatment.
(2) the symptom and sign scoring changes
The symptom and sign 7 one l5 branches of always keeping the score before the 134 routine patient treatments, average 10.2 ± 4.7 minutes, the symptom and sign 7 one l5 branches of always keeping the score in treatment back average 3.9 ± 3.1 minutes, relatively had significant difference before and after the treatment.P<0.05。
(3) curative effect is judged
According to the clinical efficacy criterion, produce effects 91 examples account for 67.9%; Effective 28 examples account for 20.9%, and total effective rate is 88.8%.The bimester of stopping to treat the back, recur 19 examples altogether, total relapse rate 14.2% in January after stopping to treat, recurs 3 examples, relapse rate 2.2%; The bimester of stopping to treat the back, recur 16 examples again, total relapse rate 14.2%.
6 conclusions
Chinese medicine preparation total effective rate provided by the present invention reaches 88.8%, can significantly improve patient's clinical symptoms, and the symptom and sign scoring dropped to average 3.9 ± 3.1 minutes by average 10.2 ± 4.7 minutes before and after the treatment, relatively had significant difference before and after the treatment, and P < 0.05.It is lower to stop to treat the back relapse rate, and few side effects, 5 routine patients is only arranged when first week, feels slight gastrointestinal upset, does not do special handling, its uncomfortable anesthesia in the time of second week.This shows that the present invention has nourishing YIN and clearing away heat, the sensible merit of circulation of qi promoting, is effective, safe, the inexpensive medicine of treatment allergia nose-sinusitis.
The invention has the advantages that: 1. effect is good, can not only improve the rhinitis symptom, can also regulate from the immunology angle, reaches the antianaphylactic effect of antiinflammatory, treating both the principal and secondary aspects of a disease, and the patient who merges asthma for rhinitis helps the control of asthma, and untoward reaction is very little.2. compare with the rhinitis medicine that ARIA recommends, it is convenient to make simple medication, meets compatriots' medication custom, and easy is that extensive patients is accepted, and cheap, has alleviated the problem of patient's high cost of getting medical treatment.3. relapse rate is low.4. drug safety, few side effects.
The specific embodiment
Embodiment 1 gets Cortex Moutan 300g, Flos Magnoliae 350g, Fructus Mume 300g and Radix Glycyrrhizae 100g by proportion relation, mixes the back decocte with water and produces decocting liquid, decocts altogether 3 times, adds water 4200 grams at every turn, decocts 2 hours at every turn.Merge 3 times decocting liquid; It is 1.28-1.30 (80 ℃) clear paste (crude product) that concentrating under reduced pressure becomes density; In clear paste (crude product), adding ethanol purifies; Supernatant is evaporated to the clear paste (elaboration) that density is 1.32-1.34 (60 ℃); In clear paste (elaboration), add dextrin, sucrose then; Process drug particles again and be packaged into bag, every bag of 6g.
Embodiment 2 gets Cortex Moutan 450g, Flos Magnoliae 150g, Fructus Mume 450g and Radix Glycyrrhizae 300g by proportion relation, mixes the back decocte with water and produces decocting liquid, decocts altogether 3 times, adds water 5400 grams at every turn, decocts 2 hours at every turn.Merge 3 times decocting liquid; It is 1.28-1.30 (80 ℃) clear paste (crude product) that concentrating under reduced pressure becomes density; In clear paste (crude product), adding ethanol purifies; Supernatant is evaporated to the clear paste (elaboration) that density is 1.32-1.34 (60 ℃); In clear paste (elaboration), add dextrin, sucrose then; Process drug particles again and be packaged into bag, every bag of 6g.
Embodiment 3 gets Cortex Moutan 600g, Flos Magnoliae 500g, Fructus Mume 600g and Radix Glycyrrhizae 500g by proportion relation, mixes the back decocte with water and produces decocting liquid, decocts altogether 3 times, adds water 8800 grams at every turn, decocts 2 hours at every turn.Merge 3 times decocting liquid; It is 1.28-1.30 (80 ℃) clear paste (crude product) that concentrating under reduced pressure becomes density; In clear paste (crude product), adding ethanol purifies; Supernatant is evaporated to the clear paste (elaboration) that density is 1.32-1.34 (60 ℃); In clear paste (elaboration), add dextrin, sucrose then; Process drug particles again and be packaged into bag, every bag of 6g.
Claims (2)
1. a Chinese medicine preparation of treating rhinitis is characterized in that raw material composition and the weight proportion thereof of processing this effective ingredient are: Cortex Moutan 6-12g, Flos Magnoliae 3-10g, Fructus Mume 6-12g, Radix Glycyrrhizae 2-10g.
2. the Chinese medicine preparation of treatment rhinitis according to claim 1 is characterised in that the raw material of processing this effective ingredient is formed and weight proportion is: Cortex Moutan 8-10g, Flos Magnoliae 5-8g, Fructus Mume 8-10g, Radix Glycyrrhizae 5-8g.
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CN201110287482A CN102302584A (en) | 2011-09-26 | 2011-09-26 | Chinese medicinal preparation for treating rhinitis |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105056185A (en) * | 2015-08-12 | 2015-11-18 | 梁海通 | Traditional Chinese medicine for treating rhinitis |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1742825A (en) * | 2005-09-28 | 2006-03-08 | 骆斌 | Medicine preparation for preventing and treating allergic rhinitis and compliance rhinitis |
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1742825A (en) * | 2005-09-28 | 2006-03-08 | 骆斌 | Medicine preparation for preventing and treating allergic rhinitis and compliance rhinitis |
Non-Patent Citations (2)
Title |
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刘敬等: "中医治疗变应性鼻炎概况", 《河北中医》 * |
刘秀林等: "祝谌予过敏煎加味治疗过敏性鼻炎60例", 《河南中医》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105056185A (en) * | 2015-08-12 | 2015-11-18 | 梁海通 | Traditional Chinese medicine for treating rhinitis |
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Application publication date: 20120104 |