CN102289085B - Color contact lens with colloid crystal aquogel serving as pigment and preparation method thereof - Google Patents
Color contact lens with colloid crystal aquogel serving as pigment and preparation method thereof Download PDFInfo
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- CN102289085B CN102289085B CN 201110243803 CN201110243803A CN102289085B CN 102289085 B CN102289085 B CN 102289085B CN 201110243803 CN201110243803 CN 201110243803 CN 201110243803 A CN201110243803 A CN 201110243803A CN 102289085 B CN102289085 B CN 102289085B
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Abstract
The invention discloses a color contact lens with colloid crystal aquogel serving as a pigment. The color contact lens disclosed by the invention is characterized by comprising a contact lens body (12), wherein the colloid crystal aquogel (11) serving as a pigment component of color elements is mixed in the contact lens body (12); and the colloid crystal aquogel and the aquogel of the contact lens body (12) form interpenetrating grids. The contact lens disclosed by the invention is bright in color, is elegant in appearance and has the advantages of good biocompatibility and good practicality.
Description
Technical field
The invention belongs to the contact lens material studying technological domain, be specifically related to a kind of colorful contact lens take the colloidal crystal hydrogel as pigment and preparation method thereof.
Background technology
In in the past 30 years, the total number of persons that contact lenses are worn in the whole world has increased by 35 times, and colorful contact lens is also gradually popular owing to the drive of global fashion world.According to incompletely statistics, China's colorful contact lens accounts for more than 35% of contact lenses market at present.
Colorful contact lens can be divided into two large classes: the first kind is a kind of contact lenses that only have transparent or opaque colored pattern in contact lenses iris district, and this contact lenses iris district can manifest special design and color; The Equations of The Second Kind colorful contact lens is selected the color of transparent color enhancement contact lenses, the colorant of this substantial transparent is to be dispersed in uniformly whole contact lenses inside, this type of colorful contact lens not only can be deepened eye color, and can make eyes more lively, more life-like.Yet, because present contact lenses mostly are single color, still aobvious dull in aesthetic; In addition, current colorful contact lens is many need to have mixed colored pigment in contact lenses, these pigment often exist biocompatibility low, the problems such as surface irregularity, when the patient is worn serious foreign body sensation is arranged, the lighter causes wearing discomfort, and the problems such as corneal edema, cornea blood vessel hyperplasia, epithelial cell shedding may appear in severe patient, cause the disease of cornea such as acute blood-shoot-eye illness, and then may affect one's power of vision.
That considers client wears the mirror safety and health, and satisfying sense of loving to make up and wearing beautiful clothes, therefore, the needs exploitation is a kind of can satisfy the life requirement that people like to be beautiful, and can guarantee that again colored pigment can not affect eyes, can not cause any eye illness and uncomfortable colorful contact lens.The present invention therefore.
Summary of the invention
The object of the invention is to provide a kind of colorful contact lens take the colloidal crystal hydrogel as pigment, the pigment that has solved the available technology adopting colour injects and causes the biocompatibility of contact lenses low, surface irregularity has the serious problems such as foreign body sensation when the patient is worn.
In order to solve these problems of the prior art, technical scheme provided by the invention is:
A kind of colorful contact lens take the colloidal crystal hydrogel as pigment, comprise the contact lenses body, it is characterized in that sneaking into the colloidal crystal hydrogel as the pigment composition of color element in the described contact lenses body, described colloidal crystal hydrogel and contact lenses body hydrogel form the IPN grid.
Preferably, described colloidal crystal hydrogel is uniformly distributed in regional area or the Zone Full of contact lenses body.
Preferably, described colloidal crystal hydrogel be close packing or not closed packing opal structural or counter opal structure; The shape of colloidal crystal hydrogel is selected from one or more the combination in any in sphere, semisphere, the thin slice; The size of colloidal crystal hydrogel is between 100 nanometers to 100 micron.
Preferably, described colloidal crystal hydrogel is selected from one or more any mixing in methyl methacrylate, poly hydroxy ethyl acrylate, acetylbutyrylcellulose, siloxane methacrylate, fluorine silicon methacrylate, perfluor ether, N-vinylpyrrolidone, polyvinyl alcohol (PVA), glycidyl methacrylate or the Ethylene glycol dimethacrylate, contains or do not contain the colloidal nanoparticles material in the described hydrogel pigment.
Preferably, described colloidal nanoparticles is selected from one or more combination in any of nano silicon, polystyrene, polymethylmethacrylate, titania, iron oxide, gold, silver.
Preferably, the polymerization precursor of described contact lenses body hydrogel is selected from one or more any mixing in methyl methacrylate, poly hydroxy ethyl acrylate, acetylbutyrylcellulose, siloxane methacrylate, fluorine silicon methacrylate, perfluor ether, N-vinylpyrrolidone, polyvinyl alcohol (PVA), glycidyl methacrylate or the Ethylene glycol dimethacrylate.
Another object of the present invention is to provide a kind of preparation method of the colorful contact lens take the colloidal crystal hydrogel as pigment, it is characterized in that said method comprising the steps of:
(1) preparation process of colloidal crystal hydrogel pigment solution:
The colloidal crystal hydrogel of close packing or not closed packing is cut into small fragment, and in the front aggressiveness solution that adding preparation contact lenses are used, ultrasonic dispersion makes it be distributed in uniformly in the solution;
(2) the curing treatment step of solution in mould:
The colloidal crystal hydrogel pigment solution of step (1) preparation is added in the mould that is used for the contact lenses preparation, mould is placed high-pressure sodium lamp by the ultra-violet curing method or places in the baking oven by thermal curing method schemochrome colloidal solution is cured just sheet of formation contact lenses;
(3) the hydration process step of colorful contact lens:
Place salt solution aquation to the expansivity of hydrogel to stablize the first sheet of the contact lenses that solidify in the step (2) constant, make the colorful contact lens take the colloidal crystal hydrogel as pigment.
Preferably, when carrying out hydration process in the described method step (3), then in the salt solution of pH value at 8.0-10.0 aquation 12-24 hour first be that aquation expansivity of sheet at the beginning of the contact lenses is stablized the constant colorful contact lens that the colloidal crystal hydrogel is pigment that namely is able in 7.2 the salt solution in the pH value.
The colorful contact lens of the present invention take the colloidal crystal hydrogel as pigment is take colloidal crystal hydrogel pigment as color element, and colloidal crystal hydrogel pigment can be distributed in the whole contact lenses or be distributed in the regional area of contact lenses.The shape of colloidal crystal hydrogel can be rule, half rule or irregular.In experiment, this colloidal crystal hydrogel pigment can be single color or multicolour.
The pigment of the present invention take the colloidal crystal hydrogel as color element, this colloidal crystal hydrogel has interference effect to light, and then makes contact lenses with bright outward appearance.For other colorful contact lens, more gorgeous, more elegant in appearance based on the contact lenses color of colloidal crystal hydrogel pigment, and good biocompatibility, have good practicality.
Pigment can be solid color and multiple color, the present invention can use a kind of colloidal crystal hydrogel of color as pigment, also can use the colloidal crystal hydrogel of multiple color as pigment, that concrete color can be is red, orange, yellow, green, blue, in the indigo, purple one or more.
With respect to scheme of the prior art, advantage of the present invention is:
The present invention obtains a kind of colorful contact lens, and described contact lenses are take colloidal crystal hydrogel pigment as color element, and this pigment has interference effect to light, and then makes contact lenses with bright outward appearance.For other colorful contact lens, more gorgeous, more elegant in appearance based on the contact lenses color of colloidal crystal hydrogel pigment, and good biocompatibility, have good practicality.
Description of drawings
The invention will be further described below in conjunction with drawings and Examples:
Fig. 1 is the structural representation of the colorful contact lens of the embodiment of the invention take the colloidal crystal hydrogel as pigment; Wherein, 11 is the colloidal crystal hydrogel; 12 is the contact lenses body.
Embodiment
Below in conjunction with specific embodiment such scheme is described further.Should be understood that these embodiment are not limited to limit the scope of the invention for explanation the present invention.The implementation condition that adopts among the embodiment can be done further adjustment according to the condition of concrete producer, and not marked implementation condition is generally the condition in the normal experiment.
The colorful contact lens of embodiment 1 take the colloidal crystal hydrogel as pigment
1. the preparation of colloidal crystal hydrogel pigment solution:
Be that the monodispersive silica nano spherical particle of 100 nanometers is dispersed in the mixed solution of acrylamide and methylene diacrylamide with diameter, polymerization obtains colloid crystal film, shear the pigment units that film becomes particulate, nano particle in the corrosion micro unit, and after it is carried out drying, product is distributed to the hydrogel solution (mixed solution (mol ratio 20: 1) of hydroxyethyl methylacrylate (HEMA) and Ethylene glycol dimethacrylate (EGDMA), the different two fourth cyanogen mass volume ratios 0.1% of initiating agent azo) for preparing for contact lenses.
2. the curing of hydrogel solution in mould is processed:
The above-mentioned hydrogel solution of 100 microlitre volumes is added in the mould that is used for the contact lenses preparation, and 4 ℃ of lower high voltage mercury lamp radiation 30min solidify colloidal solution;
3. the hydration process of colorful contact lens:
Colloidal polymer after solidifying is peeled off from mould, directly hydration process; Hydration process divides two ones to carry out, and in the salt solution of pH8.0-10.0 aquation 12-24 hour first, then aquation to contact lenses expansivity was stablized constantly in the salt solution of pH7.2, finally obtains the bright contact lenses that contain colloidal crystal hydrogel pigment.
The colorful contact lens of embodiment 2 take the colloidal crystal hydrogel as pigment
1. the preparation of colloidal crystal hydrogel pigment solution:
Be that the monodispersive silica nano spherical particle of 100 nanometers is dispersed in the mixed solution of acrylamide and methylene diacrylamide with diameter, polymerization obtains colloid crystal film, shear the pigment units that film becomes particulate, nano particle in the corrosion micro unit, and after it is carried out drying, product is distributed to the hydrogel solution (mixed solution (mass ratio 20: 1) of siloxane methacrylate (SMA) and Ethylene glycol dimethacrylate (EGDMA), the different two fourth cyanogen mass volume ratios 0.1% of initiating agent azo) for preparing for contact lenses.
2. the curing of hydrogel solution in mould is processed:
The above-mentioned hydrogel solution of 100 microlitre volumes is added in the mould that is used for the contact lenses preparation, and 4 ℃ of lower high voltage mercury lamp radiation 30min solidify colloidal solution;
3. the hydration process of colorful contact lens:
Colloidal polymer after solidifying is peeled off from mould, directly hydration process; Hydration process divides two ones to carry out, and in the salt solution of pH8.0-10.0 aquation 12-24 hour first, then aquation to contact lenses expansivity was stablized constantly in the salt solution of pH7.2, finally obtains the bright contact lenses that contain colloidal crystal hydrogel pigment.
The performance test of the colorful contact lens of embodiment 3 take the colloidal crystal hydrogel as pigment
(1) light transmission test:
Select the colorful contact lens take the colloidal crystal hydrogel as pigment to be tested object, it is carried out the light transmission test, the result shows that the transmitance of white light reaches more than 94%;
(2) water cut test:
With oven drying method the colorful contact lens take the colloidal crystal hydrogel as pigment is carried out the water cut test, the result shows that its water percentage is higher than 60%;
(3) cytotoxicity test:
Because the cytotoxicity test can be prepared the genotoxic potential of objective reaction test sample, adopt ISO9363-1 method of testing commonly used, investigate the cytotoxicity of contact lenses and can accurately react its security, in the method, the grade that cell-cytotoxic reaction is divided into the 0-4 level, progression is lower, and the security of tested material is higher.Colorful contact lens take the colloidal crystal hydrogel as pigment and commercially available Hydron ultra-thin concealed glasses are done the contrast test of cytotoxicity, the result shows that the cytotoxicity of the colorful contact lens take the colloidal crystal hydrogel as pigment is the same with commercially available Hydron ultra-thin concealed glasses, be 0 grade, illustrated that eyeglass has higher security.
Above-mentioned example only is explanation technical conceive of the present invention and characteristics, and its purpose is to allow the people who is familiar with technique can understand content of the present invention and according to this enforcement, can not limit protection scope of the present invention with this.All equivalent transformations that Spirit Essence is done according to the present invention or modification all should be encompassed within protection scope of the present invention.
Claims (7)
1. colorful contact lens take the colloidal crystal hydrogel as pigment, comprise contact lenses body (12), it is characterized in that sneaking in the described contact lenses body (12) colloidal crystal hydrogel (11) as the pigment composition of color element, described colloidal crystal hydrogel and contact lenses body (12) hydrogel form the IPN grid; Opal structural or counter opal structure that described colloidal crystal hydrogel is close packing or not closed packing; The shape of colloidal crystal hydrogel is selected from one or more the combination in any in sphere, semisphere, the thin slice; The size of colloidal crystal hydrogel is between 100 nanometers to 100 micron.
2. the colorful contact lens take the colloidal crystal hydrogel as pigment according to claim 1 is characterized in that described colloidal crystal hydrogel (11) is uniformly distributed in regional area or the Zone Full of contact lenses body (12).
3. the colorful contact lens take the colloidal crystal hydrogel as pigment according to claim 1, it is characterized in that described colloidal crystal hydrogel is selected from one or more any mixing in methyl methacrylate, poly hydroxy ethyl acrylate, acetylbutyrylcellulose, siloxane methacrylate, fluorine silicon methacrylate, perfluor ether, N-vinylpyrrolidone, polyvinyl alcohol (PVA), glycidyl methacrylate or the Ethylene glycol dimethacrylate, contains or do not contain the colloidal nanoparticles material in the described hydrogel pigment.
4. the colorful contact lens take the colloidal crystal hydrogel as pigment according to claim 3 is characterized in that described colloidal nanoparticles is selected from one or more combination in any of nano silicon, polystyrene, polymethylmethacrylate, titania, iron oxide, gold, silver.
5. the colorful contact lens take the colloidal crystal hydrogel as pigment according to claim 1, the polymerization precursor that it is characterized in that described contact lenses body hydrogel are selected from one or more any mixing in methyl methacrylate, poly hydroxy ethyl acrylate, acetylbutyrylcellulose, siloxane methacrylate, fluorine silicon methacrylate, perfluor ether, N-vinylpyrrolidone, polyvinyl alcohol (PVA), glycidyl methacrylate or the Ethylene glycol dimethacrylate.
6. the preparation method of the colorful contact lens take the colloidal crystal hydrogel as pigment claimed in claim 1 is characterized in that said method comprising the steps of:
(1) preparation process of colloidal crystal hydrogel pigment solution:
The colloidal crystal hydrogel of close packing or not closed packing is cut into small fragment, and in the front aggressiveness solution that adding preparation contact lenses are used, ultrasonic dispersion makes it be distributed in uniformly in the solution;
(2) the curing treatment step of solution in mould:
The colloidal crystal hydrogel pigment solution of step (1) preparation is added in the mould that is used for the contact lenses preparation, mould is placed high-pressure sodium lamp by the ultra-violet curing method or places in the baking oven by thermal curing method schemochrome colloidal solution is cured just sheet of formation contact lenses;
(3) the hydration process step of colorful contact lens:
Place salt solution aquation to the expansivity of hydrogel to stablize the first sheet of the contact lenses that solidify in the step (2) constant, make the colorful contact lens take the colloidal crystal hydrogel as pigment.
7. according to claim 6 method, when it is characterized in that carrying out hydration process in the described method step (3), then in the salt solution of pH value at 8.0-10.0 aquation 12-24 hour first be that aquation expansivity of sheet at the beginning of the contact lenses is stablized the constant colorful contact lens that the colloidal crystal hydrogel is pigment that namely is able in 7.2 the salt solution in the pH value.
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| CN 201110243803 CN102289085B (en) | 2011-08-25 | 2011-08-25 | Color contact lens with colloid crystal aquogel serving as pigment and preparation method thereof |
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| CN 201110243803 CN102289085B (en) | 2011-08-25 | 2011-08-25 | Color contact lens with colloid crystal aquogel serving as pigment and preparation method thereof |
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| CN102289085B true CN102289085B (en) | 2013-03-06 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103175957A (en) * | 2013-03-01 | 2013-06-26 | 东南大学 | Angle-unbiased visualized detection method based on colloidal crystal gel |
| CN103149702B (en) * | 2013-03-12 | 2014-05-28 | 东南大学 | Color contact lens taking scales of morphidae wings as pigment and manufacture method thereof |
| CN103941418B (en) * | 2014-03-28 | 2016-04-13 | 中国科学院深圳先进技术研究院 | There are contact lenses of colloidal photon crystal schemochrome and preparation method thereof |
| CN106810717A (en) * | 2015-11-30 | 2017-06-09 | 鸿富锦精密工业（深圳）有限公司 | Ophthalmic lens materials and eye lens |
| TWI636297B (en) * | 2016-02-05 | 2018-09-21 | 逢甲大學 | Hydrogel film of contact lenses and manufacturing method thereof |
| WO2018090330A1 (en) * | 2016-11-18 | 2018-05-24 | 深圳先进技术研究院 | Implantable device and preparation method therefor |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20050033210A1 (en) * | 2003-08-07 | 2005-02-10 | Parsa Shahinpoor | Soft Contact Patch for Treatment of Amblyopia |
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| CN1374356A (en) * | 2001-02-23 | 2002-10-16 | 庄臣及庄臣视力保护公司 | Stainer for stained contact lens and its producing process |
| CN1658020A (en) * | 2004-02-20 | 2005-08-24 | 范大铭 | Making method of color contact lenses |
| CN101695874A (en) * | 2005-02-22 | 2010-04-21 | 庄臣及庄臣视力保护公司 | hydrogel processing |
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Non-Patent Citations (2)
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