CN102283663A - Primitive event detection module for all-digital processing unit - Google Patents
Primitive event detection module for all-digital processing unit Download PDFInfo
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- CN102283663A CN102283663A CN 201110132995 CN201110132995A CN102283663A CN 102283663 A CN102283663 A CN 102283663A CN 201110132995 CN201110132995 CN 201110132995 CN 201110132995 A CN201110132995 A CN 201110132995A CN 102283663 A CN102283663 A CN 102283663A
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Abstract
The invention discloses a primitive event detection module for an all-digital processing unit, relating to the technical field of medical imaging, in particular to the field of positron emission tomography. The primitive event detection module disclosed by the invention is provided with a device, which can judge whether the position and time signal of a gamma photo-event captured by detectors belongs to a valid event by using arrival time triggering and energy discrimination, and if so, latches the position and time signal of the gamma photo-event according to the format of the primitive gamma photo-event characters and outputs the position and time signal. The invention can satisfy the demands for the all-digital processing unit in an all-digital processing positron emission tomography electronic system.
Description
Technical field
The present invention relates to the medical imaging technology field, particularly the positron emission tomography field.
Background technology
(Positron Emission Tomography PET) is a kind of nuclear medicine technology to positron emission tomography.It can be on molecular level to the function information of people's in-vivo tissue, as physiology, pathological change etc. carry out in real time, noinvasive, dynamic imaging in vivo, have irreplaceable effect at earlier detection, diagnosis, classification, therapeutic scheme formulation, therapeutic evaluation and aspects such as tracking, recurrence detection such as cancer.
The ultimate principle of PET imaging is: pass through radiosiotope (as F to the human injection
18Deng) medicine of labelling, these medicines arrive the organ and the tissue of inside of human body.Radiosiotope is because decay discharges beta-particle.Beta-particle is buried in oblivion the back and is produced the opposite γ photon of a pair of direction in human body.This a pair of γ photon passes and is projected in detector array respectively after the tissue and lists.Two detector modules that detector array lists detect this two γ photons simultaneously, are called to meet (coincidence) detection.How much lines between two detectors have reflected the direction that the γ photon passes human body, be called line of response (Line of Response, LOR).After all line of response were carried out data acquisition, by the computerized three-dimensional reconstruction technology, space, concentration and the time that can obtain radiosiotope medicine in the human body distributed, and can adopt the form of image to be shown visually and present.From above-mentioned image-forming principle also as can be seen, the PET imaging the major function unit comprise detector, electronic system and computerized algorithm and three parts of software.
Traditional PET imaging device is a very complicated system.Electronic system wherein need be finished functions such as the reading of detector signal, signal processing, coincidence detection and data acquisition.Traditional way is to adopt a plurality of separated components to realize these functions, and is bulky, and the connection complexity between the parts detects and debug loaded down with trivial details, and not only cost is higher, and the entire system poor reliability.Because these separated components function singlenesses are fixed, the adjustment and the upgradability of systemic-function are poor, difficult renewal and the development of satisfying modern technologies and clinical practice.
These factors have all caused traditional PET imaging device structure more complicated, design and production cost height, and the production cycle is long.
For simplified system, the inventor proposes a kind of totally digitilized blood processor of positron emission tomography electronic system of total digitalization processing, owing to adopt the mode of total digitalization to realize PET signal detection, processing and data acquisition etc., the level of integrated system height, powerful, the processing real-time is good, and is stable and reliable for performance, and systemic-function adjustment and upgrading are convenient.
Core component is with the γ photo-event position and the time signal primitive event detection module that capture in the totally digitilized blood processor of the positron emission tomography electronic system that total digitalization is handled.
Summary of the invention
The object of the invention is exactly to study the supporting primitive event detection module of totally digitilized blood processor a kind of and the totally digitilized positron emission tomography electronic system of handling.
Primitive event detection module of the present invention has the arrival of utilization Time Triggered and energy discrimination judges whether γ photo-event position and time signal that each detector is caught belong to validity event, if belong to validity event, then this γ photo-event position and time signal are latched the device of back output according to the form of original γ photo-event word.
, move and the influence of pile-up events at first by base line restorer with pile up restorer from the γ photo-event position of detector module and time signal, and then the incident after will piling up is separated and is reduced with the erasure signal baseline; The time of advent, detector extracted the time of advent of incident from time signal; The event time computer is the time value of unit to giving one the time of advent of incident with the system clock, and the event time computer can be that an enumerator adds one and latchs output unit; Digital integrator carries out Integral Processing to position signalling, and the essence of integration is the accumulation of quantities of charge, and the starting point of the time of integration can be the aforesaid incident time of advent, and terminal point can be determined by integration time constant; The incident energy calculator is extracted the energy information of incident from the integrated value of position and signal, be the integration numerical value and the relation of the demarcation between the actual event energy of position and signal; The event location computer from position signalling the calculating incident in the two-dimensional coordinate value of detector surface, because detector often adopts the form of crystal array, therefore the surperficial two-dimensional coordinate value that calculates can correspond to the corresponding crystal unit by the crystal look-up table, and as final event location output.The energy discrimination device is by determining to the judgement of incident energy whether the incident that detector captures is a good incident, and the energy discrimination device can be a comparator, and the upper and lower bound of comparator has been represented the set energy window of system respectively.Latch output after the format permutation of relevant information primitive event word by appointment of incident that primitive event word splicer will be by energy discrimination.
The present invention can well reduce from the γ photo-event position and the time signal of detector reception, so that the classification and the transmission of system event are provided.The present invention can satisfy the needs of the totally digitilized blood processor of the totally digitilized positron emission tomography electronic system of handling, a pair of γ photon can be passed two detectors that are detected after the tissue on the device ring catches simultaneously and handles accordingly and coincidence detection after formed incident receives, form coincident event and corresponding line of response information, again all line of response information is sent to image workstation with the form of list mode data, so that carry out date processing and three-dimensional reconstruction.
Concrete described primitive event detection module can comprise the position signalling base line restorer, position signalling is piled up restorer, the position signalling digital integrator, the time signal base line restorer, time signal is piled up restorer, the time of advent detector, the event time computer, X position signalling base line restorer, the X position signalling is piled up restorer, X position signalling digital integrator, Y position signalling base line restorer, the Y position signalling is piled up restorer, Y position signalling digital integrator, the incident energy calculator, the event location computer, the crystal look-up table, energy discrimination device and primitive event word splicer;
Described position signalling base line restorer, time signal base line restorer, X position signalling base line restorer and Y position signalling base line restorer are connected on the corresponding detector by A/D conversion parallel operation respectively;
Described position signalling base line restorer is piled up restorer by described position signalling and is connected with the position signalling digital integrator;
Described X position signalling base line restorer is piled up restorer by the X position signalling and is connected with X position signalling digital integrator;
Described Y position signalling base line restorer is piled up restorer by the Y position signalling and is connected with Y position signalling digital integrator;
Described time signal base line restorer by time signal pile up restorer with the time of advent detector be connected;
Described time of advent detector signal output part be connected to incident can the time computer and position signalling digital integrator, X position signalling digital integrator, Y position signalling digital integrator;
Described incident can the time computer input be connected on the described primitive event word splicer;
The signal output part of described crystal look-up table, position signalling digital integrator, X position signalling digital integrator, Y position signalling digital integrator is connected on the described primitive event word splicer;
The signal output part of described position signalling digital integrator also is connected on described energy discrimination device and the primitive event word splicer by described incident energy calculator;
The signal output part of described energy discrimination device is connected on the described primitive event word splicer.
Description of drawings
Fig. 1 is the functional block diagram of primitive event detection module of the present invention.
The specific embodiment
As shown in Figure 1, the primitive event detection module comprises the position signalling base line restorer, position signalling is piled up restorer, the position signalling digital integrator, the time signal base line restorer, time signal is piled up restorer, the time of advent detector, the event time computer, X position signalling base line restorer, the X position signalling is piled up restorer, X position signalling digital integrator, Y position signalling base line restorer, the Y position signalling is piled up restorer, Y position signalling digital integrator, the incident energy calculator, the event location computer, the crystal look-up table, energy discrimination device and primitive event word splicer.
Position signalling base line restorer, time signal base line restorer, X position signalling base line restorer and Y position signalling base line restorer are connected on the corresponding detector by A/D converter respectively.
The position signalling base line restorer is piled up restorer by described position signalling and is connected with the position signalling digital integrator.
X position signalling base line restorer is piled up restorer by the X position signalling and is connected with X position signalling digital integrator.
Y position signalling base line restorer is piled up restorer by the Y position signalling and is connected with Y position signalling digital integrator.
The time signal base line restorer by time signal pile up restorer with the time of advent detector be connected.
The time of advent detector signal output part be connected to incident can the time computer and position signalling digital integrator, X position signalling digital integrator, Y position signalling digital integrator.
The input of computer is connected on the described primitive event word splicer during incident energy.
The signal output part of crystal look-up table, position signalling digital integrator, X position signalling digital integrator, Y position signalling digital integrator is connected on the described primitive event word splicer.
The signal output part of position signalling digital integrator also is connected on described energy discrimination device and the primitive event word splicer by described incident energy calculator.
The signal output part of energy discrimination device is connected on the described primitive event word splicer.
, move and the influence of pile-up events at first by base line restorer with pile up restorer from the position of detector module and time signal with the erasure signal baseline.As a kind of implementation, some somes signals before base line restorer can arrive incident average, and as the reference value of baseline, and input signal is deducted corresponding reference value reach the purpose that baseline recovers.As a kind of implementation, pile up restorer and can utilize the signal waveform template of calculated in advance storage that input signal is carried out matching treatment, and then the incident after will piling up is separated and reduction.
The time of advent, detector extracted the time of advent of incident from time signal.As a kind of implementation, the time of advent, detector can adopt the method that rising edge is differentiated, perhaps constant component is differentiated (Constant Fractional Discriminator, method CFD).
The event time computer is the time value of unit to giving one the time of advent of incident with the system clock.As a kind of implementation, the event time computer can be that an enumerator adds one and latchs output unit.
Digital integrator carries out Integral Processing to position signalling.The essence of integration is the accumulation of quantities of charge.As a kind of implementation, digital integrator can adopt accumulator that the value of the digital signal in a period of time scope is added up.The starting point of the time of integration can be the aforesaid incident time of advent, and terminal point can be determined by integration time constant.
The incident energy calculator is extracted the energy information of incident from the integrated value of position and signal.As a kind of implementation, the incident energy calculator can be a look-up table, and the content of table is the integration numerical value and the relation of the demarcation between the actual event energy of position and signal.
The event location computer from position signalling the calculating incident in the two-dimensional coordinate value of detector surface.As a kind of implementation, the event location computer can calculate x position and position and ratio as the X position coordinates of incident, calculate y position and position and ratio as the Y position coordinates of incident.Because detector often adopts the form of crystal array, therefore the surperficial two-dimensional coordinate value that calculates can correspond to the corresponding crystal unit by the crystal look-up table, and as final event location output.
The energy discrimination device is by determining to the judgement of incident energy whether the incident that detector captures is a good incident.As a kind of implementation, the energy discrimination device can be a comparator, and the upper and lower bound of comparator has been represented the set energy window of system respectively.
Latch output after the format permutation of relevant information primitive event word by appointment of incident that primitive event word splicer will be by energy discrimination.
Claims (2)
1. the primitive event detection module of a totally digitilized blood processor, it is characterized in that: described primitive event detection module has the arrival of utilization Time Triggered and energy discrimination judges whether γ photo-event position and time signal that each detector is caught belong to validity event, if belong to validity event, then this γ photo-event position and time signal are latched the device of back output according to the form of original γ photo-event word.
2. according to the totally digitilized electronic system of the described totally digitilized blood processor of claim 1, it is characterized in that: described primitive event detection module comprises the position signalling base line restorer, position signalling is piled up restorer, the position signalling digital integrator, the time signal base line restorer, time signal is piled up restorer, the time of advent detector, the event time computer, X position signalling base line restorer, the X position signalling is piled up restorer, X position signalling digital integrator, Y position signalling base line restorer, the Y position signalling is piled up restorer, Y position signalling digital integrator, the incident energy calculator, the event location computer, the crystal look-up table, energy discrimination device and primitive event word splicer;
Described position signalling base line restorer, time signal base line restorer, X position signalling base line restorer and Y position signalling base line restorer are connected on the corresponding detector by A/D conversion parallel operation respectively;
Described position signalling base line restorer is piled up restorer by described position signalling and is connected with the position signalling digital integrator;
Described X position signalling base line restorer is piled up restorer by the X position signalling and is connected with X position signalling digital integrator;
Described Y position signalling base line restorer is piled up restorer by the Y position signalling and is connected with Y position signalling digital integrator;
Described time signal base line restorer by time signal pile up restorer with the time of advent detector be connected;
Described time of advent detector signal output part be connected to incident can the time computer and position signalling digital integrator, X position signalling digital integrator, Y position signalling digital integrator;
Described incident can the time computer input be connected on the described primitive event word splicer;
The signal output part of described crystal look-up table, position signalling digital integrator, X position signalling digital integrator, Y position signalling digital integrator is connected on the described primitive event word splicer;
The signal output part of described position signalling digital integrator also is connected on described energy discrimination device and the primitive event word splicer by described incident energy calculator;
The signal output part of described energy discrimination device is connected on the described primitive event word splicer.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105249983A (en) * | 2015-09-30 | 2016-01-20 | 沈阳东软医疗系统有限公司 | Effective event recognition device |
| CN112075949A (en) * | 2020-09-07 | 2020-12-15 | 北京永新医疗设备有限公司 | Method, device and equipment for quickly searching event position of Anger detector |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008190967A (en) * | 2007-02-02 | 2008-08-21 | Hitachi Ltd | Nuclear medicine diagnosis device |
| US20110073764A1 (en) * | 2009-09-29 | 2011-03-31 | Tilahun Woldeselassie Woldemichael | Method and System for Nuclear Imaging Using Multi-Zone Detector Architecture |
| CN102028491A (en) * | 2009-10-01 | 2011-04-27 | 株式会社东芝 | Positron emission tomography photography system and its information processing method |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008190967A (en) * | 2007-02-02 | 2008-08-21 | Hitachi Ltd | Nuclear medicine diagnosis device |
| US20110073764A1 (en) * | 2009-09-29 | 2011-03-31 | Tilahun Woldeselassie Woldemichael | Method and System for Nuclear Imaging Using Multi-Zone Detector Architecture |
| CN102028491A (en) * | 2009-10-01 | 2011-04-27 | 株式会社东芝 | Positron emission tomography photography system and its information processing method |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105249983A (en) * | 2015-09-30 | 2016-01-20 | 沈阳东软医疗系统有限公司 | Effective event recognition device |
| CN105249983B (en) * | 2015-09-30 | 2018-04-27 | 沈阳东软医疗系统有限公司 | A kind of validity event identification device |
| CN112075949A (en) * | 2020-09-07 | 2020-12-15 | 北京永新医疗设备有限公司 | Method, device and equipment for quickly searching event position of Anger detector |
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