CN102283647A - Closed cornea electrode for visual electrophysiology detection - Google Patents
Closed cornea electrode for visual electrophysiology detection Download PDFInfo
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- CN102283647A CN102283647A CN2011101859659A CN201110185965A CN102283647A CN 102283647 A CN102283647 A CN 102283647A CN 2011101859659 A CN2011101859659 A CN 2011101859659A CN 201110185965 A CN201110185965 A CN 201110185965A CN 102283647 A CN102283647 A CN 102283647A
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Abstract
The invention belongs to the technical field of physiological test apparatuses, and particularly relates to a closed cornea electrode for visual electrophysiology detection. The electrode comprises a light shield, an annular cornea electrode, a main shading tube and a light-emitting diode (LED) illuminant light source, wherein the light shield is used for being tightly attached with an experimental animal for preventing light leakage; the LED illuminant light source is positioned at the rear end part of the main shading tube, and is connected with a visual electrophysiology recording instrument for controlling the light source; and the annular cornea electrode is made from filamentary silver, is annular, is positioned at the central part of the front end opening of the main shading tube, and real-timely records the electric signal of the retina through an electrode connection line and an external visual electrophysiology recording instrument. The closed cornea electrode for visual electrophysiology detection can realize respective light adaptation and independent visual electrophysiology recording of the two eyes in the animal visual electrophysiology tests, and has very important application value.
Description
Technical field
The invention belongs to the physiological test Instrument technology field, be specifically related to a kind of laboratory animal visual electricity physiological detection Corneal electrode.
Background technology
It is to use the electrophysiology instrument device that visual electrophysiology detects, when measuring retina by rayed or image stimulation, and the bioelectric that in visual system, produces.Mainly comprise three kinds of electroretinogram (ERG), electro-oculogram (EOG) and visual evoked potentials (VEP).
In clinical and zoopery, visual electrophysiology detects has become the detection means commonly used that visual performance is assessed.The main points that visual electrophysiology detects are to lay electrode at eyeball surface and brain occipital lobe district, and record is because the signal of telecommunication that flash stimulation excites retina and visual cortex to produce simultaneously.
At present, be positioned over eyeball surface by a filamentary silver as electrode usually, write down amphiblestroid current potential and electric current and change.Following several groups of data of essential record in the visual electrophysiology:
1, light intensity and ERG, VEP amplitude of variation curve during the light adaptation stable state.In bright luminous environment, the stable back test of visual system study subject, record produces corresponding ERG and VEP amplitude along with intensity variations, and calculates the threshold value of study subject visual system under this environment.
2, dark adaptation process time-histories figure.After changing dark environment over to from bright light environments, because visual system will adapt to new luminous environment, corresponding time point carries out flash stimulation to retina, writes down the variation of ERG and VEP data in the vision dark adaptation process simultaneously.
Light intensity and ERG, VEP amplitude of variation curve during 3, dark adaptation stable state.When the ERG of study subject and VEP no longer changed along with the prolongation of time, study subject reached the dark adaptation steady statue.At this moment, give study subject one group of photostimulation, ERG and VEP amplitude that record produces along with intensity variations, and the threshold value of calculating study subject visual system under this environment.
Because the opening of visual electrophysiology grapher, at present can't be stable two eyes are carried out independently electrophysiological recording simultaneously.This deficiency, the scientific research that causes being correlated with can't be carried out.Such as: be the visual electrophysiology data under some special state of proof in the middle of the scientific research, need utilize the method for own control, give two different intensities of illumination of eyes and adapt to, between exciting eye, contrast eye, switch fast; At this moment, the light that light source is leaked out when an eye is stimulated will inevitably adapt to eye (contrast eye) to other one and exert an influence, thus the accuracy of influence experiment.To such an extent as to can't make eyes carry out relatively independent stimulation and photopia process simultaneously, thereby can't obtain test data accurately.Common solution is that the visual electrophysiology monitor covers an other eye in eye of a record.And when two transposings, need again electrode to be changed.The transposing electrode is a quite technical profession of trouble.In the process of transposing, singly need expend a large amount of time, and owing to need adjust reliability, success rate and the efficient of influence experiment greatly having under the visual state of light.Another deficiency of this detection method is that a large amount of Key Experiment data can't record owing to change electrode.
Summary of the invention
The object of the present invention is to provide and a kind ofly can carry out simultaneously that independent light adapts to and stimulate the laboratory animal eyes, thereby laboratory animal visual electricity physiological detection Corneal electrode that can the accurate recording experimental data.
Laboratory animal visual electricity physiological detection Corneal electrode provided by the invention is gone up a kind of closed Corneal electrode, and its structure comprises: shade 1, cornea globosa electrode 2, main cone 3, led light source 4, see shown in Figure 1.Wherein, described shade 1 is used for fitting tightly with laboratory animal, prevents that light from leaking.The front port of described main cone 3 is connected with the rear port transition of shade 1; Described LED illuminating source 4 is positioned at the rearward end of main cone 3, and the power line 5 of LED illuminating source is connected with the visual electrophysiology monitor, realizes the control to light source.Described cornea globosa electrode 2 adopts filamentary silver to constitute, in the form of a ring, be positioned at main cone 3 front port centres, the front port place of main shading barrel 3 is fixed at the electrode two ends, and by placing the electrode connecting line 6 in the main shading barrel interlayer to draw, external visual electrophysiology monitor is realized the real time record to the retina signal of telecommunication.
The present invention adopts built-in illuminating source, and adopts the built-in ring-type filamentary silver that is closed in the freestanding environment as the cornea recording electrode outside light source.Two electrodes place two respectively during use, make cornea be affixed on ring electrode.The outer shade of electrode this moment can be confined to the light that light source sent in the electrode, by electric physiological apparatus driving light sources such as powerlab data record analytical systems the test eye is carried out photopia and stimulation, forms independently environment of partial closure.When not awarding voltage when output since light shade cover every light action, promptly form this dark surrounds, it is become covers eye.After giving continual and steady voltage output, promptly form a stable bright environment this eye is carried out photopia this moment in the part.But driving light source produces flash of light when giving pulse voltage output, and electroretinogram is carried out record by the ring electrode that is contacted with cornea, when using this electrode simultaneously for two, two-way light source driving voltage is controlled respectively with visual electrophysiology instruments such as crossing powerlab data record analytical system, can realize that eyes are to photopia, branch hole is kept dark (promptly covering eye), perhaps eyes keep dark for thorn laser offside eye, and can be with crossing two (light adapted eyes of above two kinds of situations that the control of powerlab data record analytical system to voltage output realizes eyes, cover the eye) quick switching.Also can finish simultaneously two eyes and give light or dark simultaneously, thereby solve because need be to the simple eye problem of carrying out individual adaptation and stimulation of animal.
Beneficial effect of the present invention
The present invention is a kind of brand-new animal visual electrophysiology measuring technology and device, can realize eyes independently photopia and independently visual electrophysiology record separately in the experiment of animal visual electrophysiology.The present invention has important use and is worth in the research of animal visual electrophysiology.
Description of drawings
Fig. 1 is a structural diagrams of the present invention
Number in the figure: 1 shade, 2 cornea globosa electrodes, 3 main cones, 4LED light source, 5 light source lines, 6 electrode connecting lines.
The specific embodiment
As shown in Figure 1, the visual electrophysiology detection of the present invention's design mainly comprises following components with the structure and the function of closed Corneal electrode:
Shade 1: this shade is made skeleton with the rubber-like iron wire, is that lining is made with the nylon cloth, can fit tightly with animal, prevents that light from leaking.
Cornea globosa electrode 2: this electrode is made of filamentary silver, in the form of a ring, is arranged at the front port place of main cone 3, and main shading barrel is fixed at the electrode two ends, and by placing the electrode connecting line 6 in the main shading barrel interlayer to draw external visual electrophysiology monitor.
Main cone 3: this light tube inwall posts reflectorized material, and outer wall covers light screening material.Its diameter generally can be 1.5cm--5 cm, and length is 5 cm--10 cm.Rat is 1.5cm with closed Corneal electrode master cone diameter at present, and length is 5 cm.Cat is with closed Corneal electrode master cone diameter 2.5cm, and length is 7cm.
Light source power line 5: connect the power line of LED illuminating source, be connected, realize control to light source with the visual electrophysiology monitor.
Electrode connecting line 6: connect the lead of annular Corneal electrode, external visual electrophysiology monitor is realized the real time record to the retina signal of telecommunication.
Above-mentioned each parts are pressed the described assembling of Fig. 1, promptly get the closed Corneal electrode of required visual electrophysiology detection.
Claims (1)
1. a visual electrophysiology detects and uses closed Corneal electrode, it is characterized in that comprising: shade (1), cornea globosa electrode (2), main cone (3), LED illuminating source (4); Wherein, described shade (1) is used for fitting tightly with laboratory animal, prevents that light from leaking; The front port of described main cone (3) is connected with the rear port transition of shade (1); Described LED illuminating source (4) is positioned at the rearward end of main cone (3), and the power line of LED illuminating source (5) is connected with the visual electrophysiology monitor, realizes the control to light source; Described cornea globosa electrode (2) adopts filamentary silver to make, in the form of a ring, be positioned at main cone (3) front port centre, the front port place of main shading barrel (3) is fixed at the electrode two ends, and by placing the electrode connecting line (6) in the main shading barrel interlayer to draw, external visual electrophysiology monitor is realized the real time record to the retina signal of telecommunication.
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| CN2011101859659A CN102283647A (en) | 2011-07-05 | 2011-07-05 | Closed cornea electrode for visual electrophysiology detection |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1060021A (en) * | 1990-09-26 | 1992-04-08 | 中国人民解放军白求恩国际和平医院 | A kind of monitor electrode for visual electrophysiotogic operation |
| CN101019760A (en) * | 2007-03-20 | 2007-08-22 | 重庆大学 | System and method for separating binocular vision induced potentials |
| CN201752412U (en) * | 2010-08-06 | 2011-03-02 | 北京太阳电子科技有限公司 | Electrode for non-interference electrophysiological detection |
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2011
- 2011-07-05 CN CN2011101859659A patent/CN102283647A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1060021A (en) * | 1990-09-26 | 1992-04-08 | 中国人民解放军白求恩国际和平医院 | A kind of monitor electrode for visual electrophysiotogic operation |
| CN101019760A (en) * | 2007-03-20 | 2007-08-22 | 重庆大学 | System and method for separating binocular vision induced potentials |
| CN201752412U (en) * | 2010-08-06 | 2011-03-02 | 北京太阳电子科技有限公司 | Electrode for non-interference electrophysiological detection |
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Application publication date: 20111221 |