CN102274550B - Interventional medical device - Google Patents

Interventional medical device Download PDF

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Publication number
CN102274550B
CN102274550B CN201010201511.1A CN201010201511A CN102274550B CN 102274550 B CN102274550 B CN 102274550B CN 201010201511 A CN201010201511 A CN 201010201511A CN 102274550 B CN102274550 B CN 102274550B
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sulfonic acid
medical device
coating
interventional medical
acid groups
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Expired - Fee Related
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CN201010201511.1A
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CN102274550A (en
Inventor
李俊菲
胡玺
乐承筠
王大伟
黄鹏
唐智荣
罗七一
常兆华
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Shanghai Microport Medical Group Co Ltd
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Shanghai Microport Medical Group Co Ltd
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Priority to CN201010201511.1A priority Critical patent/CN102274550B/en
Application filed by Shanghai Microport Medical Group Co Ltd filed Critical Shanghai Microport Medical Group Co Ltd
Priority to JP2013513543A priority patent/JP5818881B2/en
Priority to RU2013100292/15A priority patent/RU2013100292A/en
Priority to EP11795174.9A priority patent/EP2581099B1/en
Priority to BR112012031810-1A priority patent/BR112012031810B1/en
Priority to PCT/CN2011/075648 priority patent/WO2011157208A1/en
Priority to US13/703,855 priority patent/US9226994B2/en
Publication of CN102274550A publication Critical patent/CN102274550A/en
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Publication of CN102274550B publication Critical patent/CN102274550B/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

本申请公开了一种介入医疗器械，该介入医疗器械外表面设置有至少一层涂层，且涂层中最外层涂层的材料为含有磺酸基团的聚合物。本申请实施例中，该介入医疗器械最外层涂层的材料为含有磺酸基团的聚合物，该磺酸基团的存在，使得聚合物具有与肝素相同的表面特性和适当的亲水性。当该介入医疗器械植入人体后，在体液环境下，介入医疗器械的表面不仅能够形成一层亲水表面，而且带有负电荷，与细胞相容性增强，细胞容易在其表面贴壁生长；而且其与肝素相同的表面特性，也赋予了材料优异的抗凝血性能，从而可以抑制血栓的形成，降低术后并发症的发生率。

The present application discloses an interventional medical device. The outer surface of the interventional medical device is provided with at least one layer of coating, and the material of the outermost coating in the coating is a polymer containing sulfonic acid groups. In the embodiment of the present application, the material of the outermost layer coating of the interventional medical device is a polymer containing sulfonic acid groups. The presence of the sulfonic acid groups makes the polymer have the same surface characteristics as heparin and appropriate hydrophilicity. sex. When the interventional medical device is implanted into the human body, in the body fluid environment, the surface of the interventional medical device can not only form a layer of hydrophilic surface, but also has a negative charge, which enhances the compatibility with cells, and the cells are easy to grow on the surface. ; and the same surface properties as heparin also endow the material with excellent anticoagulant properties, which can inhibit the formation of thrombus and reduce the incidence of postoperative complications.

Description

A kind of interventional medical device
Technical field
The application relates to medical instruments field, particularly relates to a kind of interventional medical device.
Background technology
Interventional medical device is the emerging medical device technology of recent two decades, in the wound reducing patient, improves disease therapeuticing effect aspect and plays very important effect.For example, be applied in the various intraluminal intervention apparatus of human body, as intravascular stent, biliary tract rack, esophageal stents appear, intestinal support, stents of pancreatic duct, urethra rack or trachea bracket etc., and corresponding interposing catheter, sacculus, filter etc.Wherein, support is especially outstanding in the performance in interventional medical device field.In the angiopathy causing because of angiemphraxis or other reasons, support is proved to be a kind of relatively successfully interventional medical device of long-term implantable intravascular.When operation, support is transported to the obstruction diseased region of blood vessel by carrier, then releasing bracket, utilizes support to expand the vascular opening blocking, and makes the blood vessel blocking keep unimpeded.
For improving interventional medical device bio-compatible effect and therapeutic effect in vivo, can also be on these a certain parts of apparatus body or whole surface coated medicament and/or polymer.For example rack surface can apply the polymer coating that contains medicine, after the support implant into body that contains medication coat, not only can be by the vascular opening blocking, and on it, medication coat can also constantly discharge medicine to the lesion vessels tissue contacting with it, thereby reach the object of thorough healing.
Yet, due to the complexity of physiological make-up in body, the application of interventional medical device in human body, itself also exists the problem of complicated biocompatibility, when polymeric material is coated on interventional medical device in addition, equally also can there is in vivo the problem of biocompatibility.Conventional polymeric material mainly contains polymethacrylate polymer, fluoropolymer, polyethylene based polymers or polystyrene base polymer at present, and these polymer are commercial Application at the beginning of application, and biocompatibility is poor.
Therefore existing interventional medical device is after long-term implant into body, because biocompatibility causes comparatively serious thrombosis and post-operative complication compared with missionary society.
Summary of the invention
For solving the problems of the technologies described above, the embodiment of the present application provides a kind of interventional medical device, and technical scheme is as follows:
An interventional medical device, described interventional medical device outer surface is provided with at least one deck coating, and in described coating, the material of outermost layer coating is the polymer that contains sulfonic acid group.
Preferably, the thermoplastic elastomer (TPE) that the polymer that contains sulfonic acid group described in is sulfonation.
Preferably, the thermoplastic elastomer (TPE) of described sulfonation is sulfonated phenylethylene-olefin copolymer.
Preferably, described styrene-olefin copolymer is styrene-isobutene. diblock or triblock copolymer.
Preferably, in described styrene-isobutene. diblock or triblock copolymer, styrene weight percentage is 25%～55%.
Preferably, the sulphonation rate of the polymer that contains sulfonic acid group in described outermost layer coating is 5%～30%.
Preferably, the sulphonation rate of the polymer that contains sulfonic acid group in described outermost layer coating is 10%～20%.
In this interventional medical device, when described coating is multilamellar, layer coating material of other except outermost layer is the polymer that contains sulfonic acid group.
Preferably, the sulphonation rate of the polymer that contains sulfonic acid group in described other layer of coating except outermost layer is less than the sulphonation rate of the polymer that contains sulfonic acid group in outermost layer.
The sulphonation rate of the polymer that preferably, contains sulfonic acid group in described other coating except outermost layer is 0%～15%.
The sulphonation rate of the polymer that preferably, contains sulfonic acid group in described other coating except outermost layer is 5%～10%.
Preferably, in described coating, at least one deck contains medicine.
In this interventional medical device, when described medicine with described in contain sulfonic acid group polymer while reacting, described in contain medicine the material of coating do not adopt the polymer that contains sulfonic acid group.Preferably, described in contain medicine coating and the polymer coating that contains sulfonic acid group between have one deck sealing coat at least, the material of described sealing coat does not adopt the polymer that contains sulfonic acid group.
Preferably, described interventional medical device is stent for human body lumens.
Preferably, described stent for human body lumens comprises: coronary artery stent, intracranial vessel support, peripheral blood vessel support, art medium-height trestle, heart valve bracket, biliary tract rack, esophageal stents appear, intestinal support, stents of pancreatic duct, urethra rack or trachea bracket.
The interventional medical device that the embodiment of the present application provides, its outermost layer coating material is the polymer that contains sulfonic acid group, surface characteristic that polymer is identical with heparin and suitable hydrophilic have been given in the existence of this sulfonic acid group.After this interventional medical device implant into body, under body fluid environment, the existence of material surface sulfonic acid group, not only makes material can form the hydrophilic film of skim molecular level, and surface band negative charge, strengthens with cell compatibility.
Therefore, after this interventional medical device implant into body, outermost layer has cell close friend's surface, and cell is easily in its surperficial adherent growth, but also has the surface characteristic identical with heparin, can suppress the formation of thrombosis, reduces the incidence rate of post-operative complication.
In addition, in this polymer that contains sulfonic acid group, also contain lipophilic main chain, can to reach molecular level compatible with medicine, so the polymer coating that contains sulfonic acid group of this interventional medical device can also carry bioactive medicine, and can control the slow release of medicine, improve therapeutic effect.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present application or technical scheme of the prior art, to the accompanying drawing of required use in embodiment or description of the Prior Art be briefly described below, apparently, the accompanying drawing the following describes is only some embodiment that record in the application, for those of ordinary skills, do not paying under the prerequisite of creative work, can also obtain according to these accompanying drawings other accompanying drawing.
The structural representation of a kind of interventional medical device that Fig. 1 provides for the embodiment of the present application one;
The structural representation of a kind of interventional medical device that Fig. 2 provides for the embodiment of the present application two;
The structural representation of a kind of interventional medical device that Fig. 3 provides for the embodiment of the present application three;
The structural representation of a kind of interventional medical device that contains medicine that Fig. 4 provides for the embodiment of the present application four;
The structural representation of the interventional medical device that the another kind that Fig. 5 provides for the embodiment of the present application four contains medicine;
Fig. 6 is the polymer that contains sulfonic acid group and the polymer controls medicine-releasing performance comparison diagram that does not contain sulfonic acid group.
The specific embodiment
A kind of interventional medical device that the embodiment of the present application provides, the material of its outermost layer polymer coating is to have the hydrophilic polymer that contains sulfonic acid group, after implant into body, at the outer surface of this interventional medical device, can form the friendly layer of cellular environment with cytocompatibility, thereby cell is easily in its surperficial adherent growth, and this surface also has the surface characteristic identical with heparin, can suppress the formation of thrombosis, reduce the generation of complication.
It is more than the application's core concept, in order to make those skilled in the art person understand better the technical scheme in the application, below in conjunction with the accompanying drawing in the embodiment of the present application, technical scheme in the embodiment of the present application is clearly and completely described, obviously, described embodiment is only the application's part embodiment, rather than whole embodiment.Embodiment based in the application, those of ordinary skills are not making all other embodiment that obtain under creative work prerequisite, all should belong to the scope of the application's protection.
Embodiment mono-:
The structural representation of a kind of interventional medical device that Fig. 1 provides for the embodiment of the present application one.
As shown in Figure 1, this interventional medical device comprises rack body 1 and the coating 2 that is arranged on rack body 1 outer surface, wherein: the material of coating 2 is the polymer that contains sulfonic acid group.
The embodiment of the present application, the polymer that contains sulfonic acid group that coating 2 is used is including, but not limited to the thermoplastic elastomer (TPE) of sulfonation, be preferably sulfonated phenylethylene-olefin copolymer, more preferably styrene-isobutene. diblock or triblock copolymer, and wherein styrene weight percentage is 25～55%.In addition the thermoplastic elastomer (TPE) of this sulfonation can also be other copolymer well known to those of ordinary skill in the art.
The embodiment of the present application, the sulphonation rate in the polymer that contains sulfonic acid group that coating 2 is used is preferably 5%～30%, because the introduction volume of sulfonic acid group (being the content of sulfonic acid group) is very large to the performance impact of copolymer material in copolymer.Sulfonic acid group introduction volume uses sulphonation rate (having the phenyl ring of how much percentage ratio to be sulfonated) to characterize conventionally, take polystyrene butylene copolymer as example, and when sulphonation rate is greater than 50%, material just can follow the string and film property; When sulphonation rate is greater than 30%, the insufficient strength of material, adhesion is also poor.So in the embodiment of the present application, sulphonation rate in the polymer that contains sulfonic acid group is 5%～30%, within the scope of this, the polymer-coated that contains sulfonic acid group on rack body 1 after, coating is not easy to crack when stressed, peel off, and physical property meets the demands.In the embodiment of the present application, the sulphonation rate in the polymer that contains sulfonic acid group that coating 2 is used more preferably 10%～20%.
The embodiment of the present application, the human lumen support that this interventional medical device is well known to those skilled in the art, including, but not limited to: coronary artery stent, intracranial vessel support, peripheral blood vessel support, art medium-height trestle, heart valve bracket, biliary tract rack, esophageal stents appear, intestinal support, stents of pancreatic duct, urethra rack or trachea bracket, be preferably coronary artery stent.
Embodiment bis-:
The structural representation of a kind of interventional medical device that Fig. 2 provides for the embodiment of the present application two.
As shown in Figure 2, this interventional medical device comprises rack body 1, is coated in outermost layer coating 2 and the internal layer coating 3 of rack body 1 outer surface, wherein: the material of outermost layer coating 2 is the polymer that contains sulfonic acid group, and the sulphonation rate in the polymer that contains sulfonic acid group that outermost layer coating 2 is used is 5%～30%, more preferably 10%～20%.
The material of internal layer coating 3 can be inorganic coating, organic coating or traditional polymer coating, can also be for containing the polymer coating of sulfonic acid group, when the material of internal layer coating 3 is the polymer that contains sulfonic acid group, because internal layer coating 3 is different from the residing environment of outermost layer coating 2, so require also different to material behavior, need the adhesion property of material stronger, so contain the sulphonation rate that the sulphonation rate of the polymer of sulfonic acid group is less than the polymer that contains sulfonic acid group in outermost layer coating 2 in internal layer coating 3, in the embodiment of the present application, the sulphonation rate that contains the polymer of sulfonic acid group in internal layer coating 3 should be controlled at below 15%, be preferably 5～10%.
Embodiment tri-:
The structural representation of a kind of interventional medical device that Fig. 3 provides for the embodiment of the present application three.
As shown in Figure 3, on the basis of embodiment bis-, can also between internal layer coating 3 and rack body 1, increase one deck primer coating 4 as required.
The same with the internal layer coating 3 in embodiment bis-, the material of primer coating 4 can be inorganic coating, organic coating or traditional polymer coating equally, can also be for containing the polymer coating of sulfonic acid group.When the material of primer coating 4 is the polymer that contains sulfonic acid group, the sulphonation rate that contains the polymer of sulfonic acid group in primer coating 4 should be controlled at below 15%, is preferably 5～10%.
Embodiment tetra-:
The embodiment of the present application, rack body 1 outer surface is provided with laminated coating, wherein: the material of outermost layer coating is the polymer that contains sulfonic acid group, and the sulphonation rate in the polymer that contains sulfonic acid group that outermost layer coating 2 is used is 5%～30%, more preferably 10%～20%, and at least in one deck coating, contain medicine in laminated coating.
As shown in Figure 4, in the embodiment of the present application, the outer surface of support 1 is coated with three layers of coating, is respectively outermost layer coating 2, internal layer coating 3 and primer coating 4, wherein: internal layer coating 3 contains medicine.
In other embodiment of the application, in order to prevent that the polymer that contains sulfonic acid group in some specific medicine and outermost layer coating 2 from reacting, between the internal layer coating that contains medicine and outermost layer, be also provided with sealing coat 5 as shown in Figure 5, and the material of the internal layer coating 3 that contains medicine can not adopt the polymer that contains sulfonic acid group.
The embodiment of the present application, the active medicine that the medicine containing in coating is well known to those skilled in the art, including, but not limited to anticoagulant, cancer therapy drug, microorganism immunosuppressant, hormone and/or other anti-angiogenic restenosis medicaments, be preferably rapamycin.
The interventional medical device that the embodiment of the present application provides, the material of its outermost layer coating is the polymer that contains sulfonic acid group.The existence of this sulfonic acid group, makes polymer have the surface characteristic identical with heparin and suitable hydrophilic.After this interventional medical device implant into body, under body fluid environment, the surface of interventional medical device not only can form one deck water-wetted surface, and with negative charge, strengthens with cell compatibility, and cell is easily in its surperficial adherent growth; And its surface characteristic identical with heparin, also give the anticoagulation function of material excellence, thereby can suppress the formation of thrombosis, reduce the incidence rate of post-operative complication.
In addition, in this polymer, also contain lipophilic main chain, can to reach molecular level compatible with medicine, as shown in Figure 6, be the polymer that contains sulfonic acid group and the polymer controls medicine-releasing performance comparison diagram that does not contain sulfonic acid group.In figure, the material of 1 curve is not for containing the polymer of sulfonic acid group, the material of n curve is that sulphonation rate is 5% the polymer that contains sulfonic acid group, the material of m curve is that sulphonation rate is 25% the polymer that contains sulfonic acid group, in figure, can draw, the polymer coating that contains sulfonic acid group of this interventional medical device, can also carry bioactive medicine, and can control the slow release of medicine, improve therapeutic effect.
The explanation of above embodiment is just for helping to understand method of the present invention and core concept thereof.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of the claims in the present invention.

Claims (8)

1.一种介入医疗器械，其特征在于，所述介入医疗器械外表面设置有至少一层涂层，且所述涂层中最外层涂层的材料为含有磺酸基团的聚合物；  1. An interventional medical device, characterized in that the outer surface of the interventional medical device is provided with at least one layer of coating, and the material of the outermost coating in the coating is a polymer containing sulfonic acid groups; 所述最外层涂层中的含有磺酸基团的聚合物的磺化率为5％～30％；  The sulfonation rate of the polymer containing sulfonic acid groups in the outermost coating is 5% to 30%; 或者  or 所述最外层涂层中的含有磺酸基团的聚合物的磺化率为10％～20％；  The sulfonation rate of the polymer containing sulfonic acid groups in the outermost coating is 10% to 20%; 所述含有磺酸基团的聚合物为苯乙烯－异丁烯二嵌段或三嵌段共聚物；  The polymer containing sulfonic acid groups is a styrene-isobutylene diblock or triblock copolymer; 当所述涂层为多层时，除最外层以外的其它层涂层的材料为含有磺酸基团的聚合物；  When the coating is multi-layer, the material of the coating of other layers except the outermost layer is a polymer containing sulfonic acid groups; 所述除最外层以外的其它涂层中含有磺酸基团的聚合物的磺化率为5％～10％。  The sulfonation rate of the polymer containing sulfonic acid groups in the other coatings except the outermost layer is 5%-10%. the 2.根据权利要求1所述的介入医疗器械，其特征在于，所述苯乙烯－异丁烯二嵌段或三嵌段共聚物中苯乙烯重量百分含量为25％～55％。  2. The interventional medical device according to claim 1, characterized in that, the styrene weight percentage in the styrene-isobutylene di-block or tri-block copolymer is 25%-55%. the 3.根据权利要求1所述的介入医疗器械，其特征在于，所述除最外层以外的其它层涂层中的含有磺酸基团的聚合物的磺化率小于最外层中的含有磺酸基团的聚合物的磺化率。  3. The interventional medical device according to claim 1, characterized in that, the sulfonation rate of the polymer containing sulfonic acid groups in the coatings of other layers except the outermost layer is less than that of the polymer containing sulfonic acid groups in the outermost layer The sulfonation rate of polymers with sulfonic acid groups. the 4.根据权利要求1所述的介入医疗器械，其特征在于，所述涂层中至少一层含有药物。  4. The interventional medical device according to claim 1, wherein at least one layer of the coatings contains a drug. the 5.根据权利要求4所述的介入医疗器械，其特征在于，当所述药物与所述含有磺酸基团的聚合物发生反应时，所述含有药物的涂层的材料不采用含有磺酸基团的聚合物。  5. The interventional medical device according to claim 4, characterized in that, when the drug reacts with the polymer containing sulfonic acid groups, the material of the drug-containing coating does not contain sulfonic acid group of polymers. the 6.根据权利要求5所述的介入医疗器械，其特征在于，所述含有药物的涂层与含有磺酸基团的聚合物涂层之间至少有一层隔离层，所述隔离层的材料不采用含有磺酸基团的聚合物。  6. The interventional medical device according to claim 5, characterized in that there is at least one isolation layer between the coating containing the drug and the polymer coating containing sulfonic acid groups, and the material of the isolation layer is not Polymers containing sulfonic acid groups are used. the 7.根据权利要求4所述的介入医疗器械，其特征在于，所述介入医疗器械为人体管腔支架。  7. The interventional medical device according to claim 4, characterized in that the interventional medical device is a human body lumen stent. the 8.根据权利要求7所述的介入医疗器械，其特征在于，所述人体管腔支架包括：冠状动脉血管支架、颅内血管支架、外周血管支架、术中支架、心脏瓣膜支架、胆道支架、食道支架、肠道支架、胰管支架、尿道支架或气管支架。  8. The interventional medical device according to claim 7, wherein the human body lumen stent comprises: coronary artery stent, intracranial vascular stent, peripheral vascular stent, intraoperative stent, heart valve stent, biliary tract stent, Esophageal stent, intestinal stent, pancreatic duct stent, urethral stent, or tracheal stent. the
CN201010201511.1A 2010-06-13 2010-06-13 Interventional medical device Expired - Fee Related CN102274550B (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN201010201511.1A CN102274550B (en) 2010-06-13 2010-06-13 Interventional medical device
RU2013100292/15A RU2013100292A (en) 2010-06-13 2011-06-13 INTERVENTIONAL SURGICAL PROCEDURAL MEDICAL DEVICE AND ITS MANUFACTURE
EP11795174.9A EP2581099B1 (en) 2010-06-13 2011-06-13 Intervention medical device and preparation thereof
BR112012031810-1A BR112012031810B1 (en) 2010-06-13 2011-06-13 INTERVENTIONAL MEDICAL DEVICE, METHOD FOR PRODUCING THE SAME AND USE OF THE POLYMER CONTAINING THE SULFONATE GROUP
JP2013513543A JP5818881B2 (en) 2010-06-13 2011-06-13 Intervention medical device and manufacturing method thereof
PCT/CN2011/075648 WO2011157208A1 (en) 2010-06-13 2011-06-13 Intervention medical device and preparation thereof
US13/703,855 US9226994B2 (en) 2010-06-13 2011-06-13 Intervention medical device and preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201010201511.1A CN102274550B (en) 2010-06-13 2010-06-13 Interventional medical device

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US9226994B2 (en) 2016-01-05
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JP5818881B2 (en) 2015-11-18
CN102274550A (en) 2011-12-14
BR112012031810A2 (en) 2021-02-02
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US20130296806A1 (en) 2013-11-07
WO2011157208A1 (en) 2011-12-22

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