CN102268753A - Manufacture method for high-molecular fiber and wound dressing, and obtained wound dressing - Google Patents
Manufacture method for high-molecular fiber and wound dressing, and obtained wound dressing Download PDFInfo
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- CN102268753A CN102268753A CN2010101985750A CN201010198575A CN102268753A CN 102268753 A CN102268753 A CN 102268753A CN 2010101985750 A CN2010101985750 A CN 2010101985750A CN 201010198575 A CN201010198575 A CN 201010198575A CN 102268753 A CN102268753 A CN 102268753A
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Abstract
The invention provides a manufacture method for high-molecular fibers and a wound dressing, and an obtained wound dressing. The manufacture method for high-molecular fibers comprises the following steps: carrying out wet spinning on aqueous dope containing natural high-molecular materials and spinning molding liquid to form wet high-molecular protofilament; immersing the wet high-molecular protofilament in a softener to obtain softener-treated wet high-molecular protofilament; immersing the softener-treated wet high-molecular protofilament in a volatile solvent to remove moisture in the high-molecular protofilament so as to obtain high-molecular fibers. The invention also provides a method for manufacturing a wound dressing with the obtained high-molecular fibers and provides the obtained wound dressing. The wound dressing is obtained by forming a high-molecular fiber nonwoven fabric from the obtained high-molecular fibers and treating the nonwoven fabric with a natural high-molecular solution to form a porous coating on the high-molecular fibers of the nonwoven fabric. According to the invention, manufacture time for the wound dressing is shortened and energy consumption needed for drying is reduced.
Description
Technical field
The present invention relates to a kind of method of macromolecular fibre and method of making the wound dressing of forming by macromolecular fibre made.The present invention also relates to wound dressing with the inventive method manufacturing.
Background technology
Wound dressing commonly used at present mostly is based on glue, film or spongiform structural material.Though these dressing have used the quite a long time on market, owing to for example problems such as mechanical strength, liquid absorption and rate of liquid aspiration cause the restriction of these materials on using.Point out that according to the past scholar's research general solid space configuration is modal spongy and Nonwovens shape, and wherein the permeability of Nonwovens shape and water imbibition are better than spongy.And the Nonwovens configuration has preferable stereochemical structure, makes cell that the preferable space absorption and the function of hyperplasia can be arranged.In addition, the Nonwovens configuration has good flexibility and certain mechanical strength, and can reduce its manufacturing cost by the method for continuous production of textile technology, produces the deposited material of hindering of inexpensive pharmaceutical grade.
Common wound dressing is with the manufacturing of natural regeneration macromolecular fibre.Wound dressing generally is to make with wet type spinning moulding technology, and uses freeze-dried technology to carry out fiber drying.But freeze-dried manufacture method is not only time-consuming but also consume energy; And in the Nonwovens manufacture method, if make water copy forming technique, need the time-consuming freeze-drying manufacture method of power consumption again again, the pinprick forming technique then needs extra pinprick machine equipment.When therefore, making natural regeneration macromolecular fibre or Nonwovens fiber as the wound dressing consumption energy consumption and need expensive equipment with conventional method.
Summary of the invention
In order to overcome in the prior art the fiber that wound dressing uses or the problem of Nonwovens made, the invention provides a kind of method of making wound dressing, it replaces freeze-dried with different drying modes, not only shorten the time of manufacture method and the consumption on the minimizing energy.
Therefore, the present invention at first provides a kind of manufacture method of macromolecular fibre, it is characterized in that comprising the following step:
(i) the water-based spinning solution (aqueous dope) that will contain natural macromolecular material forms wet type macromolecule precursor with the spinning of spinning moulding liquid wet type;
(ii) this wet type macromolecule precursor is immersed the wet type macromolecule precursor that obtains in the softener through the softener processing;
(iii) will be somebody's turn to do in the wet type macromolecule precursor immersion solvent flashing that softener is handled and form macromolecular fibre to remove the moisture in this macromolecule precursor.
In a specific embodiment, this natural macromolecular material is chitosan, alginate or their combination.
In a specific embodiment, this water-based spinning solution that contains natural macromolecular material is that concentration is the chitosan solution of 3 to 10 weight % (w/w%), and this spinning moulding liquid contains alkali compounds at least, and its concentration is 3 to 10 weight %.
In a specific embodiment, this water-based spinning solution that contains natural macromolecular material is that concentration is the sodium alginate soln of 3 to 10 weight %; And this spinning moulding liquid contains bivalent cation, and its concentration is 3 to 10 weight %.
In a specific embodiment, this softener is that concentration is that glycerite or the concentration of 0.1 to 25 weight % is the polysorbate ester solution of 0.1 to 10 weight %.
In a specific embodiment, this solvent flashing is low carbon number alcohol, low carbon number ketone or low carbon number ether.
The present invention also provides a kind of manufacture method of wound dressing, it is characterized in that comprising the following step:
(i) obtain macromolecular fibre with preceding method;
(ii) this macromolecular fibre is formed the macromolecular fibre Nonwovens; And
(iii) with this Nonwovens of natural polymer solution-treated, on the macromolecular fibre of this Nonwovens, being formed with the porous coating, thereby obtain wound dressing.
In a specific embodiment, comprise: natural polymer is sprayed to form on the Nonwovens have the Nonwovens of porous coating on macromolecular fibre with the step of natural polymer solution-treated macromolecular fibre Nonwovens; And the dry wound dressing that obtains of the Nonwovens that will have the porous coating.Preferably, this natural polymer is that the speed that sprays with 10 to 100 milliliters of per minutes sprays on the Nonwovens.And preferably, the Nonwovens drying with porous coating is to carry out under 35 to 85 ℃ temperature.
In a preferable specific embodiment, this natural polymer solution is selected from the group that is made up of sodium alginate, collagen, gelatin, hyaluronic acid, chitosan and derivative thereof and mixture.
On the other hand, the present invention also provides a kind of wound dressing, and it is with the method according to this invention manufacturing.Particularly, the wound dressing with the inventive method manufacturing will contain the Nonwovens dictyosome with macromolecular fibre; And be formed at porous coating on the macromolecular fibre in the Nonwovens dictyosome.
Can not need complicated drying steps can make wound dressing in a large number according to the inventive method.Therefore, the inventive method and the wound dressing that obtains with this method have great economic worth.And have the effect of the wound healing of improvement and blood coagulation aspect and can not cause the animal excitant according to the wound dressing that the inventive method obtains.
Description of drawings
Fig. 1 is the blood coagulation experimental result comparison with commercially available dressing and comparing embodiment dressing.
Fig. 2 is the blood coagulation experimental result comparison with the dressing of the inventive method acquisition and comparing embodiment dressing.
The specific embodiment
A kind of manufacture method of macromolecular fibre is characterized in that comprising the following step:
(i) will contain the water-based spinning solution of natural macromolecular material and the spinning of spinning moulding liquid wet type and form wet type macromolecule precursor;
(ii) this wet type macromolecule precursor is immersed the wet type macromolecule precursor that obtains in the softener through the softener processing;
(iii) will be somebody's turn to do in the wet type macromolecule precursor immersion solvent flashing that softener is handled and form macromolecular fibre to remove the moisture in this macromolecule precursor.
A kind of manufacture method of wound dressing is characterized in that comprising the following step:
(i) method according to claim 1 obtains macromolecular fibre;
(ii) this macromolecular fibre is formed the macromolecular fibre Nonwovens; And
(iii) with this Nonwovens of natural polymer solution-treated, on the macromolecular fibre of this Nonwovens, being formed with the porous coating, thereby obtain wound dressing.
According to the present invention, the step that forms the macromolecular fibre Nonwovens comprises any method of being made Nonwovens by the fiber of suitable length well known in the prior art.For example, the Nonwovens with this macromolecular fibre can form by the mode that comb and parallel cotton fibers prior to spinning and water are copied.
In a preferable specific embodiment, the step that forms the macromolecular fibre Nonwovens comprises: macromolecular fibre is carried out comb and parallel cotton fibers prior to spinning obtain the macromolecular fibre cotton-wool.
In a preferable specific embodiment, macromolecular fibre is dispersed in then carries out macromolecular fibre bonding (bonding) on the winding roller (collecting roller).
In a preferable specific embodiment, the step that forms the macromolecular fibre Nonwovens comprises: macromolecular fibre is cut into staple fibre is laid on formation wet type Nonwovens in the water then.
According to the present invention, natural macromolecular material can be chitosan, alginate or their combination.
In preferred embodiment of the present invention, the water-based spinning solution that contains natural macromolecular material is that concentration is the chitosan solution of 3 to 10 weight %; And this spinning moulding liquid contains alkali compounds at least, and its concentration is 3 to 10 weight %.
In another preferred embodiment of the present invention, the water-based spinning solution that contains natural macromolecular material is that concentration is the sodium alginate soln of 3 to 10 weight %; And this spinning moulding liquid contains bivalent cation, and its concentration is 3 to 10 weight %.
According to the present invention, this bivalent cation includes but not limited to calcium ion.
According to the present invention, softener can make wet type macromolecule precursor keep suitable pliability.
According to the present invention, softener includes but not limited to glycerine, polysorbate and derivative thereof, for example, and Tween-20 (Tween-20), Tween-60, Tween-80 and Si Pan-80 (Span-80).Preferably, softener is that concentration is that glycerite or the concentration of 0.1 to 25 weight % is the polysorbate ester solution of 0.1 to 10 weight %.
According to the present invention, will immerse in the solvent flashing through the wet type macromolecule precursor that softener is handled.This solvent flashing is preferably low carbon number alcohols, low carbon number ketone or low carbon number ethers.
The low carbon number alcohols can be methyl alcohol, ethanol, propyl alcohol, butanols, amylalcohol, hexanol.The low carbon number ketone can be C
1To C
6Ketone.The low carbon number ethers can be C
2To C
6Ether.
In a preferable specific embodiment of the present invention, be in order to increase interfibrous bonding (bonding) effect with the step of this Nonwovens of natural polymer solution-treated, it comprises:
Natural polymer solution sprayed be formed on the Nonwovens that has the porous coating on the macromolecular fibre on the Nonwovens; And
This had the Nonwovens drying of porous coating, to obtain wound dressing.
Preferably, natural polymer solution is that the speed that sprays with 10 to 100 milliliters of per minutes sprays on the Nonwovens.
Preferably, the Nonwovens drying with porous coating is carried out under 35 to 85 ℃ temperature, to obtain wound dressing.
According to the present invention, natural polymer solution contains following at least a: sodium alginate, collagen, gelatin, hyaluronic acid, chitosan and derivative thereof and mixture.
According to the above description, a kind of wound dressing that makes according to the inventive method will contain the Nonwovens dictyosome with macromolecular fibre; And be formed at porous coating on the macromolecular fibre in the Nonwovens dictyosome.
Used term " macromolecular fibre Nonwovens dictyosome " is meant by according to the prepared macromolecular fibre of method of the present invention in the literary composition, utilizes any prepared fabric of method that is used to prepare Nonwovens known in this technical field.
Below further set forth the present invention by the embodiment of the invention and reach technological means that goal of the invention takes and relevant experimental result.
Comparing embodiment: make the chitosan composite fibre with prior art
Preparation comprises the alkaline shaping dope of alkali compounds at least.Prepare the chitosan solution of 5 weight %, and it is extruded moulding in (extruded into) aforesaid shaping dope, carry out the wet type spinning, form the spinning of wet type chitosan.The spinning of wet type chitosan is through freeze-dried acquisition chitosan fiber.Get the chitosan fiber of definite composition amount, cut into 2 to 3 centimeters length, be scattered in the water, and disperse, form chitosan fiber Nonwovens in the water mode of copying then, remove moisture with freeze drying more at last with the high-speed stirred disperser.In this comparing embodiment, successively use freeze-dried manufacture method twice, each needs cost freeze-drying in 2 to 3 days, and Production Time is tediously long, and needs a large amount of power consumptions during the freeze dryer running.
Embodiment 1: make the chitosan composite fibre with the inventive method
Prepare chitosan (the about 300k dalton of the molecular weight) solution of 5 weight %.Preparation comprises the alkaline shaping dope of the NaOH of 5 weight % at least.Chitosan solution is extruded in aforesaid shaping dope moulding, carried out the wet type spinning, form the spinning of wet type chitosan.The wet type chitosan spinning that obtains was soaked in the Tween-20 of 2 volume % 5 minutes, after then being soaked in the ethanol of 50 volume %, 60 volume %, 70 volume % respectively each carrying out solvent exchange in 5 minutes, to press the suction machine that unnecessary solvent is got rid of, obtained the chitosan composite fibre in 2 hours with 60 ℃ of oven dryings then.Whole making time-histories is 4 hours.
Embodiment 2: make sodium alginate composite fiber with the inventive method
Prepare the sodium alginate soln of 5 weight %.Preparation contains the shaping dope of 5% calcium chloride.Sodium alginate soln is extruded in aforesaid shaping dope moulding, carried out the wet type spinning, form the spinning of wet type sodium alginate.The wet type sodium alginate spinning that obtains was soaked in the Tween-20 of 2 volume % 5 minutes, then be soaked in respectively after each carried out solvent exchange in 5 minutes in the ethanol of 50 volume %, 60 volume %, 70 volume %, to press the suction machine that unnecessary solvent is got rid of, obtained sodium alginate composite fiber in 2 hours with 60 ℃ of oven dryings then.Whole making time-histories is 4 hours.
Embodiment 3: utilize the porous biological macromolecular material to prepare compound wound dressing
To be cut into the short fiber of suitable length by the chitosan composite fibre that embodiment 1 obtains, carry out fiber process with carding machine, on winding roller, chitosan composite fibre web sprayed simultaneously 0.5% sodium alginate soln, the unit interval amount of spraying is 50 milliliters of per minutes, it is bonding to carry out fiber, the then dry porous biological macromolecular material that contains sodium alginate that forms.When carrying out this step, sodium alginate soln can be replaced with various biological macromolecular solutions, as collagen, gelatin, hyaluronic acid etc., to form various porous biological macromolecular material.
Then with the porous biological macromolecular material that obtains with after pressing the suction machine and getting rid of excessive moisture, with 60 ℃ of oven dryings 2 hours, obtain to possess simultaneously the wound dressing of Nonwovens and the compound kenel of porous at last.The compound wound dressing of this chitosan is used for the following examples.
Embodiment 4: the basic weight test of compound wound dressing
The compound wound dressing of chitosan that obtains is cut into size is the square of 10cm * 10cm, measure weight with electronic balance, the results averaged of nine samples of record, measurement result is as shown in table 1.Through drawing the Nonwovens average basis weight after calculating is 0.0146g/cm
2, basic weight is 146g/m behind the unit conversion
2
Compound wound dressing (the 100cm of table 1 chitosan
2) the basic weight test result
Embodiment 5: the liquid absorption test of compound wound dressing
1. experiment material and equipment:
A. the compound wound dressing of chitosan that obtains with embodiment 3 methods;
B. the normal saline solution of deionized water and variable concentrations.
2. experimental technique:
A. the compound wound dressing of getting a certain size is prior to measuring weight on the electronic balance.
B. the compound wound dressing that will survey weight again was soaked in respectively in the normal saline solution of the following variable concentrations that indicates about 8 hours.
C. take out because of soaking compound wound dressing that normal saline solution expands and measuring weight after the imbibition with electronic balance.
D. calculate weight differential and imbibition degree numerical value before and after soaking.
Result of calculation is shown in table 2.By table 2 as seen, under the normal saline solution solution-treated of variable concentrations, its pick up is all greater than more than 100%, and along with the increase of employed normal saline solution solution concentration can make its pick up descend.
Table 2 pick up test result
| Solution concentration (%) | 0 | 0.25 | 0.5 | 1 |
| Pick up (%) | 707.79 | 522.03 | 439.77 | 402.29 |
Embodiment 6: the blood coagulation test of compound wound dressing
1. experiment material and equipment:
A. the compound wound dressing of chitosan that obtains with embodiment 3 methods;
B. the chitosan wound dressing that obtains with the comparing embodiment method;
C. normal saline solution;
D. volunteer's whole blood blood;
e.ELISA(BioAssay?Systems?QuantiChromTM?Hemoglobin?Assaykit)；
F. commercially available wound dressing (trade name Kaltostat
, ConvaTec is USA) as the control group of this experiment.
2. experimental technique:
A. extract volunteer's vein whole blood blood, uncap and rocked oxygenation 30 minutes;
B. the chitosan wound dressing with 0.1g mixes with 30 μ L blood, and takes out dressing respectively and rocked in normal saline solution 4 minutes after mixing 30,60,90 and 120 seconds;
C. take out supernatant with the light absorption value of ELISA measurement at 540nm, reference wavelength is 650nm.
The ELISA experimental result is shown in Fig. 1 and Fig. 2.Fig. 1 shows commercially available dressing Kaltostat
, the wound dressing made with the wet type spinning of the commercially available dressing made from the tailor's cushion technology and comparing embodiment the comparison of blood coagulation effect, comparing embodiment has similar effect to commercially available dressing.The result of rhombus and the commercially available dressing of square expression, triangle is represented in the comparing embodiment result of the wound dressing made with the wet type spinning.As seen from the figure, it is similar with commercially available dressing effect with the acquisition of tailor's cushion technology that comparing embodiment is used the blood coagulation effect of wet type spinning acquisition dressing.
Fig. 2 shows that the blood coagulation effect of using the embodiment of the invention 3 dressing and comparing embodiment dressing compares, and rhombus is represented the result of comparing embodiment, and triangle is represented the result with the wound dressing of embodiment 3.As seen from the figure, compare with the dressing of comparing embodiment, the dressing of embodiment 3 has blood coagulation effect preferably.
Embodiment 7: the short more test of compound wound dressing animal
1. experiment material and equipment:
A. the compound wound dressing of chitosan that obtains with embodiment 3 methods;
B. the chitosan wound dressing that obtains with the comparing embodiment method;
C. big white mouse (wistar big white mouse);
D. microscope.
2. experimental technique:
A. with muscle injection mode to big white mouse injection anesthetic (0.001mL/g), treat to experimentize after it enters deep anaesthesia;
B. with shaver shave except that the big white mouse both sides the hair, use the thorough defeathering of defeathering cream again;
C. test the position with iodine disinfection, go out the wound of two 2cm x 2cm in the big white mouse back surgery;
D. the compound wound dressing that obtains with the inventive method in big white mouse back wound covering respectively and the dressing of comparing embodiment;
E. observe the wound healing situation continuously, measure and record.Observe skin and wound healing process, utilize the dressing of digital still camera Taking Pictures recording respectively and organize applying situation, wound liquid secretory volume, wound tissue infection situation and wound size situation all around.
3. result:
The wound location perusal and the wound area measurement result of the chitosan wound dressing that obtains with the compound wound dressing of chitosan of embodiment 3 methods acquisition and comparing embodiment method used in table 3 demonstration.
Table 3 compares with the wound healing situation that comparing embodiment obtains dressing with embodiment 3
The dressing experimental result of using embodiment 3 and comparing embodiment to obtain is restored situation at area and is well.Use the wound of comparing embodiment dressing to be rectangular incrustation shape in restoring haply in the 3rd week; Use the wound of embodiment 3 dressing to be circle shape wound in then restoring in the 3rd week.Dressing is removed easily, is difficult for being stained with sticking wound.
Embodiment 8: the cytotoxicity test of compound kenel wound dressing
1. experiment material and equipment:
A. the compound wound dressing of chitosan that obtains with embodiment 3 methods;
B.L929 mouse phoirocyte;
C. fluorescent electron microscope (The Olympus FSX100 Bio Imaging Navigatorall-in-one microscope).
2. experimental technique:
This test is the evaluation test of carrying out the cytotoxicity (cyctotxicity) of compound wound dressing according to ANSI/AAMI/ISO10993-5:1999 (name is called " the in vitro toxicity test of medical material ").With cultivate L929 cell in culture dish as negative control group, make the L929 mouse cell handle as positive controls with known cytotoxic phenol and only use the PE film to handle and make comparisons as the blank group with the experimental group of wound dressing of the present invention.
The cell of negative control group, blank group, positive controls and experimental group (the compound wound dressing of chitosan that embodiment 3 obtains) is accepted with trypan blue (trypan blue) dyeing and counting later stage cell number, be the results are shown in table 4.Table 4 result shows that the number of the resulting cell number of the compound wound dressing of chitosan that uses embodiment 3 and negative control group and reagent control group is approaching, and it is dead that the normal mouse fibroblast is produced, and does not therefore have any cytotoxicity.
The cytotoxicity test result of the compound wound dressing of table 4
| Group | Cell number mean value (cells/mL) |
| Negative control group | 1.27?x?10 6 |
| The reagent control group | 1.3?x?10 6 |
| Positive controls | 1.67?x?10 4 |
| Experimental group | 1.11?x?10 6 |
Embodiment 9: compound wound dressing intracutaneous stimulates test
1. experiment material and equipment:
A. the compound wound dressing of chitosan that obtains with embodiment 3 methods;
B. normal saline solution;
C. male New Zealand White Rabbit.
2. experimental technique:
A. prepare sample according to ANSI/AAMI/ISO10993-12:2007 (name is called " biological assessment-Di 12 parts of medical equipment: sample preparation and reference material ").As extract, the extraction ratio is 6cm with normal saline solution and cottonseed oil
2/ mL.Substances is soaked in the extractant in proportion, and placing rotary speed is on the oscillator of 100rpm, and extraction is 72 hours under 37 ℃ of temperature.In addition, extractant under the situation that does not contain substances, is handled with the same terms, as blank;
B. this test is tested with 2 rabbits, and preceding 18-24 hour of test is removed the rabbit back by hair with electronic hairclipper, the about 15cm x 10cm of area size.Before the test, visual inspection test rabbit skin of back guarantees not have any damage;
When c. testing, substances normal saline solution extract is injected in 5 positions of 2 rabbit back front left side respectively in the intracutaneous injection mode.Simultaneously, in test 5 positions of left rear side, rabbit back in contrast with the intracutaneous injection of blank liquid.In the same manner with substances cottonseed oil extract and the intracutaneous injection of blank liquid in test right side, rabbit back.Each position injection volume is 0.2mL;
D. finishing the injection back 24,48 and 72 hours, observe according to intradermal reaction points-scoring system (as table 5), erythema that record test position and each injection point of contrast position are manifested and oedema situation are in table 6.
Table 5 intradermal reaction points-scoring system
Table 6 rabbit skin irritant reaction score-sheet
By table 6 result as can be known, the compound wound dressing of chitosan that obtains according to the inventive method does not have irritative response on animal skin.
Embodiment 10: compound wound dressing scratch test
1. experiment material and equipment:
A. the compound wound dressing of chitosan that obtains with embodiment 3 methods;
B. normal saline solution;
C. male guinea pig.
2. experimental technique:
A. prepare sample according to ANSI/AAMI/ISO10993-12:2007.As extract, the extraction ratio is 3cm with normal saline solution
2/ mL.Extraction process is soaked in substances in the extractant in proportion, and placing rotary speed is on the oscillator of 100rpm, and extraction is 72 hours under 37 ℃ of temperature.In addition, extractant under the situation that does not contain substances, is handled with the same terms, as blank;
B. the test before, with 15 guinea pig Random assignments to test group and control group.Test group and control group respectively use 10 and 5 guinea pigs to test;
C. the test before 18-24 hour, with electronic hairclipper shave except that all experimental animal omoplate positions by the hair, the about 5cm x of area 7cm.Before the test, visual inspection test rabbit skin of back guarantees not have any damage;
D. test the previous day, the extract of preparation is shaved the position of hair with the volume intracutaneous injection of 0.1mL in every animal omoplate both sides;
E. test and to test being shaved and remove of position on the 6th day once more, and smear the vaseline that contains 10% dodecyl sodium sulfate by hair;
F. tested the 7th day, with 0.5mL substances extract or blank drop on the about 2cm x of size 4cm gauze, after it was fully absorbed, the mode of pasting skin with the part puts on test group or the control animals omoplate is shaved the position of removing by hair, and takes off dermal patch after 48 hours;
G. after taking off dermal patch, any allergic reaction that may occur every animal experiment position according to standards such as commenting of table 7 is observed and is marked.
Table 7 sensitivity test (Magnusson-Kligman) such as comments at standard
Paster test reaction score value
There is not visible variation 0
The erythema 1 of dispersion or sheet
Moderate and the erythema 2 that joins together
Serious erythema and oedema 3
In dermal patch takes off back 24 hours, 48 hours, 72 hours detection, all there is not the subcutaneous irritant reaction of the guinea pig of causing.That is to say that the compound wound dressing of the chitosan that obtains according to the present invention is through vacuum response generation on animal skin after the scratch test.
The above only is preferred embodiment of the present invention, is not the present invention is done any pro forma restriction, though invention is with the preferred embodiment exposure as above, yet be not in order to limit the present invention.Those skilled in the art are not in departing from the scope of the present invention, can utilize the technology contents of above-mentioned announcement to make a little change or be modified to the equivalent embodiment of equivalent variations, in every case be the content that does not break away from technical solution of the present invention,, all still belong in the scope of technical solution of the present invention any simple modification, equivalent variations and modification that above embodiment did according to technical spirit of the present invention.
Claims (13)
1. the manufacture method of a macromolecular fibre is characterized in that comprising the following step:
(i) the water-based spinning solution and the spinning moulding liquid that will contain natural macromolecular material carries out wet type spinning formation wet type macromolecule precursor;
(ii) this wet type macromolecule precursor is immersed the wet type macromolecule precursor that obtains in the softener through the softener processing;
(iii) will be somebody's turn to do in the wet type macromolecule precursor immersion solvent flashing that softener is handled and form macromolecular fibre to remove the moisture in this macromolecule spinning.
2. the manufacture method of macromolecular fibre according to claim 1, wherein said natural macromolecular material is chitosan, alginate or their combination.
3. the manufacture method of macromolecular fibre according to claim 1, the wherein said water-based spinning solution that contains natural macromolecular material is that concentration is the chitosan solution of 3 to 10 weight %, and described spinning moulding liquid contains alkali compounds at least, and its concentration is 3 to 10 weight %.
4. the manufacture method of macromolecular fibre according to claim 1, the wherein said water-based spinning solution that contains natural macromolecular material is that concentration is the sodium alginate soln of 3 to 10 weight %, and described spinning moulding liquid contains bivalent cation, and its concentration is 3 to 10 weight %.
5. the manufacture method of macromolecular fibre according to claim 1 and 2, wherein said softener are that concentration is that glycerite or the concentration of 0.1 to 25 weight % is the polysorbate ester solution of 0.1 to 10 weight %.
6. the manufacture method of macromolecular fibre according to claim 1 and 2, wherein said solvent flashing is low carbon number alcohol, low carbon number ketone or low carbon number ether.
7. the manufacture method of macromolecular fibre according to claim 5, wherein said solvent flashing is low carbon number alcohol, low carbon number ketone or low carbon number ether.
8. the manufacture method of a wound dressing is characterized in that comprising the following step:
(i) obtain macromolecular fibre according to the described method of claim 1;
(ii) described macromolecular fibre is formed the macromolecular fibre Nonwovens; And
(iii),, thereby obtain wound dressing with formation porous coating on the macromolecular fibre of Nonwovens with the described Nonwovens of natural polymer solution-treated.
9. the manufacture method of wound dressing according to claim 8, wherein the step with natural polymer solution-treated Nonwovens comprises:
Natural polymer solution sprayed be formed on the Nonwovens that has the porous coating on the macromolecular fibre on the Nonwovens; And
With the described dry wound dressing that obtains of Nonwovens with porous coating.
10. the manufacture method of wound dressing according to claim 9, wherein said natural polymer sprays on the Nonwovens with the speed that sprays of 10 to 100 milliliters of per minutes.
11. the manufacture method of wound dressing according to claim 9, the Nonwovens drying that wherein has the porous coating is carried out under 35 to 85 ℃ temperature.
12. according to Claim 8 or the manufacture method of 9 described wound dressings, wherein said natural polymer solution is selected from the group that is made up of sodium alginate, collagen, gelatin, hyaluronic acid, chitosan and derivative thereof and mixture.
13. a wound dressing is characterized in that utilizing that the manufacture method of each described wound dressing makes in the claim 8 to 12.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102704326A (en) * | 2012-05-25 | 2012-10-03 | 绍兴蓝海纤维科技有限公司 | Preparation method of alginic acid system nonwoven |
| CN108018716A (en) * | 2017-12-29 | 2018-05-11 | 梅庆波 | A kind of preparation method of wear-resisting hydroscopicity non-woven fabrics |
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| WO2006130117A1 (en) * | 2005-06-03 | 2006-12-07 | National University Of Singapore | Novel polymer blends and applications for their use in hollow polymer fibers |
| CN101240468A (en) * | 2008-03-14 | 2008-08-13 | 东华大学 | Polyacrylonitrile-chitin composite fiber and its production process |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102704326A (en) * | 2012-05-25 | 2012-10-03 | 绍兴蓝海纤维科技有限公司 | Preparation method of alginic acid system nonwoven |
| CN102704326B (en) * | 2012-05-25 | 2014-07-02 | 绍兴蓝海纤维科技有限公司 | Preparation method of alginic acid system nonwoven |
| CN108018716A (en) * | 2017-12-29 | 2018-05-11 | 梅庆波 | A kind of preparation method of wear-resisting hydroscopicity non-woven fabrics |
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