CN102266596A - Medicine coating titanium nail using calcium alginate fibers as carrier - Google Patents
Medicine coating titanium nail using calcium alginate fibers as carrier Download PDFInfo
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- CN102266596A CN102266596A CN2011102094033A CN201110209403A CN102266596A CN 102266596 A CN102266596 A CN 102266596A CN 2011102094033 A CN2011102094033 A CN 2011102094033A CN 201110209403 A CN201110209403 A CN 201110209403A CN 102266596 A CN102266596 A CN 102266596A
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- sorbsan
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Abstract
The invention belongs to the field of medical appliances, and particularly relates to a medicine coating titanium nail using calcium alginate fibers as a carrier, which is characterized in that the thickness of the titanium nail coating is 0.001-10mm; the calcium alginate fibers can be used for calcium alginate fiber coating treatment on the human body implant, artificial internal organ and catheter, or coating treatment by using the calcium alginate fibers as the medicine controlled-release carrier; and the titanium nail is used for coatings of titanium nail TA1, TA2 and metal nail 316LVM stainless steel, self-enhanced poly-L-lactide SR-PLLAl2 nails and self-enhanced poly-L-polyglycolide SR-PGA nails of open stitching anastomats, skin stitching instruments, linear type anastomats under endoscopes, and the diameters of the nails are 0.1-0.5. The invention effectively enhances the use of surgical operation tissue anastomosis for tissues and alimentary tracts, including stomachs, lungs and the like, lowers the occurrence of complications of the patients, enhances the survival rate and life quality of the patients, and has the advantages of simple process and low cost and uniform coating; and the uploading amount of the medicine and controlled-release carrier is greatly enhanced.
Description
Technical field:
The invention belongs to the medical device field, relating to a kind of specifically is the medication coat titanium nail of carrier with the Sorbsan.
Background technology:
The titanium nail is widely used in medical instruments field, is usually used in tissue and the uses of operation on digestive tract tissue kiss such as surgery stomach, lung, but because the biologically inert of titanium can cause sewing up failure under situations such as seam area oozing of blood, inflammation.When titanium nail and the organization healing around it, titanium nail surface nature is to organizing pivotal role, therefore, medical instruments field has proposed the technical method of many titanium nail surface modifications, comprise improvement titanium nail surface physicochemical property, surface topography and biochemical property etc., though though medication coat method technological operation at present is simple, coating is easy to occur in the network structure defectives such as the sticking or Local enrichment of the company of generation.
Summary of the invention:
The purpose of this invention is to provide a kind of surface evenly, stable, the titanium nail do not form adhesion phenomenon, coating success rate high be that a kind of of carrier is the medication coat titanium nail of carrier with the Sorbsan with the Sorbsan, to overcome above-mentioned deficiency.
The objective of the invention is to realize by following technical scheme:
A kind of is the medication coat titanium nail of carrier with the Sorbsan, it is characterized in that: being arranged on the coating layer thickness that titanium nails on is: 0.001-10MM, described titanium nail is used for open and the chamber mirror is kissed stiching instrument down, the skin seam, linear anastomat, the nail diameter of Clip Applier is at the titanium nail material TA1 of 0.1-0.5, TA2 and peg material 316LVM rustless steel, self strengthen a poly-L one lactide SR-PLLAl2 nail and self strengthen the coating that a poly-L one gathers Acetic acid, hydroxy-, bimol. cyclic ester (SR-PGA) nail, described Sorbsan can be to body implant, artificial organ, conduit carries out that the Sorbsan coating is handled or is that the coating of medicine controlled release carrier is handled with the Sorbsan.
Advantage of the present invention is:
The present invention can improve tissue and the uses of operation on digestive tract tissue kiss such as surgery stomach, lung effectively, and the complication that lowers patient significantly takes place, and improves patient's survival rate and quality of life;
The present invention is simple and easy to do, and flow process is simple, and cost is low, and the medication coat titanium that uses the present invention to produce follows closely that not only coating is even, and the also raising greatly of the last carrying capacity of medicine and controlled release carrier;
The present invention be widely used under the mirror of chamber kiss (seam) close the nail diameter of device, skin seam, linear anastomat, Clip Applier at titanium nail (material TA1, TA2) and the peg (material 316LVM rustless steel) of 0.1-0.5, self strengthen a poly-L one lactide (SR-PLLA) l2 nail and gather the coating that a L one gathers Acetic acid, hydroxy-, bimol. cyclic ester (SR-PGA) nail with self enhancing.
Below in conjunction with embodiment the present invention is further described,
The specific embodiment:
Embodiment 1:
A kind of is the medication coat titanium nail of carrier with the Sorbsan, it is characterized in that: being arranged on the coating layer thickness that titanium nails on is: 0.001-10MM, described titanium nail is used for open and the chamber mirror is kissed stiching instrument down, the skin seam, linear anastomat, the nail diameter of Clip Applier is at the titanium nail material TA1 of 0.1-0.5, TA2 and peg material 316LVM rustless steel, self strengthen a poly-L one lactide SR-PLLAl2 nail and self strengthen the coating that a poly-L one gathers Acetic acid, hydroxy-, bimol. cyclic ester (SR-PGA) nail, described Sorbsan can be to body implant, artificial organ, conduit carries out that the Sorbsan coating is handled or is that the coating of medicine controlled release carrier is handled with the Sorbsan
The present invention is the medication coat titanium nail of carrier with the Sorbsan, wherein face coat is by the 1-40% polymer support, the 20-90% solvent, 0.5-10% additive and 5-40% active component therapeutic agent are formed, the thickness of coating is 0.001-10MM, it is after the pretreatment of titanium nail, before coating liquid is uploaded, at titanium nail surface adsorption one deck bivalent metal ion chemical compound, because bivalent metal ion can produce cross-linking and curing reaction with Sorbsan, therefore adsorb the titanium of going up bivalent metal ion and follow closely surface energy, improved the absorption affinity that controlled release carrier and Titanium are followed closely the surface indirectly at part and alginic acid generation cross-linking and curing reaction.The present invention is simple and easy to do, flow process is simple, cost is low, the medication coat titanium of producing follows closely that not only coating is even, and the last carrying capacity of medicine and controlled release carrier also improves greatly, can improve effectively in surgery, the department of cerebral surgery work fracture and control the fixedly usefulness of having dislocated, the complication that lowers patient significantly takes place, and improves patient's survival rate and quality of life.
Embodiment 2
The present invention is that the coating step of medication coat titanium nail of carrier is as follows with the Sorbsan:
(1) titanium nail pretreatment: adopt organic solvent (as acetone, methanol, ethanol, dichloromethane) supersound process Titanium nail, with cleaning titanium nail;
(2) at titanium nail surface adsorption one deck bivalent metal ion chemical compound: step (1) gained titanium nail is soaked into 0.02//mlCaCl2 solution, 25 ℃ of immersion taking-ups after 20 hours down, use the centrifuge centrifuge dripping, the CaCl2 solution concentration that is used to soak can be at 0.02～0.3//ml, soak time can be at 18～24 hours, the solution concentration height, then soak time is short; Solution concentration is low, and then soak time is long;
(3) coating liquid is uploaded: the titanium nail of step (2) gained is soaked in the coating solution for preparing, soaked 4 minutes down at 20 ℃, and after at the uniform velocity slowly taking out, centrifuge dripping.Used coating liquid composition is 1g Sorbsan, 250mg paclitaxel, 20ml deionized water.
(4) post processing: step (3) gained titanium nail is soaked into 0.02g/mICaCl2 solution, takes out after 1 minute, with deionized water rinsing 3 times, 20 ℃ of following airings 1.5 hours, sealing is preserved, irradiation sterilization.
Embodiment 3
The present invention is that the coating step of medication coat titanium nail of carrier is as follows with the Sorbsan:
(1) titanium nail pretreatment: adopt organic solvent (as acetone, methanol, ethanol, dichloromethane) supersound process Titanium nail, with cleaning titanium nail.This titanium nail 60 ℃ of dryings 1 hour, is taken out;
(2) at titanium nail surface adsorption one deck bivalent metal ion chemical compound: 1 * 104g/mlBaCl2 solution evenly is sprayed at step (1) gained titanium nail surface through watering can, evenly rotate the titanium nail during sprinkling, can not there be obvious liquid enrichment on titanium nail surface, 60 ℃ of dryings are 2 hours after the been sprayed, to remove moisture, airing, the BaCl2 solution concentration that is used for spraying can also be 1 * 104～1 * 10-g/ml;
(3) coating liquid is uploaded: step (2) gained titanium is bound be written into centrifugal device, used centrifugal device adopts conventional centrifugal device, and titanium nail and centrifugal device are soaked in the coating solution for preparing, and 25 ℃ of room temperatures kept 6 minutes, after the taking-up, and centrifuge dripping.Coating liquid process for preparation is as follows: get 1g Sorbsan, 250mg paclitaxel, 20ml deionized water, continue to stir, supersound process makes that solution becomes evenly, the tiny finely dispersed mixing suspension of insoluble granule;
(4) post processing: step (3) gained titanium nail is soaked into 0.3 coffee l BaCl2 solution, takes out after 3 minutes, with deionized water rinsing 3 times, spend the night airing 2 hours of room temperature decompression, sealing is preserved, irradiation sterilization.
Embodiment 4
The present invention is that the production of coatings step of medication coat titanium nail of carrier is as follows with the Sorbsan:
(1) pretreatment of titanium nail: adopt organic solvent (as acetone, methanol, ethanol, dichloromethane) supersound process Titanium nail, with cleaning titanium nail;
(2) at titanium nail surface adsorption one deck bivalent metal ion chemical compound: step (1) gained titanium nail is soaked into 0.3g/mlMgCl2 or 0.1g/mlSrCl2 solution, titanium is followed closely as negative electrode, graphite electrode is as anode, MgCl2 or SrCl2 solution are as electrolyte, electroplate, take out after plating finishes, use the centrifuge centrifuge dripping;
(3) coating liquid is uploaded: step (2) gained titanium nail is soaked in the coating solution for preparing at the uniform velocity lentamente, soaked 10 minutes down at 35 ℃, and after the taking-up, centrifuge dripping.Coating liquid process for preparation is as follows: get Sorbsan 1g, paclitaxel 250mg, deionized water 20ml, continue to stir, supersound process makes that solution becomes evenly, the tiny finely dispersed mixing suspension of insoluble granule:
(4) post processing: step (3) gained titanium nail is soaked into 0.3 coffee lMgcl2 or 0.1g/mlSrCl2 solution solution, takes out after 5 minutes, with deionized water rinsing 3 times, 40 ℃ of following airings 1.8 hours, sealing is preserved, irradiation sterilization.
This method can be carried out that the Sorbsan coating is handled or is that the coating of medicine controlled release carrier is handled with the Sorbsan body implant, artificial organ, conduit.
Claims (3)
1. one kind is the medication coat titanium nail of carrier with the Sorbsan, it is characterized in that: comprise that being arranged on the coating layer thickness that titanium nails on is: 0.001-10MM.
2. according to claim 1 a kind of be the medication coat titanium nail of carrier with the Sorbsan, it is characterized in that: described titanium nail with open and chamber mirror down the nail diameter of kiss stiching instrument, skin seam, linear anastomat, Clip Applier at titanium nail material TA1, TA2 and the peg material 316LVM rustless steel of 0.1-0.5, self strengthen a poly-L one lactide SR-PLLAl2 nail and self strengthen the coating that a poly-L one gathers Acetic acid, hydroxy-, bimol. cyclic ester (SR-PGA) nail.
3. according to claim 1 a kind of be the medication coat titanium nail of carrier with the Sorbsan, it is characterized in that: described Sorbsan titanium nail can carry out that the Sorbsan coating is handled or is that the coating of medicine controlled release carrier is handled with the Sorbsan body implant, artificial organ, conduit.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011102094033A CN102266596A (en) | 2011-07-26 | 2011-07-26 | Medicine coating titanium nail using calcium alginate fibers as carrier |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011102094033A CN102266596A (en) | 2011-07-26 | 2011-07-26 | Medicine coating titanium nail using calcium alginate fibers as carrier |
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| CN102266596A true CN102266596A (en) | 2011-12-07 |
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| CN2011102094033A Pending CN102266596A (en) | 2011-07-26 | 2011-07-26 | Medicine coating titanium nail using calcium alginate fibers as carrier |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106377290A (en) * | 2016-08-19 | 2017-02-08 | 北京派尔特医疗科技股份有限公司 | Drug-loaded titanium nail and preparation method thereof |
| CN112516372A (en) * | 2020-11-12 | 2021-03-19 | 盐城工学院 | Composite drug-loaded fiber for absorbable surgical suture |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1915440A (en) * | 2006-08-10 | 2007-02-21 | 原子高科股份有限公司 | Method for preparing coating of drug-coated stent by taking alginate as carrier |
| WO2007086832A2 (en) * | 2006-01-13 | 2007-08-02 | Biodynamics, L.L.C | Surgical fasteners and related implant devices having bioabsorbable components |
| CN101549177A (en) * | 2009-05-22 | 2009-10-07 | 熊焱昊 | Medicament coating applied to fixation screw in rachis, preparation method thereof and application thereof |
-
2011
- 2011-07-26 CN CN2011102094033A patent/CN102266596A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007086832A2 (en) * | 2006-01-13 | 2007-08-02 | Biodynamics, L.L.C | Surgical fasteners and related implant devices having bioabsorbable components |
| CN1915440A (en) * | 2006-08-10 | 2007-02-21 | 原子高科股份有限公司 | Method for preparing coating of drug-coated stent by taking alginate as carrier |
| CN101549177A (en) * | 2009-05-22 | 2009-10-07 | 熊焱昊 | Medicament coating applied to fixation screw in rachis, preparation method thereof and application thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106377290A (en) * | 2016-08-19 | 2017-02-08 | 北京派尔特医疗科技股份有限公司 | Drug-loaded titanium nail and preparation method thereof |
| CN106377290B (en) * | 2016-08-19 | 2018-06-22 | 北京派尔特医疗科技股份有限公司 | A kind of medicine-carried titanium nail and load medicine titanium nail and preparation method thereof |
| US10286117B2 (en) | 2016-08-19 | 2019-05-14 | B.J. Zh. F. Panther Medical Equipment Co. Ltd. | Titanium nail capable of loading drug and drug-loaded titanium nail and preparing method of the same |
| CN112516372A (en) * | 2020-11-12 | 2021-03-19 | 盐城工学院 | Composite drug-loaded fiber for absorbable surgical suture |
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Application publication date: 20111207 |