CN102266255B - Electrostatic spinning production method of conical corrugated small-caliber artificial blood vessel - Google Patents
Electrostatic spinning production method of conical corrugated small-caliber artificial blood vessel Download PDFInfo
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- CN102266255B CN102266255B CN201110127497XA CN201110127497A CN102266255B CN 102266255 B CN102266255 B CN 102266255B CN 201110127497X A CN201110127497X A CN 201110127497XA CN 201110127497 A CN201110127497 A CN 201110127497A CN 102266255 B CN102266255 B CN 102266255B
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Abstract
The invention provides a conical corrugated small-caliber artificial blood vessel as well as an electrostatic spinning production method and equipment thereof. The conical corrugated small-caliber artificial blood vessel comprises a conical artificial blood vessel body, the inner wall of which is provided with spiral corrugation. The electrostatic spinning production method of the conical corrugated small-caliber artificial blood vessel comprises: dissolving a spinning polymer in a solvent to prepare a spinning solution, carrying out electrostatic spinning on the spinning solution, collecting by using an electrostatic spinning collection device, after the electrostatic spinning is completed, firstly opening a fixing device, then rotating and taking off a conical membrane from the small end of a conical collecting roller, and then drawing-off a spiral corrugation treatment device from a conical membrane cavity to obtain the conical corrugated small-caliber artificial blood vessel. The conical corrugated small-caliber artificial blood vessel provided by the invention can meet the bridging needs of the blood vessels with different diameters; and the spiral corrugation can not only promote the improvement of blood flow rate near the wall of the blood vessel, favor smooth washing of the inner wall and inhibit the thrombus formation, but also ensure that the bent positions of the blood vessels are not easy to block while bridging.
Description
Technical field
The present invention relates to the small-bore artificial blood vessel of a kind of taper ripple and static thereof and spin production method and device, belong to medical artificial human organ field.
Background technology
In vascular bypass and replacement operation, small-bore artificial blood vessel easily produces thrombosis and causes implanting early stage failure.Studies show that the formation of thrombosis at first is hematoblastic sticking collection, forming process afterwards just depends on position and the local blood flow rate that thrombosis takes place.In order to address this problem, the patent No. is 200610054134.7, the Chinese patent that name is called " a kind of artificial blood vessel " proposes to design helicla flute at the inwall of blood vessel, thereby increase the wall blood flow rate, the artificial blood vessel inwall is washed, reduce material such as platelet in the deposition of wall, and then reach and suppress thrombotic purpose.But the shortcoming that this patent exists is: (1) only sets forth the preparation method of not mentioned helical corrugation in theory to helical corrugation.(2) object of study is the small-bore artificial blood vessel of equal diameter, but according to the different shape of lesion vessels, the small-bore artificial blood vessel of equal diameter is when overlapping, and meeting is owing to artificial blood vessel and host blood vessel diameter not matching, and cause blood flow to form eddy current at seam, and then form thrombosis.(3) molding parameter of helical corrugation has only been considered the improvement of blood flow state, does not consider that the blood vessel bending place easily produces inaccessible problem when putting up a bridge.
Summary of the invention
The purpose of this invention is to provide the small-bore artificial blood vessel of a kind of taper ripple and production method and device, to overcome above-mentioned defective, be about to the small-bore artificial blood vessel of uiform section that electro-spinning is equipped with and be transformed into the small-bore artificial blood vessel of taper, and the chamber wall forms helical corrugation within it.The small-bore artificial blood vessel of this kind can satisfy the needs of putting up a bridge between the different-diameter blood vessel, in addition, reasonably the design of helical corrugation not only can impel the raising of the blood flow velocity at the nearly wall of blood vessel place, be conducive to make interior sidewall surface to obtain smooth washing away, suppress the formation of thrombosis, can also guarantee that the vascular bending place is difficult for taking place inaccessible when putting up a bridge.
In order to achieve the above object, the invention provides the small-bore artificial blood vessel of a kind of taper ripple, it is characterized in that, comprise taper artificial blood vessel body, the inwall of described taper artificial blood vessel body is provided with helical corrugation.
The present invention also provides a kind of static to spin gathering-device, it is characterized in that, comprises the cone-shaped collection roller bearing, and the two ends of cone-shaped collection roller bearing are fixed by fixture, and fixedly there is the helical corrugation blood processor in the outside of cone-shaped collection roller bearing.
Preferably, described helical corrugation blood processor is for being wrapped in the terylene strand in the cone-shaped collection roller bearing outside in the helical corrugation mode, and its diameter is 1mm, and the spiral head number of helical corrugation is 1～6, and the lead angle maximum is 5 °～45 °, and flight pitch is 2mm.
Preferably, described cone-shaped collection roller bearing tapering be 1 °～3 °.
The present invention also provides the static of the small-bore artificial blood vessel of a kind of taper ripple to spin production method, it is characterized in that, concrete steps are: spinning is dissolved in macromolecule makes spinning liquid in the solvent, spinning liquid is carried out electrostatic spinning, adopting above-mentioned static to spin gathering-device collects, after electrostatic spinning is finished, at first fixture is opened, then cone-shaped membrane is revolved from the small end of cone-shaped collection roller bearing and take off, again the helical corrugation blood processor is extracted from the cone-shaped membrane intracavity, namely obtain the small-bore artificial blood vessel of taper ripple.
Preferably, described spinning macromolecule is terylene or polylactic acid.
Preferably, the condition of described electrostatic spinning is: voltage is 20kV, and pole span is 12cm, and flow velocity is 1.5mL/h, and spin duct syringe needle internal diameter is 0.8mm, and the rotating speed of cone-shaped collection roller bearing is 1000rpm.
Preferably, the small end internal diameter of the small-bore artificial blood vessel of taper ripple of gained is 2mm～6mm, and holding internal diameter greatly is 4mm～8mm.
The present invention compared with prior art has following beneficial effect:
(1) owing to adopted cone-shaped collection roller bearing and helical corrugation blood processor, makes static spin small-bore artificial blood vessel and strip in the process at film and peel off easily.
(2) helical corrugation that utilizes " loosing core " legal system to be equipped with artificial blood vessel is simple and easy to molding, and can not destroy electrostatic spinning artificial blood vessel wall.
(3) spiral head number and lead angle that can the adjustable screw ripple make its hydromechanics performance that both can improve blood, and it is inaccessible to guarantee that small-bore artificial blood vessel is difficult in the bending place, thereby reduces the thrombosis probability.
(4) can prepare the small-bore artificial blood vessel of different taperings and different end diameters (outside diameter).
Description of drawings
Fig. 1 spins the gathering-device structural representation for static;
Fig. 2 is " loosing core " method sketch map;
Fig. 3 is that the helical corrugation blood processor is at artificial blood vessel intracavity model;
Fig. 4 is that the A of Fig. 3 is to view.
The specific embodiment
Below in conjunction with embodiment, further set forth the present invention.Should be understood that these embodiment only to be used for explanation the present invention and be not used in and limit the scope of the invention.Should be understood that in addition those skilled in the art can do various changes and modification to the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute limited range equally.
Embodiment 1
As shown in Figure 1, for static spins the gathering-device structural representation, described static spins gathering-device and comprises cone-shaped collection roller bearing 3, and the two ends of cone-shaped collection roller bearing 3 are fixed by fixture 1, and fixedly there is helical corrugation blood processor 2 in the outside of cone-shaped collection roller bearing 3.Described cone-shaped collection roller bearing 3 is 1 ° for cone angle, and length is that the aluminum matter truncated cone of 20cm is collected roller bearing.Described helical corrugation blood processor 2 is for being wrapped in the terylene strand (15D/130F * 3) in cone-shaped collection roller bearing 3 outsides in the helical corrugation mode, its diameter is 1mm, and the spiral head number of helical corrugation is 1, and the lead angle maximum is 5 °, and flight pitch is 2mm.
Be that 0.8 terylene chips is dissolved in the mixed solution of trifluoroacetic acid and dichloromethane (volume ratio is 4: 1) with intrinsic viscosity, make mass fraction and be 10% spinning liquid, spinning liquid is sucked in the spin duct, the syringe needle internal diameter of spin duct is 0.8mm, regulating cone-shaped collection roller bearing 3 rotating speeds is 1000rpm, be 20kV at voltage, pole span is 12cm, flow velocity is to carry out electrostatic spinning under the condition of 1.5mL/h, adopting above-mentioned static to spin gathering-device collects, after electrostatic spinning is finished, at first fixture 1 is opened, then cone-shaped membrane 4 is revolved from the small end of cone-shaped collection roller bearing 3 and take off, as shown in Figure 3, for the helical corrugation blood processor at artificial blood vessel intracavity model, Fig. 4 is that the A of Fig. 3 is to view, adopt " loosing core " method that helical corrugation blood processor 2 is extracted from cone-shaped membrane 4 intracavity again, as shown in Figure 2, be " loosing core " method sketch map, namely obtain the small-bore artificial blood vessel of taper ripple, the small-bore artificial blood vessel of described taper ripple comprises taper artificial blood vessel body, and the inwall of described taper artificial blood vessel body is provided with helical corrugation.The small end head bore of the small-bore artificial blood vessel of taper ripple is 4mm, and big termination bore is 6mm.
As shown in Figure 1, for static spins the gathering-device structural representation, described static spins gathering-device and comprises cone-shaped collection roller bearing 3, and the two ends of cone-shaped collection roller bearing 3 are fixed by fixture 1, and fixedly there is helical corrugation blood processor 2 in the outside of cone-shaped collection roller bearing 3.Described cone-shaped collection roller bearing 3 is 3 ° for cone angle, and length is that the aluminum matter truncated cone of 20cm is collected roller bearing.Described helical corrugation blood processor 2 is for being wrapped in the terylene strand (15D/130F * 3) in cone-shaped collection roller bearing 3 outsides in the helical corrugation mode, its diameter is 1mm, and the spiral head number of helical corrugation is 6, and the lead angle maximum is 45 °, and flight pitch is 2mm.
Be that 100000 polylactic acid (PLLA) is dissolved in the mixed solution of chloroform and acetone (volume ratio is 2: 1) with molecular weight, make mass fraction and be 5% spinning liquid, spinning liquid is sucked in the spin duct, the syringe needle internal diameter of spin duct is 0.8mm, regulating cone-shaped collection roller bearing 3 rotating speeds is 1000rpm, be 20kV at voltage, pole span is 12cm, flow velocity is to carry out electrostatic spinning under the condition of 1.5mL/h, adopting above-mentioned static to spin gathering-device collects, after electrostatic spinning is finished, at first fixture 1 is opened, then cone-shaped membrane 4 is revolved from the small end of cone-shaped collection roller bearing 3 and take off, as shown in Figure 3, for the helical corrugation blood processor at artificial blood vessel intracavity model, Fig. 4 is that the A of Fig. 3 is to view, adopt " loosing core " method that helical corrugation blood processor 2 is extracted from cone-shaped membrane 4 intracavity again, as shown in Figure 2, be " loosing core " method sketch map, namely obtain the small-bore artificial blood vessel of taper ripple, the small-bore artificial blood vessel of described taper ripple comprises taper artificial blood vessel body, and the inwall of described taper artificial blood vessel body is provided with helical corrugation.The small end head bore of the small-bore artificial blood vessel of taper ripple is 4mm, and big termination bore is 6mm.
Claims (4)
1. the static of the small-bore artificial blood vessel of taper ripple spins production method, it is characterized in that, concrete steps are: spinning is dissolved in macromolecule makes spinning liquid in the solvent, spinning liquid is carried out electrostatic spinning, adopting static to spin gathering-device collects, described static spins gathering-device and comprises cone-shaped collection roller bearing (3), the two ends of cone-shaped collection roller bearing (3) are fixed by fixture (1), fixedly there is helical corrugation blood processor (2) in the outside of cone-shaped collection roller bearing (3), after electrostatic spinning is finished, at first fixture (1) is opened, then cone-shaped membrane (4) is revolved from the small end of cone-shaped collection roller bearing (3) and take off, again helical corrugation blood processor (2) is extracted from cone-shaped membrane (4) intracavity, namely obtain the small-bore artificial blood vessel of taper ripple, the small-bore artificial blood vessel of described taper ripple comprises taper artificial blood vessel body, and the inwall of taper artificial blood vessel body is provided with helical corrugation; Described helical corrugation blood processor (2) is for being wrapped in the terylene strand in cone-shaped collection roller bearing (3) outside in the helical corrugation mode, its diameter is 1mm, and the spiral head number of helical corrugation is 1～6, and the lead angle maximum is 5 °～45 °, and flight pitch is 2mm; The condition of described electrostatic spinning is: voltage is 20kV, and pole span is 12cm, and flow velocity is 1.5mL/h, and spin duct syringe needle internal diameter is 0.8mm, and the rotating speed of cone-shaped collection roller bearing (3) is 1000rpm.
2. the static of the small-bore artificial blood vessel of taper ripple as claimed in claim 1 spins production method, it is characterized in that, the tapering of described cone-shaped collection roller bearing (3) is 1 °～3 °.
3. the static of the small-bore artificial blood vessel of taper ripple as claimed in claim 1 spins production method, it is characterized in that, described spinning macromolecule is terylene or polylactic acid.
4. the static of the small-bore artificial blood vessel of taper ripple as claimed in claim 1 spins production method, it is characterized in that, the small end internal diameter of the small-bore artificial blood vessel of taper ripple of gained is 2mm～6mm, and holding internal diameter greatly is 4mm～8mm.
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| CN201110127497XA CN102266255B (en) | 2011-05-17 | 2011-05-17 | Electrostatic spinning production method of conical corrugated small-caliber artificial blood vessel |
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| CN201110127497XA CN102266255B (en) | 2011-05-17 | 2011-05-17 | Electrostatic spinning production method of conical corrugated small-caliber artificial blood vessel |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103876859A (en) * | 2014-03-25 | 2014-06-25 | 南开大学 | Artificial blood vessel composed of micrometer fiber and provided with large-hole structure and preparation method and application thereof |
| CN104398316A (en) * | 2014-11-25 | 2015-03-11 | 北京航空航天大学 | Tapered spiral small-diameter artificial blood vessel capable of generating swirl flow |
| CN105107020A (en) * | 2015-08-25 | 2015-12-02 | 清华大学 | Artificial blood vessel prepared by weaving PHBV (polyhydroxybutyrate-hydroxyvalerate) and PLA (polylactic acid) in blending manner |
| CN105755554B (en) * | 2016-04-01 | 2017-08-22 | 重庆大学 | A kind of small-caliber artificial blood vessel preparation method based on electrostatic spinning |
| CN105671657B (en) * | 2016-04-01 | 2017-08-22 | 重庆大学 | A kind of small-caliber artificial blood vessel preparation facilities based on electrostatic spinning |
| CN114250523B (en) * | 2021-12-22 | 2022-10-14 | 芜湖滤森净化设备有限公司 | Production device and use method of arc-shaped melt-blown filter element |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1817328A (en) * | 2006-03-14 | 2006-08-16 | 重庆大学 | Artificial blood vessel |
| CN201343585Y (en) * | 2008-12-19 | 2009-11-11 | 青岛大学 | Electrostatic spinning device for producing nanofiber |
| CN101843578A (en) * | 2010-05-14 | 2010-09-29 | 东华大学 | Nanofiber membrane carrying anti-tumor photosensitizer and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0227369D0 (en) * | 2002-11-23 | 2002-12-31 | Tayside Flow Technologies Ltd | A helical formation for a conduit |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1817328A (en) * | 2006-03-14 | 2006-08-16 | 重庆大学 | Artificial blood vessel |
| CN201343585Y (en) * | 2008-12-19 | 2009-11-11 | 青岛大学 | Electrostatic spinning device for producing nanofiber |
| CN101843578A (en) * | 2010-05-14 | 2010-09-29 | 东华大学 | Nanofiber membrane carrying anti-tumor photosensitizer and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 人造血管的纺织设计与加工技术;凌凯等;《上海生物医学工程》;20030630;第24卷(第2期);第51页右栏第1-10行 * |
| 凌凯等.人造血管的纺织设计与加工技术.《上海生物医学工程》.2003,第24卷(第2期),第49-52页. |
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