CN102258947A - Lecithin self-assembly cross-linking bionic modified polymer membrane material and preparation method thereof - Google Patents
Lecithin self-assembly cross-linking bionic modified polymer membrane material and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a lecithin self-assembly cross-linking bionic modified polymer membrane material and a preparation method thereof. The preparation method disclosed by the invention comprises the following steps: dissolving natural lecithin, a cross-linking agent and a photoinitiator into ethanol to prepare a lecithin modified ethanol solution; carrying out constant-pressure medium barrier discharge plasma processing on a polymer membrane material; soaking the polymer membrane material into the lecithin modified ethanol solution; and after carrying out ultraviolet light radiation for 1-40 minutes, washing with deionized water and drying at room temperature. In the invention, the self-assembly can be carried out on natural lecithin molecules containing unsaturated alkyl chains on the surface of a lyophobic polymer; and the cross-linking is carried out on the natural lecithin molecules containing the unsaturated alkyl chains by combining a sulfydryl-alkenyl click reaction, thereby forming a uniform, durable and stable lecithin bionic layer on the surface of a lyophobic polymer membrane material and endowing the lyophobic polymer membrane with excellent protein-absorption-resistant performance. According to the invention, the process is simple, the processing effect is good, the cost is low, no environmental pollution exists, and high efficiency and energy conservation are achieved.
Description
Technical field
The present invention relates to a kind of polymeric film material and preparation method thereof, relate in particular to crosslinked biomimetic modification polymeric film material of lecithin self assembly of anti-protein absorption and preparation method thereof.
Background technology
Polymeric film material has been widely used in fields such as industry, agricultural, medicine, environmental protection.Membrane material commonly used at present mostly is macromolecular materials such as polyethylene, polypropylene, polysulfones, polyether sulfone, Kynoar or polytetrafluoroethylene (PTFE), and this base polymer surface energy is low, hydrophobicity is stronger; Polymeric film material is especially as the application of bio-medical material at aspects such as the Separation ﹠ Purification of artificial organ (artificial liver, artificial kidney), biological products and living things catalysis, more and more be subjected to people's common concern, become the focus that competitively research and develop countries in the world.Yet this class hydrophobic film material tends to cause protein to adsorb in a large number with after protein, blood or body tissue contact, and can produce harmful effect simultaneously or cause lesion tissue, and then the host is caused tangible clinical response.These shortcomings have restricted further applying of they.Adopt process for modifying surface can optimize surface property, especially hydrophilicity and the biocompatibility of separation membrane, and don't can destroy its bulk properties, can widen the scope of application of film, improved the service efficiency of film, prolonged the service life of film.
The method of membrane surface modification mainly comprise surface plasma handle (CN1539550A, CN1546214A), ultraviolet light irradiation graft modification (CN1618509A), gamma-radiation radiation modification (CN1569934A), ozone graft modification (CN1640533A) and surfactant coated modification (CN1257747A) etc.Through specific modifying process, film can be endowed different surfaces characteristic, possess such as functions such as hydrophily, compatibility, pH response, temperature-responsive, biocompatibility, resistance tocrockings, be widely used in fields such as sewage disposal, printing and dyeing, bio-pharmaceuticals, fine chemistry industry.Above hydrophilic modifying and biocompatibility method of modifying exist respectively active particle density not strong, the inconvenient operation of easy-regulating, radiation, be unfavorable for shortcomings such as continuous operation, power consumption are big.Therefore, be necessary to develop a kind of simple efficient, be suitable for industrial continuous production hydrophobic polymer membrane material biomimetic modification method, and then give the surface of separating film of polymer excellent biocompatibility.
Class phosphatide is to constitute one of biomembranous chief component, is bringing into play extremely important biological function in vital movement, and numerous physiology courses is had deep effect, therefore, their research and sign is become more and more important.Class phosphatide is the amphiphatic molecule that contains polar component and nonpolarity element, thereby the hydrophilic-hydrophobic double-deck fat structure that causes most of biomembrane all to have, and every layer of phospholipid molecule hydrophobic tail in the double-layer of lipoid all pointed to double-layer inner, and their hydrophilic head then provides the two layers of hydrophilic ion surface outwardly.Wherein phosphatidyl-ethanolamine (PE), phosphatid ylcholine (PC) and three kinds of glycerophosphatides of phosphatidylserine (PS) are biomembranous main members, and the just this double-layer of lipoid structure that is referred to as liposome has given biomembrane natural biocompatibility.In recent years, class phosphatide is introduced in the material, utilized the biocompatibility and the recognition reaction of class phosphatide, obtained certain effect in fields such as food, medicine, clinical diagnosis, cosmetics, Separation of Proteins.But that this class methods exist is complicated such as synthetic class phosphatide monomer difficulty, loaded down with trivial details, the consuming time length of modifying process and inefficiency, be unfavorable for deficiency such as the continuous production of industrialization.
Therefore, be necessary to develop a kind of simple efficient, be suitable for industrial continuous production hydrophobic polymer membrane material biomimetic modification method, and then give the polymeric film material surface even, stable biocompatibility.
Summary of the invention
Poor at present polymer film surface hydrophily and biocompatibility, and the deficiency of the phospholipid modified polymer film technology existence of class, one of technical problem to be solved by this invention provides the preparation method of the crosslinked biomimetic modification polymeric film material of a kind of lecithin self assembly, utilizes to originate widely that natural phosphatidyl choline carries out biomimetic modification to polymer film.
Two of technical problem to be solved by this invention provides the crosslinked biomimetic modification polymeric film material of a kind of lecithin self assembly, adopts method for preparing to form.
The present invention is achieved by following technical proposals:
The preparation method of the crosslinked biomimetic modification polymeric film material of a kind of lecithin self assembly, be made up of following step:
Step 1, natural phosphatidyl choline, crosslinking agent and light trigger are dissolved in the ethanol preparation lecithin modification ethanolic solution;
Step 2, polymeric film material is placed between two sparking electrodes of dielectric barrier discharge, carry out the atmospheric dielectric barrier discharge plasma and handle;
Step 3, the polymeric film material after step 2 handled are immersed in the lecithin modification ethanolic solution of step 1 preparation, carry out ultraviolet light irradiation after 1～40 minute, utilize washed with de-ionized water again, and at room temperature dry, can make the crosslinked biomimetic modification polymeric film material of lecithin self assembly.
Preferably,
In the described step 1, the mass percent concentration of natural phosphatidyl choline, crosslinking agent and light trigger is respectively 0.1～10%, 0.05～2% and 0.001～0.1% in the described lecithin modification ethanolic solution.
In the described step 1, described natural phosphatidyl choline is soybean lecithin or egg yolk lecithin.
In the described step 1, described crosslinking agent is 1,2-dithioglycol, 1,4-succinimide mercaptans or 1,6-ethanthiol.
In the described step 1, described light trigger is diphenyl (2,4, the 6-trimethylbenzoyl) phosphine oxide, styrax dimethyl ether, benzophenone, 9-thioxanthones or camphorquinone.
In the described step 2, described polymeric film material is polyethylene, polypropylene, polystyrene, polyacrylonitrile, polysulfones, polyether sulfone, Kynoar or polytetrafluoroethylene (PTFE).
In the described step 2, atmospheric dielectric barrier discharge plasma treatment conditions are: the distance between two sparking electrodes is 1.5～3 centimetres, feeds inert gas, 0.5～10 liter/minute of gas flow during discharge; Discharge frequency is 10 KHzs, and discharge power is 50～150 watts, and the processing time is 5～30 seconds.
Above-mentioned inert gas is preferably helium or argon gas.
The invention also discloses the crosslinked biomimetic modification polymeric film material of a kind of lecithin self assembly, adopt method for preparing to form.
The crosslinked biomimetic modification polymeric film material of lecithin self assembly of the present invention is in the polymer separation film modifying process, the natural phosphatidyl choline molecular energy that utilization contains the unsaturated alkyl chain carries out self assembly on the hydrophobic polymer surface, and carry out crosslinked in conjunction with the natural phosphatidyl choline that mercapto-alkene click-reaction will contain unsaturated long alkyl chain, and then at the bionical layer of hydrophobic polymer membrane material surface formation lecithin even, lasting stability, thereby the anti-protein absorption property of hydrophobic property polymer film excellence.Technology of the present invention is simple, treatment effect good, cost is low, non-environmental-pollution, energy-efficient.
The specific embodiment
Below in conjunction with embodiment the present invention is further described the present invention.
Atmospheric dielectric barrier discharge plasma equipment among the following embodiment, the inferior airglow discharge process machine of selecting for use Nanjing Su Man Electronics Co., Ltd. to produce, concrete model is HPD-2400.
Embodiment 1
With egg yolk lecithin, 1,2-dithioglycol and benzophenone are dissolved in the ethanol, preparation egg yolk lecithin, 1, and the mass percent concentration of 2-dithioglycol and benzophenone is respectively 0.1%, 0.05% and 0.001% mixed solution; (membrane aperture is 0.1～0.9 μ m with polypropylene screen, the film surface contact angle is 108.4 ± 1.3 °) be placed between two sparking electrodes of the dielectric barrier discharge in the atmospheric dielectric barrier discharge plasma equipment, regulating between two sparking electrodes distance is 1.5 centimetres, feed helium, 0.5 liter/minute of gas flow during discharge; Discharge frequency is 10 KHzs, and discharge power is 50 watts, and the processing time is 5 seconds; To be immersed in through the polypropylene screen of plasma treatment in the lecithin modification ethanolic solution of above-mentioned preparation, carry out ultraviolet lighting simultaneously 40 minutes.Taking-up is dried under the room temperature after deionized water is cleaned, and promptly gets the crosslinked biomimetic modification polypropylene separation membrane of lecithin, and film surface hydrophilic performance sees Table 1 before and after the modification.
Embodiment 2
With egg yolk lecithin, 1,2-dithioglycol and benzophenone are dissolved in the ethanol, preparation egg yolk lecithin and 1, and the mass percent concentration of 2-dithioglycol and benzophenone is respectively 2.0%, 0.2% and 0.005% mixed solution; (membrane aperture is 0.1～0.9 μ m with polypropylene screen, the film surface contact angle is 108.4 ± 1.3 °) be placed between two sparking electrodes of atmospheric dielectric barrier discharge plasma equipment medium barrier discharge, regulating between two sparking electrodes distance is 2 centimetres, feed helium, 1 liter/minute of gas flow during discharge; Discharge frequency is 10 KHzs, and discharge power is 80 watts, and the processing time is 10 seconds; To be immersed in through the polypropylene screen of plasma treatment in the lecithin modification ethanolic solution of above-mentioned preparation, carry out ultraviolet lighting simultaneously 1 minute.Taking-up is dried under the room temperature after deionized water is cleaned, and promptly gets the crosslinked biomimetic modification polypropylene separation membrane of lecithin, and its hydrophilicity sees Table 1.
Embodiment 3
With egg yolk lecithin, 1,4-succinimide mercaptans and diphenyl (2,4, the 6-trimethylbenzoyl) phosphine oxide is dissolved in the ethanol, preparation egg yolk lecithin, 1, the amount percent concentration of 4-succinimide mercaptans and diphenyl (2,4, the 6-trimethylbenzoyl) phosphine oxide matter is respectively 5.0%, 1% and 0.05% mixed solution; (membrane aperture is 0.1～0.9 μ m with polypropylene screen, the film surface contact angle is 108.4 ± 1.3 °) be placed between two sparking electrodes of atmospheric dielectric barrier discharge plasma equipment medium barrier discharge, regulating between two sparking electrodes distance is 3 centimetres, feed helium, 4 liters/minute of gas flows during discharge; Discharge frequency is 10 KHzs, and discharge power is 100 watts, and the processing time is 20 seconds; To be immersed in through the polypropylene screen of plasma treatment in the lecithin modification ethanolic solution of above-mentioned preparation, carry out ultraviolet lighting simultaneously 20 minutes.Taking-up is dried under the room temperature after deionized water is cleaned, and promptly gets the crosslinked biomimetic modification polypropylene separation membrane of lecithin, and its hydrophilicity sees Table 1.
Embodiment 4
With egg yolk lecithin, 1,4-succinimide mercaptans and diphenyl (2,4, the 6-trimethylbenzoyl) phosphine oxide is dissolved in the ethanol, preparation egg yolk lecithin, 1, the mass percent concentration of 4-succinimide mercaptans and diphenyl (2,4, the 6-trimethylbenzoyl) phosphine oxide is respectively 10.0%, 2% and 0.1% mixed solution; (membrane aperture is 0.1～0.9 μ m with polypropylene screen, the film surface contact angle is 108.4 ± 1.3 °) be placed between two sparking electrodes of atmospheric dielectric barrier discharge plasma equipment medium barrier discharge, regulating between two sparking electrodes distance is 3 centimetres, feed helium, 8 liters/minute of gas flows during discharge; Discharge frequency is 10 KHzs, and discharge power is 120 watts, and the processing time is 30 seconds; To be immersed in through the polypropylene screen of plasma treatment in the lecithin modification ethanolic solution of above-mentioned preparation, carry out ultraviolet lighting simultaneously 5 minutes.Taking-up is dried under the room temperature after deionized water is cleaned, and promptly gets the crosslinked biomimetic modification polypropylene separation membrane of lecithin, and its hydrophilicity sees Table 1.
Embodiment 5
With egg yolk lecithin, 1,4-succinimide mercaptans and styrax dimethyl ether are dissolved in the ethanol, preparation egg yolk lecithin, 1, and the mass percent concentration of 4-succinimide mercaptans and styrax dimethyl ether is respectively 10.0%, 0.2% and 0.001% mixed solution; Polypropylene screen (membrane aperture is 0.1～0.9 μ m, and the film surface contact angle is 108.4 ± 1.3 °) is placed in the atmospheric dielectric barrier discharge plasma equipment, and regulating between two sparking electrodes distance is 2 centimetres, feeds argon gas, 10 liters/minute of gas flows during discharge; Discharge frequency is 10 KHzs, and discharge power is 150 watts, and the processing time is 30 seconds; To be immersed in through the polypropylene screen of plasma treatment in the lecithin modification ethanolic solution of above-mentioned preparation, carry out ultraviolet lighting simultaneously 10 minutes.Taking-up is dried under the room temperature after deionized water is cleaned, and promptly gets the crosslinked biomimetic modification polypropylene separation membrane of lecithin, and its hydrophilicity sees Table 1.
Embodiment 6
With soybean lecithin, 1,4-succinimide mercaptans and styrax dimethyl ether are dissolved in the ethanol, preparation soybean lecithin, 1, and the mass percent concentration of 4-succinimide mercaptans and styrax dimethyl ether is respectively 4.0%, 1% and 0.05% mixed solution; (membrane aperture is 0.02～0.5 μ m with PS membrane, the film surface contact angle is 91.6 ± 2.3 °) be placed between two sparking electrodes of atmospheric dielectric barrier discharge plasma equipment medium barrier discharge, regulating between two sparking electrodes distance is 3 centimetres, feed helium, 5 liters/minute of gas flows during discharge; Discharge frequency is 10 KHzs, and discharge power is 100 watts, and the processing time is 20 seconds; To be immersed in through the polypropylene screen of plasma treatment in the lecithin modification ethanolic solution of above-mentioned preparation, carry out ultraviolet lighting simultaneously 40 minutes.Taking-up is dried under the room temperature after deionized water is cleaned, and promptly gets the crosslinked biomimetic modification polysulfones of lecithin diffusion barrier, and its hydrophilicity sees Table 1.
Embodiment 7
With soybean lecithin, 1,4-succinimide mercaptans and 9-thioxanthones are dissolved in and prepare soybean lecithin, 1 in the ethanol, and the mass percent concentration of 4-succinimide mercaptans and 9-thioxanthones is respectively 8.0%, 0.05% and 0.1% mixed solution; (membrane aperture is 0.1～0.5 μ m with polyethylene film, the film surface contact angle is 98.5 ± 1.1 °) be placed between two sparking electrodes of atmospheric dielectric barrier discharge plasma equipment medium barrier discharge, regulating between two sparking electrodes distance is 1.5 centimetres, feed argon gas, 5 liters/minute of gas flows during discharge; Discharge frequency is 10 KHzs, and discharge power is 50 watts, and the processing time is 10 seconds; To be immersed in through the polypropylene screen of plasma treatment in the lecithin modification ethanolic solution of above-mentioned preparation, carry out ultraviolet lighting simultaneously 30 minutes.Taking-up is dried under the room temperature after deionized water is cleaned, and promptly gets the crosslinked biomimetic modification polyethylene of lecithin diffusion barrier, and its hydrophilicity sees Table 1.
Wherein, 9-thioxanthones, molecular formula: C
13H
8OS, Chinese synonym: thioxanthones; The 9-thioxanthones; Thioxanthene-9-one; Thioxanthene-9-ketone, chemical structural formula is
Embodiment 8
With soybean lecithin, 1,4-succinimide mercaptans and 9-thioxanthones are dissolved in the ethanol, preparation soybean lecithin, 1, and the mass percent concentration of 4-succinimide mercaptans and 9-thioxanthones is respectively 1.0%, 1% and 0.1% mixed solution; (membrane aperture is 0.02～0.5 μ m with polystyrene film, the film surface contact angle is 93.4 ± 3.4 °) be placed between two sparking electrodes of atmospheric dielectric barrier discharge plasma equipment medium barrier discharge, regulating between two sparking electrodes distance is 3 centimetres, feed helium, 1 liter/minute of gas flow during discharge; Discharge frequency is 10 KHzs, and discharge power is 100 watts, and the processing time is 5 seconds; To be immersed in through the polypropylene screen of plasma treatment in the lecithin modification ethanolic solution of above-mentioned preparation, carry out ultraviolet lighting simultaneously 20 minutes.Taking-up is dried under the room temperature after deionized water is cleaned, and promptly gets the crosslinked biomimetic modification polystyrene separation of lecithin film, and its hydrophilicity sees Table 1.
Embodiment 9
With soybean lecithin, 1,6-ethanthiol and camphorquinone are dissolved in the ethanol, preparation soybean lecithin, 1, and the mass percent concentration of 6-ethanthiol and camphorquinone is respectively 10.0%, 2% and 0.1% mixed solution; (membrane aperture is 0.01～0.3 μ m with poly (ether sulfone) film, the film surface contact angle is 89.2 ± 1.6 °) be placed between two sparking electrodes of atmospheric dielectric barrier discharge plasma equipment medium barrier discharge, regulating between two sparking electrodes distance is 3 centimetres, feed helium, 10 liters/minute of gas flows during discharge; Discharge frequency is 10 KHzs, and discharge power is 150 watts, and the processing time is 20 seconds; To be immersed in through the polypropylene screen of plasma treatment in the lecithin modification ethanolic solution of above-mentioned preparation, carry out ultraviolet lighting simultaneously 10 minutes.Taking-up is dried under the room temperature after deionized water is cleaned, and promptly gets the crosslinked biomimetic modification polyethersulfone separating membrane of lecithin, and its hydrophilicity sees Table 1.
Wherein, described camphorquinone, CAS:465-29-2, molecular formula: C
10H
14O
2, English name: 3-dione, 1,7,7-trimethyl-Bicyclo[2.2.1] and heptane-2.
Embodiment 10
With soybean lecithin, 1,6-ethanthiol and camphorquinone are dissolved in and prepare soybean lecithin, 1 in the ethanol, and the mass percent concentration of 6-ethanthiol and camphorquinone is respectively 6.0%, 0.08% and 0.05% mixed solution; (membrane aperture is 0.01～0.8 μ m with polyacrylonitrile film, the film surface contact angle is 64.8 ± 4.1 °) be placed between two sparking electrodes of atmospheric dielectric barrier discharge plasma equipment medium barrier discharge, regulating between two sparking electrodes distance is 1.5 centimetres, feed helium, 8 liters/minute of gas flows during discharge; Discharge frequency is 10 KHzs, and discharge power is 80 watts, and the processing time is 10 seconds; To be immersed in through the polypropylene screen of plasma treatment in the lecithin modification ethanolic solution of above-mentioned preparation, carry out ultraviolet lighting simultaneously 5 minutes.Taking-up is dried under the room temperature after deionized water is cleaned, and promptly gets the crosslinked biomimetic modification polyacrylonitrile of lecithin diffusion barrier, and its hydrophilicity sees Table 1.
Embodiment 11
With soybean lecithin, 1,6-ethanthiol and benzophenone are dissolved in the ethanol, preparation soybean lecithin, 1, and the mass percent concentration of 6-ethanthiol and benzophenone is respectively 5.0%, 0.8% and 0.1% mixed solution; (membrane aperture is 0.01～0.2 μ m with polyvinylidene fluoride film, the film surface contact angle is 125.4 ± 2.0 °) be placed in the atmospheric dielectric barrier discharge plasma equipment, regulating between two sparking electrodes distance is 1.5 centimetres, feeds helium, 8 liters/minute of gas flows during discharge; Discharge frequency is 10 KHzs, and discharge power is 80 watts, and the processing time is 10 seconds; To be immersed in through the polypropylene screen of plasma treatment in the lecithin modification ethanolic solution of above-mentioned preparation, carry out ultraviolet lighting simultaneously 1 minute.Taking-up is dried under the room temperature after deionized water is cleaned, and promptly gets the crosslinked biomimetic modification polyvinylidene fluoride separation membrane of lecithin, and its hydrophilicity sees Table 1.
Embodiment 12
With soybean lecithin, 1,6-ethanthiol and benzophenone are dissolved in and prepare soybean lecithin, 1 in the ethanol, and the mass percent concentration of 6-ethanthiol and benzophenone is respectively 10.0%, 0.2% and 0.01% mixed solution; (membrane aperture is 0.01～0.1 μ m with poly tetrafluoroethylene, the film surface contact angle is 132.5 ± 2.3 °) be placed in the atmospheric dielectric barrier discharge plasma equipment, regulating between two sparking electrodes distance is 1.5 centimetres, feeds helium, 8 liters/minute of gas flows during discharge; Discharge frequency is 10 KHzs, and discharge power is 80 watts, and the processing time is 10 seconds; To be immersed in through the polypropylene screen of plasma treatment in the lecithin modification ethanolic solution of above-mentioned preparation, carry out ultraviolet lighting simultaneously 40 minutes.Taking-up is dried under the room temperature after deionized water is cleaned, and promptly gets the crosslinked biomimetic modification polytetrafluorethyleseparation separation membrane of lecithin, and its hydrophilicity sees Table 1.
Adopt sessile drop method (Sessile drop method) to measure the water contact angle on film surface.To be fixed on behind the film cleaning-drying on the smooth bright and clean slide in room temperature (25 ± 1 ℃, relative humidity 45～50%).The Static Water contact angle generally is to get about 5 μ L water droplets to drop in the film surface, photographs the drop curved surface with digital camera immediately, then through the computer The Fitting Calculation, draws the Static Water contact angle of sample.Each sample parallel testing 10 times is obtained mean value, and the result is as shown in table 1.As can be seen, polymer film surface water contact angle through hydrophilic modifying all significantly reduces, and keep stable through the long-term modifying polymer film surface water contact angle that cleans, and then confirmed to adopt hydrophily that the present invention can hydrophobic property polymer separation film lasting stability and biocompatibility.
In a word, the present invention can also have multiple conversion and remodeling, is not limited to the concrete structure of above-mentioned embodiment, and protection scope of the present invention should comprise those conspicuous to those skilled in the art conversion or substitute and remodeling.
Table 1: different hydrophilic lecithin self assembly crosslinked biomimetic modification polymeric film material surface hydrophilicity and persistence table with test results
Claims (9)
1. the preparation method of the crosslinked biomimetic modification polymeric film material of lecithin self assembly is characterized in that, is made up of following step:
Step 1, natural phosphatidyl choline, crosslinking agent and light trigger are dissolved in the ethanol preparation lecithin modification ethanolic solution;
Step 2, polymeric film material is placed between two sparking electrodes of dielectric barrier discharge, carry out the atmospheric dielectric barrier discharge plasma and handle;
Step 3, the polymeric film material after step 2 handled are immersed in the lecithin modification ethanolic solution of step 1 preparation, carry out ultraviolet light irradiation after 1 ~ 40 minute, utilize washed with de-ionized water again, and at room temperature dry, can make the crosslinked biomimetic modification polymeric film material of lecithin self assembly.
2. the preparation method of the crosslinked biomimetic modification polymeric film material of lecithin self assembly as claimed in claim 1 is characterized in that:
In the described step 1, the mass percent concentration of natural phosphatidyl choline, crosslinking agent and light trigger is respectively 0.1 ~ 10%, 0.05 ~ 2% and 0.001 ~ 0.1% in the described lecithin modification ethanolic solution.
3. the preparation method of the crosslinked biomimetic modification polymeric film material of lecithin self assembly as claimed in claim 1 is characterized in that:
In the described step 1, described natural phosphatidyl choline is soybean lecithin or egg yolk lecithin.
4. the preparation method of the crosslinked biomimetic modification polymeric film material of lecithin self assembly as claimed in claim 1 is characterized in that:
In the described step 1, described crosslinking agent is 1,2-dithioglycol, 1,4-succinimide mercaptans or 1,6-ethanthiol.
5. the preparation method of the crosslinked biomimetic modification polymeric film material of lecithin self assembly as claimed in claim 1 is characterized in that:
In the described step 1, described light trigger is diphenyl (2,4, the 6-trimethylbenzoyl) phosphine oxide, styrax dimethyl ether, benzophenone, 9-thioxanthones or camphorquinone.
6. the preparation method of the crosslinked biomimetic modification polymeric film material of lecithin self assembly as claimed in claim 1 is characterized in that:
In the described step 2, described polymeric film material is polyethylene, polypropylene, polystyrene, polyacrylonitrile, polysulfones, polyether sulfone, Kynoar or polytetrafluoroethylene (PTFE).
7. the preparation method of the crosslinked biomimetic modification polymeric film material of lecithin self assembly as claimed in claim 1 is characterized in that:
In the described step 2, the condition that described atmospheric dielectric barrier discharge plasma is handled is: the distance between two sparking electrodes is 1.5～3 centimetres, feeds inert gas, 0.5～10 liter/minute of gas flow during discharge; Discharge frequency is 10 KHzs, and discharge power is 50～150 watts, and the processing time is 5～30 seconds.
8. the preparation method of the crosslinked biomimetic modification polymeric film material of lecithin self assembly as claimed in claim 7 is characterized in that: described inert gas is helium or argon gas.
9. crosslinked biomimetic modification polymeric film material of lecithin self assembly is characterized in that: adopt that each described method is prepared from the claim 1 ~ 8.
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