CN102252908A - Device and method for stretching elastic tissue under simulated physiological condition - Google Patents
Device and method for stretching elastic tissue under simulated physiological condition Download PDFInfo
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- CN102252908A CN102252908A CN 201110177957 CN201110177957A CN102252908A CN 102252908 A CN102252908 A CN 102252908A CN 201110177957 CN201110177957 CN 201110177957 CN 201110177957 A CN201110177957 A CN 201110177957A CN 102252908 A CN102252908 A CN 102252908A
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Abstract
The invention aims to overcome the defects in the prior art and provides a device for stretching elastic tissue under a simulated physiological condition. The device comprises a lower fixed piece and an upper fixed piece, wherein the lower fixed piece is connected with the table surface of a stretching machine and is provided with a lower clamping piece; the upper fixed piece is connected with a hoisting piece of the stretching machine and is provided with an upper clamping piece; a water bath cavity for accommodating normal saline is formed between a sealing sleeve arranged on the lower fixed piece and the lower clamping piece; and the upper fixed piece is provided with a liquid nitrogen container which is provided with a piston and surrounds the upper clamping piece. The invention also provides a method for simulating the physiological condition in vitro and stretching the elastic tissue. The method comprises the steps of extracting the tissue, performing embedding processing, loading the samples, simulating the physiological condition, stretching and the like. By the device and the method provided by the invention, the small elastic tissue can be stretched under the simulated physiological condition in vitro.
Description
Technical field
The present invention relates to the preclinical medicine experiment, the experimental provision and the experimental technique of simulation physiological condition particularly is provided.
Background technology
The physiological property research cost of carrying out elastic fibrous tissues such as ligament or tendon in vivo is huge, and the cycle is very long, so be the difficult problem that present preclinical medicine experiment needs to be resolved hurrily at in-vitro simulated physiological condition and to elastic fibrous tissue research.At present, the equipment of the in vitro study of elastic fibrous tissue is mainly produced by instron company and bose company.But existing equipment can only be done some as the bigger ligament of the dorsal muscles tendon of ox and the stretching of tendon tissue, when stretching some little ligaments or tendon, holding force hour can cause tendon or tough belt surface landing, when holding force is big, can cause damage and fracture occur tendon or ligament, can not finish experiment well.And prior art can not the interior physiological condition of analogue body.
Publication number is: the patent of invention of CN1987408A discloses a kind of biologic soft tissue and has tested with freezing stretching chuck.This device makes biologic soft tissue and anchor clamps adhesion mutually by freezing, thereby realizes in the biomechanics experiment clamping to the tissue sample of experiment usefulness.When using this device and experimentizing, sample need send into the long distance of clamping hole and fully freezing after could guarantee clamping stability, thereby can not guarantee the sample biologically active.On the other hand, when doing the experiment of reduced size ligament tension, the laboratory sample size is little, and adhesion point is short, can not guarantee stability; When doing the experiment of large-size ligament tension, pulling force is bigger, and freezing adhesion point easily comes off.The refrigeration part of this device is arranged in 37 ℃ the water-bath, need be outside anchor clamps installation capability insulation material preferably, and need waterproof part.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, provide a kind of device at in-vitro simulated physiological condition tensile elasticity tissue to measure the required maximum faulting stress of elastic fibrous tissue, maximum elongation amount and the Young modulus of position elastic fibrous tissue prosthetic such as joint.Folder part dimension of the present invention is adjustable, the folder chilling temperature is controlled, makes the laboratory sample of different size stably be held, and the biologically active of described sample is maintained; Water-bath of the present invention chamber depth-adjustment joint can make sample be in the water-bath in the process of stretching experiment always, guarantees its biologically active.
Another object of the present invention provides a kind of method at in-vitro simulated physiological condition, tensile elasticity tissue.Can record the maximum faulting stress and the maximum elongation amount of the required elastic fibrous tissue of position elastic fibrous tissue prosthetic such as joint by described method at in-vitro simulated physiological condition, and determine the Young modulus of described elastic fibrous tissue.
For realizing that the technical scheme that the object of the invention adopts is such, be a kind of elastic fibrous tissue stretching device of simulating under the physiological condition: comprise the following fixture that connects the drawing machine table top and lower clamping piece is installed and be connected the upper fixing element that rises the drawing machine lifting member and upper clamping piece is installed, described lower clamping piece and upper clamping piece retaining part size adjustable, form the water-bath chamber that holds physiological saline between Sealed casing pipe of installing on the described fixture down and the described lower clamping piece, described upper fixing element is equipped with the liquid nitrogen container with piston around upper clamping piece, described lower clamping piece and upper clamping piece have the through hole that ammunition feed sex organization is passed, the degree of depth in described water-bath chamber is by regulating with described lower clamping piece and Sealed casing pipe that described fixture down is connected by screw thread, and described liquid nitrogen container is connected by screw thread is adjustable with upper fixing element.Regulate the relative position of described upper fixing element and liquid nitrogen container, can control the temperature of embedding place, prevent to come off.The depth-adjustment in described water-bath chamber can make sample be in the water-bath as much as possible.The retaining part of described lower clamping piece and upper clamping piece comprises left folder and the right folder that is connected by taper bolt.Laboratory sample is fixed in two folders, can prevents that sample comes off in the process that stretches.
The retaining part of described lower clamping piece and upper clamping piece comprises left folder and the right folder that is connected by taper bolt.
Have the measuring flume that inserts for temperature sensor between described left folder and the right folder, can guarantee the simulation of physiological condition.
Described lower clamping piece links to each other with temperature sensor, has guaranteed that bath temperature is about 37 ℃.
Described upper fixing element links to each other with mechanics sensor so that control and measure amount of tension.
Described water-bath chamber is equipped with the well heater with temperature control function.
The invention provides a kind of elastic fibrous tissue drawing process of simulating under the physiological condition, comprise step down:
1). extract tissue: extract the elastic fibrous tissue of an end band bone as sample from animal body as the firm death of experiment product;
2). sample preparation: wipe out elastic fibrous tissue surrounding soft tissue, and measure described elastic fibrous tissue length and width, thick;
3). embedding treatment: adopt and organize freezing embedding medium that described sample is not carried out embedding treatment with an end of bone;
4). apparatus for assembling: the upper fixing element of described stretching device is connected the lifting member of drawing machine, the following fixture of described stretching device is connected the bottom fixture of drawing machine;
5). the physiological condition simulation: the lower clamping piece of described stretching device is mounted in down on the fixture, form the water-bath chamber that holds physiological saline between Sealed casing pipe of installing on the described fixture down and the described lower clamping piece, the upper clamping piece of described stretching device is mounted on the upper fixing element, described upper fixing element is equipped with the liquid nitrogen container around upper clamping piece, the physiological saline that adds 37 ℃ in the water-bath chamber charges into liquid nitrogen in having the liquid nitrogen container of piston;
6). sample loads: the lower clamping piece that an end of the band bone of described sample is fixed on stretching device, make sample in experimentation, be in the described physiological saline of step 5 always, described sample is fixed on the upper clamping piece of stretching device through an end of embedding treatment, open the piston of described liquid nitrogen container, make the liquid nitrogen distillation to guarantee that embedding partly is in freezing state;
7). start-up loading: start drawing machine, begin to load, record the maximum faulting stress of sample, maximum elongation amount, Young modulus.
The present invention is because above-mentioned steps, and its advantage is: the chilling temperature controllability, and by the up-down adjustment liquid nitrogen container, make and freezingly go up the anchor clamps temperature change, so that being in complete freezing state, laboratory sample deformation can not take place when stressed; Simulated in the articular cavity muscle and bone as the direct stress point of ligament/tendon, overcome directly infringement ligament/the tendon effect causes; The result can accurately reflect the mechanical characteristic of physiological condition inferior ligament/tendon.Simultaneously, the physiological water bath temperature is in 37 ± 1 ℃, has kept the physiologically active of laboratory sample.
Description of drawings
Device of the present invention can further specify by the indefiniteness embodiment that accompanying drawing provides.
Fig. 1 is a cut-open view of the present invention;
Fig. 2 is the cut-open view of folder of the present invention;
Fig. 3 is the front view of the measuring flume on the folder of the present invention.
Among the figure: fixture under the 1-, 2-Sealed casing pipe, 3-lower clamping piece, 5-upper clamping piece, 8-upper fixing element, 6-liquid nitrogen container, 12-sample, 13-water-bath chamber, 14-left side folder, the right folder of 15-, 16-taper bolt, 17-measuring flume.
Embodiment
The invention will be further described below in conjunction with embodiment:
Embodiment 1:
A kind of elastic fibrous tissue stretching device of simulating under the physiological condition, comprise the following fixture 1 that connects the drawing machine table top and lower clamping piece 3 is installed and be connected the upper fixing element 8 that rises the drawing machine lifting member and upper clamping piece 5 is installed, described lower clamping piece 3 and upper clamping piece 5 retaining part size adjustable, form the water-bath chamber 13 that holds physiological saline between Sealed casing pipe of installing on the described fixture 1 down 2 and the described lower clamping piece 3, described upper fixing element 8 is equipped with the liquid nitrogen container with piston 6 around upper clamping piece 5, described lower clamping piece 3 and upper clamping piece 5 have the through hole that ammunition feed sex organization is passed, the degree of depth in described water-bath chamber 13 is regulated by the described lower clamping piece 3 and the Sealed casing pipe 2 that are connected with described fixture 1 down by screw thread, and described liquid nitrogen container 6 is connected by screw thread is adjustable with upper fixing element 8.
The retaining part of described lower clamping piece 3 and upper clamping piece 5 comprises left folder 14 and the right folder 15 that is connected by taper bolt 16.
Has the measuring flume 17 that inserts for temperature sensor between described left folder 14 and the right folder 15.
Described lower clamping piece 3 links to each other with temperature sensor.
Described upper fixing element 8 links to each other by locating shaft with mechanics sensor.
Described water-bath chamber 13 is equipped with thermostat.
The upper fixing element 8 that links to each other with stretching testing machine upper end mechanics sensor; The upper clamping piece 5 that links to each other by screw thread with upper fixing element 8; Movable up and down to regulate the liquid nitrogen container 6 of chipware temperature by screw thread in upper clamping piece 5 outsides, upper clamping piece 5 clampings have the muscle or the bone of sample 12 and connect temperature sensor.
Upper fixing element 8 directly links to each other with stretching testing machine with following fixture 1, makes mechanics sensor is subjected on the stretching testing machine tension variations more can accurately reflect the mechanical characteristic of ligament or tendon.The heat-barrier material and the lid of liquid nitrogen container 6 outside surfaces, behind the injection liquid nitrogen, on the one hand by contacting with upper clamping piece spare, temperature conduction makes upper clamping piece spare and folder and muscle freezing rapidly, and heat-barrier material prevents that unnecessary energy scatters and disappears on the other hand.
When using liquid nitrogen container, open the liquid nitrogen container piston, pour liquid nitrogen into, cover piston.Because liquid nitrogen container has an osculum in the middle of heat-barrier material and piston are arranged outward, the violent boiling during the liquid nitrogen distillation can not damage container.Liquid nitrogen container device ring-type superscribes the folder tool and the folder of muscle samples has been housed, can make its rapidly, evenly freezing, prevented the freezing phenomenon of topical hypothermia.
Though metal generally all has good thermal conductivity and certain tension physical strength, because the requirement of stretching testing machine mechanics sensor range is 50 ± 0.1N, 500 ± 1N, 5000 ± 10N and need uses 37 ℃ of salt solution physiological environments.So device will adopt light weight and anticorrosion metal, the data that make mechanics sensor record more can reflect the mechanical characteristic under the physiological condition of articular cavity internal ligament or tendon.
Temperature sensor just in time contacts with tendon muscle junction, can accurately demonstrate the binding site temperature, by up-down adjustment liquid nitrogen container and water bath with thermostatic control bucket, makes the binding site temperature maintenance at a specified temp.This temperature makes on the one hand that muscle is in freezing state in the folder, muscle is not slided and the rupture of tendon point be in the middle of and be under tendon or ligament physiologically active.Temperature sensor 15 is in the upper clamping piece cavity, mainly measures cavity temperature, by the up-down adjustment liquid nitrogen container, makes to be in freezing low temperature in the chamber always.Temperature sensor is in the water bath with thermostatic control bucket, measures the physiological saline temperature, in order to make it to be in 37 ℃ physiological condition always, by Constant Temperature Circulator, keeps physiological condition.
The tension test device of ligament or tendon physiological condition lower stress mode in this simulated joint cavity of the present invention, simple in structure, processing and manufacturing is more convenient, and does not need expensive refrigeration plant, thereby cost is lower.Data when environment in addition can also simulated joint cavity, experimental result approach in the articular cavity more have the certain significance to the physiological property of in vitro study ligament/tendon.
Embodiment 2:
A kind of elastic fibrous tissue drawing process of simulating under the physiological condition may further comprise the steps:
1). extract tissue: extract the elastic fibrous tissue of an end band bone as sample from animal body as the firm death of experiment product;
2). sample preparation: wipe out elastic fibrous tissue surrounding soft tissue, and measure described elastic fibrous tissue length and width, thick;
3). embedding treatment: adopt and organize freezing embedding medium that described sample is not carried out embedding treatment with an end of bone;
4). apparatus for assembling: the upper fixing element of described stretching device is connected the lifting member of drawing machine, the following fixture of described stretching device is connected the bottom fixture of drawing machine;
5). the physiological condition simulation: the lower clamping piece of described stretching device is mounted in down on the fixture, form the water-bath chamber that holds physiological saline between Sealed casing pipe of installing on the described fixture down and the described lower clamping piece, the upper clamping piece of described stretching device is mounted on the upper fixing element, described upper fixing element is equipped with the liquid nitrogen container around upper clamping piece, the physiological saline that adds 37 ℃ in the water-bath chamber charges into liquid nitrogen in having the liquid nitrogen container of piston;
6). sample loads: the lower clamping piece that an end of the band bone of described sample is fixed on stretching device, make sample in experimentation, be in the described physiological saline of step 5 always, described sample is fixed on the upper clamping piece of stretching device through an end of embedding treatment, open the piston of described liquid nitrogen container, make the liquid nitrogen distillation to guarantee that embedding partly is in freezing state;
7). start-up loading: start drawing machine, begin to load, record the maximum faulting stress of sample, maximum elongation amount, Young modulus.
Lower clamping piece is connected with following fixture by screw thread, and transparent Sealed casing pipe is connected with lower clamping piece by sealing thread, and following fixture is connected with the mechanical test machine base and passes through locating shaft.Temperature sensor is connected on the lower clamping piece.
Upper clamping piece is connected with upper fixing element by screw thread, and liquid nitrogen container is connected with upper clamping piece by deep thread, and upper fixing element links to each other by locating shaft with the mechanics sensor of mechanical test machine.
Record the long 6.50 ± 0.20mm of heel string after the pruning, wide 2.60 ± 0.10mm, thick 1.10 ± 0.10mm. be the freezing medium embedding of using-system muscle one end then.
Sample is packed into, and sandwich is regulated ligament or tendon exports length, width, make it ligament or tendon are passed through, and the muscle at its two ends or bone can not pass through, and fix with taper bolt then.
Pour liquid nitrogen in the liquid nitrogen container into, utilize ebullator to inject 37 ℃ of physiological saline in the thermostatted water bathtub.By up-down adjustment liquid nitrogen container and thermostatted water bathtub, make temperature sensor keep the cryogenic freezing state on the one hand, make muscle freezing rapidly, make the temperature sensor reading keep certain temperature range on the other hand, muscle can not slide and the rupture of tendon point is the tendon that is in the physiological saline when stretching.
After muscle is fully freezing, starts the mechanics test machine and carry out the mechanics loading experiment.Record the maximum faulting stress 144.5N of mouse heel string, maximum elongation amount 30.78mm, Young modulus 30.93MPa.
Claims (7)
1. elastic fibrous tissue stretching device of simulating under the physiological condition, it is characterized in that: comprise the following fixture (1) that connects the drawing machine table top and lower clamping piece (3) is installed and be connected the drawing machine lifting member and the upper fixing element (8) of upper clamping piece (5) is installed, described lower clamping piece (3) and upper clamping piece (5) retaining part size adjustable, form the water-bath chamber (13) that holds physiological saline between Sealed casing pipe (2) that described fixture (1) is down upward installed and the described lower clamping piece (3), described upper fixing element (8) is equipped with the liquid nitrogen container with piston (6) around upper clamping piece (5), described lower clamping piece (3) and upper clamping piece (5) have the through hole that ammunition feed sex organization is passed, the degree of depth in described water-bath chamber (13) is by regulating with described lower clamping piece (3) and Sealed casing pipe (2) that described fixture (1) down is connected by screw thread, and described liquid nitrogen container (6) is connected by screw thread is adjustable with upper fixing element (8).
2. a kind of elastic fibrous tissue stretching device of simulating under the physiological condition according to claim 1 is characterized in that: the retaining part of described lower clamping piece (3) and upper clamping piece (5) comprises left folder (14) and the right folder (15) that is connected by taper bolt (16).
3. a kind of elastic fibrous tissue stretching device of simulating under the physiological condition according to claim 2 is characterized in that: have the measuring flume (17) that inserts for temperature sensor between described left folder (14) and the right folder (15).
4. a kind of elastic fibrous tissue stretching device of simulating under the physiological condition according to claim 1, it is characterized in that: described lower clamping piece (3) links to each other with temperature sensor.
5. a kind of elastic fibrous tissue stretching device of simulating under the physiological condition according to claim 1, it is characterized in that: described upper fixing element (8) links to each other with mechanics sensor.
6. a kind of elastic fibrous tissue stretching device of simulating under the physiological condition according to claim 1, it is characterized in that: described water-bath chamber (13) is equipped with the well heater with temperature control function.
7. elastic fibrous tissue drawing process of simulating under the physiological condition is characterized in that: may further comprise the steps:
1). extract tissue: extract the elastic fibrous tissue of an end band bone as sample from animal body as the firm death of experiment product;
2). sample preparation: wipe out elastic fibrous tissue surrounding soft tissue, and measure described elastic fibrous tissue length and width, thick;
3). embedding treatment: adopt and organize freezing embedding medium that described sample is not carried out embedding treatment with an end of bone;
4). apparatus for assembling: the upper fixing element of described stretching device is connected the lifting member of drawing machine, the following fixture of described stretching device is connected the bottom fixture of drawing machine;
5). the physiological condition simulation: the lower clamping piece of described stretching device is mounted in down on the fixture, form the water-bath chamber that holds physiological saline between Sealed casing pipe of installing on the described fixture down and the described lower clamping piece, the upper clamping piece of described stretching device is mounted on the upper fixing element, described upper fixing element is equipped with the liquid nitrogen container around upper clamping piece, the physiological saline that adds 37 ℃ in the water-bath chamber charges into liquid nitrogen in having the liquid nitrogen container of piston;
6). sample loads: the lower clamping piece that an end of the band bone of described sample is fixed on stretching device, make sample in experimentation, be in the described physiological saline water-bath of step 5 chamber always, described sample is fixed on the upper clamping piece of stretching device through an end of embedding treatment, open the piston of described liquid nitrogen container, make the liquid nitrogen distillation to guarantee that embedding partly is in freezing state;
7). start-up loading: start drawing machine, begin to load, record the maximum faulting stress of sample, maximum elongation amount, Young modulus.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110177957XA CN102252908B (en) | 2011-06-29 | 2011-06-29 | Method for stretching elastic tissue under simulated physiological condition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110177957XA CN102252908B (en) | 2011-06-29 | 2011-06-29 | Method for stretching elastic tissue under simulated physiological condition |
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| CN102252908A true CN102252908A (en) | 2011-11-23 |
| CN102252908B CN102252908B (en) | 2012-10-31 |
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| CN201110177957XA Expired - Fee Related CN102252908B (en) | 2011-06-29 | 2011-06-29 | Method for stretching elastic tissue under simulated physiological condition |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106596247A (en) * | 2016-11-24 | 2017-04-26 | 安徽瑞研新材料技术研究院有限公司 | Cryogenic environment material mechanical property test device |
| CN107966361A (en) * | 2017-12-18 | 2018-04-27 | 宋越 | Liquid nitrogen refrigerating type fixture and biological mechanics determining equipment |
| CN108507877A (en) * | 2018-04-09 | 2018-09-07 | 宝鸡文理学院 | A kind of test method of metal material mechanics performance |
| CN108593414A (en) * | 2018-06-26 | 2018-09-28 | 宋越 | Liquid nitrogen frozen mold and soft biological tissue's mechanics test device |
| CN109658796A (en) * | 2018-11-14 | 2019-04-19 | 华中科技大学 | A kind of soft tissue injury and abnormal connection simulation experiment method |
| CN110132723A (en) * | 2019-04-23 | 2019-08-16 | 江苏科技大学 | Organization mechanics performance testing device and test method under a kind of imitative biological living environment |
| TWI790105B (en) * | 2022-01-25 | 2023-01-11 | 中國鋼鐵股份有限公司 | Material testing device capable of water testing |
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| CN2102511U (en) * | 1991-11-07 | 1992-04-22 | 山东医科大学 | Measuring device of boilogical material mechanics |
| EP0916947A1 (en) * | 1997-11-12 | 1999-05-19 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Method and device for measurement of tension or tenderness of animal tissue such as meat |
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| CN201215537Y (en) * | 2008-07-01 | 2009-04-01 | 中国核动力研究设计院 | Special clamp for metal material tensile test after radiation |
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| CN2102511U (en) * | 1991-11-07 | 1992-04-22 | 山东医科大学 | Measuring device of boilogical material mechanics |
| EP0916947A1 (en) * | 1997-11-12 | 1999-05-19 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Method and device for measurement of tension or tenderness of animal tissue such as meat |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106596247A (en) * | 2016-11-24 | 2017-04-26 | 安徽瑞研新材料技术研究院有限公司 | Cryogenic environment material mechanical property test device |
| CN107966361A (en) * | 2017-12-18 | 2018-04-27 | 宋越 | Liquid nitrogen refrigerating type fixture and biological mechanics determining equipment |
| CN108507877A (en) * | 2018-04-09 | 2018-09-07 | 宝鸡文理学院 | A kind of test method of metal material mechanics performance |
| CN108593414A (en) * | 2018-06-26 | 2018-09-28 | 宋越 | Liquid nitrogen frozen mold and soft biological tissue's mechanics test device |
| CN109658796A (en) * | 2018-11-14 | 2019-04-19 | 华中科技大学 | A kind of soft tissue injury and abnormal connection simulation experiment method |
| CN109658796B (en) * | 2018-11-14 | 2021-04-20 | 华中科技大学 | Soft tissue injury and abnormal connection simulation test method |
| CN110132723A (en) * | 2019-04-23 | 2019-08-16 | 江苏科技大学 | Organization mechanics performance testing device and test method under a kind of imitative biological living environment |
| CN110132723B (en) * | 2019-04-23 | 2021-07-27 | 江苏科技大学 | Device and method for testing tissue mechanical properties in bionic living body environment |
| TWI790105B (en) * | 2022-01-25 | 2023-01-11 | 中國鋼鐵股份有限公司 | Material testing device capable of water testing |
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