CN102245157B - Novel use of triple polymer system and a source of fluoride ions in oral care composition - Google Patents
Novel use of triple polymer system and a source of fluoride ions in oral care composition Download PDFInfo
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- CN102245157B CN102245157B CN200980149603.5A CN200980149603A CN102245157B CN 102245157 B CN102245157 B CN 102245157B CN 200980149603 A CN200980149603 A CN 200980149603A CN 102245157 B CN102245157 B CN 102245157B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/594—Mixtures of polymers
Abstract
A oral care composition comprising a triple polymer system and a source of fluoride ions for combating (i.e. helping to prevent, inhibit and/or treat) dental erosion and/or tooth wear is described. Such compositions are also of use in combating dental caries.
Description
Invention field
The present invention relates to the oral care composition that comprises trimer system and fluoride sources, it is for anti-(that is, contribute to prevention, suppress and/or treatment) dental erosion and/or odontotripsis.This compositions is also for dental caries.
Background of invention
Tooth mineral are mainly by hydroxyapatite Ca
10(PO
4)
6(OH)
2form, it can be partly replaced as zinc or magnesium ion as carbanion or fluoride ion and cation ratio by anion ratio.Tooth mineral also can comprise non-apatite mineral phase, such as OCP and calcium carbonate.
Absence of tooth (tooth loss) may be the result of dental caries, it is a kind of multi-factor disease, wherein Production by Bacteria acid (bacterial acids) is such as lactic acid produces demineraliting (sub-surface demineralisation) under the surface that there is no complete remineralization (remineralise), cause gradual tissue loss, and finally form cavity.The biomembranous existence of plaque is the essential condition of dental caries, and when level lasting rise a period of time of easy fermentable saccharide (carbohydrate) such as sucrose, acidogenic bactria is such as Streptococcus mutans becomes pathogenic bacterium.
Even without ill, as the result of acid attack and/or physics odontotripsis, can there is hard tooth tissue loss; It is believed that these processes are collaborative carries out.Hard tooth tissue is exposed to acid and causes demineraliting, causes surface to be softened and mineral density reduction.Under normal physiological conditions, the tissue of demineraliting carries out selfreparing by the remineralization effect of saliva.Saliva is oversaturated to calcium and phosphate, and the salivation of Healthy People plays the effect that washes away acid attack, and the pH that raises is to change balance to be conducive to mineral deposition.
Dental erosion (being acid attack or sour wastage) relates to the superficial phenomena that demineraliting and final dental surface are all dissolved by the acid of non-bacterial origin.The most normally, acid derives from diet, and such as citric acid is from fruit or soda pop, phosphoric acid is from cola drink, and acetic acid is such as from vinegar.Dental erosion also can repeatedly be contacted and cause by the hydrochloric acid producing in stomach (HCl), this hydrochloric acid can be by natural reaction such as gastroesophageal reflux (gastroesophageal reflux), or by as can be that the induced reaction that polyphagia patient suffers enters oral cavity.
Odontotripsis (being physics odontotripsis) is to cause by wearing away and/or wearing and tearing.When dental surface rubs each other, wear away, it is the form of Two body wear (two-body wear).Common obvious example is to observe in suffering from the experimenter of odontorisis, and odontorisis is a kind of custom of grinding one's teeth in sleep, and its active force is large, and the particularly accelerated wear test on occlusal surface of take is feature.The result of three-body-abrasion typically of wearing and tearing, modal example is brushed teeth relevant with using toothpaste.With regard to the enamel of permineralization, the abrasion levels being caused by commercially available obtainable toothpaste is minimum, almost there is no clinical consequences.Yet, if enamel due to be exposed to corrode to attack in by demineraliting and softening, enamel will become more responsive to odontotripsis.Dentin is much softer than enamel, therefore more responsive to wearing and tearing.Expose the toothpaste that Dentinal experimenter should avoid using high abrasive, such as based on those of aluminium oxide.In addition, by erosion, attacking the dentin causing softens and will increase tissue to the sensitivity of wearing and tearing.
Dentin is the vital tissue in body, and it is covered by enamel or cementum conventionally, depends on position i.e. corona and root of the tooth respectively.Dentin has the organic content more much higher than enamel, and its structure embodies feature and in existence, be full of the tubule of liquid, this tubule from dentin-adamantine surface or dentin-cementum joint lead to odontoblast/dental pulp interface.The cause of generally acknowledging widely dentin allergy relates to the mobile variation (fluid dynamic theory) of fluid in exposure tubule, and its mechanoreceptor (mechanoreceptor) that causes being considered to be positioned at odontoblast/dental pulp near interface is upset.The dentin of not all exposure is all responsive because its conventionally coated (smear layer) cover; Stop up mixture and mainly comprise mineral and the protein that derives from dentin self, but also comprise the organic component from saliva.Along with passage of time, the chamber of tubule may be stopped up by mineralized tissue gradually.The formation of reparative dentin is also confirmed well in response to wound or the chemical irritation of dental pulp.But aggressivity is attacked and can be removed coating and tubule " filler ", cause that dentin fluid outwards flows, dentin is stimulated to external world such as heat, cold-peace pressure are more responsive.As noted, aggressivity attack also can be so that dentin surface be more responsive to wearing and tearing.In addition, along with comprising that the diameter of tubule increases, dentin allergy worsens, and because tubule diameter along with this pipe increases towards odontoblast/dental pulp interface direction, gradual dentin abrasion can cause allergy to increase, and in dentin abrasion, is particularly fast in situation.
The wearing and tearing that erosion and/or acid get involved cause the loss of protectiveness adamantine layer by the dentin exposing below, so it is the developing Etiological factor of dentin allergy.
It is said diet acid increase picked-up and depart from the sickness rate that dinner number of times has been attended by dental erosion and odontotripsis and rise.Given this, helping the oral care composition of prevention dental erosion and odontotripsis will be useful.
The present invention is the effect that the oral care composition based on having found the fluoride ion source of the trimer system that existence is comprised of xanthan gum, carboxymethyl cellulose and copolyvidone has strengthened the anti-dental erosion of fluorion.
The oral cavity composition that comprises this trimer system is described in WO 2006/013081 (Glaxo Group Ltd), for by lubricated and hydration (hydrating) dental care or alleviate dry mouth (dry mouth) symptom.This compositions can comprise fluoride sources as dental caries agent.Here do not point out that this compositions can resist dental erosion or described trimer system can strengthen the effect of the anti-dental erosion of fluorion.
The people such as Van der Reijden (Caries Res., 1997,31,216-23) describe the compositions that a series of use comprises thickening agent and substituted saliva to study its dental caries protective nature, comprise the in vitro tests to demineraliting and remineralization.It has described the impact of a large amount of polymeric materials dissolving in the pH of 50mM 5.0 acetic acid on hydroxyapatite crystal, and wherein baurodont enamel is exposed to the demineraliting buffer (pH4.8) of the polymer that comprises a large amount of dissolvings and the pH cyclic test in remineralization buffer (pH 7.0).These tests show that some polymer that comprise xanthan gum and carboxymethyl cellulose can reduce external adamantine demineraliting, show that this can, owing to forming the polymeric layer of absorption on enamel surface, provide the protection that acid-resisting is attacked.
WO 00/13531 (SmithKline Beecham) has described as the multiple viscosity modulating polymer material of dental erosion inhibitor at the acidic composition of oral administration such as the purposes in acidic beverages or acid oral hygiene care composition.The example of polymer comprises xanthan gum, carboxymethyl cellulose and polyvinylpyrrolidone.
The effect of some polymeric materials in the anti-dental erosion of protection is described in WO 2004/054529 (Procter & Gamble), it has advocated a kind of guard method of anti-dental erosion, comprise and use that to comprise polymer-mineral matter surfactant (be polyelectrolyte, such as Quadrafos, the polymer of polycarboxylate or some carboxyl substituted) oral care composition, wherein, after use and afterwards, continue at least one hour immediately, independently there is (substantive) in tooth and be deposited as to take care of one's teeth and avoid the layer of instant erosion damage in polymer-mineral matter surfactant.This shows that described oral care composition can optionally comprise fluoride sources, but does not instruct the effect of the anti-dental erosion of protection that can strengthen fluorion of polymer-mineral matter surfactant.This also shows that this oral cavity composition can comprise the multiple thickening agent that comprises xanthan gum and carboxymethyl cellulose.Do not propose this thickening agent and be independently present in the tooth anti-dental erosion that maybe can take care of one's teeth.
The people such as Schaad (Colloids and Surfaces A:Physiochemical and Engineering Aspects 1994; 83; 285-292) described the dissolving that suppresses hydroxyapatite powder by the anionic polymer of absorption, and wherein some of proposition may be the potent reagent for preventing enamel or osseous tissue to dissolve.
EP-A-691124 (Sara Lee) has described the oral care product that comprises NVP and acrylic acid copolymer, and it causes the picked-up of the enamel fluoride that strengthens in enamel.At the 11st page, the relative enamel fluoride picked-up effect of having described the several formulations that comprises different thickening agents, wherein thickening agent comprises the combination of the copolymer of combination, xanthan gum and the NVP of carboxymethyl cellulose, xanthan gum and carbopol and the combination of acrylic acid copolymer and xanthan gum and methyl vinyl ether and maleic acid or maleic anhydride.
French Patent (FRP) No.2755010 (Sara Lee) has described a kind of fluoride oral care product of the combination that comprises xanthan gum and carboxylation polyvinyl, wherein points out that described combination can strengthen the effect of fluoride in dental caries.
Invention summary
Aspect first, the invention provides the oral care composition for anti-dental erosion and/or odontotripsis, the trimer system that it comprises fluoride sources and is comprised of xanthan gum, carboxymethyl cellulose and copolyvidone.
Described trimer system helps fluoride to remain on tooth surface, thereby increases the remineralization of tooth and strengthen tooth acid resistance, thereby provides than the surface protection of the better anti-dental erosion effect of independent fluoride.
Therefore, compositions of the present invention is for strengthening fluorion in the effect of anti-dental erosion and/or odontotripsis.This compositions can be protected simultaneously and the enamel that rehardens is avoided the effect of diet acid.
This compositions is also for dental caries.
Detailed Description Of The Invention
The amount of xanthan gum can be 0.001 to 1.0% weight of whole compositionss, for example 0.005 to 0.5% or 0.005 to 0.1% weight of whole compositionss.
The carboxymethyl cellulose using in the present invention is the form of sodium salt, i.e. sodium carboxymethyl cellulose.The amount of carboxymethyl cellulose can be 0.02 to 20% weight of whole compositionss, for example 0.04 to 10% or 0.1 to 1.0% weight of whole compositionss.
(it is the copolymer of vinyl pyrrolidone and vinyl acetate to copolyvidone, the l-vinyl-2-pyrrolidone that particularly mass ratio is 3: 2 and the copolymer of vinyl acetate) amount can be all 0.1 to 20% weight of compositionss, for example 0.2 to 10% or 0.5 to 5% weight.
The example of the fluoride sources using in the present invention comprises that alkali metal fluoride is such as sodium fluoride, and alkali metal mono-fluor phosphate is such as sodium monofluorophosphate, stannous fluoride or amine fluoride, and consumption is for providing 25 to 3500pm fluorion, and preferably 100 to 1500ppm.Suitable fluoride source is that alkali metal fluoride is such as sodium fluoride, for example described compositions can comprise 0.05 to 0.5% weight, for example the sodium fluoride of 0.1% weight (equaling the fluorion of 450ppm), 0.205% weight (equaling the fluorion of 927ppm), 0.2542% weight (equaling the fluorion of 1150ppm) or 0.315% weight (equaling the fluorion of 1426ppm).
Compositions of the present invention will comprise suitable reagent preparation, such as abrasive, surfactant, thickening agent, wetting agent, flavoring agent, buffer agent, sweeting agent, opacifier or coloring agent, antiseptic and water, be selected from oral care composition in the object for such normally used those.These example is described in WO 2006/013081 (Glaxo Group Ltd) and WO 2004/054529 (Procter & Gamble), and its content is incorporated herein by reference.
The present invention's compositions used is typically mixed with to toothpaste, spray, collutory, gel, lozenge, chewing gum, tablet, pastille (pastilles), instant powder (instant powder), oral cavity bar (oralstrips) and mouth paster.Preferred compositions is toothpaste and collutory.
Other mouth care active component can be included in compositions of the present invention.Compositions of the present invention may further include the desensitizer for anti-dentin allergy.The example of desensitizer comprises tubule blocker or neural desensitizer and composition thereof, for example, in WO 02/15809, describe.Suitable desensitizer comprises strontium salt, such as strontium chloride, strontium acetate or strontium nitrate, or potassium salt, such as potassium citrate, potassium chloride, potassium bicarbonate, potassium gluconate, especially potassium nitrate.
The desensitization amount of potassium salt is 2 to 8% weight of whole compositionss normally, can use for example potassium nitrate of 5% weight.
One further aspect, the invention provides comprise fluoride sources and as defined above trimer system for the collutory compositions of anti-dental erosion and/or odontotripsis.
The amount of fluoride sources in collutory compositions can be stipulated the maximum allowing for any particular market at the most.For example, under EU regulation, collutory can comprise the product of ion fluoride/every single container of 125mg at the most.At US, the collutory of OTC purposes can comprise the fluoride that is no more than 225ppm.Conventionally, collutory compositions comprises 100 to 1500ppm fluorion, for example 150 to 1000ppm or 200 to the 600ppm fluorions such as 225ppm or 450ppm.
In this collutory compositions, fluoride sources can be alkali metal fluoride, such as sodium fluoride.
0.005 to 0.02% weight that the amount of the xanthan gum that suitably, collutory compositions comprises is whole compositionss.
0.1 to 0.4% weight that the amount of the carboxymethyl cellulose that suitably, collutory compositions comprises is whole compositionss.
0.5 to 1.5% weight that the amount of the copolyvidone that suitably, collutory compositions comprises is whole compositionss.
This collutory compositions can advantageously be used together with fluoride dental cream, particularly use together with strengthening the fluoride dental cream of effect, the type of for example describing in WO2006/100071, be incorporated to herein as a reference, and comprise suitably alkali metal fluoride as fluoride source, amphoteric surfactant or low ionic surface active agent, it is that methyl cocoa base taurine sodium methide (methyl sodium methyl cocoyl taurate) or its mixture are as surfactant, with silica dental abrasive as abrasive, relative dentin abrasion degree (RDA) value that described compositions has is 20 to 60, pH is scope 6.5 to 7.5, and not containing orthophosphate buffer, water miscible C
10-18alkyl sodium sulfate ester and calcium salt.
Therefore, further, the present invention comprises the oral care regimen for anti-dental erosion and/or odontotripsis, and it comprises and uses collutory compositions of the present invention and fluoride dental cream every day.Suitably, in oral care regimen of the present invention, described collutory and fluoride dental cream are used at least twice separately every day.
In order to improve the compliance of consumer, the present invention is also provided for the oral care agent box of anti-dental erosion and/or odontotripsis, and it comprises collutory compositions of the present invention, fluoride dental cream and the operation instruction in oral care regimen of the present invention thereof.
Compositions of the present invention can by by described composition with any order easily and mix with suitable relative quantity, if necessary, regulate pH to obtaining expected value, for example 4.0 to 9.5, for example 5.5 to 9.0, such as 6.0 to 8.0 or 6.5 to 7.5.
The present invention is also provided for the method for anti-dental erosion and/or odontotripsis, and it comprises compositions as defined above from effective dose to its individuality of needs that use.
The present invention also provides fluoride sources and the trimer system that is comprised of xanthan gum, carboxymethyl cellulose and the copolyvidone purposes in the oral care composition for the preparation of anti-dental erosion and/or odontotripsis.
The present invention further sets forth by following embodiment.
Embodiment 1
Dynamic secondary ion mass spectrometry (SIMS) (DSIMS)
Dynamically secondary ion mass spectrometry (SIMS) is a kind of semi-quantitative analysis technology, and it can have the quick element depth distribution of nanoscale depth resolution and parts per billion (ppb) sensitivity, and has the chemical spectrogram of submicron detailed data.DSIMS in the past for study adamantine composition and measure fluoride join human enamel surface degree.In this research, the existence of using DSIMS to study described trimer system joins the impact comprising in artificial erosion vitiator enamel surface on fluoride.In this test, trimer system is comprised of 0.75% copolyvidone, 0.2% carboxymethyl cellulose and 0.01% xanthan gum, and they are all the weighing scales with whole compositionss.
Use 1200 and 2400 order carborundum papers by the human enamel's sample polishing that is embedded into acrylic resin of～2 * 2mm size.Then, sample is divided into one of following four processed group (n=5): i) deionized water, ii) the trimer system in deionized water, iii) 300ppm fluoride aqueous solution (fluoride source=sodium fluoride) and iv) the trimer system in 300ppm fluoride (fluoride source=sodium fluoride), every kind of Treatment Solution all has the pH that falls into approximately 6.5 to 7.0 scopes.By sample being immersed in 1.0% citric acid solution of pH 3.8 5 minutes, in enamel, produce the artificial infringement of corroding.After using subsequently washed with de-ionized water enamel, under agitation, sample is placed in one of above-mentioned solution to 1 minute.Before carrying out DSIMS analysis, carry out last cleaning step (use deionized water).Use DSIMS to measure fluoride and join enamel/the remain on degree on enamel.The initial depth profile pattern of using is determined at the relative fluoride concentration in surperficial initial several microns.Then the vertical component of working sample, then, is embedded in epoxy resin and polishing.The cross section obtaining is carried out to gold and apply, and by enamel DSIMS imaging inspection, the fluoride to～200 μ m degree of depth distributes.From a plurality of regions (size 200 μ m * 160 μ m and 100 μ m * 80 μ m) of each sample, obtain data.
Representative cross-sectional view from enamel sample is presented in Fig. 1.The sample that water or the trimer system in water are processed does not demonstrate the evidence of fluoride in sample in any degree of depth (data not have demonstration).With the sample that independent fluoride aqueous solution or the fluoride aqueous solution that comprises described trimer system are processed, all demonstrate the fluoride bands of a spectrum (band) at enamel surface, the degree of depth is in both cases all about 60 μ m (Fig. 1 a and b).Yet, with the enamel of described trimer system and Fluoridizing, at the top of tissue surface 6 μ m (Fig. 1 a and b), comprise in fact than the more fluoride of the enamel of the Fluoridizing with independent.Fig. 1 shows the dynamic secondary ion mass spectrometry (SIMS) cross sectional image of human enamel after being exposed to solution, and described solution is b under described trimerization system exists a)) described trimerization system comprises isocyatic sodium fluoride in the presence of not.
Embodiment 2
White light interference (3DP)
White light interference technique provides the quick visualization of surface topography, and determines roughness parameter with cordless, wherein can obtain nano level height resolution.In this research, use the artificial erosion of white light interference monitoring to attack the impact on human enamel.The solution and the adamantine impact of pretreatment that combines with fluoride that comprise independent trimer system for research.In this test, described trimer system is comprised of 0.75% copolyvidone, 0.2% carboxymethyl cellulose and 0.01% xanthan gum, and they are all the weighing scales with whole compositionss.
By the polishing of human enamel's sample, be divided into one of four processed group (n=5): i) deionized water, ii) 300ppm fluoride (sodium fluoride), iii) the trimer system in 300ppm fluoride, and iv) the trimer system in deionized water, each Treatment Solution has the pH that falls into approximately 6.5 to 7.0 scopes.Sample is cultivated in Treatment Solution 1 minute, then used washed with de-ionized water.Before acid exposes, by being stained with tape portion, cover sample surfaces, to the reference point that can measure any a large amount of tissue loss is provided.During the erosion phase, sample is immersed in 1.0% citric acid solution of pH 3.8 5 minutes.Use the surface topography of ADE PhaseShift MicroXAM White Light Interferometer study sample.From a plurality of regions (size 200 μ m * 160 μ m and 100 μ m * 80 μ m) of each sample, obtain data.Removing from sample after adhesive tape shelters, carry out other measurement and whether occur any a large amount of tissue loss to be determined at duration of test.
The result of this research is summarised in Fig. 1 and 2.The measurement of the adamantine Sa (surface roughness) processing with deionized water and Sz (10 height) is shown to acid attack increases the surface roughness (Fig. 2) of sample significantly.Yet, use the analysis of the sample of the solution-treated that comprises fluoride and/or trimer system to show that these preprocessing solutions provide the protection of the anti-surface variation of observing after only with water pretreatment.With the described trimer system enamel of processing that combines with fluoride, have minimum Sa value, show to contrast any independent reagent, when being used in combination, these two kinds of reagent have other protective effect (Fig. 1).
The contourograph measurement that carry out at the interface, region of then, region/adhesive tape of processing being covered shows that a large amount of tissue loss with the sample of multiple solution-treated have reflected the trend (Fig. 2) of the surface roughness value of above-mentioned detailed description.The maximum average tissue loss of measuring the sample of only processing with deionized water, is about 20 μ m.With the average tissue loss of the sample of the solution-treated that comprises independent trimer system, be approximately 2.5 μ m, with the average tissue loss of the sample of the solution-treated of the combination of the solution that comprises independent fluoride or fluoride and trimer system for being less than 1 μ m (Fig. 2).
Chart 1. is exposed to the adamantine average surface roughness value of citric acid after by multiple solution-treated
Chart 2. is exposed to the adamantine average rise of flight value of citric acid after by multiple solution-treated
Embodiment 3
The adamantine of aching and limpization rehardened
The human enamel who is fixed in acrylic resin by polishing carries out the artificial infringement of corroding.By making fixing sample contact 30 minutes in the citric acid solution of the 1.0%w/w of pH 3.8, damage.Use the Struers Duramin Microindentor of equipment Vickers diamond indenter to measure the base baseline hardness (baseline hardness) that each corrodes sample.Hardness number can be expressed as Vickers hardness number (VHN).The load of giving sample administration 1.961N, the time of staying is 20 seconds.Then, sample is divided at random to 4 processing (n=6).
By six enamel samples put into two kinds of oral cavity cleaning agents a kind of, water or by strengthen prepared by fluoride dental cream (1450ppmF) 1: 3w/w stirs serosity 120s.Described enhancing fluoride dental cream is described in WO2006/100071, as Sensodyne Pronamel, sells.Described two kinds of oral cavity cleaning agents are Colgate Plax Sensitive (225ppmF) and ProRinse (450ppmF),, be described in the present invention's test collutory used of the type in WO2006/013081, it has 7.0 pH, and the trimer system that comprises 0.1% sodium fluoride and be comprised of the xanthan gum of 0.75% copolyvidone, 0.2% carboxymethyl cellulose and 0.01%, they are all the weighing scales with whole compositionss.Sensodyne Pronamel toothpaste is processed to post (treatment leg) and be included in this research, for the effectiveness of this research provides confirmation.Then, shift out sample, put into not containing mucinous artificial saliva.After 24 hours and 48 hours, use micro-indentations method (microindentation) working sample to reharden.At each time point, obtain six indentures of each sample.
The result of the research of rehardening is summarised in Fig. 3.With respect to the value obtaining after aching and limpization of enamel, the value of standardization enamel hardness.Therefore, the data at follow-up time point have reflected adamantine rehardening.At two time points, all enamel samples therein they be exposed to artificial saliva during reharden in process, and use the processing of any oral cavity cleaning agent or Sensodyne Pronamel toothpaste all to obtain than statistically rehardening more significantly with water treatment.In addition, after the remineralization of 24 hours, compare with Colgate Plax Sensitive oral cavity cleaning agent, with Sensodyne Pronamel toothpaste or ProRinse, process and all cause that statistics rehardens more significantly.Yet, with artificial saliva, cultivating after 48 hours, after any or toothpaste processing with two kinds of oral cavity cleaning agents, between remineralization degree, there is no difference.
Chart 3. after processing with oral cavity cleaning agent (or Sensodyne Pronamel toothpaste),
Through rehardening of 48 hours human enamels' artificial erosion infringement
Embodiment 4
The protection of acid resistance effect
This research of carrying out comprises the citric acid (pH 3.8) that human enamel is exposed to 1%, then with a kind of, the water in above-mentioned two kinds of oral cavity cleaning agents (using in the research of rehardening) or the processing of Sensodyne Pronamel toothpaste 2 minutes.Between processing and acid exposure, water cleans sample.The acid attack time of research is 10,20 and 30 minutes, at each time point, after again thoroughly cleaning sample with distilled water, carries out micro-hardness measurement.At all time points, each enamel sample obtains six indentures.Each process all to six independently sample carry out.
The result of softening research is summarised in Fig. 4.With respect to baseline microhardness value independently, standardization enamel hardness value, therefore, in the data of follow-up time point, reflect adamantine softening.After the acid of 10 minutes expose, Prorinse preparation provides than any other and processes the larger softening protection of anti-enamel surface of statistics.After the acid of 20 minutes expose, Prorinse oral cavity cleaning agent and Sensodyne Pronamel toothpaste are processed and are caused than using the enamel that water treatment statistics is less to soften, but process directed less softening than Colgate Plax Sensitive oral cavity cleaning agent.Erosion time point at 30 minutes, Prorinse preparation provides the anti-surface softening protection larger than water treatment statistics, and than directionally (directionally) the larger anti-softening protection of Colgate Plax Sensitive oral cavity cleaning agent.
Chart 4. is after processing with oral cavity cleaning agent (or Sensodyne Pronamel toothpaste)
Be exposed to the human enamel's of citric acid relative microhardness value
Claims (6)
1. fluoride sources and the trimer system that formed by xanthan gum, carboxymethyl cellulose and the copolyvidone application in the oral care composition for the preparation of anti-dental erosion and/or odontotripsis, wherein xanthan gum exists with 0.001 to 1.0% weight of whole compositionss, carboxymethyl cellulose exists with 0.02 to 20% weight of whole compositionss, and copolyvidone exists with 0.1 to 20% weight of whole compositionss.
2. application as claimed in claim 1, wherein said fluoride sources is alkali metal fluoride.
3. application as claimed in claim 1 or 2, wherein said compositions comprises desensitizer.
4. application as claimed in claim 3, wherein said desensitizer is strontium salt or potassium salt.
5. application as claimed in claim 1 or 2, wherein said compositions is collutory compositions.
6. application as claimed in claim 5, wherein said collutory compositions is used for the oral care regimen of anti-dental erosion and/or odontotripsis every day together with fluoride dental cream.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0822434.7A GB0822434D0 (en) | 2008-12-09 | 2008-12-09 | Novel use |
| GB0822434.7 | 2008-12-09 | ||
| PCT/EP2009/066473 WO2010066655A1 (en) | 2008-12-09 | 2009-12-07 | Novel use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102245157A CN102245157A (en) | 2011-11-16 |
| CN102245157B true CN102245157B (en) | 2014-05-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980149603.5A Active CN102245157B (en) | 2008-12-09 | 2009-12-07 | Novel use of triple polymer system and a source of fluoride ions in oral care composition |
Country Status (15)
| Country | Link |
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| US (2) | US20110256074A1 (en) |
| EP (1) | EP2373280B1 (en) |
| JP (2) | JP2012511507A (en) |
| CN (1) | CN102245157B (en) |
| AR (1) | AR074502A1 (en) |
| AU (1) | AU2009326295B2 (en) |
| BR (1) | BRPI0922116B1 (en) |
| CA (1) | CA2746234C (en) |
| ES (1) | ES2634871T3 (en) |
| GB (1) | GB0822434D0 (en) |
| MX (1) | MX2011006090A (en) |
| RU (1) | RU2553365C2 (en) |
| TW (1) | TWI469796B (en) |
| WO (1) | WO2010066655A1 (en) |
| ZA (1) | ZA201103888B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2609862C2 (en) * | 2011-12-15 | 2017-02-06 | Колгейт-Палмолив Компани | Aqueous oral care composition |
| WO2014124950A1 (en) | 2013-02-14 | 2014-08-21 | Glaxo Group Limited | Novel composition |
| AU2016219956B2 (en) | 2015-02-19 | 2020-08-13 | Lifecell Corporation | Tissue processing device and associated systems and methods |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1325277A (en) * | 1998-09-09 | 2001-12-05 | 史密丝克莱恩比彻姆有限公司 | Composition comprising a viscosity modulating polymer material and its use |
| CN1649563A (en) * | 2001-09-19 | 2005-08-03 | 宝洁公司 | Oral compositions providng enhanced overall cleaning effect |
| CN101180099A (en) * | 2005-03-21 | 2008-05-14 | 葛兰素集团有限公司 | Alkyl sulfate free and orthophosphate free dentifrice composition comprising a fluoride source and a silica dental abrasive |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9110721D0 (en) * | 1991-05-17 | 1991-07-10 | Unilever Plc | Dentifrice compositions |
| JP2000063250A (en) * | 1998-08-18 | 2000-02-29 | Lion Corp | Composition for oral cavity |
| US6685920B2 (en) * | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| EP1331919A4 (en) * | 2000-08-21 | 2005-11-16 | Block Drug Co | Dental composition for hypersensitive teeth |
| US20040115140A1 (en) * | 2002-12-12 | 2004-06-17 | Joziak Marilou T. | Liquid dentifrice compositions of optimized fluoride uptake |
| US20060008423A1 (en) * | 2004-01-09 | 2006-01-12 | Abraham Araya | Dentifrice compositions and abrasive systems |
| US20050281757A1 (en) * | 2004-06-17 | 2005-12-22 | Sayed Ibrahim | Oral care film |
| WO2006013081A1 (en) * | 2004-08-02 | 2006-02-09 | Glaxo Group Limited | Novel composition for xerostomia |
| CA2602396C (en) * | 2005-03-21 | 2013-12-03 | Glaxo Group Limited | Alkyl sulfate free and orthophosphate free dentifrice composition comprising a fluoride source and a silica dental abrasive |
| US20070237726A1 (en) * | 2006-04-07 | 2007-10-11 | The Procter & Gamble Company | Oral care regimens and kits |
| GB0712113D0 (en) * | 2007-06-21 | 2007-08-01 | Glaxo Group Ltd | Novel composition |
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2008
- 2008-12-09 GB GBGB0822434.7A patent/GB0822434D0/en not_active Ceased
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2009
- 2009-12-07 US US13/132,371 patent/US20110256074A1/en not_active Abandoned
- 2009-12-07 AU AU2009326295A patent/AU2009326295B2/en active Active
- 2009-12-07 TW TW98141738A patent/TWI469796B/en not_active IP Right Cessation
- 2009-12-07 CN CN200980149603.5A patent/CN102245157B/en active Active
- 2009-12-07 BR BRPI0922116-6A patent/BRPI0922116B1/en active IP Right Grant
- 2009-12-07 ES ES09768364.3T patent/ES2634871T3/en active Active
- 2009-12-07 AR ARP090104734A patent/AR074502A1/en unknown
- 2009-12-07 EP EP09768364.3A patent/EP2373280B1/en active Active
- 2009-12-07 CA CA2746234A patent/CA2746234C/en active Active
- 2009-12-07 RU RU2011121045/15A patent/RU2553365C2/en active
- 2009-12-07 JP JP2011539044A patent/JP2012511507A/en active Pending
- 2009-12-07 WO PCT/EP2009/066473 patent/WO2010066655A1/en active Application Filing
- 2009-12-07 MX MX2011006090A patent/MX2011006090A/en active IP Right Grant
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2011
- 2011-05-26 ZA ZA2011/03888A patent/ZA201103888B/en unknown
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2013
- 2013-06-28 US US13/929,852 patent/US9259379B2/en active Active
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2015
- 2015-06-03 JP JP2015113169A patent/JP6154853B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1325277A (en) * | 1998-09-09 | 2001-12-05 | 史密丝克莱恩比彻姆有限公司 | Composition comprising a viscosity modulating polymer material and its use |
| CN1649563A (en) * | 2001-09-19 | 2005-08-03 | 宝洁公司 | Oral compositions providng enhanced overall cleaning effect |
| CN101180099A (en) * | 2005-03-21 | 2008-05-14 | 葛兰素集团有限公司 | Alkyl sulfate free and orthophosphate free dentifrice composition comprising a fluoride source and a silica dental abrasive |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201032829A (en) | 2010-09-16 |
| RU2011121045A (en) | 2013-01-20 |
| EP2373280B1 (en) | 2017-05-10 |
| BRPI0922116B1 (en) | 2022-04-12 |
| ES2634871T3 (en) | 2017-09-29 |
| MX2011006090A (en) | 2011-09-30 |
| RU2553365C2 (en) | 2015-06-10 |
| GB0822434D0 (en) | 2009-01-14 |
| US20110256074A1 (en) | 2011-10-20 |
| TWI469796B (en) | 2015-01-21 |
| AU2009326295A1 (en) | 2011-06-30 |
| WO2010066655A9 (en) | 2010-09-16 |
| CN102245157A (en) | 2011-11-16 |
| JP2015205898A (en) | 2015-11-19 |
| CA2746234A1 (en) | 2010-06-17 |
| US20140037556A1 (en) | 2014-02-06 |
| BRPI0922116A2 (en) | 2016-01-05 |
| WO2010066655A1 (en) | 2010-06-17 |
| US9259379B2 (en) | 2016-02-16 |
| JP2012511507A (en) | 2012-05-24 |
| JP6154853B2 (en) | 2017-06-28 |
| EP2373280A1 (en) | 2011-10-12 |
| AR074502A1 (en) | 2011-01-19 |
| ZA201103888B (en) | 2012-10-31 |
| CA2746234C (en) | 2017-01-10 |
| AU2009326295B2 (en) | 2015-11-26 |
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Effective date of registration: 20210107 Address after: Meade Sykes Patentee after: GlaxoSmithKline Consumer Healthcare (UK) IP Ltd. Address before: British Ahmed Sykes Patentee before: GLAXO Group Ltd. |