CN102239266A - 通过质谱分析法检测双氢睾酮的方法 - Google Patents

通过质谱分析法检测双氢睾酮的方法 Download PDF

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Publication number
CN102239266A
CN102239266A CN2009801488128A CN200980148812A CN102239266A CN 102239266 A CN102239266 A CN 102239266A CN 2009801488128 A CN2009801488128 A CN 2009801488128A CN 200980148812 A CN200980148812 A CN 200980148812A CN 102239266 A CN102239266 A CN 102239266A
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CN
China
Prior art keywords
ions
dht
mass spectrometry
amount
sample
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Pending
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CN2009801488128A
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English (en)
Chinese (zh)
Inventor
A·戈沙尔
N·J·克拉克
R·瑞茨
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Quest Diagnostics Investments LLC
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Quest Diagnostics Investments LLC
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42075045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102239266(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Quest Diagnostics Investments LLC filed Critical Quest Diagnostics Investments LLC
Priority to CN201611163981.7A priority Critical patent/CN106770756A/zh
Publication of CN102239266A publication Critical patent/CN102239266A/zh
Pending legal-status Critical Current

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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN2009801488128A 2008-10-06 2009-09-30 通过质谱分析法检测双氢睾酮的方法 Pending CN102239266A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201611163981.7A CN106770756A (zh) 2008-10-06 2009-09-30 通过质谱分析法检测双氢睾酮的方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10320208P 2008-10-06 2008-10-06
US61/103,202 2008-10-06
US12/272,663 US7804063B2 (en) 2008-10-06 2008-11-17 Methods for detecting dihydrotestosterone by mass spectrometry
US12/272,663 2008-11-17
PCT/US2009/059090 WO2010042370A1 (en) 2008-10-06 2009-09-30 Methods for detecting dihydrotestosterone by mass spectrometry

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201611163981.7A Division CN106770756A (zh) 2008-10-06 2009-09-30 通过质谱分析法检测双氢睾酮的方法

Publications (1)

Publication Number Publication Date
CN102239266A true CN102239266A (zh) 2011-11-09

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ID=42075045

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CN2009801488128A Pending CN102239266A (zh) 2008-10-06 2009-09-30 通过质谱分析法检测双氢睾酮的方法
CN201611163981.7A Pending CN106770756A (zh) 2008-10-06 2009-09-30 通过质谱分析法检测双氢睾酮的方法

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CN201611163981.7A Pending CN106770756A (zh) 2008-10-06 2009-09-30 通过质谱分析法检测双氢睾酮的方法

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US (4) US7804063B2 (enExample)
EP (2) EP2344661B1 (enExample)
JP (2) JP6096412B2 (enExample)
CN (2) CN102239266A (enExample)
AU (1) AU2009302641B2 (enExample)
BR (1) BRPI0920028A8 (enExample)
CA (1) CA2739506C (enExample)
MX (1) MX2011003653A (enExample)
WO (1) WO2010042370A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104040343A (zh) * 2012-01-05 2014-09-10 Dh科技发展私人贸易有限公司 增强含有酮类固醇和酮基或醛的分析物的灵敏度和特异性
CN107525857A (zh) * 2017-03-29 2017-12-29 中国检验检疫科学研究院 一种洗护用品中孕激素化学风险物质的筛查方法
CN109633041A (zh) * 2019-02-26 2019-04-16 广东食品药品职业学院 衍生化hplc法测定药物中双氢睾酮的方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7893399B2 (en) * 2008-09-09 2011-02-22 Quest Diagnostics Investments Incorporated Methods for detecting dehydroepiandrosterone by mass spectrometry
US7804063B2 (en) * 2008-10-06 2010-09-28 Quest Diagnostics Investments Incorporated Methods for detecting dihydrotestosterone by mass spectrometry
EP3486648B1 (en) 2008-12-24 2025-04-30 Quest Diagnostics Investments Incorporated Mass spectrometry assay for congenital adrenal hyperplasia
US9834578B2 (en) * 2010-05-27 2017-12-05 University Of Utah Research Foundation Enhanced sensitivity for analysis of ketosteroid compounds using mass spectrometry
SG192661A1 (en) * 2011-02-07 2013-09-30 Lab Corp America Holdings Methods and systems for determining the presence or amount of testosterone in a sample
CN107064400B (zh) * 2017-04-20 2018-09-21 博厚健康科技股份有限公司 同时检测血清中五种类固醇激素的方法
US11536733B2 (en) * 2019-04-16 2022-12-27 Laboratory Corporation Of America Holdings Methods and systems for the detection of 11-oxo androgens by LC-MS/MS
KR102046488B1 (ko) * 2019-07-02 2019-11-19 건국대학교 글로컬산학협력단 모유은행 기증 모유의 다차원 분석방법

Citations (1)

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US20080166697A1 (en) * 2003-09-08 2008-07-10 Quest Diagnostics Investments Incorporated Determination of testosterone by mass spectrometry

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US8016A (en) * 1851-04-01 Improvement in the manufacture of india-rubber
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
ATE242485T1 (de) * 1993-05-28 2003-06-15 Baylor College Medicine Verfahren und massenspektrometer zur desorption und ionisierung von analyten
US5772874A (en) * 1995-11-02 1998-06-30 Cohesive Technologies, Inc. High performance liquid chromatography method and apparatus
EP0840893B1 (en) * 1996-01-19 1999-09-15 Cohesive Technologies Inc. High performance liquid chromatography method and apparatus
GB9717926D0 (en) * 1997-08-22 1997-10-29 Micromass Ltd Methods and apparatus for tandem mass spectrometry
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AU4299301A (en) * 2000-02-29 2001-09-12 National University Of Singapore, The A method for modulating steroidogenic activity
WO2003012445A1 (en) * 2001-07-30 2003-02-13 Quest Diagnostics Investments Incorporated Methods and kits for detecting ita in a biological sample
JP3774888B2 (ja) * 2001-11-28 2006-05-17 日本化薬株式会社 ステロイド類化合物のｌｃ−ｍｓによる高感度検出法
US20040033530A1 (en) * 2002-04-08 2004-02-19 Awrey Donald E. High throughput purification, characterization and identification of recombinant proteins
JP3686657B2 (ja) * 2003-02-27 2005-08-24 帝国臓器製薬株式会社 ステロイド性生体内微量物質の測定方法
CN101248069A (zh) * 2004-05-17 2008-08-20 阿卡蒂亚药品公司 雄激素受体调节剂及用其治疗疾病的方法
US7935921B2 (en) * 2006-05-26 2011-05-03 Laboratory Corporation Of America Holdings Methods and systems for the quantitative analysis of biomarkers
US20080176269A1 (en) * 2006-10-06 2008-07-24 Mohler James L Method for determination of DHT levels in tissue samples
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US7893399B2 (en) * 2008-09-09 2011-02-22 Quest Diagnostics Investments Incorporated Methods for detecting dehydroepiandrosterone by mass spectrometry
US7804063B2 (en) * 2008-10-06 2010-09-28 Quest Diagnostics Investments Incorporated Methods for detecting dihydrotestosterone by mass spectrometry
EP3486648B1 (en) * 2008-12-24 2025-04-30 Quest Diagnostics Investments Incorporated Mass spectrometry assay for congenital adrenal hyperplasia

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US20080166697A1 (en) * 2003-09-08 2008-07-10 Quest Diagnostics Investments Incorporated Determination of testosterone by mass spectrometry

Non-Patent Citations (2)

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ATSUSHI YAMAMOTO ET AL.,: "Steroid Hormone Profiles of Urbanand Tidal Rivers Using LC/MS/MS Equipped with Electrospray Ionization and Atmospheric Pressure Photoionization Sources", 《ENVIRON. SCI. TECHNOL.》 *
STEVE SHIRAISHI: "Simultaneous Measurement of SerumTestosterone and Dihydrotestosterone by Liquid Chromatography–Tandem Mass Spectrometry", 《CLINICAL CHEMISTRY》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104040343A (zh) * 2012-01-05 2014-09-10 Dh科技发展私人贸易有限公司 增强含有酮类固醇和酮基或醛的分析物的灵敏度和特异性
CN107525857A (zh) * 2017-03-29 2017-12-29 中国检验检疫科学研究院 一种洗护用品中孕激素化学风险物质的筛查方法
CN107525857B (zh) * 2017-03-29 2019-11-12 中国检验检疫科学研究院 一种洗护用品中孕激素化学风险物质的筛查方法
CN109633041A (zh) * 2019-02-26 2019-04-16 广东食品药品职业学院 衍生化hplc法测定药物中双氢睾酮的方法
CN109633041B (zh) * 2019-02-26 2021-07-02 广东食品药品职业学院 衍生化hplc法测定药物中双氢睾酮的方法

Also Published As

Publication number Publication date
CA2739506A1 (en) 2010-04-15
US8563922B2 (en) 2013-10-22
MX2011003653A (es) 2011-09-06
US7804063B2 (en) 2010-09-28
AU2009302641A1 (en) 2010-04-15
JP2015143699A (ja) 2015-08-06
US20120175517A1 (en) 2012-07-12
JP2012504766A (ja) 2012-02-23
US8158931B2 (en) 2012-04-17
US8410428B2 (en) 2013-04-02
JP6096412B2 (ja) 2017-03-15
CN106770756A (zh) 2017-05-31
EP2344661A1 (en) 2011-07-20
US20110006197A1 (en) 2011-01-13
US20130228680A1 (en) 2013-09-05
EP2344661A4 (en) 2012-08-01
JP6151291B2 (ja) 2017-06-21
EP2344661B1 (en) 2019-02-20
CA2739506C (en) 2019-02-12
US20100084546A1 (en) 2010-04-08
AU2009302641B2 (en) 2015-05-21
BRPI0920028A8 (pt) 2017-11-21
BRPI0920028A2 (pt) 2015-12-15
EP3124617A1 (en) 2017-02-01
WO2010042370A1 (en) 2010-04-15

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Application publication date: 20111109