CN102238899A - Device for optically examining the interior of a turbid medium - Google Patents
Device for optically examining the interior of a turbid medium Download PDFInfo
- Publication number
- CN102238899A CN102238899A CN200980148495XA CN200980148495A CN102238899A CN 102238899 A CN102238899 A CN 102238899A CN 200980148495X A CN200980148495X A CN 200980148495XA CN 200980148495 A CN200980148495 A CN 200980148495A CN 102238899 A CN102238899 A CN 102238899A
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- China
- Prior art keywords
- light
- turbid medium
- equipment
- stayed surface
- support
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
- A61B5/4528—Joints
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/14—Coupling media or elements to improve sensor contact with skin or tissue
- A61B2562/146—Coupling media or elements to improve sensor contact with skin or tissue for optical coupling
Abstract
A device for optically examining the interior of a turbid medium is provided. The device comprises a light source (3) adapted to emit light for irradiating the turbid medium; a detector unit (4) adapted for detecting light emanating from the turbid medium; and a light guide adapted for guiding light emitted by the light source to the turbid medium. The light guide comprises a support (10; 100) comprising a support surface (20; 120) for supporting the turbid medium to be examined and for coupling the light emitted by the light source (3) through the support surface (20; 120) into the turbid medium. The device is structured such that light from the light source (3) exits through the support surface (20; 120) only at positions at which the support surface is contacted.
Description
Technical field
The present invention relates to a kind of equipment that is used for the inside of optical check turbid medium.
Background technology
Under the application's background, term " light " is interpreted as mean the unionized electromagnetic radiation, particularly, the scope of wavelength between 400nm and 1400nm.Term " optical check " means by means of light to be checked.Term " body part " means the part of the mankind or animal health.
In recent years, the some dissimilar equipment of the inside that is used for the optical check turbid medium have been developed, wherein, use, and detector cell detects from the light of turbid medium radiation for how much with transmission or reflection from the turbid medium in the inspection of photoirradiation such as the body part of light source.In this equipment, the light that is detected is used to collect the information relevant with the inside of turbid medium.According to the device type of the inside that is used for the optical check turbid medium, can rebuild for example two dimension or the 3-D view of the inside of turbid medium, perhaps can from the light that is detected, extract with turbid medium in the concentration dependent information of different material.
US 5 415 655 shows a kind of Medical Equipment that is used for by means of the optical test tissue.Described Medical Equipment has flexible light guide, and described flexible light guide has luminous energy input and the luminous energy outfan that is suitable for being connected to light energy source.Described luminous energy outfan light energy output bundle.
Recently, advised using the equipment of the inside that is used for the optical check turbid medium, by with the joint of the body part in the photoirradiation inspection and intermediate structure and detect from the light of body part radiation and come the disease activity of the joint disease of optical detection such as rheumatic arthritis.
Disposal to this joint disease is stage by stage.Usually, the patient at first receives analgesic.Thereafter normally non-steroidal anti-inflammatory drug thing (NSAID) and disease modification antirheumatic thing (DMARD).Under many circumstances, the final stage of utilizing medicine to dispose is the use Biotherapeutics.Particularly, last classification is expensive, and may tens thousand of dollars for the disposal in every patient every year.In addition, employed medicine causes more serious negative interaction usually in the disposal of later phases.For this joint disease, the disease activity that the medical expert provides based on quantity and seriousness by the inflammation joint is made about the decision of change to treatment.
Because rheumatic arthritis is gradual disease, and diagnose as soon as possible and begin to dispose and to help to postpone the ill effect of disposal and high cost, therefore need be used to provide method and apparatus relevant with the situation in joint, gratifying information, its auxiliary medical expert obtains the conclusion at actual joint condition.Traditionally, the rheumatologist uses so-called disease activity scoring (DAS-28) to diagnose and dispose monitoring.Since this method be consuming time, depend on the operator and have limited sensitivity, therefore need be used to detect the suitable device of disease activity.Use is used for showing the result who has hope as the disease activity monitor by means of the equipment of the corresponding body part of optical test.
Equipment according to the inside that is used for the optical check turbid medium, it is known as the disease activity that is particularly suitable for detecting joint disease for the applicant, will be placed on the pan of being made by transparent material by the turbid medium that the body part that comprises at least one joint (for example staff) forms.In order to check,, and detect light by the detector cell that is positioned at respect to the opposite side of the turbid medium of light source with how much of transmissions with the expansion light source irradiation turbid medium that places the pan below.For example, detector cell can be formed by the CCD camera.Yet, in this layout, be that the light that is used for the irradiation turbid medium also will be transmitted to detector cell from light source under the situation of hands (this is typical situation for the joint disease movement monitoring) under the situation of not passing turbid medium for example at turbid medium.For example, under the situation that turbid medium is formed by hands, light will transmission between finger.Because this light will can not be attenuated in turbid medium, so other part light that the intensity of this part light on detector cell has more been passed turbid medium want high.Therefore, the light that does not pass turbid medium may make detector cell saturated, makes the result can only pass the relative photo of turbid medium with lower accuracy detection.
Summary of the invention
The object of the present invention is to provide a kind of equipment that is used to check the inside of turbid medium, the light that can be decayed by turbid medium with higher accuracy detection wherein, and prevent that unbated light from making detector cell saturated.
This purpose be by according to claim 1 be used to check that the equipment of inside of turbid medium realizes.This equipment comprises: light source, and it is suitable for launching the light that is used for the irradiation turbid medium; Detector cell, it is suitable for detecting the light from the turbid medium radiation; And photoconduction, it is suitable for the light by light emitted is directed to turbid medium.Described photoconduction comprises support, and the stayed surface that described support comprises is used for supporting the turbid medium of examine and is used for the light by light emitted is coupled to described turbid medium by stayed surface.Described equipment is constructed to make that the light from light source only leaves by stayed surface in the position that stayed surface is touched.Therefore, guarantee that light only leaves by stayed surface in the position that has turbid medium, and the light that leaves support is coupled in the turbid medium.Therefore, do not pass the arriving detector cell and make it saturated of turbid medium from the light of light source.Therefore, can pass the light of turbid medium with the accuracy detection of improving.
Preferably, be adapted such that from the light path of the light of light source light carries out internal reflection in the surface-supported position that stayed surface is not touched in supporting and supporting.In this case, can prevent from easily to leave by stayed surface, and can guarantee easily and will couple light in the turbid medium by utilization at difference from the coefficient of refraction of the light of light source at the position light that stayed surface is not touched.
If stayed surface comprises curved shape, particularly, be under the situation of turbid medium of examine at the mankind's body part, improved the comfort level of the personnel in checking.Preferably, surface-supported curved shape is particularly suitable for the shape of the turbid medium of examine.For example, curved shape can be particularly suitable for the shape of staff, and in this case, equipment is particularly suitable for the optical detection such as the joint disease of rheumatic arthritis.
According to preferred aspect, for stayed surface provides soft top layer, with the turbid medium of contact examine.In this case, make turbid medium and surface-supported contact area become big by turbid medium being pressed in the soft top layer to carry out optical check.Therefore, realized the enhanced coupling of light in the turbid medium.
Preferably, support comprises force transducer, and it is used for measuring the surface-supported pressure of contact.In this case, can monitor contact pressure, and when excessive or too small exerting pressure, adjust contact pressure.Therefore, can further improve the result's of optical check quality.
According on the one hand, be supported for a pan, and two main surfaces of pan are adapted such that the total internal reflection that takes place from the light of light source in the inside of supporting.In this case, saving of specially suitable space and cost benefit have been realized.Realized effective guiding of the light from the light source to the turbid medium.
Be suitable for supporting the turbid medium of staff if support, then become possibility to carrying out optical detection such as the joint disease of rheumatic arthritis in mode easily as examine.
Preferably, equipment also is included in the camera of arranging with respect to the opposite side of surface-supported support.In this case, can monitor turbid medium in mode especially easily contacts with surface-supported.In addition, can monitor and adjust position with respect to the turbid medium that supports.
Preferably, equipment is the medical optics testing fixture.According to concrete aspect, equipment is suitable for optical detection rheumatic arthritis.
Description of drawings
According to the detailed description of embodiment and with reference to the accompanying drawings, will find out further feature of the present invention and advantage.
Fig. 1 is schematically illustrated in the roughly setting of the known device of the inside that is used for the optical check turbid medium;
Fig. 2 has schematically shown the position as the joint of the staff of the example of the turbid medium of examine;
Fig. 3 has schematically shown the embodiment of the equipment of the inside that is used for the optical check turbid medium;
Fig. 4 has schematically shown the modification of embodiment;
Fig. 5 has schematically shown another modification of embodiment.
The specific embodiment
At first, use description to the roughly setting of legacy equipment of the inside of optical check turbid medium at Fig. 1, described equipment is particularly suitable for checking the situation in joint.Fig. 1 has schematically shown the setting of this equipment of realizing transmission geometry.As seen from Figure 1, turbid medium 5 is placed in the support 1, described support 1 comprises that turbid medium 5 relies on its stayed surface 2.In example, form turbid medium 5 by staff, and form support 1 by the transparent disk thing.Emission light (schematically by arrow 7 indication) is located at the light source 3 of irradiation turbid medium 5 and supports 1 below, promptly on the opposite side with respect to the support of turbid medium 5.As from the opposite side of light source 3 being seen turbid mediums 5, arrange that detector cell 4 is to detect the light (still schematically by the arrow indication) from turbid medium 5 radiation.Detector cell 4 can for example be formed by the CCD camera.In apparatus shown,, and detect the light of the opposite side that arrives turbid medium 5 in two dimension resolution mode by detector cell 4 by the whole turbid medium 5 of light source 3 irradiation.Yet as has been described above, in this layout, a part that is used for the light of irradiation turbid medium 5 arrives detector cell 4 under the situation of not passing turbid medium 5.For example, formed in the example shown of turbid medium 5 by hands, a part that is used to carry out the light of irradiation may be passed between finger.Compare this part optical attenuation ground much less with the light that passes turbid medium 5.Therefore, the less light of decaying may cause the saturated of detector cell 4, this so that reduced sensitivity for the light that passes turbid medium 5.
The exemplary area-of-interest that is used for the joint disease movement monitoring that shows of Fig. 2, the i.e. joint 6 that exists in the turbid medium 5.In example shown in Figure 2, turbid medium 5 is formed by staff.
To describe an embodiment now, utilize this embodiment can overcome the problems referred to above.The general arrangement of equipment of inside that is used for the optical check turbid medium is similar to the structure of describing with reference to figure 1.Yet, compared to Figure 1, the layout of light source 3 and to support 20 structure be different.These differences will be described in detail with reference to figure 3.
With to turbid medium 5 as to carry out the layout of support 2 shown in Fig. 1 of irradiation and light source 3 different by supporting 2 integral body, realized different layouts according to embodiment.Should be noted that not shown in the accompanying drawings detector cell 4.Yet, with the transmission geometric position provide detector cell 4 (for example, with Fig. 1 in situation about describing similar).Light source 3 among the embodiment for example can be wideband light source, for example, and electric filament lamp or such as the monochromater of LED or laser.Detector cell for example can be formed by the CCD camera.
In the embodiment shown in fig. 3, the pan by transparent material forms support 10.For example, support can be made by clear glass, PMMA or other suitable transparent materials.At first, will the situation that turbid medium 5 does not contact stayed surface 20 be described.To laterally introduce from the light 7 of light source 3 and support in 10.Support 10 with respect to from the coefficient of refraction of the light of light source 3 and will introduce from the light of light source 3 and support 10 angle and be selected as making that the light from light source 3 does not leave by stayed surface 20 supporting internal reflection in 10, wherein said stayed surface 20 is not touched in the outside.Therefore, support 10 as the photoconduction of wherein advancing with total internal reflection from the light of light source 3.From another viewpoint, this layout is chosen as makes and total reflection takes place at place, the inboard of stayed surface 20 and at the place, inboard of corresponding main surfaces 22.This means from the light of light source 3 and meet the demands: α＞α from the angle [alpha] that supports 10 inside and arrive stayed surface 20
GWherein, be α
GThe critical angle of total reflection.This critical angle α
GSatisfy equation
sinα
G＝n
2/n
1 (1)
Wherein, n
2For at from the light of light source 3 coefficient of refraction at the place, outside of stayed surface 20, and n
1For supporting the coefficient of refraction of 10 material.For simplifying reason, can for example form the medium at surface-supported outside place by surrounding air, make coefficient of refraction n
2Approximately corresponding to very aerial coefficient of refraction n
0Therefore, select from the light of light source 3 from supporting the angle [alpha] that 10 inside arrives stayed surface 20, to satisfy:
α＞α
G＝sin
-1(n
2/n
1) (2)
The situation of turbid medium 5 contact stayed surfaces 20 will be described now.With the device-dependent situation of the inside that is used for the optical check turbid medium, the turbid medium 5 of examine will be normally such as the body part of staff.Situation when this particularly is suitable for the joint disease monitoring for the equipment in the inside that is used for the optical check turbid medium.This turbid medium 5 will have the coefficient of refraction n different with the coefficient of refraction of surrounding air
tTherefore, in the position of turbid medium 5 contact stayed surfaces 20, for the different critical angle α of total reflection
GtTo be effectively, wherein:
sinα
Gt＝n
t/n
1 (3)
At the equipment according to the inside that is used for the optical check turbid medium of embodiment, selected angle is to satisfy:
α
Gt＞α＞α
G (4)
Therefore, locate, light 7 total reflections from source 3 will take place in the inside of supporting 10, and light can not leave by stayed surface 20 in the position (that is, for example having surrounding air or another kind of suitable medium) that stayed surface 20 is not touched.On the other hand, stayed surface 20 by turbid medium 5 position contacting places, the requirement of total reflection is no longer satisfied, and will enter turbid medium 5 by stayed surface 20 from the light of light source 3.Because the scattering properties of turbid medium 5, light will distribute by turbid medium 5.The light that enters turbid medium 5 will be detected after transmission is by turbid medium 5.
Should be noted that, provide support the surface 22 at 10 side places relative in the corresponding way, make in the support 10 inboard a plurality of total internal reflections that realize from the light of light source 3 as photoconduction with stayed surface 20.
Therefore, guarantee to use from the light of light source 3 irradiation turbid medium 5 reliably, and meanwhile, the light that does not pass turbid medium 5 arrives detector cell 4.In other words, do not contact in the zone of stayed surface 20 at turbid medium 5, light will remain on and support in 10, and can't disturb the signal on the detector cell 4.Therefore, realized high sensitivity at the light that passes turbid medium 5.
In a word, according to embodiment, with greater than be all-trans to the suitable angle of critical angle light is inserted in the support 10 that forms photoconduction.The light that is inserted is advanced by supporting 10.When turbid medium 5 being placed as when contacting with the stayed surface 20 that supports 10, the coefficient of refraction on the stayed surface 20 changes, and stops total internal reflection.In this position, enter turbid medium 5 via stayed surface 20 from the light that supports 10 emissions.
Can carry out to be incorporated into from the light of light source 3 and support in 10 by the window that enters that supports a horizontal side place of 10.Can perhaps can be provided for utilizing again non-radiative illuminator for relative horizontal side (deviating from light source 3) is provided for non-light absorbing beam cut-off device for it.Under the situation of illuminator, need significant care so that reflected light remains on the correct angle of total internal reflection.In situation as the laser of coherent source 3, for example can select the different angles that enters window and leave the angle of window, be coupled back in the laser to prevent reflected light.
Although in the embodiment shown in fig. 3, support 10 is depicted as has complete planar stayed surface 20, and according to the modification of embodiment, stayed surface 20 can have (slightly) crooked shape.Particularly, the curved shape of stayed surface 20 can specifically be suitable for the shape of the turbid medium of examine.For example, for the particular case of joint disease monitoring, stayed surface 20 can specifically be suitable for the shape of staff.The shape of this bending obtains the comfort level that its health branch is in the lifting of the people in the inspection.
Now the preferred modification of support 100 of the equipment of the inside that is used to check turbid medium will be described at Fig. 4.This modification is different with the above embodiment that describes in surface-supported structure.Leave at the light from the total internal reflection of the light of light source 3 and the position that only is touched in stayed surface, this is revised corresponding to embodiment described above.Below, only describe the difference of embodiment, and will no longer repeat the detailed description of individual features.
As among Fig. 4 schematically, according to preferred embodiment, for supporting the 100 soft top layers 110 that provide support surperficial 120 sides.This soft top layer 110 can be for example being combined to form by soft polymer, gel, fluid or these.The optical characteristics of soft top layer 110 is selected as making the support 100 that comprises soft top layer 110 still as photoconduction, and only is coupled out by stayed surface 120 (via soft top layer 110) with turbid medium 5 position contacting places at stayed surface 120 from the light of light source 3.According to modification, this result realizes as changing by the coefficient of refraction of using total internal reflection and locate in the outside of stayed surface 120 when turbid medium 5 contacts stayed surfaces 120 in the above-described embodiments.
Owing to soft top layer 110, therefore can push the turbid medium 5 of examine to stayed surface 120, make to compress soft top layer 110 slightly, and the contact area between turbid medium 5 and the stayed surface 120 becomes big.Therefore, realized light more effectively is coupled in the turbid medium 5.
(do not illustrate in the drawings) in another preferred embodiment, force transducer is attached to according to embodiment (10) or according to the support 10,100 of revising (100).Utilize force transducer, can measure the pressure that turbid medium 5 is pushed to stayed surface 20,120.According to modification, provide another control unit, its monitoring force pick off and the pressure that provides feedback to push to stayed surface 20,120 with the adjustment turbid medium.For example can provide feedback to the personnel under the body part of the turbid medium in form checking or to the operator as vision or audible signal.According to the implementation that comprises force transducer, can avoid too high pressure, for example forming by staff under the situation of turbid medium, excess pressure will cause that blood extrudes from the tissue of turbid medium.In addition, can prevent reliably and will cause the low-pressure excessively of very few contact between turbid medium 5 and the stayed surface 20,120.Therefore, can prevent the situation that couples light to turbid medium 5 with insufficient.
Figure 5 illustrates the another modification of the equipment of the inside that is used for the optical check turbid medium.Although describe this modification, also be possible with basic embodiment (not having soft top layer) or with combining of carrying out of arbitrary modification based on the modification that comprises soft top layer 110.According to the modification shown in Fig. 5, camera 200 is placed on supports 100 sides relative with stayed surface 120.At turbid medium 5 and stayed surface 120 position contacting places, not only be coupled in the turbid medium 5 from the light of light source 3, and will be reflected and leave tissue.Reflected light can be advanced by the material that supports 100, and leaves by surface 22 and support 100 supporting 100 sides that deviate from turbid medium 5.According to the modification that comprises camera, this light is caught by camera 200, makes it possible to discern the zone that turbid medium 5 contacts with stayed surface 120.Therefore, utilize this implementation, can assess the correct placement of the turbid medium 5 that is used to check.In addition, also can be with catoptrical amount as the amount that is coupled to the light in the turbid medium 5 via stayed surface 120.
In addition, the embodiment that comprises camera 200 can be adapted such that in the specific mode of wavelength and monitor reflected light.Particularly, determine that for example the position and the special catoptrical combination of monitoring wavelength in joint can help the analysis of joint inflammation.
For the optical detection of the disease activity of rheumatic arthritis or other joint diseases, the joint and the intermediate structure of body part (particularly staff) are carried out irradiation and detected transillumination or reflected light particularly.The foregoing description and modification allow for example particularly to comprise the body part in joint with the correct interested turbid medium of mode irradiation, make to prevent that undesirable light from arriving detector cell.Therefore, with the precision of improving provide with check in the relevant expectation information in inside of turbid medium.This for example and then allow the earlier detection such as the joint disease of rheumatic arthritis.The detection by quantitative that reaches in early days for the joint inflammation allows the disposal of the early stage cost of disposing and will obtaining reducing for the disposal joint disease to monitor.
According to the foregoing description and modification, realize irradiation as the total reflection of the inside of the support of photoconduction to the improvement of the turbid medium of examine by utilization.Yet, in principle, substitute the utilization total reflection, for example the optical absorption of the surface-supported position that is not touched also can by utilization as with prevent light by stayed surface leave alternative.
Claims (11)
1. equipment that is used for the inside of optical check turbid medium comprises:
Light source (3), it is suitable for launching the light that is used for the described turbid medium of irradiation;
Detector cell (4), it is suitable for detecting the light of emitting from described turbid medium; And
Photoconduction, it is suitable for the light by described light emitted is directed to described turbid medium;
Wherein, described photoconduction comprises support (10; 100), described support comprises stayed surface (20; 120), it is used to support the described turbid medium of examine and is suitable for the light by described light source (3) emission is passed through described stayed surface (20; 120) be coupled in the described turbid medium,
Wherein, described equipment is constructed to make that the light from described light source (3) only passes through described stayed surface (20 in the position that described stayed surface is touched; 120) leave.
2. equipment according to claim 1, wherein, described support (10; 100) and from the light path of light in described support of described light source (3) be adapted such that light is at described stayed surface (20; 120) position that stayed surface is not touched described in is by internal reflection.
3. according to each the described equipment in claim 1 or 2, wherein, described stayed surface (20; 120) comprise crooked shape.
4. equipment according to claim 3, wherein, described stayed surface (20; The shape of the described turbid medium of the special and examine of the shape of described bending 120) is suitable.
5. according to each the described equipment in the claim 1 to 4, wherein, be described stayed surface (20; 120) be provided for the soft top layer (110) that contacts with the turbid medium of examine.
6. according to each the described equipment in the claim 1 to 5, wherein, described support (10; 100) comprise force transducer, it is used for measuring the described surface-supported pressure of contact.
7. according to each the described equipment in the claim 1 to 6, wherein, described support (10; 100) be a pan, and two main surfaces of described pan are adapted such that the total internal reflection that takes place from the light of described light source (3) in the inside of described support.
8. according to each the described equipment in the claim 1 to 7, wherein, described support (10; 100) be suitable for supporting staff as the turbid medium of examine.
9. according to each the described equipment in the claim 1 to 8, wherein, described equipment also is included in respect to described stayed surface (20; 120) described support (10; 100) camera of arranging on the opposite side (200).
10. according to each the described equipment in the claim 1 to 9, wherein, described equipment is the medical optics testing fixture.
11. according to each the described equipment in the claim 1 to 10, wherein, described equipment is suitable for optical detection rheumatic arthritis.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08165818.9 | 2008-10-03 | ||
| EP08165818 | 2008-10-03 | ||
| PCT/IB2009/054292 WO2010038207A1 (en) | 2008-10-03 | 2009-10-01 | Device for optically examining the interior of a turbid medium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102238899A true CN102238899A (en) | 2011-11-09 |
Family
ID=41445454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980148495XA Pending CN102238899A (en) | 2008-10-03 | 2009-10-01 | Device for optically examining the interior of a turbid medium |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2385785A1 (en) |
| CN (1) | CN102238899A (en) |
| WO (1) | WO2010038207A1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1274447A (en) * | 1998-07-28 | 2000-11-22 | 数字人公司 | Method and appts. for illuminating fingerprint |
| US20060159317A1 (en) * | 2005-01-19 | 2006-07-20 | E-Pin International Tech Co., Ltd. | Optical engine for fingerprint reader |
| US20080192988A1 (en) * | 2006-07-19 | 2008-08-14 | Lumidigm, Inc. | Multibiometric multispectral imager |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040021100A1 (en) * | 2002-04-12 | 2004-02-05 | Mikhail Gouzman | Fiber-optic sensor for measuring level of fluid |
| US20050119587A1 (en) * | 2003-07-01 | 2005-06-02 | University Of Michigan | Method and apparatus for evaluating connective tissue conditions |
-
2009
- 2009-10-01 WO PCT/IB2009/054292 patent/WO2010038207A1/en active Application Filing
- 2009-10-01 EP EP09787339A patent/EP2385785A1/en not_active Withdrawn
- 2009-10-01 CN CN200980148495XA patent/CN102238899A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1274447A (en) * | 1998-07-28 | 2000-11-22 | 数字人公司 | Method and appts. for illuminating fingerprint |
| US20060159317A1 (en) * | 2005-01-19 | 2006-07-20 | E-Pin International Tech Co., Ltd. | Optical engine for fingerprint reader |
| US20080192988A1 (en) * | 2006-07-19 | 2008-08-14 | Lumidigm, Inc. | Multibiometric multispectral imager |
Non-Patent Citations (2)
| Title |
|---|
| MAXIME BOULET-AUDET ET AL: "Attenuated Total Reflection Infrared Spectroscopy：An Efficient Technique to Quantitatively Determine the Orientation and Conformation of Proteins in Single Silk Fibers", 《SOCIETY OF APPLIED SPECTROSOPY》 * |
| U BINDIG ET AL: "Fibre-optic laser-assisted infrared tumour diagnostics(FLAIR)", 《JOURNAL OF PHYSICS D:APPLIED PHYSICS》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010038207A1 (en) | 2010-04-08 |
| EP2385785A1 (en) | 2011-11-16 |
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