CN102234302B - 一种酮内酯衍生物、制备方法及其药物组合物 - Google Patents

一种酮内酯衍生物、制备方法及其药物组合物 Download PDF

Info

Publication number
CN102234302B
CN102234302B CN201010171484.8A CN201010171484A CN102234302B CN 102234302 B CN102234302 B CN 102234302B CN 201010171484 A CN201010171484 A CN 201010171484A CN 102234302 B CN102234302 B CN 102234302B
Authority
CN
China
Prior art keywords
compound
acid
reagent
general formula
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201010171484.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN102234302A (zh
Inventor
梁建华
安堃
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Institute of Technology BIT
Original Assignee
Beijing Institute of Technology BIT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Institute of Technology BIT filed Critical Beijing Institute of Technology BIT
Priority to CN201010171484.8A priority Critical patent/CN102234302B/zh
Priority to PCT/CN2011/073762 priority patent/WO2011137758A1/fr
Publication of CN102234302A publication Critical patent/CN102234302A/zh
Application granted granted Critical
Publication of CN102234302B publication Critical patent/CN102234302B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN201010171484.8A 2010-05-07 2010-05-07 一种酮内酯衍生物、制备方法及其药物组合物 Expired - Fee Related CN102234302B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201010171484.8A CN102234302B (zh) 2010-05-07 2010-05-07 一种酮内酯衍生物、制备方法及其药物组合物
PCT/CN2011/073762 WO2011137758A1 (fr) 2010-05-07 2011-05-06 Nouveaux dérivés de kétolides, procédés d'élaboration et compositions pharmaceutiques correspondants

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201010171484.8A CN102234302B (zh) 2010-05-07 2010-05-07 一种酮内酯衍生物、制备方法及其药物组合物

Publications (2)

Publication Number Publication Date
CN102234302A CN102234302A (zh) 2011-11-09
CN102234302B true CN102234302B (zh) 2014-05-07

Family

ID=44885473

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201010171484.8A Expired - Fee Related CN102234302B (zh) 2010-05-07 2010-05-07 一种酮内酯衍生物、制备方法及其药物组合物

Country Status (2)

Country Link
CN (1) CN102234302B (fr)
WO (1) WO2011137758A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104961785B (zh) * 2015-06-19 2019-01-11 北京理工大学 一种新型酰内酯衍生物及其制备方法
CN106916194B (zh) * 2017-01-13 2020-05-08 北京理工大学 一种新型含有氨基的酮内酯衍生物、制备方法及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020019355A1 (en) * 2000-02-24 2002-02-14 Zhenkun Ma Anti-infective agents useful against multidrug-resistant strains of bacteria
WO2002032919A2 (fr) * 2000-10-16 2002-04-25 Abbott Laboratories Derives d'erythromycine substitue en 6-o possedant une tolerance gastro-intestinale amelioree

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020019355A1 (en) * 2000-02-24 2002-02-14 Zhenkun Ma Anti-infective agents useful against multidrug-resistant strains of bacteria
WO2002032919A2 (fr) * 2000-10-16 2002-04-25 Abbott Laboratories Derives d'erythromycine substitue en 6-o possedant une tolerance gastro-intestinale amelioree

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Constantin Agouridas, et al..Synthesis and Antibacterial Activity of Ketolides (6-O-Methyl-3-oxoerythromycin Derivatives): A New Class of Antibacterials Highly Potent Against Macrolide-Resistant and -Susceptible Respiratory Pathogens.《J. Med. Chem.》.1998,第41卷(第21期),4080-4100.
Constantin Agouridas, et al..Synthesis and Antibacterial Activity of Ketolides (6-O-Methyl-3-oxoerythromycin Derivatives): A New Class of Antibacterials Highly Potent Against Macrolide-Resistant and-Susceptible Respiratory Pathogens.《J. Med. Chem.》.1998,第41卷(第21期),4080-4100. *
Ghilsoo Nama,et al..Synthesis and antibacterial activity of new 9-O-arylpropenyloxime ketolides.《Bioorganic & Medicinal Chemistry Letters》.2010,第20卷2671-2674.
Ghilsoo Nama,et al..Synthesis and antibacterial activity of new 9-O-arylpropenyloxime ketolides.《Bioorganic &amp *
Medicinal Chemistry Letters》.2010,第20卷2671-2674. *

Also Published As

Publication number Publication date
CN102234302A (zh) 2011-11-09
WO2011137758A1 (fr) 2011-11-10

Similar Documents

Publication Publication Date Title
JP3315704B2 (ja) ４”−置換−９−デオキソ−９ａ−アザ−９ａ−ホモエリスロマイシンＡ誘導体
TW448174B (en) 9-oxime erythromycin derivatives, the preparation process thereof and pharmaceutical composition for treating bacterial infection or protozoa infection
CA2359708C (fr) Antibiotiques cetolides
ES2216581T3 (es) Azalidas de 13 miembros y su uso como agentes antibioticos.
UA70298C2 (uk) Похідні с-4"-заміщених макролідів, спосіб їх одержання, проміжні сполуки, фармацевтична композиція та спосіб лікування бактеріальної інфекції або протозойної інфекції
Fajdetić et al. 4 ″-O-(ω-Quinolylamino-alkylamino) propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens
Kapić et al. Synthesis of macrolones with central piperazine ring in the linker and its influence on antibacterial activity
CN102146085B (zh) 一种9-肟醚酮内酯衍生物、制备方法及其药物组合物
CN102234302B (zh) 一种酮内酯衍生物、制备方法及其药物组合物
Qin et al. Synthesis and antibacterial activity of novel 3-O-arylalkylcarbamoyl-3-O-descladinosyl-9-O-(2-chlorobenzyl) oxime clarithromycin derivatives
Kumar et al. Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens
KR100458240B1 (ko) 신규 에리트로마이신 유도체, 그의 제조방법 및 의약으로서의용도
Zhang et al. Synthesis and antibacterial activity of new 4 ″-O-carbamates of 11, 12-cyclic carbonate erythromycin A 6, 9-imino ether
CN109942654B (zh) 一种大环内酯和喹诺酮杂合物及其制备方法
AU2010331867A1 (en) Composition comprising an amorphous non- crystalline glass form of azithromycin
WO2005030786A1 (fr) Derives d'erythronolide a 3'-n-substitues-3-o-substitues
CN100526325C (zh) 大环内酯类药物红霉素a衍生物、合成方法和用途
CN101148460B (zh) 阿奇霉素衍生物及其应用
US20020025937A1 (en) 9-oxime erythromycin derivatives
CN101148461B (zh) 阿奇霉素衍生物及其应用
CN106916194B (zh) 一种新型含有氨基的酮内酯衍生物、制备方法及应用
CN101148462B (zh) 阿奇霉素衍生物及其应用
JP2000351793A (ja) エリスロマイシン誘導体
CN101899076A (zh) 阿奇霉素衍生物、制备方法及中间体
CN109942653A (zh) 一种红霉素衍生物及其制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20140507

Termination date: 20190507

CF01 Termination of patent right due to non-payment of annual fee