CN102232556A

CN102232556A - Food additive resisting unsymmetrical dimethylhydrazine

Info

Publication number: CN102232556A
Application number: CN2010101642110A
Authority: CN
Inventors: 李德远; 胡杰; 郑哲君
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-04-30
Filing date: 2010-04-30
Publication date: 2011-11-09

Abstract

The invention particularly relates to a food additive resisting unsymmetrical dimethylhydrazine. The product consists of vitamin B6, curcumin and melatonin. Raw materials such as the vitamin B6, the curcumin, the melatonin and the like can be purchased from the special market; the purities of the vitamin B6, the curcumin and the melatonin are 99 percent, 99 percent and 98 percent respectively; the ratio of the vitamin B6 to the curcumin to the melatonin is 20:20:1; and the raw materials are mixed uniformly under the clean condition of meeting good manufacturing practice (GMP), sealed and packaged. 4g of the food additive is added into health-care foods for each person every day. Through animal experiments, the food additive has a good effect of preventing unsymmetrical dimethylhydrazine damage.

Description

A kind of food additives of anti-uns-dimethylhydrazine

Affiliated technical field

The present invention relates to a kind of health food of anti-uns-dimethylhydrazine, the constituent of these food additives comprises vitamin, epiphysin, curcumin etc., confirm through zoopery, biologically active with opposing uns-dimethylhydrazine damaging action, and effects such as tranquilizing and allaying excitement, protecting liver and detoxication are arranged, can be used for producing the health food of anti-uns-dimethylhydrazine.

Background technology

Uns-dimethylhydrazine is good liquid rocket propellant, is widely used in the military and space field.Epidemiology survey shows that symptoms in various degree such as nerve, breathing, digestive system can appear in the staff who contacts UDMH for a long time.Uns-dimethylhydrazine has excitation to central nervous system, the low dose of excitability that increases central nervous system, and heavy dose causes convulsion.Show as typically tetanic-palmospasmus.Subacute, the slow poisoning of uns-dimethylhydrazine can cause the active rising of slight fatty liver and serum glutamic pyruvic transminase.Because anti-Zhiduo County of uns-dimethylhydrazine relates to the tender subject of space flight and military field, little bibliographical information outside the native land.Research is limited to the angle of dressing breathing mask and drug therapy more both at home and abroad at present, and is less about the research of nutrition protection.

Cobastab ₆Claim again how hot pyrrole is, is the constituent of some coenzyme in the human body, participates in multiple metabolic response, especially with amino acid metabolism substantial connection arranged.Cobastab ₆Long-term lacking can cause the unify infringement of hematopoiesis function of skin, central nervous system.Relate to the enzymatic reaction that many 5-phosphopyridoxal pyridoxal phosphates participate in the nervous system, neurotransmitter levels is raise, comprise serotonin, taurine, dopamine, norepinephrine, histamine and GABA.Along with going deep into of studying, find that it is evident in efficacy on central nervous system diseases such as treatment shaking plasy, convulsions spasm in recent years.The generation of these diseases and glutamate decarboxylase and phosphopyridoxal pyridoxal phosphate affinity are low, and the central nervous system alpha-aminobutyric acid content reduces substantial connection.Replenishing vitamins B ₆After can recover the glutamate decarboxylase activity, correct synthetic, the dysbolism of GABA, improve the content of GABA in the central nervous system, thereby make disappearance of convulsion.

Turmeric is a kind of plant of extensively planting in the torrid areas, Asia, and the active component that extracts from its rhizome is mainly curcumin, and it is a kind of phenolic compound, and the past curcumin is mainly with imitating element and flavouring.Recently the curcumin of discovering of more than ten years has anti-inflammatory, anti-HIV, antitumor, anti-sudden change, anti-oxidant, reducing blood lipid and study of anti-atherogenic effect and can suppress the kinase whose activity of multiple protein.Find also that in recent years curcumin has certain therapeutic action to some nerve degenerative diseases.It may be by reducing intracellular reactive oxygen species, approach protection cortical neurogenic cells such as protection mitochondrial function and adjusting apoptosis protein.Curcumin also may reduce Ca by acting on the nmda receptor on the neuronal cell film ²⁺Interior stream is kept Ca in the neuronal cell ²⁺Stable state is alleviated Glu to neuronic excitatory toxicity and damage, thus the protection hippocampal neuron.Curcumin falls enzyme and protects liver, prevents that the effect of the liver fibrosis due to the chronic hepatitis also is confirmed.Curcumin is brought into play anti-oxidant, the anti-radical action that anti-apoptotic effect mainly depends on it and metabolite thereof.Curcumin is as a kind of natural plant extracts, and toxic and side effect is very little, and its application in health food comes into one's own day by day.

Epiphysin (MT), promptly N-acetyl group-5-methoxytryptamine is the peptide hormone that a class is mainly secreted by pinealocyte.Epiphysin does not exist only in all mammalian bodies, and also can detect epiphysin in non-mammiferous vertebrate, non-vertebrate (comprising algae and bacterium) and multiple food.Epiphysin has multiple important physiological function: as direct removing free radical, inhibition peroxidatic reaction of lipid, the activity that increases other antioxidase and gene expression, immunoregulation effect, adjustment circadian clock body clock, inhibition hormone, secretion of growth hormone etc.Lot of domestic and foreign studies show that: the disappearance of epiphysin may be relevant with the morbidity of some nervous system degenerative disease.As AD and parkinsonism etc.MT has stabilization to the central nervous system electrical activity, can improve the tic thresholding, reduces epileptic attack.MT is that a kind of inhibition of CNS is regulated material, and is inhibited to the CNS excitability, can strengthen the activity of inhibitory transmitter.The neurocyte protection mechanism of MT may be: but the Ca that MT antagonism glutamic acid causes ²⁺Overload reduces Ca in the cell ²⁺Concentration, thus the multiple free-radical generating that it brings out can be suppressed.Because MT scope safe in utilization is wide, will be widely used in field of health care food.

Compare with drug therapy, nutrition protects that not only effect is remarkable, and has more the advantage of aspects such as security, persistence, economy.At present, also not about the health food appearance of uns-dimethylhydrazine nutrition protection, therefore develop a kind of food additives of anti-uns-dimethylhydrazine both at home and abroad, this product is owing to have Cobastab ₆, curcumin, epiphysin etc. the multiple physiological function, in the functional food of anti-uns-dimethylhydrazine, good application prospects will be arranged.

Summary of the invention

In order to study the food additives that obtain a kind of highly purified anti-uns-dimethylhydrazine, for relevant health food exploitation provides a kind of new functional raw material.The raw material Cobastab of this product ₆, curcumin, epiphysin etc. can purchase Cobastab from specialized market ₆Purity 99%, curcumin 99%, epiphysin 98%, Cobastab ₆, curcumin, epiphysin ratio be 20: 20: 1, mixes meeting under the GMP cleaning condition, pack.Addition is everyone gram every days 4 in the health food.Confirm to have opposing uns-dimethylhydrazine damaging action through zoopery.

Claims

1. the food additives of an anti-uns-dimethylhydrazine are with Cobastab ₆, curcumin, epiphysin be raw material.

2. according to the food additives of right 1 described anti-uns-dimethylhydrazine, it is characterized in that Cobastab ₆Purity 99%, curcumin 99%, epiphysin 98%, three's ratio are 20: 20: 1.

3. according to the food additives of right 1 described anti-uns-dimethylhydrazine, it is characterized in that addition is everyone gram every days 4 in the health food.