CN102232388B - Flusilazole water dispersible granule and preparation technology thereof - Google Patents
Flusilazole water dispersible granule and preparation technology thereof Download PDFInfo
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- CN102232388B CN102232388B CN201110114731.5A CN201110114731A CN102232388B CN 102232388 B CN102232388 B CN 102232388B CN 201110114731 A CN201110114731 A CN 201110114731A CN 102232388 B CN102232388 B CN 102232388B
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Abstract
The invention provides a kind of flusilazole water dispersible granule, composite containing flusilazole 5% ~ 40%, solvent 0 ~ 5%, surfactant 5% ~ 20%, adsorbent 10% ~ 20% and inert filler etc.Flusilazole solvent and surfactant are heating and are dissolving under the condition stirred by its preparation technology, form homogeneous organic liquid phase, then with adsorbent, organic liquid is adsorbed as solid-state wet feed mutually, then the solid-state siccatives such as inert filler are mixed into wherein, after mediating in kneader, extruder grain, oven dry, screening and obtaining.This water dispersible granules active constituent content is high, has good water dispersible and suspension, can give full play to Flusilazole drug effect, and store, transport, metering, safe and convenient to use, meet the demand for development of environmental protection agricultural chemicals.
Description
Technical field
The present invention relates to the Flusilazole bactericide in agricultural chemicals, refer in particular to water dispersible granules and preparation technology thereof that a kind of principle active component is Flusilazole.
Background technology
Flusilazole, molecular formula: C16H15F2N3Si, chemical name: two (4-fluorophenyl)-(1H-1,2,4-triazol-1-yl methyl) monosilane, chemical structural formula:
Flusilazole can be used as disinfectant use in agriculture; At present, the formulation of Flusilazole bactericide is mainly missible oil (57%), aqueous emulsion (16%) and microemulsion (18%), owing to containing a large amount of organic solvent in the product of these formulations, active ingredient is on the low side, can cause negative effect to environment; Also have fraction formulation to be pulvis, dust pollution air during use, and crops malabsorption, drug effect reduces.
The aqueous emulsion of the number of applying for a patent a kind of composite containing flusilazole disclosed in the specification of 200810101142.1 and the microemulsion of the number of applying for a patent a kind of composite containing flusilazole disclosed in the specification of 200410033766.6, active ingredient accounting is little, stores and transport inconvenience.The number of applying for a patent is a kind of Flusilazol smoking agent disclosed in the specification of 03109575.5, and except active ingredient accounting is little, smog has certain harm to operating personnel.The bactericidal composition of the number of applying for a patent a kind of Flusilazole and kresoxim-methyl disclosed in the specification of 200610013029.9 can be made into multiple formulation, the constituent of water dispersion granule is wherein too complicated, and it is too simple to configure technique, allocation ratio is too fuzzy, lack theoretical and experimental basis, do not reach the drug effect of two kinds of predetermined medicines, even can bring unpredictalbe side effect.
Summary of the invention
Goal of the invention: the shortcoming overcoming traditional Flusilazole bactericide, provide that a kind of comprehensive function is strong, environmental protection, broad-spectrum high efficacy flusilazole water dispersible granule.
Technical scheme: flusilazole water dispersible granule of the present invention, using Flusilazole as effective sterilization component, is water dispersible granular formulation, adopts water as binding agent in this water dispersible granules preparation process.Include multiple constituent: the adsorbent that the surfactant that the solvent that the Flusilazole that weight ratio is 5% ~ 40%, weight ratio are 0 ~ 5%, weight ratio are 5% ~ 20%, weight ratio are 10% ~ 20%, weight ratio are the water of 0.01% ~ 3%, another containing part inert filler.
Described solvent be one in toluene, dimethylbenzene, heavy aromatic solvent or several.
Described surfactant is the mixture of one or more in anion, cation, nonionic surface active agent.Mainly comprise alkyl naphthalene sulfonic acid condensation polymer sodium salt, enhancement mode naphthalenesulfonate, lignosulfonates, carboxylate, sodium isopropyl xanthate, sodium alklyarylsulfonate mixture, block copolymer etc.
Described adsorbent is silica gel, white carbon, activated alumina, corn starch, lactose or dextrin etc.
Described filler is diatomite, kaolin, bentonite or attapulgite etc.
In the present invention, Flusilazole is preferably 10% ~ 25%, and now the bacteria-eliminating efficacy of bactericide is better.When solvent preferably uses No. 150 heavy aromatic solvents or No. 200 heavy aromatic solvents, solute effect is better.
In the present invention, can also containing weight ratio be 3% ~ 10% dispersant and weight ratio be 0 ~ 7% wetting agent; The trade mark of described dispersant or model are T2020, D425 or YUS-WG4; The trade mark of described wetting agent or model are TERWET1004, SD200 or YUS-SXC.
The particle diameter of water dispersion granule of the present invention can be 500 μm ~ 5mm.
Another object of the present invention: the preparation technology that a kind of flusilazole water dispersible granule large-scale production is provided.
For realizing this object of the present invention, adopt such technical scheme: comprise following preparation process:
One, bactericide flusilazole solvent and surfactant to be dissolved under the condition stirred at heating water bath, form homogeneous organic liquid phase, the temperature of heating water bath may be selected to be the scope of 50 DEG C ~ 70 DEG C.
Two, with adsorbent, organic liquid is adsorbed as mutually the solid-state wet feed of pasty state.
Three, after dispersant, wetting agent, filler fully being mixed, pulverized solid siccative is become through air-flow crushing.
Four, in kneader, solid-state wet feed and solid-state siccative are mixed, add suitable quantity of water and make binding agent, fully mediate.
Five, by the express material granulation after kneading, oven dry, screening, flusilazole water dispersible granule is obtained; The particle diameter of express material granulation is 500 μm ~ 5mm.
Beneficial effect:
Flusilazole water dispersible granule of the present invention has good water dispersible and suspension, and entering after water can disintegration rapidly, and dispersion, forms higher suspension dispersion.Working concentration lower surface tension force is low, can give full play to drug effect.Liquid preparation solidification, active constituent content is high, has good physical stability and chemical stability in storage period.Without dust from flying during use, avoid the harm because dust from flying causes.Than great, packaging volume is little, stores and transports convenient and safe.Good fluidity, is easy to metering, can fully pours out from packaging bag.Reduce impact on environment, meet the formulations of pesticide in the world towards the water-based aerosol of high safety, environmental protection and non-dusting solid particulate preparation future development.
Accompanying drawing explanation
Accompanying drawing is preparation technology's flow chart of the present invention.
Embodiment
Below in conjunction with drawings and Examples, the present invention is more specifically illustrated; Adopt technological process as shown in the drawings, preparation has the flusilazole water dispersible granule of following constituent respectively:
Embodiment 1: choose 5 grams of flusilazoles, 2 grams of xylene solvents, 5 grams of alkyl naphthalene sulfonic acid condensation polymer sodium salt surface active agent mixing, be dissolved into homogeneous organic liquid phase under 55 DEG C of water-baths, adsorb into solid-state wet feed by 30 grams of activated alumina adsorbents; Again by 6 grams of T2020 dispersants, 3 grams of TERWET1004 wetting agents, 34 grams of kaolin clay filler mixing, become solid-state siccative through air-flow crushing; Solid-state wet feed and solid-state siccative are carried out kneading process, add suitable quantity of water and make binding agent; Finally carry out extruder grain, drying, screening, obtaining particle diameter is 500 μm ~ 5mm, and active ingredient is about the flusilazole water dispersible granule of 6%.It is 81% that experiment records sample physical suspension rate, and chemical suspensibility is 92%.
Embodiment 2:25 gram of flusilazole, 3 grams of No. 200 heavy aromatic solvents, 5 grams of enhancement mode naphthalenesulfonate surfactant mixing, be dissolved into homogeneous organic liquid phase, adsorb into solid-state wet feed with 30 grams of corn starchs under 60 DEG C of water-baths; Again by 7 grams of YUS-WG4 dispersants, 2 grams of YUS-SXC wetting agents and 18 grams of tripolite filling material mixing, become solid-state siccative through air-flow crushing; Solid-state wet feed and solid-state siccative are carried out kneading process, add suitable quantity of water and make binding agent; Finally carry out extruder grain, drying, screening, show that obtaining particle diameter is 500 μm ~ 5mm, active ingredient is about the flusilazole water dispersible granule of 28%.It is 83% that experiment records sample physical suspension rate, and chemical suspensibility is 95%.
Embodiment 3:40 gram of flusilazole, 3 grams of No. 150 heavy aromatic solvents, 5 grams of nonionic block copolymers surfactant mixing, under 70 DEG C of water-baths, be dissolved into homogeneous organic liquid phase, become solid-state wet feed with 8 grams of corn starchs with 20 grams of white carbon adsorbent; Again by 5 grams of D425 dispersants, 4 grams of SD200 wetting agents and 15 grams of attapulgite filler mixing, become solid-state siccative through air-flow crushing; Solid-state wet feed and solid-state siccative are carried out kneading process, add suitable quantity of water and make binding agent; Finally carry out extruder grain, drying, screening, show that obtaining particle diameter is 500 μm ~ 5mm, active ingredient is about the flusilazole water dispersible granule of 40%.It is 80% that experiment records sample physical suspension rate, and chemical suspensibility is 91%.
Claims (2)
1. a flusilazole water dispersible granule, using Flusilazole as effective sterilization component, it is characterized in that: this Flusilazole bactericide is water dispersible granular formulation, adopt water as binding agent in this water dispersible granules preparation process, include multiple constituent: weight ratio be 10% ~ 25% Flusilazole, weight ratio be not more than surfactant that solvent, the weight ratio of 5% are 5% ~ 20%, adsorbent that weight ratio is 10% ~ 20%, weight ratio be the water of 0.01% ~ 3%, separately has part inert filler;
Described solvent is No. 150 heavy aromatic solvents or No. 200 heavy aromatic solvents, described surfactant is the one in alkyl naphthalene sulfonic acid condensation polymer sodium salt, lignosulfonates, carboxylate, sodium isopropyl xanthate, described adsorbent be one in silica gel, white carbon, activated alumina, corn starch, lactose, dextrin or several, described filler be one in diatomite, kaolin, bentonite, attapulgite or several;
The particle diameter of described water dispersion granule is 500 μm ~ 5mm;
The preparation technology of this Flusilazole bactericide mainly comprises following technical process:
One, bactericide flusilazole solvent and surfactant to be dissolved under the condition stirred at heating water bath, form homogeneous organic liquid phase, the temperature of described heating water bath is 50 DEG C ~ 70 DEG C;
Two, with adsorbent, organic liquid is adsorbed as mutually the solid-state wet feed of pasty state;
Three, after dispersant, wetting agent, filler fully being mixed, pulverized solid siccative is become through air-flow crushing;
Four, in kneader, solid-state wet feed and solid-state siccative are mixed, add suitable quantity of water and make binding agent, fully mediate;
Five, by the express material granulation after kneading, oven dry, screening, flusilazole water dispersible granule is obtained.
2. flusilazole water dispersible granule according to claim 1, it is characterized in that: the dispersant described in technical process three to be weight ratio be 3% ~ 10% T2020 or YUS-WG4, described wetting agent to be weight ratio be not more than 7% TERWET1004 or YUS-SXC.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110114731.5A CN102232388B (en) | 2010-07-28 | 2011-04-19 | Flusilazole water dispersible granule and preparation technology thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010238198 | 2010-07-28 | ||
| CN2010102381989 | 2010-07-28 | ||
| CN201010238198.9 | 2010-07-28 | ||
| CN201110114731.5A CN102232388B (en) | 2010-07-28 | 2011-04-19 | Flusilazole water dispersible granule and preparation technology thereof |
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| CN102232388A CN102232388A (en) | 2011-11-09 |
| CN102232388B true CN102232388B (en) | 2015-07-29 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102696584A (en) * | 2012-05-09 | 2012-10-03 | 安徽华星化工股份有限公司 | Method for preparing pesticide granules |
| CN105410035A (en) * | 2015-12-08 | 2016-03-23 | 济南舜昊生物科技有限公司 | Compounded preparation containing flusilazole |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837651A (en) * | 1993-08-05 | 1998-11-17 | American Cyanamid Company | Solid formulation |
| CN101632355A (en) * | 2009-08-31 | 2010-01-27 | 桂林集琦生化有限公司 | Pesticide water dispersible granule containing organic silicon surface active agent and preparation method thereof |
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2011
- 2011-04-19 CN CN201110114731.5A patent/CN102232388B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837651A (en) * | 1993-08-05 | 1998-11-17 | American Cyanamid Company | Solid formulation |
| CN101632355A (en) * | 2009-08-31 | 2010-01-27 | 桂林集琦生化有限公司 | Pesticide water dispersible granule containing organic silicon surface active agent and preparation method thereof |
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| CN102232388A (en) | 2011-11-09 |
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