CN102229570B - New method for synthesizing telmisartan intermediates - Google Patents
New method for synthesizing telmisartan intermediates Download PDFInfo
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- CN102229570B CN102229570B CN 201110101574 CN201110101574A CN102229570B CN 102229570 B CN102229570 B CN 102229570B CN 201110101574 CN201110101574 CN 201110101574 CN 201110101574 A CN201110101574 A CN 201110101574A CN 102229570 B CN102229570 B CN 102229570B
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- 0 C*C(C)C(CC(C*(C)C)CC1C)C1O* Chemical compound C*C(C)C(CC(C*(C)C)CC1C)C1O* 0.000 description 9
- ZNKKYYNWFKHNHZ-UHFFFAOYSA-N CC1C=CC=CC1 Chemical compound CC1C=CC=CC1 ZNKKYYNWFKHNHZ-UHFFFAOYSA-N 0.000 description 1
- ILXRSCZVHSZGCS-UHFFFAOYSA-N CCCc([nH]c1c2)nc1c(C)cc2-c1nc2ccccc2[n]1C Chemical compound CCCc([nH]c1c2)nc1c(C)cc2-c1nc2ccccc2[n]1C ILXRSCZVHSZGCS-UHFFFAOYSA-N 0.000 description 1
- RMMXLENWKUUMAY-UHFFFAOYSA-N CCCc1nc(c(C)cc(-c2nc3ccccc3[n]2C)c2)c2[n]1Cc(cc1)ccc1-c(cccc1)c1C(O)=O Chemical compound CCCc1nc(c(C)cc(-c2nc3ccccc3[n]2C)c2)c2[n]1Cc(cc1)ccc1-c(cccc1)c1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 description 1
- BAKYASSDAXQKKY-UHFFFAOYSA-N Cc(cc(C=O)cc1)c1O Chemical compound Cc(cc(C=O)cc1)c1O BAKYASSDAXQKKY-UHFFFAOYSA-N 0.000 description 1
- OYMIIKBORUBGQN-UHFFFAOYSA-N Cc(cc(C=O)cc1[N+]([O-])=O)c1O Chemical compound Cc(cc(C=O)cc1[N+]([O-])=O)c1O OYMIIKBORUBGQN-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention provides a new method for synthesizing telmisartan. The method comprises the following steps: a compound XI is treated as an initial raw material to prepare a compound IV through hydroformylation, nitration and ammoniation; the compound IV is subjected to a cyclization reaction with N-methyl-o-phenylenediamine to prepare a compound VII in the presence of sodium bisulfite; the compound VII is acylated, and then is subjected to reactions of reduction and cyclization under the Fe/HOAc condition to prepare a compound IX which is a key intermediate; the compound VII can also be directly reacted with aldehyde to prepare the compound IX; and the compound IX is subjected to a condensation reaction with 4'-bromomethyl biphenyl-2-carboxylate to prepare a condensation compound, and thecondensation compound is hydrolyzed to obtain telmisartan. The method of the present invention has the advantages of easily controllable and simple reaction, cheap and easily obtained raw materials, and convenient operation.
Description
Technical field:
The present invention relates to a kind of synthetic method of medicine, more specifically, the present invention relates to the synthetic method of telmisartan, novel reaction intermediate, the preparation method and use of this intermediate.
Background technology:
Telmisartan is a kind of Angiotensin II receptor antagonist, chemistry is by name 4 '-[(Isosorbide-5-Nitrae '-dimethyl-2 '-propyl group [2 ', 6-, two-1H-benzoglyoxaline]-1 '-yl) methyl]-[1,1 '-biphenyl]-2-carboxylic acid, its structure is as shown below:
So far, mainly contain 3 syntheti c routes about telmisartan synthetic.Their main difference is the biphenyl carboxylic acids part.They are take 3-methyl-PABA methyl esters as starting raw material, obtain key intermediate 2-n-propyl-4-methyl-6-(1-tolimidazole-2-yl) benzoglyoxaline through N-acidylate, nitrated, reduction, cyclization, ester hydrolysis, condensation reaction.This compound respectively with 4 '-bromomethylbiphenyl-2-carboxylic acid tert-butyl ester condensation (J.Med.Chem., 1993,36:4040-4051), 4 '-bromomethylbiphenyl-2-carboxylic acid first (second) ester condensation (CN1344712A), 4 '-brooethyl-2-cyanobiphenyl (CN1412183A) condensation, at last hydrolysis obtains telmisartan.Its reaction formula is as follows:
Summary of the invention
One of the object of the invention has provided telmisartan key intermediate (compound V, VI, VII, VIII) of a kind of novelty and preparation method thereof; What two of purpose had provided a kind of novelty prepares the method for telmisartan according to above-mentioned intermediate, thus more convenient, efficient, economic synthetic and suitability for industrialized production.Be in particular in:
1) to utilize Ortho Cresol or derivatives thereof (compounds X I) be starting raw material in the present invention, more cheap and easy to get with respect to the raw material (3-methyl-PABA methyl esters) of the synthesis technique of report before;
2) the most reactions of the present invention are all carried out in methyl alcohol or methanol/water system, methyl alcohol, water are not only the most cheap industrial solvent, and since these solvents through whole piece technique, recursive recovery, not only save cost, also alleviated the pressure to environment.
3) all very easily crystallizations of intermediate of the present invention's nearly all (except Compound I I, compound III), separation and purification is very convenient, and is highly beneficial for the suitability for industrialized production of product.
In a first aspect of the present invention, provide a kind of intermediate that can be used for the synthetic novelty of telmisartan:
But R comprises Ms for leavings group, Ts, CF
3Etc., also can be alkyl, preferred C1-C6 alkyl comprises methyl, ethyl, propyl group, sec.-propyl, tertiary butyl etc., also can be hydrogen.
In another aspect of this invention, provide the preparation method of 2-methyl-4-(1-tolimidazole-2-yl)-6-N-methyl-p-nitroaniline (VII), described method comprises:
2-methyl-4-formyl radical-6-N-methyl-p-nitroaniline reacts with the N-methyl-o-phenylenediamine in the presence of sodium bisulfite,
The reaction times of this reaction can be 2-8 hour, is preferably 4 hours;
Temperature of reaction is preferably 70 ℃.
This reaction can be carried out in suitable organic solvent, described organic solvent can be any suitable, include but not limited to methyl alcohol, ethanol, dioxane, acetonitrile, THF, DMF, DMSO, N,N-dimethylacetamide or N-Methyl pyrrolidone etc.
In embodiment further, 4-formyl radical-2-aminotoluene (IV) can be prepared by the following method:
Compound III is reacted in the alcoholic solution of liquefied ammonia, ammoniacal liquor or ammonia,
The reaction times of this reaction can be 5～40 hours, is preferably 20 hours;
Preferable reaction temperature is 50～120 ℃, is preferably 100 ℃.
But above-mentioned R comprises Ms for leavings group, Ts, CF
3Etc., also can be alkyl, preferred C1-C6 alkyl comprises methyl, ethyl, propyl group, sec.-propyl, tertiary butyl etc., also can be hydrogen.In one embodiment, but preferred group R is leavings group; In another embodiment, preferred R is alkyl, more preferably the C1-C6 alkyl.
In the further embodiment of above-mentioned embodiment, the formula III compound can be prepared by the following method:
Under-10 ℃～room temperature, make the reaction of formula II compound and nitrosonitric acid,
In this reaction, the volume ratio of preferred compound II and nitrosonitric acid is 1: 5～20, more preferably 1: 10;
The reaction times of this reaction can be 0.5～4 hour, is preferably 1 hour.
Preferred this reaction is carried out under-5～0 ℃.
In the further embodiment of above-mentioned embodiment, Compound I I can be prepared by the following method:
Formula XI and chloroform are reacted in the NaOH aqueous solution,
In preferably should reacting, compounds X I, CHCl
3, the NaOH mol ratio is 1: 1～5: 1～10 more preferably 1: 2: 8;
The reaction times of this reaction can be 1～10 hour, is preferably 6 hours;
Temperature of reaction is preferably 60 ℃.
This reaction can be carried out in the presence of suitable organic solvent, described organic solvent can be any suitable, include but not limited to toluene, chlorobenzene, dimethylbenzene, tetrachloroethane, dioxane, DMF etc.
The preparation method of 2 methyl-4-(1-tolimidazole-2-yl)-6-N-methyl-p-nitroaniline (VII) also can prepare by the following method, specifically comprises:
Compound vi in the alcoholic solution of liquefied ammonia, ammoniacal liquor or ammonia with ammonia gas react,
But R comprises Ms for leavings group, Ts, CF
3Etc., also can be alkyl, the C1-C6 alkyl comprises methyl, ethyl, propyl group, sec.-propyl, tertiary butyl etc., also can be hydrogen
In preferably should reacting, the mol ratio of compound vi and ammonia is 1: 1～25, more preferably 1: 10;
The reaction times of this reaction can be 1～30 hour, is preferably 20 hours;
Temperature of reaction is preferably 100 ℃～120 ℃.
This reaction can be carried out in the presence of suitable organic solvent, described organic solvent can be any suitable, include but not limited to methyl alcohol, ethanol, Virahol, propyl carbinol, dioxane, DMF etc.
In the further embodiment of above-mentioned embodiment, compound (VI) can be prepared by the following method:
Compound V and methyl-sulfate are reacted in the presence of alkali
The mol ratio of preferred compound V, methyl-sulfate and alkali is 1: 1～2: 1～4.
Reaction times can be 5～20 hours, is preferably 10～15 hours.
This reaction can be carried out under 0～50 ℃, preferred room temperature.
Above-mentioned alkali can be that organic bases also can be mineral alkali.Organic bases includes but not limited to sodium alkoxide, pyridine, triethylamine, Tributylamine, DBU etc.Mineral alkali includes but not limited to NaOH, KOH, NaH, K
2CO
3, Na
2CO
3Etc..
In the further embodiment of above-mentioned embodiment, compound (V) can be prepared by the following method:
Compound III and O-Phenylene Diamine are reacted in the presence of hydrogen peroxide,
The mol ratio of preferred compound III, O-Phenylene Diamine and hydrogen peroxide is 1: 1～4: 1～4, more preferably 1: 2.5: 3.
Reaction times can be 1～10 hour, is preferably 4～5 hours.
This reaction can be carried out under 0～100 ℃, preferred room temperature.
This reaction can be carried out in the presence of suitable organic solvent, described organic solvent can be any suitable, include but not limited to methyl alcohol, ethanol, Virahol, propyl carbinol, dioxane, DMF, THF, acetonitrile etc.
In one embodiment, the invention provides the preparation method of telmisartan, described method comprises, in the time of 0～100 ℃, in suitable solvent, make 4 '-[(1,4 '-dimethyl-2 '-propyl group [2 ', 6-two-1H-benzoglyoxaline]-1 '-yl) methyl]-[1,1 '-biphenyl]-2-carboxylicesters (X) is hydrolyzed under the alkali effect
R wherein
1Be alkyl, preferred C1-C6 alkyl
The reaction times of this reaction can be 2-12 hour, is preferably 8 hours;
Temperature of reaction is preferably 80 ℃.
Described solvent can be any suitable dissolving but not with the solvent of reactant reaction, include but not limited to DMF, N,N-dimethylacetamide, water, methyl alcohol, ethanol, dioxane etc. or their mixture.
In the further embodiment of above-mentioned embodiment, 4 '-[(Isosorbide-5-Nitrae '-dimethyl-2 '-propyl group [2 ', 6-, two-1H-benzoglyoxaline]-1 '-yl) methyl]-[1,1 '-biphenyl]-2-carboxylicesters (X) is prepared by the following method:
In the time of 0 ℃～50 ℃, make 2-n-propyl-4-methyl-6-(1-tolimidazole-2-yl) benzoglyoxaline (IX in the presence of alkali with 4 '-bromomethylbiphenyl-2-carboxylicesters condensation.
R wherein
1Be alkyl, preferred C1-C6 alkyl
Preferred 2-n-propyl-4-methyl-6-(1-tolimidazole-2-yl) benzoglyoxaline (IX), 4-brooethyl-1, the mol ratio of 1 '-biphenyl-2 '-carboxylicesters and alkali is 1: 1: 1～3.
Reaction times can be 5～30 hours, is preferably 10～20 hours.
This reaction can be carried out under 0～50 ℃, preferred room temperature.
Above-mentioned alkali can be that organic bases also can be mineral alkali.Organic bases includes but not limited to sodium alkoxide, pyridine, triethylamine, Tributylamine, DBU etc.Mineral alkali includes but not limited to NaOH, KOH, NaH, K
2CO
3, Na
2CO
3Etc..
In the further embodiment of above-mentioned embodiment, 2-n-propyl-4-methyl-6-(1-tolimidazole-2-yl) benzoglyoxaline (IX) is prepared by the following method:
Compound vi I and butyraldehyde are reacted in the presence of vat powder (V-Brite B) to be obtained
The mol ratio of compound vi I, butyraldehyde and vat powder is 1: 1～5: 3～8, more preferably 1: 2: 6.
Reaction times can be 6～24 hours, is preferably 10 hours.
This reaction can be carried out under 50～120 ℃, preferred 60～80 ℃.
2-n-propyl-4-methyl-6-(1-tolimidazole-2-yl) benzoglyoxaline (IX) also can be prepared by the following method:
Make N-(2-methyl-4-(1-tolimidazole-2-yl)-6-nitro) butyramide at Fe/CH
3Reductive ring closure among the COOH,
N-(2-methyl-4-(1-tolimidazole-2-yl)-6-nitro) butyramide (VIII) is 1: 3～10 with the mol ratio of iron powder, more preferably 1: 3～4.
Reaction times can be 1～6 hour, is preferably 3 hours.
This reaction can be carried out under 50～120 ℃.
In the further embodiment of above-mentioned embodiment, N-(2-methyl-4-(1-tolimidazole-2-yl)-6-nitro) butyramide (VIII) can be prepared by the following method:
In suitable organic solvent, 2-methyl-4-(1-tolimidazole-2-yl)-6-N-methyl-p-nitroaniline (VII) and butyryl chloride reaction,
In this reaction, the mol ratio of preferred 2-methyl-4-(1-tolimidazole-2-yl)-6-N-methyl-p-nitroaniline (VII) and butyryl chloride is 1: 1
The reaction times of this reaction can be 1～5 hour, is preferably 3 hours.
Temperature of reaction can be-20 ℃～40 ℃, is preferably 0 ℃ to room temperature.
Above-mentioned alkali can be that organic bases also can be mineral alkali.
Described organic solvent can be any suitable, include but not limited to methylene dichloride, ethylene dichloride, tetrachloroethane, chloroform, acetone, benzene,toluene,xylene, dioxane, acetonitrile, THF, DMF, DMSO, N,N-dimethylacetamide or N-Methyl pyrrolidone etc.
In the further embodiment of above-mentioned embodiment, 2-methyl-4-(1-tolimidazole-2-yl)-6-N-methyl-p-nitroaniline (VII) can be prepared by the following method:
In suitable organic solvent, 2-methyl-4-formyl radical-6-N-methyl-p-nitroaniline (IV) reacts with the N-methyl-o-phenylenediamine in the presence of sodium bisulfite,
The mol ratio of 2-methyl-4-formyl radical-6-N-methyl-p-nitroaniline, N-methyl-o-phenylenediamine and sodium bisulfite is 1: 1～2: 1～5, preferred 1: 1.5: 3,
The reaction times of this reaction can be 2-8 hour, is preferably 4 hours;
Temperature of reaction is preferably 70 ℃.
Described organic solvent can be any suitable dissolving but not with the solvent of reactant reaction, include but not limited to methyl alcohol, ethanol, dioxane, acetonitrile, THF, DMF, DMSO, N,N-dimethylacetamide or N-Methyl pyrrolidone etc.
In the further embodiment of above-mentioned embodiment, 4-formyl radical-2-aminotoluene (IV) can be prepared by the following method:
In suitable organic solvent, compound III is reacted in the alcoholic solution of liquefied ammonia, ammoniacal liquor or ammonia,
The reaction times of this reaction can be 5～40 hours, is preferably 20 hours;
Preferable reaction temperature is 50～120 ℃, is preferably 100 ℃.
But above-mentioned R comprises Ms for leavings group, Ts, CF
3Etc., also can be that alkyl comprises methyl, ethyl, propyl group, sec.-propyl, tertiary butyl etc., also can be hydrogen, just reaction yield is different, but leavings group＞alkyl＞H.
In the further embodiment of above-mentioned embodiment, compound III can be prepared by the following method:
Under-10 ℃～room temperature, make the reaction of Compound I I and nitrosonitric acid,
In this reaction, the volume ratio of preferred compound II and nitrosonitric acid is 1: 1～20 more preferably 1: 10;
The reaction times of this reaction can be 0.5～4 hour, is preferably 1 hour.
Preferred this reaction is carried out under-5～0 ℃.
In the further embodiment of above-mentioned embodiment, Compound I I can be prepared by the following method:
In the NaOH aqueous solution, make compounds X I and CHCl
3React,
Preferably this reaction in, compounds X I, NaOH and CHCl
3Mol ratio be 1: 1～10: 1～5 more preferably 1: 8: 2;
The reaction times of this reaction can be 1～10 hour, is preferably 6 hours;
Preferable reaction temperature is 60 ℃.
Reaction scheme of the present invention can be summarized as follows:
Embodiment
Further specify the present invention below by embodiment.The preparation method who it should be understood that the embodiment of the invention is only used for illustrating the present invention, rather than limitation of the present invention, and the simple modifications to preparation method of the present invention under design prerequisite of the present invention all belongs to the scope of protection of present invention.
Embodiment one: preparation 2-methyl-4-formyl radical phenol
Ortho-cresol (54g, 1eq) is dissolved in 10% NaOH (800mL, 4eq), at 60 ℃ of lower chloroforms (100mL) that slowly drip, roughly drips 5～6 hours, add rear continuation reaction 1 hour.Stopped heating is chilled to room temperature.Use dichloromethane extraction, organic phase is concentrated, and the oil pump underpressure distillation of gained liquid gets Compound I I-1 (40.9g, 60%yield).
1H?NMR(CDCl
3，400MHz)δ2.37(s，3H，ArCH
3)，6.95(d，J＝8.0Hz，1H，ArH)，7.70(d，J＝8.0Hz，1H，ArH)，7.80((s，1H，ArH)；
13C?NMR(CDCl
3，100MHz)δ15.8，115.3，125.2，129.6，130.5，133.1，160.4，191.8；Ms(+C，ESI)：M＝136，Found?137(M+1)；
Embodiment two: preparation 2-methyl-4-formyl radical-6-nitrophenols
The 300mL nitrosonitric acid is chilled to about 0 ℃ under the ice-water bath cooling, slowly drips Compound I I-1 (30g) under this temperature, temperature maintains and is lower than 5 ℃ in keeping, and adds in the 45min, adds rear stirring and just can process in 1 hour.This reaction solution slowly is poured in the frozen water mixed solution of 600mL, adds rear continuation and stirred 1 hour, suction filtration, washing is drained and is obtained compound III-1 (26g, 65%yield).
1H?NMR(400MHz，CDCl
3)δ2.43(s，3H，CH
3)，8.02(s，1H，ArH)，8.50(s，1H，ArH)，9.92(s，1H，CHO)，11.39(s，1H，ArOH)；
13C?NMR(100MHz，CDCl
3)δ16.0，126.5，128.2，131.2，133.3，136.2，158.1，188.9；Ms(+C，ESI)：M＝181，Found(182，M+1)
Embodiment three: preparation 2-methyl-4-formyl radical-6-nitrophenols methanesulfonates
Compound III-1 (18.1g) is dissolved in the 100mL methylene dichloride, under the ice-water bath cooling, adds triethylamine (27.8ml, 2eq), then slowly drip Methanesulfonyl chloride (17g, 1.5eq).Reacted 4 hours 0 ℃ of lower continuation.Add the shrend reaction of going out, use dichloromethane extraction, organic phase is concentrated to get compound III-2 (23.5g, productive rate 90%) by separation and purification.
1H NMR (400MHz, CDCl
3) δ 2.61 (s, 3H, CH
3), 3.44 (s, 3H ,-SO
2-CH
3), 8.08 (s, 1H, ArH), 8.32 (s, 1H, ArH), 10.03 (s, 1H, CHO);
13C NMR (100MHz, CDCl
3) δ 17.6,40.0,124.6,134.4,136.2,137.7,143.3,144.1,188.8; Ms (+C, ESI): M=259, Found 260 (M
++ 1).
Embodiment four: preparation 4-methoxyl group-3-methyl-5-nitro phenyl aldehyde
NaOH (4.4g, 1.1eq) is mixed with the aqueous solution of 2.7M/L and with the frozen water cooling, drips compound III-1 (18.1g, 1eq), add rear continuation and stir 0.5h.Then newly steam Me 0 ℃ of lower dropping
2SO
4(11mL, 1.1eq) keeps temperature not to be higher than 10 ℃.Be warming up to 70 ℃ after adding and continue reaction 6～7 hours.Stopped heating is chilled to room temperature, has solid to separate out, and suction filtration gets yellow solid compound III-3 (15.7g, productive rate 80%)
1HNMR (400MHz, CDCl
3) δ: 2.45 (s, 3H, CH
3), 3.98 (s, 3H, OMe), 7.96 (s, 1H, ArH), 8.14 (s, 1H, ArH), 9.95 (s, 1H, CHO);
13C NMR (100MHz, d-DMSO) δ: 16.4,62.1,124.8,131.5,135.2,135.8,144.2,156.4,189.2; Ms (+C, ESI): M=195, and Found (196, M+1)
Embodiment five: preparation 2-methyl-4-formyl radical-6-N-methyl-p-nitroaniline
Compound III-2 (26g, 100mmol) is suspended in the 100mL methyl alcohol, adds the 100mL strong aqua.Heating reflux reaction 6 hours, cooling, suction filtration get yellow solid compound IV (12.2g, productive rate 68%)
1H NMR (400MHz, DMSO-d) δ 2.22 (s, 3H, CH
3), 7.67 (s, 1H, ArH), 7.83 (br, s, 2H, NH
2), 8.41 (s, 1H, ArH), 9.70 (s, 1H, CHO);
13C NMR (100MHz, DMSO-d) δ 18.4,124.3,127.8,129.9,130.5,132.9,148.8,190.2; Ms (+C, ESI): M=180, Found181 (M
++ 1).
Embodiment six: preparation 2-(4-methoxyl group-3-methyl-5-nitro benzene)-1H-benzoglyoxaline
O-Phenylene Diamine (67g, 2.5eq) is dissolved in the 500mL methyl alcohol, then adds compound III-3 (50g, 1eq), and slowly drip hydrogen peroxide (87mL, 3eq).Question response fully after, reaction solution is poured in the frozen water, have a large amount of solids to separate out this moment, suction filtration, dries to get compound V-1 (54g, productive rate 75%).
1HNMR(400MHz，d-DMSO)δ：2.41(s，3H，CH
3)，3.89(s，3H，OMe)，7.22(s，br，2H，ArH)，7.57-7.66(m，2H，ArH)，8.36(s，1H，ArH)，8.50(s，1H，ArH)，13.08(s，br，1H，NH)；
13C?NMR(100MHz，d-DMSO)δ：15.9，61.8，111.5，118.8，120.4，122.0，122.6，122.9，126.0，133.3，135.0，143.6，144.0，148.9，151.7；Ms(+C，ESI)：M＝283，Found(284，M+1)
Embodiment seven: preparation 2-methyl-4-(1-tolimidazole-2-yl)-6-N-methyl-p-nitroaniline
Compound IV (18g, 100mmol) is dissolved in the 120mL methyl alcohol, adds sodium bisulfite (10.4g, 1eq) and N-methyl-o-phenylenediamine (18.3g, 1.5eq), stirring at room 1 hour, then reflux is 5 hours.With getting compound vi I (20.8g, productive rate 70%) after ethyl acetate extraction and the crystallization.
1HNMR (400MHz, CDCl
3) δ: 2.47 (s, 3H, CH
3), 3.91 (s, 3H, NMe), 3.98 (s, 3H, OMe), 7.34-7.43 (m, 3H, ArH), 7.81 (d, J=6.8Hz, 1H, ArH), 7.96 (s, 1H, ArH), 8.03 (s, 1H, ArH);
13C NMR (100MHz, CDCl
3) δ: 14.2,16.3,62.1,109.8,119.8,122.8,123.3,123.4,126.0,135.5,136.3,136.6,142.7,144.0,151.0,152.7; Ms (+C, ESI): M=297, and Found (298, M+1)
Embodiment eight: preparation N-(2-methyl-4-(1-tolimidazole-2-yl)-6-nitrophenyl) butyramide
Compound vi I (28.2g, 100mmol) is dissolved in the 140ml methylene dichloride, adds pyridine (20mL), at 0 ℃ of lower butyryl chloride (16g, 150mmol) that drips, add this temperature of rear maintenance and continue stirring 4h.Dichloromethane extraction, washing, organic phase concentrating under reduced pressure.Residue gets compound VIII (31g, productive rate 88%) after crystallization.
1H NMR (400Hz, DMSO-d) δ 0.96 (t, J=7.2,3H, CH
3), 1.64 (q, J=7.6,2H, CH
2), 2.37 (t, J=7.2,2H ,-COCH
2), 2.43 (s, 3H, CH
3), 3.95 (s, 3H ,-NCH
3), 7.31 (m, 2H, ArH), 7.65 (d, J=8.0,1H, ArH), 7.71 (d, J=8.0,1H, ArH), 8.13 (d, J=1.6,1H, ArH), 8.20 (d, J=1.6,1H, ArH), 10.01 (s, 1H ,-NH);
13C NMR (100Hz, DMSO-d) δ 14.1,18.5,18.9,32.2,37.7,111.2,119.6,122.7,123.1,123.3,128.3,130.3,135.3,137.2,137.5,142.8,146.9,151.1,171.8; Ms (+C, ESI):: M=352, found 353 (M+1).
Embodiment nine: preparation 2-(4-methoxyl group-3-methyl-5-nitro benzene)-1-methyl isophthalic acid H-benzoglyoxaline
Compound V-1 (28.3g) is dissolved among the 150mL DMF, adds salt of wormwood (41.3g, 3eq), stirring at room was chilled to about 5 ℃ with frozen water after 0.5 hour, slowly dripped Me
2SO
4(14g, 1.1eq) dripped off in two hours.After reacting completely, reaction solution is poured in the frozen water solution, stir suction filtration after 15 minutes, get compound vi-1 (19.3g, productive rate 65%) after the oven dry.
1H NMR (400MHz, CDCl
3) δ: 2.47 (s, 3H, CH
3), 3.91 (s, 3H, NMe), 3.98 (s, 3H, OMe), 7.34-7.43 (m, 3H, ArH), 7.81 (d, J=6.8Hz, 1H, ArH), 7.96 (s, 1H, ArH), 8.03 (s, 1H, ArH);
13C NMR (100MHz, CDCl
3) δ: 14.2,16.3,62.1,109.8,119.8,122.8,123.3,123.4,126.0,135.5,136.3,136.6,142.7,144.0,151.0,152.7; Ms (+C, ESI): M=297, and Found (298, M+1)
Embodiment ten: preparation 2-n-propyl-4-methyl-6-(1-tolimidazole-2-yl) benzoglyoxaline
Compound VIII (35.2g, 100mmol) is dissolved in the 350mL acetic acid, adds iron powder (18.6g, 3.5eq), and slowly be heated to backflow, under this temperature, continue reaction 3 hours.Cooling is filtered, and adds the water ethyl acetate extraction after filtrate is concentrated.Organic phase is concentrated to get Compound I X (24.3,80%) by recrystallization.
1HNMR(400MHz，d-DMSO)δ：0.97(t，J＝6.8Hz，3H，CH
3)，1.83(m，2H，CH
2)，2.59(s，3H，CH
3)，2.85(t，J＝4.5Hz，，2H，CH
2)，3.89(s，3H，NCH
3)，7.23-7.27(m，2H，ArH)，7.44(s，br，1H，ArH)，7.56(d，J＝6.8Hz，1H，ArH)，7.68(d，J＝6.8Hz，1H，ArH)，7.78(s，br，1H，ArH)；
13C?NMR(100MHz，d-DMSO)δ：13.7，16.8，21.1，30.6，31.7，110.3，118.6，121.7，121.9，122.9，123.2，136.6，142.5，154.3，156.2；Ms(+C，ESI)：M＝304，Found(305，M+1).
Embodiment 11: preparation 2-n-propyl-4-methyl-6-(1-tolimidazole-2-yl) benzoglyoxaline
Vat powder (37g, 6eq) is dissolved in methyl alcohol (80mL), in the water (80mL), adds compound vi I (10g), then add butyraldehyde-n (64mL, 2eq), reflux 12 hours.After reacting completely reaction solution is poured in the frozen water, wash out solid, suction filtration gets Compound I X crude product.Get Compound I X (7.3g, productive rate 68%) behind the recrystallization.
1H?NMR(400MHz，d-DMSO)δ：0.97(t，J＝6.8Hz，3H，CH
3)，1.83(m，2H，CH
2)，2.59(s，3H，CH
3)，2.85(t，J＝4.5Hz，，2H，CH
2)，3.89(s，3H，NCH
3)，7.23-7.27(m，2H，ArH)，7.44(s，br，1H，ArH)，7.56(d，J＝6.8Hz，1H，ArH)，7.68(d，J＝6.8Hz，1H，ArH)，7.78(s，br，1H，ArH)；
13C?NMR(100MHz，d-DMSO)δ：13.7，16.8，21.1，30.6，31.7，110.3，118.6，121.7，121.9，122.9，123.2，136.6，142.5，154.3，156.2；Ms(+C，ESI)：M＝304，Found(305，M+1)
Embodiment 12: preparation 4 '-[(Isosorbide-5-Nitrae '-dimethyl-2 '-propyl group [2 ', 6-, two-1H-benzoglyoxaline]-1 '-yl) methyl]-[1,1 '-biphenyl]-2-carboxylate methyl ester
Compound I X (100g) is dissolved among the DMF (100mL, 10v/w), under the frozen water cooling, adds sodium hydride (0.81g, 1.02eq), under this temperature, continue to stir 1h.Then add bromide (9.75g, 1.03eq), add rear stirring and spend the night.Next day, use the ethyl acetate extraction reaction solution, organic phase is concentrated to get compounds X-(15.6g, productive rate 90%) by separation and purification.
1H?NMR(CDCl
3，400MHz)δ1.06(t，J＝7.0Hz，3H，CH
3)，1.85-1.90(m，2H，CH
2)，2.79(s，3H，ArCH
3)，2.93(t，J＝7.2Hz，2H，CH
2)，3.57(s，3H，CH
3)，3.75(s，3H，OCH
3)，5.43(s，2H，CH
2N)，7.09(d，J＝7.6Hz，2H，ArH)，7.24-7.30(m，6H，ArH)，7.37-7.49(m，4H，ArH)，7.81(d，J＝7.6Hz，2H，ArH)；
13CNMR(CDCl
3，100MHz)δ14.1，17.0，21.9，29.8，31.8，47.1，51.9，108.9，109.5，119.5，122.3，122.5，123.9，124.0，126.0，127.4，129.0，129.5，130.0，130.6，130.7，131.4，134.8，135.1，136.7，141.1，141.7，142.9，143.2，145.7，156.5，168.7；Ms(+C，ESI)：M＝528，Found?529(M+1).
Embodiment 13: the preparation telmisartan
Compounds X-1 (30g) is dissolved in methyl alcohol (600mL), adds 10%NaOH (9.2mL, 4eq) and begin reflux.Roughly react completely about 3 hours, cooling adds acetic acid and transfers pH=5, separates out solid, and suction filtration gets crude product (27.8g, productive rate 96%).Crude product is dissolved in ethanol (280mL, 10v/w), adds a certain amount of ammoniacal liquor and make it fully molten clear, add activated carbon 1.5g, refluxed 2 hours.Filtered while hot adds HOAc after the filtrate cooling and transfers pH=5, separates out solid, static spending the night, and suction filtration gets telmisartan (23.8g, purity 99.6%, yield 81%).
1H?NMR(d-DMSO，400MHz)δ1.15(t，J＝7.2Hz，3H，CH
3)，1.94-2.03(m，2H，CH
2)，2.69(s，3H，ArCH
3)，3.12(t，J＝8Hz，2H，CH
2)，3.37(s，3H，CH
3)，5.40(s，2H，CH
2N)，6.97(s，1H，ArH)，7.05(s，1H，ArH)，7.16-7.18(m，2H，ArH)，7.33-7.50(m，8H，ArH)，8.01-8.03(m，1H，ArH)，8.37-8.38(m，1H，ArH)；
13C?NMR(d-DMSO，100MHz)δ14.1，17.0，22.4，30.0，31.8，48.8，109.4，111.3，119.8，121.8，123.1，123.2，123.6，127.1，127.4，128.8，128.9，129.4，130.2，130.4，133.7，134.0，134.6，135.6，141.1，141.8，142.8，143.6，154.0，156.5，171.1；Ms(+C，ESI)：M＝514，Found?515(M+1).
Claims (22)
1. the compound that represents of following formula VII:
2. one kind prepares the as claimed in claim 1 method of compound, it is characterized in that: make compound vi I by compound IV and the reaction of N-methyl-o-phenylenediamine:
3. method as claimed in claim 2 it is characterized in that making compound IV by compound III and ammonia react, but wherein OR represents leavings group, and wherein R is Ms, Ts, CF
3, C1-C6 alkyl or hydrogen:
4. one kind prepares the as claimed in claim 1 method of compound, it is characterized in that: make compound vi I by compound vi and ammonia react, but wherein OR represents leavings group, wherein R is Ms, Ts, CF
3, C1-C6 alkyl or hydrogen:
5. method as claimed in claim 4 is characterized in that: make compound vi by compound V and methyl-sulfate reaction, but wherein OR represents leavings group, wherein R is Ms, Ts, CF
3, C1-C6 alkyl or hydrogen:
6. method as claimed in claim 5 is characterized in that: by compound III and O-Phenylene Diamine reaction preparation compound V, but wherein OR represents leavings group, and wherein R is Ms, Ts, CF
3, C1-C6 alkyl or hydrogen:
7. such as claim 3 or 6 described methods, it is characterized in that making compound III by Compound I I and nitrosonitric acid reaction, but wherein OR represents leavings group that wherein R is Ms, Ts, CF
3, C1-C6 alkyl or hydrogen:
8. method as claimed in claim 7 is characterized in that being reacted in the NaOH aqueous solution by compounds X I and chloroform and makes Compound I I, but wherein OR represents leavings group, and wherein R is Ms, Ts, CF
3, C1-C6 alkyl or hydrogen:
9. compound as claimed in claim 1 is for the preparation of the purposes of telmisartan.
10. a method for preparing Compound I X by compound vi I is characterized in that comprising the following steps:
Step 1: I makes compound VIII through acylation reaction by compound vi:
Step 2: compound VIII makes Compound I X through reduction reaction:
11. a method for preparing Compound I X by compound vi I is characterized in that comprising the following steps: making Compound I X by compound vi I and butyraldehyde reaction:
12. a method for preparing telmisartan is characterized in that comprising the following steps:
Step 1: I makes compound VIII by compound vi:
Step 2: compound VIII makes Compound I X through reduction reaction:
Step 3: Compound I X and 4 '-bromomethylbiphenyl-2-carboxylicesters reaction makes compounds X, wherein R
1Represent the C1-C6 alkyl:
Step 4: compounds X makes telmisartan I, wherein R through reduction reaction
1Represent the C1-C6 alkyl:
13. method according to claim 12, the reduction reaction that it is characterized in that described step 2 is at Fe/CH
3Carry out under the condition that COOH exists.
14. method according to claim 12, the reaction that it is characterized in that described step 1 are to carry out under temperature is-20 ℃～40 ℃ condition, the reaction times is 1～5 hour.
15. method according to claim 12, the reaction that it is characterized in that described step 1 are to carry out in the presence of alkali.
16. method according to claim 15 is characterized in that described alkali is sodium alkoxide, pyridine, triethylamine, Tributylamine, DBU, NaOH, KOH, NaH, K
2CO
3, Na
2CO
3
17. method according to claim 12, it is characterized in that by compounds X prepare reaction solvent in the step of telmisartan I be any can dissolve each other with reactant but not with the solvent of reactant reaction.
18. method according to claim 17 is characterized in that described reaction solvent is DMF, N,N-dimethylacetamide, water, methyl alcohol, ethanol, dioxane or their mixture.
19. a method for preparing telmisartan is characterized in that comprising the following steps:
Step 1: make Compound I X by compound vi I and butyraldehyde reaction:
Step 2: Compound I X and 4 '-bromomethylbiphenyl-2-carboxylicesters reaction makes compounds X, wherein R
1Represent the C1-C6 alkyl:
Step 3: compounds X makes telmisartan I, wherein R through hydrolysis
1Represent the C1-C6 alkyl:
20. the compound that following formula VI represents:
Wherein but OR represents leavings group, and wherein R is Ms, Ts, CF
3, C1-C6 alkyl or hydrogen.
21. compound as claimed in claim 20 is characterized in that R represents methyl, ethyl, propyl group, sec.-propyl or the tertiary butyl.
22. one kind prepares the as claimed in claim 20 method of compound, it is characterized in that: make compound vi by compound V and methyl-sulfate reaction:
Wherein but OR represents leavings group, and wherein R is Ms, Ts, CF
3, C1-C6 alkyl or hydrogen.
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| CN104557724B (en) * | 2014-11-17 | 2017-01-11 | 江苏中邦制药有限公司 | Telmisartan amorphous crystal and preparation method thereof |
| CN107954876B (en) * | 2017-12-01 | 2020-05-08 | 南通大学 | Preparation method of 3-methyl-4-hydroxy-5-nitrobenzaldehyde |
| CN112441983B (en) * | 2019-08-29 | 2023-09-15 | 山东福长药业有限公司 | Benzimidazole-substituted nitrobenzene-based compound and preparation method thereof |
| JP2022546126A (en) * | 2019-08-29 | 2022-11-02 | トップハーマン シャンハイ カンパニー リミティド | Benzimidazole-substituted phenyl-n-butanamide compound and method for producing same |
| CN111689903A (en) * | 2020-07-17 | 2020-09-22 | 浙江金立源药业有限公司 | Synthesis method of 2-n-propyl-4-methyl-6- (1-methylbenzimidazole-2-yl) benzimidazole |
| CN113024469A (en) * | 2021-03-12 | 2021-06-25 | 华东理工大学 | Synthesis method of telmisartan intermediate |
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