CN102225199A - Detoxification technology after absorption of tetanus vaccine - Google Patents
Detoxification technology after absorption of tetanus vaccine Download PDFInfo
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- CN102225199A CN102225199A CN2011101641983A CN201110164198A CN102225199A CN 102225199 A CN102225199 A CN 102225199A CN 2011101641983 A CN2011101641983 A CN 2011101641983A CN 201110164198 A CN201110164198 A CN 201110164198A CN 102225199 A CN102225199 A CN 102225199A
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Abstract
The invention discloses a detoxification technology after absorption of tetanus vaccine. The technology comprises the following steps (1) disinfection with steam; (2) detoxification; (3) detoxification with stirring; (4) sampling; (5) temperature control. A plurality of detoxification pots with at least a two-layer structure are parallel connected to a temperature control apparatus, and a control system is employed to control a totally enclosed magnetic stirrer and the temperature control apparatus uniformly. The invention ha s the advantages of automation of detoxification with stirring and temperature control, precision of sampling, fully temperature monitor during detoxification and automatic record and printing, as required, of corresponding temperature, etc.
Description
Technical field
The present invention relates to technology detoxification field, particularly a kind of absorption is broken hinders technology detoxification technology behind the vaccine.
Background technology
At present, poison-removing method commonly used mainly is that the goods of need detoxification are distinguished fill in the glass serum bottle of 10L or 15L, use the plug good seal, be positioned between 37 ℃ of constant-temperature house, according to each process requirements, placed 20～45 days, stirring during the detoxification is because of no agitating device, regularly carrying out craft by operator shakes all, every day at least once, after the detoxification time finishes, every bottle product is carried out being passed to super-clean bench or meeting the clean regional of sampling requirement after the outward appearance sterilization, take a sample with ready sampling articles for use, must full open seal plug during sampling, goods are exposed, after sampling finishes, change and be ready to satisfactory plug again, testing result is waited in the temperature control room that forwards 2 ~ 8 ℃ behind the good seal to, adopt electric heating tube that the room is heated, be combined to form wind circulating system with air channel and blower fan, electric heating system is divided into main heating and secondary heating, the master when temperature difference is big, secondary heating is worked simultaneously, temperature is when requiring, and main heating quitting work, by secondary heating work and keep constant temperature, owing to cause factors such as thermal loss during switch room door, the temperature in room generally can only be controlled at 37 ± 3 ℃, has frangiblely, and potential safety hazard is big, sampling process is numerous and diverse, sampling differs greatly, and temperature is inconsistent in each bottle, can not be quick, shortcomings such as the interior temperature of each bottle know for sure.
Summary of the invention
Purpose of the present invention promptly is to overcome the deficiencies in the prior art, and a kind of detoxification whipping process and temperature controlled processes automatization are provided, and the sampling precision is hindered technology detoxification technology behind the vaccine but the absorption of complete monitoring detoxification temperature is broken.
The objective of the invention is to be achieved through the following technical solutions: a kind of absorption is broken hinders technology detoxification technology behind the vaccine, and it may further comprise the steps:
(1) steam sterilization: the detoxification jar is carried out 360 ° of spray cleanings automatically in all directions by automatic clearing apparatus, sterilize by steam sterilizer;
(2) detoxification: after the cooling of detoxification jar, the goods of need detoxification are pumped into the detoxification jar, Inlet and outlet water interface, probe temperature sensing device in the detoxification jar interlayer are connected with the temperature control equipment that is positioned at the control system end, and start-up temperature control device, the goods temperature during detoxification is monitored automatically;
(3) detoxification is stirred: the unified speed of agitator in the magnetic stirring apparatus on the totally enclosed type, mixing time and the mixing time interval of being provided with in control system, after setting, control its automatic operation by control system;
(4) sampling: after detoxification finishes, the Inlet and outlet water pneumatic operated valve of automatic closing temperature control device, open compressed air thermostatted water is blown degree of rising again control device, detoxification sample valve and sampling line are sterilized in steam sterilizer, after sterilization finishes, opening sample valve takes a sample, and adopt the temperature sampler to carry out the temperature sampling, sampling is closed sample valve after finishing, and the detoxification jar is connected with-5 ℃ of coolant devices, goods are cooled to 2～8 ℃, close the coolant valve, coolant is blown back the coolant device, goods are transferred to 2～8 ℃ of freezers preserve with compressed air;
(5) temperature control: adopt Steam Heating and electrical heating, temperature control after comprising the preceding temperature control of access detoxification jar and inserting the detoxification jar:
Temperature is controlled before inserting the detoxification jar: before inserting the detoxification jar, according to the signal that is positioned at the temperature sensor of temperature control equipment outlet pipe, return pipe temperature sensor transmission, regulate and the interior temperature of control water tank, when temperature in the water tank is 20 ℃, start the steam-heating pipe diaphragm valve, the feed-tank heating, when temperature in the water tank was 35 ℃, the steam-heating pipe diaphragm valve was closed, and the electric heating tube diaphragm valve starts, when temperature in the water tank is 37 ℃, enter holding stage;
Temperature is controlled after inserting the detoxification jar: after inserting the detoxification jar, according to the signal that is positioned at the transmission of detoxification jar temperature sample sensor, when products temperature is 20 ℃ in the detoxification jar, the Inlet and outlet water pneumatic operated valve is opened automatically, the discharge of detoxification jar interlayer reaches maximum, when products temperature was 35 ℃ in the detoxification jar, the Inlet and outlet water pneumatic operated valve reduced open degree automatically, entered little gentle holding stage that adds.
Described steam sterilizer is 121 ℃ of wet-hot steam bactericidal units; Described temperature sampler uses the rustless steel fast-assembling interface of ￠ 50 to be connected with the detoxification jar for adopting the Pt100 platinum resistance temperature sensing probe of 316L rustless steel sealing; Described speed of agitator is 0～300r/min.
The invention has the beneficial effects as follows: a kind of absorption is broken hinders technology detoxification technology behind the vaccine, adopt magnetic stirring apparatus and temperature control equipment on the unified control of the control system totally enclosed type, a plurality of detoxification jars are parallel to a temperature control equipment, has safety, detoxification whipping process and temperature controlled processes automatization, sampling precision, temperature unanimity in each detoxification jar, but whole process supervision temperature during the detoxification, and record reaches advantages such as output print relevant temperature as required automatically.
The specific embodiment
The present invention will be further described below in conjunction with embodiment:
A kind of absorption is broken hinders technology detoxification technology behind the vaccine, and it may further comprise the steps:
(1) steam sterilization: the detoxification jar is carried out 360 ° of spray cleanings automatically in all directions by automatic clearing apparatus, by 121 ℃ of wet-hot steam bactericidal units sterilizations;
(2) detoxification: after the cooling of detoxification jar, the goods of need detoxification are pumped into the detoxification jar, Inlet and outlet water interface, probe temperature sensing device in the detoxification jar interlayer are connected with the temperature control equipment that is positioned at the control system end, and start-up temperature control device, the goods temperature during detoxification is monitored automatically;
(3) detoxification is stirred: in control system unified be provided with on the totally enclosed type speed of agitator in the magnetic stirring apparatus be 0～300r/min, mixing time and mixing time at interval, after setting, control its automatic operation by control system;
(4) sampling: after detoxification finishes, the Inlet and outlet water pneumatic operated valve of automatic closing temperature control device, open compressed air thermostatted water is blown degree of rising again control device, detoxification sample valve and sampling line are sterilized in 121 ℃ of wet-hot steam bactericidal units, after sterilization finishes, opening sample valve takes a sample, and the Pt100 platinum resistance temperature sensing probe that adopts the 316L rustless steel to seal, rustless steel fast-assembling interface and the tank connected temperature sampler of detoxification with ￠ 50, carry out the temperature sampling, sampling is closed sample valve after finishing, and the detoxification jar is connected with-5 ℃ of coolant devices, goods are cooled to 2～8 ℃, close the coolant valve, coolant is blown back the coolant device, goods are transferred to 2～8 ℃ of freezers preserve with compressed air;
(5) temperature control: adopt Steam Heating and electrical heating, temperature control after comprising the preceding temperature control of access detoxification jar and inserting the detoxification jar:
Temperature is controlled before inserting the detoxification jar: before inserting the detoxification jar, according to the signal that is positioned at the temperature sensor of temperature control equipment outlet pipe, return pipe temperature sensor transmission, regulate and the interior temperature of control water tank, when temperature in the water tank is 20 ℃, start the steam-heating pipe diaphragm valve, the feed-tank heating, when temperature in the water tank was 35 ℃, the steam-heating pipe diaphragm valve was closed, and the electric heating tube diaphragm valve starts, when temperature in the water tank is 37 ℃, enter holding stage;
Temperature is controlled after inserting the detoxification jar: after inserting the detoxification jar, according to the signal that is positioned at the transmission of detoxification jar temperature sample sensor, when products temperature is 20 ℃ in the detoxification jar, the Inlet and outlet water pneumatic operated valve is opened automatically, the discharge of detoxification jar interlayer reaches maximum, when products temperature was 35 ℃ in the detoxification jar, the Inlet and outlet water pneumatic operated valve reduced open degree automatically, entered little gentle holding stage that adds.
Claims (4)
1. an absorption is broken hinders technology detoxification technology behind the vaccine, and it is characterized in that: it may further comprise the steps:
(1) steam sterilization: the detoxification jar is carried out 360 ° of spray cleanings automatically in all directions by automatic clearing apparatus, sterilize by steam sterilizer;
(2) detoxification: after the cooling of detoxification jar, the goods of need detoxification are pumped into the detoxification jar, Inlet and outlet water interface, probe temperature sensing device in the detoxification jar interlayer are connected with the temperature control equipment that is positioned at the control system end, and start-up temperature control device, the goods temperature during detoxification is monitored automatically;
(3) detoxification is stirred: the unified speed of agitator in the magnetic stirring apparatus on the totally enclosed type, mixing time and the mixing time interval of being provided with in control system, after setting, control its automatic operation by control system;
(4) sampling: after detoxification finishes, the Inlet and outlet water pneumatic operated valve of automatic closing temperature control device, open compressed air thermostatted water is blown degree of rising again control device, detoxification sample valve and sampling line are sterilized in steam sterilizer, after sterilization finishes, opening sample valve takes a sample, and adopt the temperature sampler to carry out the temperature sampling, sampling is closed sample valve after finishing, and the detoxification jar is connected with-5 ℃ of coolant devices, goods are cooled to 2～8 ℃, close the coolant valve, coolant is blown back the coolant device, goods are transferred to 2～8 ℃ of freezers preserve with compressed air;
(5) temperature control: adopt Steam Heating and electrical heating, temperature control after comprising the preceding temperature control of access detoxification jar and inserting the detoxification jar:
Temperature is controlled before inserting the detoxification jar: before inserting the detoxification jar, according to the signal that is positioned at the temperature sensor of temperature control equipment outlet pipe, return pipe temperature sensor transmission, regulate and the interior temperature of control water tank, when temperature in the water tank is 20 ℃, start the steam-heating pipe diaphragm valve, the feed-tank heating, when temperature in the water tank was 35 ℃, the steam-heating pipe diaphragm valve was closed, and the electric heating tube diaphragm valve starts, when temperature in the water tank is 37 ℃, enter holding stage;
Temperature is controlled after inserting the detoxification jar: after inserting the detoxification jar, according to the signal that is positioned at the transmission of detoxification jar temperature sample sensor, when products temperature is 20 ℃ in the detoxification jar, the Inlet and outlet water pneumatic operated valve is opened automatically, the discharge of detoxification jar interlayer reaches maximum, when products temperature was 35 ℃ in the detoxification jar, the Inlet and outlet water pneumatic operated valve reduced open degree automatically, entered little gentle holding stage that adds.
2. a kind of absorption according to claim 1 is broken hinders technology detoxification technology behind the vaccine, and it is characterized in that: described steam sterilizer is 121 ℃ of wet-hot steam bactericidal units.
3. a kind of absorption according to claim 1 is broken hinders technology detoxification technology behind the vaccine, it is characterized in that: described temperature sampler uses the rustless steel fast-assembling interface of ￠ 50 to be connected with the detoxification jar for adopting the Pt100 platinum resistance temperature sensing probe of 316L rustless steel sealing.
4. a kind of absorption according to claim 1 is broken hinders technology detoxification technology behind the vaccine, and it is characterized in that: described speed of agitator is 0～300r/min.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101641983A CN102225199A (en) | 2011-06-18 | 2011-06-18 | Detoxification technology after absorption of tetanus vaccine |
| PCT/CN2012/075521 WO2012174960A1 (en) | 2011-06-18 | 2012-05-15 | Detoxification tank and detoxification process after adsorption of tetanus vaccine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101641983A CN102225199A (en) | 2011-06-18 | 2011-06-18 | Detoxification technology after absorption of tetanus vaccine |
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| Publication Number | Publication Date |
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| CN102225199A true CN102225199A (en) | 2011-10-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101641983A Pending CN102225199A (en) | 2011-06-18 | 2011-06-18 | Detoxification technology after absorption of tetanus vaccine |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102321532A (en) * | 2011-06-18 | 2012-01-18 | 成都欧林生物科技股份有限公司 | Detoxification control system and method for post-process of absorbed tetanus vaccine |
| WO2012174960A1 (en) * | 2011-06-18 | 2012-12-27 | 成都欧林生物科技股份有限公司 | Detoxification tank and detoxification process after adsorption of tetanus vaccine |
-
2011
- 2011-06-18 CN CN2011101641983A patent/CN102225199A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| 冯鹏: "不同甲醛脱毒方法对百日咳菌减毒效果的影响", 《中国医药指南》 * |
| 刘婷: "破伤风毒素C片段基因的克隆、表达及其产物的免疫生物学特性", 《中国优秀硕士学位论文全文数据库》 * |
| 朱慧林等: "反应罐生产三联四防灭活疫苗的工艺研讨", 《畜牧兽医科技信息》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102321532A (en) * | 2011-06-18 | 2012-01-18 | 成都欧林生物科技股份有限公司 | Detoxification control system and method for post-process of absorbed tetanus vaccine |
| WO2012174960A1 (en) * | 2011-06-18 | 2012-12-27 | 成都欧林生物科技股份有限公司 | Detoxification tank and detoxification process after adsorption of tetanus vaccine |
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Application publication date: 20111026 |