CN102218875B - Anti-adhesion medical composite film - Google Patents
Anti-adhesion medical composite film Download PDFInfo
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- CN102218875B CN102218875B CN201110080911.6A CN201110080911A CN102218875B CN 102218875 B CN102218875 B CN 102218875B CN 201110080911 A CN201110080911 A CN 201110080911A CN 102218875 B CN102218875 B CN 102218875B
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Abstract
The invention discloses an anti-adhesion medical composite film which is composed of a first surface layer, a second surface layer and an inner layer, wherein the inner layer is attached onto the first surface layer, and the second surface layer is attached onto the inner layer; the first surface layer and second surface layer respectively comprise the following components in parts by weight: 49-61 parts of low-density polyethylene, 38-51 parts of linear low-density polyethylene, 0.5-0.7 part of parts of and 0.04-0.06 part of lubricant; and the inner layer comprises the following components in parts by weight: 20-70 parts of low-density polyethylene and 30-80 parts of medium/high-density polyethylene. The anti-adhesion medical composite film disclosed by the invention has the advantages of stable friction factor and favorable anti-adhesion property; the medical product produced by the film does not have the adhesion phenomenon after being folded, sterilized by oxirane and the like and unfolded; and the unfolded anti-adhesion medical composite film has good transparency and favorable integral appearance effect.
Description
Technical field
The present invention relates to a kind of composite plastic film, be specifically related to a kind of medical composite film of prevent adhesion effect.
Background technology
After polluting according to article, the extent of injury of human body is divided into high-risk, middle danger, low danger three classes by hospital's article, described high-risk article means diagnosis and treatment equipment and the article that can cause serious harm after microbial contamination, such as operating theater instruments and articles for use, transfusion and blood transfusion equipment etc.The principle of hospital is that all high-risk articles must be selected the sterilizing of high-effective disinfecting method, makes its sterilizing index reach 10
-6even (microorganism survive probability ﹤ 10
-6).The disinfectant that conventional high-effective disinfecting method is used has glutaraldehyde, formaldehyde, Peracetic acid, hydrogen peroxide, oxirane and ozone etc., and the suitable employing oxirane of disposable film of wherein laying on operation table in operation is as disinfectant.
Can there is non-specific alkylating with the protein of microorganism, DNA and RNA in oxirane, strong to the penetration power of sterilizing objects, can reach article deep, can kill various pathogenic microorganisms, comprises bacterial propagule, gemma, virus and fungi.The gaseous state of oxirane and liquid form all have stronger function of killing microorganism, especially the bactericidal action of gaseous ethylene oxide is stronger, therefore multiplex its gas, carries out gas fumigation sterilization to medicine, surgery equipment and medical film etc., can obtain comparatively desirable Disinfection Effect.
But actual during to medical film disinfection, film-folding to be sterilized is folded and is placed in closed container, pass into ethylene oxide gas, sterilize and film is taken out while expansion after 8 hours, find that medical film is stacked adhesion mutually between the position at place, launch to be difficult for, separate fast if force external force, the surface of film otherwise smooth becomes coarse, does not just meet the requirement of operation.
Chinese patent literature CN 101475074A(application number 200910116112.2) a kind of self-lubricating polyethylene membrane disclosed, by skin, middle level and internal layer composition, skin comprises that weight ratio is 1: the low density polyethylene (LDPE) of (0.5～2) and LLDPE, middle level comprises that weight ratio is 1: the low density polyethylene (LDPE) of (0.5～2) and LLDPE, internal layer comprises that weight ratio is 1: (0.5～2): (1～2): (0.01～0.02): the low density polyethylene (LDPE) of (0.05～0.2), LLDPE, metallocene linear-low density polyethylene, slipping agent and auxiliary agent.This film is not through really having lubricant effect between film and film before disinfecting, once but ethane via epoxyethane gas depoisoning, the same film of folding or heap poststack that exists, from the phenomenon that adhesion each other occurs in the place of being stacked, can not meet medical requirement.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of anti-adhesion medical composite film, this film folding or stacking in the situation that after medical disinfecting especially oxirane disinfection, being stacked place's convenient separation, there is not adhesion phenomenon each other.
The technical scheme that realizes the object of the invention is: a kind of anti-adhesion medical composite film, is made up of the first surface layer film adhering to each other successively, internal layer membrane and the second surface layer film;
The first surface layer film is identical with the composition of the second surface layer film, is made up of the component of following weight portion: 49～61 parts of low density polyethylene (LDPE)s, 38～51 parts of LLDPEs, 0.5～0.8 part of silica, 0.01～0.2 part of slipping agent;
Internal layer membrane is made up of the component of following weight portion: 20～70 parts of low density polyethylene (LDPE)s, 30～80 parts of middle-high density polyethylene.
Described silica particle diameter is even, and particle diameter is between 4～20 μ m.
The particle diameter of described silica is between 7～13 μ m.
The poly density of described middle-high density is at 0.930 ~ 0.960g/cm
3between.
Described slipping agent is erucyl amide or oleamide.
The thickness of above-mentioned film is 0.04～0.05mm, and the ratio of the thickness of the first surface layer film, internal layer membrane, the second surface layer film is 1: (1～3): (0.9～1.1).
Described anti-adhesion medical composite film be by be used to form the first surface layer film feed particles shape containing 46～59 parts of the LDPE: Low-density polyethylene plastics masterbatch of slipping agent, 5～8 parts of granular 36～49 parts of the LLDPE plastic matrixs containing slipping agent and granular silica containing opening master batches; Be used to form 20～70 parts of the low density polyethylene (LDPE)s of the feed particles shape of internal layer membrane, 30～80 parts of granular medium density polyethylenes and be used to form the second surface layer film feed particles shape containing 46～59 parts of the LDPE: Low-density polyethylene plastics masterbatch of slipping agent, 5～8 parts of granular 36～49 parts of LLDPE plastic matrixs containing slipping agent and granular silica containing opening master batches respectively stirrer for mixing evenly after, extrude in unit hopper for No. 1, No. 2, No. 3 that are transferred to respectively three-layer co-extruded blow molding machine;
Described the granular of the first surface layer film and the second surface layer film that be used to form contains in the LLDPE plastic matrix of slipping agent, and the content of slipping agent is 400～600mg/kg, and described slipping agent is erucyl amide or oleamide; The described granular silica containing opening master batch that is used to form the first surface layer film and the second surface layer film, is made up of the silica of 8～15wt% and the low density polyethylene (LDPE) of 85～92wt%;
Control and extrude barrel that unit hopper is connected for No. 1 and be 155～160 ℃ with the temperature of extruding the barrel that unit hopper is connected for No. 3, control is 175～180 ℃ with the temperature of extruding the barrel that unit hopper is connected for No. 2, makes the material melting in each barrel;
Start No. 1 simultaneously, No. 2, extrude unit No. 3 and extrude operation, controlling the extruded velocity of extruding unit for No. 2 is to extrude 1～3 times of unit No. 1 and No. 3, extrude unit and mold membrane pipe inflation and form first surface layer film of arranging successively according to order from top to bottom through each, internal layer membrane and the second surface layer film, again three-layer thin-film is passed through to vane successively cooling, herringbone retraction rack is guided into traction nip rolls and makes that three-layer thin-film is superimposed to be overlayed together, hot adhesion and form laminated film, pass through again lower traction nip rolls, metering, double rubs the operations such as rolling and obtains the anti-adhesion medical composite film of rolling.
Described anti-adhesion medical composite film is to be used to form 45～58 parts of the LDPE: Low-density polyethylene plastics masterbatch of feed particles shape of the first surface layer film, 36～49 parts of granular LLDPE plastic matrixs, 0.4～0.8 part of 5～8 parts of granular silica containing opening master batches and granular smooth master batch containing slipping agent; Be used to form 20～70 parts of the low density polyethylene (LDPE)s of the feed particles shape of internal layer membrane, 30～80 parts of granular medium density polyethylenes and be used to form 46～58 parts of the LDPE: Low-density polyethylene plastics masterbatch of the feed particles shape of the second surface layer film, 36～49 parts of granular LLDPE plastic matrixs, 0.4～0.8 part of 5～8 parts of granular silica containing opening master batches and granular smooth master batch containing slipping agent, after stirrer for mixing is even, extrude in unit hopper for No. 1, No. 2, No. 3 that are transferred to respectively three-layer co-extruded blow molding machine respectively;
The described granular smooth master batch containing slipping agent that is used to form the first surface layer film and the second surface layer film is made up of the slipping agent of 8～15wt% and the low density polyethylene (LDPE) of 85～92wt%, and described slipping agent is erucyl amide or oleamide; The described granular silica containing opening master batch that is used to form the first surface layer film and the second surface layer film, is made up of the silica of 8～15wt% and the low density polyethylene (LDPE) of 85～92wt%;
Control and extrude barrel that unit hopper is connected for No. 1 and be 155～160 ℃ with extruding the barrel temperature that unit hopper is connected for No. 3, the temperature of controlling the barrel of extruding the connection of unit hopper for No. 2 is 175～180 ℃, makes the material melting in each barrel;
Start No. 1 simultaneously, No. 2, extrude unit No. 3 and extrude operation, controlling the extruded velocity of extruding unit for No. 2 is to extrude 1～3 times of unit No. 1 and No. 3, extrude unit and mold membrane pipe inflation and form first surface layer film of arranging successively according to order from top to bottom through each, internal layer membrane and the second surface layer film, again three-layer thin-film is passed through to vane successively cooling, herringbone retraction rack is guided into traction nip rolls and makes that three-layer thin-film is superimposed to be overlayed together, hot adhesion and form laminated film, pass through again lower traction nip rolls, metering, double rubs the operations such as rolling and obtains the anti-adhesion medical composite film of rolling.
The present invention has positive effect: laminated film stable friction factor of the present invention, adhesion inhibiting properties is good, after the curable product that obtains with the further machining of this laminated film is folding after the various disinfection way such as oxirane are processed without adhesion phenomenon, transparency and overall appearance effect are all better simultaneously, can meet medical requirement.
Accompanying drawing explanation
Fig. 1 is the schematic diagram while not launching after anti-adhesion medical composite film of the present invention sterilization.
Schematic diagram when Fig. 2 is rear expansion of anti-adhesion medical composite film sterilization of the present invention.
After Fig. 3 is existing film ethane via epoxyethane sterilization, the schematic diagram while expansion.
After Fig. 4 is existing film ethane via epoxyethane sterilization, schematic diagram when expansion.
The specific embodiment
(embodiment 1, anti-adhesion medical film)
The anti-adhesion medical composite film of the present embodiment is made by coextrusion method, is made up of the first surface layer film adhering to each other successively, internal layer membrane and the second surface layer film; The first surface layer film and the second surface layer film have excellent lubricity, resistance to bond and wear resistence, and internal layer membrane has anti-permeability.The gross thickness of anti-adhesion medical composite film is 0.04mm, and wherein the first surface layer film is identical with the thickness of the second surface layer film, is 0.01mm, and the thickness of internal layer membrane is 0.02mm.
The first surface layer film is identical with the composition of the second surface layer film, is made up of the component of following weight portion: 57.15 parts of low density polyethylene (LDPE)s (LDPE), 42 parts of LLDPEs (LLDPE), silica (SiO
2) 0.05 part of 0.8 part and slipping agent.
Most of low density polyethylene (LDPE) in described the first surface layer film and the second surface layer film and part slipping agent derive from product grade that Sinopec Yangzi Petrochemical Co the produces ldpe resin particle that is 2426H, this ldpe resin particle is the granular LDPE: Low-density polyethylene plastics masterbatch that contains slipping agent, is also smooth LDPE: Low-density polyethylene plastics masterbatch.Its index is: density 0.924g/cm
3, degree of crystallinity 55%～65%, 115 ℃ of melt temperatures, melt flow rate (MFR) 2 grams/10 minutes; The slipping agent adding in the ldpe resin particle of this trade mark is erucyl amide, and the content of erucyl amide in plastic matrix is that 400～600mg/kg(the present embodiment is 500mg/kg).
LLDPE in described the first surface layer film and the second surface layer film and the slipping agent of remainder derive from the linear low density polyethylene resin particle that Exxon Mobil Corporation's product sold trade mark is 1002KW, this linear low density polyethylene resin particle is the granular LLDPE plastic matrix that contains slipping agent, is also slippery linear low density polyethylene plastic matrix.Its index is: density 0.918g/cm
3, degree of crystallinity 65%～75%, 115 ℃ of melt temperatures, melt flow rate (MFR) 2 grams/10 minutes; The slipping agent adding in the linear low density polyethylene resin particle of this trade mark is erucyl amide, and the content of erucyl amide in plastic matrix is that 400～600mg/kg(the present embodiment is 500mg/kg).
In the present invention, above-mentioned smooth LDPE: Low-density polyethylene plastics masterbatch and slippery linear low density polyethylene plastic matrix are referred to as to smooth vinyon masterbatch (also referred to as masterbatch).Slipping agent erucyl amide in the first top layer and second top layer of the anti-adhesion medical composite film of the present embodiment is one of raw material of smooth vinyon masterbatch.In other embodiments, the slipping agent in the first top layer and the second top layer also can be selected oleamide, and described oleamide is also one of raw material of the corresponding smooth vinyon masterbatch of preparation.Described slipping agent erucyl amide is when preparing the raw material of masterbatch, its state is white powder, described masterbatch and other raw material are made after plastic sheeting, can significantly reduce dynamic friction coefficient and the static friction coefficient of film surface, make film there is lubricity and resistance to bond, especially during as surface layer film, make the surface lubrication of corresponding laminated film good, after laminated film is folded, between the part being superimposed together of laminated film, coefficient of friction is low, and make the expansion after folding very convenient, and the flat appearance that visually observes lower laminated film top layer is smooth.
Silica in described the first surface layer film and the second surface layer film and the low density polyethylene (LDPE) of remainder derive from commercial disignation that Beijing Si Puruite company the sells graininess opening master batch that is KK-10, this opening master batch is made up of the silica of 10wt% and the low density polyethylene (LDPE) of 90wt%, silica is one of raw material of this opening master batch of preparation, thereby is dispersed in this opening master batch.The density 0.94g/cm of this opening masterbatch
3, 115 ℃ of melt temperatures, melt flow rate (MFR) 2 grams/10 minutes.
The silica comprising in above-mentioned the first surface layer film and the second surface layer film exists with the form of micron particles, thereby make surface layer film form a kind of concave-convex structure of microcosmic, effectively reduce laminated film and the adhesion effect between top layer and top layer when other laminated film is superimposed or self is superimposed, also make the abrasion resistance on top layer greatly strengthen.
In the time preparing opening master batch, the particle size of the silica of one of raw material used is even, can within the scope of 4 ~ 20 μ m, select preferably 7～8 μ m; Thereby be also that preferably 7～8 μ are m) for 4 ~ 20 μ m(with this opening master batch as the silica dioxide granule particle diameter in prepared the first surface layer film of one of raw material and the second surface layer film.The particle diameter of the silica comprising is less, and silica disperses more difficult in top layer, bring the problem of disperseing inequality and processing difficulties, but the film clarity of making is better; The silica particle diameter comprising is larger, and the roughness of film is larger, better to the effect of prevent adhesion, but the transparency of film reduces; Because the laminated film of the present embodiment all has requirement to transparency and prevent adhesion, therefore need consider the particle diameter of selecting silica dioxide granule.
Internal layer membrane is made up of the component of following weight portion: 50 parts of low density polyethylene (LDPE)s, 50 parts of medium density polyethylenes.
Low density polyethylene (LDPE) in described internal layer membrane derives from product grade that Sinopec Yangzi Petrochemical Co the produces ldpe resin particle that is 2420H, its index is: density 0.924g/cm
3, 115 ℃ of melt temperatures, melt flow rate (MFR) 2 grams/10 minutes.
Medium density polyethylene in described internal layer membrane derives from product grade that Borouge petro-chemical corporation the produces medium density polyethylene resin particle that is 2230, its index is: density 0.93g/cm
3, 125 ℃ of melt temperatures, melt flow rate (MFR) 0.4 gram/10 minutes.
Because the density of medium density polyethylene is larger, therefore there is good buffer action, can prevent the infiltration of solvent in disinfecting process, avoid causing the adhesion between laminated film.
The preparation method of the anti-adhesion medical composite film of the present embodiment comprises the following steps:
1. take respectively as follows with the each corresponding raw material of the corresponding weight ratio of above-mentioned anti-adhesion medical composite film: 50 parts of the granular LDPE: Low-density polyethylene plastics masterbatch containing slipping agent that is used to form the first surface layer film, 8 parts of granular 42 parts of the LLDPE plastic matrixs containing slipping agent and granular silica containing opening master batches; Be used to form 50 parts of the granular low density polyethylene (LDPE)s of internal layer membrane, 50 parts of granular medium density polyethylenes; 50 parts of the granular LDPE: Low-density polyethylene plastics masterbatch containing slipping agent that is used to form the second surface layer film, 8 parts of granular 42 parts of the LLDPE plastic matrixs containing slipping agent and granular silica containing opening master batches.
Above-mentionedly be used to form granular containing in the LDPE: Low-density polyethylene plastics masterbatch of slipping agent that the first surface layer film and the second surface layer film take, contained slipping agent is erucyl amide, the content of erucyl amide in plastic matrix is 500mg/kg, and the granular LDPE: Low-density polyethylene plastics masterbatch containing slipping agent of the present embodiment derives from the ldpe resin particle that product grade that Sinopec Yangzi Petrochemical Co produces is 2426H.
Above-mentionedly be used to form granular containing in the LLDPE plastic matrix of slipping agent that the first surface layer film and the second surface layer film take, contained slipping agent is erucyl amide, the content of erucyl amide in plastic matrix is 500mg/kg, and the granular LLDPE plastic matrix containing slipping agent of the present embodiment derives from the linear low density polyethylene resin particle that Exxon Mobil Corporation's product sold trade mark is 1002KW.
Above-mentionedly be used to form the granular silica containing opening master batch that the first surface layer film and the second surface layer film take, be made up of the silica of 10wt% and the low density polyethylene (LDPE) of 90wt%, the commercial disignation that described granular silica containing opening master batch is sold from Beijing Si Puruite company is KK-
10graininess opening master batch.
Above-mentionedly be used to form granular low density polyethylene (LDPE) that internal layer membrane takes and derive from the ldpe resin particle that product grade that Sinopec Yangzi Petrochemical Co produces is 2420H, its index is: density 0.924g/cm
3, 115 ℃ of melt temperatures, melt flow rate (MFR) 2 grams/10 minutes.
The above-mentioned granular medium density polyethylene taking for internal layer membrane derives from product grade that Borouge company the produces medium density polyethylene resin particle that is 2230, its index is: density 0.93g/cm
3, degree of crystallinity 75%, 130 ℃ of melt temperatures, melt flow rate (MFR) 0.4 gram/10 minutes.
2. the raw material that is used to form the first surface layer film 1. step being taken is sent in mixer, control 65 revs/min of stir speed (S.S.)s, room temperature (5～40 ℃) stirs and makes mixing of materials even in 15 minutes, and what the extruded film pipe inflation mouth that is then transferred to three-layer co-extruded blow molding machine was arranged in top extrudes unit hopper No. 1; The raw material that is used to form internal layer membrane that 1. step is taken stirs according to the method described above, and the extruded film pipe inflation mouth that is then transferred to three-layer co-extruded blow molding machine is arranged in extrudes unit hopper No. 2 in the middle of above-below direction; The raw material that is used to form the second surface layer film that 1. step is taken stirs according to the method described above, and what the extruded film pipe inflation mouth that is then transferred to three-layer co-extruded blow molding machine was arranged in below extrudes unit hopper No. 3; Described three-layer co-extruded blow molding machine is to be produced by Wuhan Chang Xin plastics machinery Co., Ltd, and unit type is 2300 revolves blown film unit on three-layer co-extruded.
3. open heater switch, control and extrude barrel that unit hopper is connected for No. 1 and be 155 ~ 160 ℃ with extruding the barrel temperature that unit hopper is connected for No. 3, controlling the barrel temperature of extruding the connection of unit hopper for No. 2 is 175 ~ 180 ℃
,make the material melting in each barrel.
4. start No. 1 simultaneously, No. 2, extrude unit No. 3 and extrude operation, controlling the extruded velocity of extruding unit for No. 2 is to extrude 1.5 times of unit No. 1 and No. 3, form first surface layer film of arranging successively according to order from top to bottom through each extruded film pipe inflation, internal layer membrane and the second surface layer film, again three-layer thin-film is passed through to vane successively cooling, herringbone retraction rack is guided into traction nip rolls and makes that three-layer thin-film is superimposed to be overlayed together, because the resin of each layer film is now also completely not cooling, thereby between adjacent films layer, there is hot adhesion to a certain degree and form laminated film, pass through again lower traction nip rolls, metering, double rubs the operations such as rolling and obtains the anti-adhesion medical composite film of rolling.
Step is 1. transparent, smooth to the laminated film that 4. obtained, and overall appearance is effective, and light transmittance is 0.85 ~ 0.90; Detecting its coefficient of friction according to GB10006-88 standard " plastic sheeting and thin slice measuring friction coefficient method " is 0.20.
Above-mentioned anti-adhesion medical composite film is carried out to the method that ethylene oxide gas sterilization prevent adhesion performance detects is: get that appropriate anti-adhesion medical composite film folds it and the rugosity laminated film that obtains 100 foldable layers is prepared two parts of rugosity laminated films; A rugosity laminated film is put into then upper cover of disinfect box; The CO that is 90% to oxirane that to pass into by volume in container be 10% and volume
2after the mist forming, close blow vent and make disinfect box airtight; Control temperature 45 C in disinfect box, sterilize 24 hours; After sterilization, take out the laminated film of rugosity, detect complexity and the coefficient of friction of its expansion: see the picture while expansion after the anti-adhesion medical composite film sterilization of Fig. 1 the present embodiment, the film integral outward appearance after sterilization with put into before almost there is no difference; See the picture while expansion after the anti-adhesion medical composite film sterilization of Fig. 2 the present embodiment, upon deployment, laboratory technician does not sensuously have difference to the rugosity laminated film that the rugosity laminated film after sterilization and another part are not sterilized substantially; The surface appearance of the not laminated film of sterilization after its surface appearance of laminated film and expansion of sterilizing after expansion is basic identical, can not visually observe difference; According to GB10006-88 standard " plastic sheeting and thin slice measuring friction coefficient method ", it is 0.21 that the GM-1 frictionmeter that adopts Guangzhou mark Coating Equipment Co., Ltd to produce detects its coefficient of kinetic friction, confficient of static friction is 0.24, and the Mo that meets product in medical standard wipes the requirement of Xi Shuo≤0.30.
And for the current commercially available good PE medical film of common lubricity, before sterilization, the coefficient of kinetic friction of film is 0.19, confficient of static friction is that 0.22(detection method is the same); After folding 100 layers of film that obtains rugosities, carry out disinfection according to the method described above, take out film after sterilization, see the picture while expansion after the sterilization of the existing PE medical film of Fig. 3 ethane via epoxyethane, the out-of-flatness of film integral outward appearance has concavo-convex; , there is adhesion phenomenon between film and film in the picture while seeing the rear expansion of the existing PE medical film of Fig. 4 ethane via epoxyethane sterilization, compared with this kind of film not carrying out disinfection, naked eyes it seems that its surface is obviously coarse; After launching by force, the surface appearance of adhesion part is worse; Be 0.40 according to its skin-friction coefficient of GB10006-88 standard detection, do not meet medical requirement.
(embodiment 2, anti-adhesion medical film)
The remainder of the present embodiment is identical with embodiment 1, and difference is:
Most of low density polyethylene (LDPE) in described the first surface layer film and the second surface layer film derives from product grade that Sinopec Yangzi Petrochemical Co the produces ldpe resin particle that is 2420H, in this ldpe resin particle, do not contain slipping agent, its index is: density 0.924g/cm
3, 115 ℃ of melt temperatures, melt flow rate (MFR) 2 grams/10 minutes.
LLDPE in described the first surface layer film and the second surface layer film derives from the linear low density polyethylene resin particle that Exxon Mobil Corporation's product sold trade mark is 1002YB, in this linear low density polyethylene resin particle, do not contain slipping agent, its index is: density 0.918g/cm
3, degree of crystallinity 65%～75%, 115 ℃ of melt temperatures, melt flow rate (MFR) 2 grams/10 minutes.
Slipping agent in described the first surface layer film and the second surface layer film and fraction low density polyethylene (LDPE) derive from commercial disignation that Changzhou Shuan Cheng masterbatch company the sells granular smooth master batch that is PE-1, the described smooth master batch containing slipping agent is made up of the erucyl amide of 10wt% and the low density polyethylene (LDPE) of 90wt%, and erucyl amide is dispersed in smooth master batch.Bulk density 0.51 ~ the 0.61g/cm of this smooth master batch
3, 115 ℃ of melt temperatures, melt flow rate (MFR) 8 ~ 10.5 grams/10 minutes.
Silica in described the first surface layer film and the second surface layer film and the low density polyethylene (LDPE) of remainder derive from commercial disignation that Beijing Si Puruite company the sells graininess opening master batch that is KK-10, described opening master batch is identical with embodiment 1.
The preparation method's of the preparation method of the anti-adhesion medical composite film of the present embodiment and embodiment 1 difference is:
1. step takes respectively as follows with the each corresponding raw material of the above-mentioned corresponding weight ratio of anti-adhesion medical composite film: be used to form 49.5 parts of the granular LDPE: Low-density polyethylene plastics masterbatch of the first surface layer film, 0.5 part of 42 parts of granular LLDPE plastic matrixs, 8 parts of granular silica containing opening master batches and granular smooth master batch containing slipping agent; Be used to form 50 parts of the granular low density polyethylene (LDPE)s of internal layer membrane, 50 parts of granular medium density polyethylenes; Be used to form 49.5 parts of the granular LDPE: Low-density polyethylene plastics masterbatch of the second surface layer film, 42 parts of granular LLDPE plastic matrixs, 0.5 part of 8 parts of granular silica containing opening master batches and granular smooth master batch containing slipping agent.
Above-mentionedly be used to form the granular smooth master batch containing slipping agent that the first surface layer film and the second surface layer film take and be made up of the erucyl amide of 10wt% and the low density polyethylene (LDPE) of 90wt%, erucyl amide is dispersed in smooth master batch.The active ingredient of the present embodiment is the smooth master batch of erucyl amide to derive from commercial disignation that Changzhou Shuan Cheng masterbatch company sells be PE-1 smooth master batch.
Above-mentionedly be used to form granular low density polyethylene (LDPE) that the first surface layer film and the second surface layer film take and derive from the ldpe resin particle that product grade that Sinopec Yangzi Petrochemical Co produces is 2420H, its index is: density 0.924g/cm
3, 115 ℃ of melt temperatures, melt flow rate (MFR) 2 grams/10 minutes.
Above-mentionedly be used to form the granular LLDPE that the first surface layer film and the second surface layer film take and derive from the linear low density polyethylene resin particle that Exxon Mobil Corporation's product sold trade mark is 1002YB, its index is: density 0.918g/cm
3, degree of crystallinity 65%～75%, 115 ℃ of melt temperatures, melt flow rate (MFR) 2 grams/10 minutes.
Above-mentionedly be used to form granular silica containing opening master batch that the first surface layer film takes with the second surface layer film, be used to form granular low density polyethylene (LDPE) that internal layer membrane takes and the medium density polyethylene raw material used with embodiment 1 is identical.
(embodiment 3, anti-adhesion medical film)
The remainder of the present embodiment is identical with embodiment 2, and difference is:
The particle diameter of the silica in described the first surface layer film and the second surface layer film is 11～13 μ m, and wherein contained slipping agent is oleamide.
Slipping agent in described the first surface layer film and the second surface layer film and fraction low density polyethylene (LDPE) derive from commercial disignation that Changzhou Shuan Cheng masterbatch company the sells granular smooth master batch that is PE-2, the described smooth master batch containing slipping agent is made up of the oleamide of 10wt% and the low density polyethylene (LDPE) of 90wt%, and oleamide is dispersed in smooth master batch.Bulk density 0.51 ~ the 0.61g/cm of this smooth master batch
3, 115 ℃ of melt temperatures, melt flow rate (MFR) 4.0 ~ 5.0 grams/10 minutes.
All the other are identical with embodiment 2 for the preparation method of the anti-adhesion medical composite film of the present embodiment, and difference is:
Silica particle diameter in the opening master batch that 1. step taken is 11～13 μ m.
The granular smooth master batch containing slipping agent that is used to form the first surface layer film and the second surface layer film taking is made up of oleamide and the 90wt% low density polyethylene (LDPE) of 10wt%; The present embodiment active ingredient is the smooth master batch of oleamide to derive from commercial disignation that Changzhou Shuan Cheng masterbatch company sells be PE-2 smooth master batch.
(embodiment 4, anti-adhesion medical film)
The remainder of the present embodiment is identical with embodiment 1, and difference is:
Medium density polyethylene in described internal layer membrane derives from product grade that mitsui petrochemical industry company the produces medium density polyethylene resin particle that is 4505, its index is: density is 0.944,128 ℃ of melt temperatures, melt flow rate (MFR) 0.4 gram/10 minutes.
(embodiment 5 to embodiment 10, anti-adhesion medical film)
The remainder of the laminated film of each corresponding embodiment is identical with embodiment 1, and by difference: the low density polyethylene (LDPE) (LDPE) in the first surface layer film and the second surface layer film, LLDPE (LLDPE), silica (SiO
2), slipping agent parts by weight separately, the particle diameter R(SiO of silica
2), the low density polyethylene (LDPE) (LDPE) in internal layer membrane, medium density polyethylene (MDPE) parts by weight separately, the density p (MDPE) of medium density polyethylene is listed in table 1.
Table 1
The unit of the density p (MDPE) of the medium density polyethylene in above-mentioned table 1 is g/cm
3.
(embodiment 11, anti-adhesion medical film)
The remainder of the present embodiment is identical with embodiment 1, and difference is: the gross thickness of the present embodiment film is 0.04mm, and the thickness of three layers is identical, is 0.013mm.
(embodiment 12, anti-adhesion medical film)
The remainder of the present embodiment is identical with embodiment 1, and difference is: the gross thickness of the present embodiment film is 0.05mm, and wherein the first top layer is identical with the thickness on the second top layer, is 0.01mm, and the thickness of internal layer is 0.03mm.
(embodiment 13, anti-adhesion medical film)
The remainder of the present embodiment is identical with embodiment 1, and difference is: the gross thickness of the present embodiment film is 0.045mm, and wherein the first top layer is identical with the thickness on the second top layer, is 0.01mm, and the thickness of internal layer is 0.025mm.
Claims (8)
1. an anti-adhesion medical composite film, is characterized in that: be made up of the first surface layer film adhering to each other successively, internal layer membrane and the second surface layer film;
The first surface layer film is identical with the composition of the second surface layer film, is made up of the component of following weight portion: 49～61 parts of low density polyethylene (LDPE)s, 38～51 parts of LLDPEs, 0.5～0.8 part of silica, 0.01～0.2 part of slipping agent;
Internal layer membrane is made up of the component of following weight portion: 20～70 parts of low density polyethylene (LDPE)s, 30～80 parts of medium density polyethylenes.
2. anti-adhesion medical composite film according to claim 1, is characterized in that: described silica particle diameter is even, and particle diameter is between 4～20 μ m.
3. anti-adhesion medical composite film according to claim 2, is characterized in that: the particle diameter of described silica is between 7～13 μ m.
4. anti-adhesion medical composite film according to claim 1, is characterized in that: the density of described medium density polyethylene is at 0.930 ~ 0.960g/cm
3between.
5. anti-adhesion medical composite film according to claim 1, is characterized in that: described slipping agent is erucyl amide or oleamide.
6. according to the anti-adhesion medical composite film one of claim 1 to 5 Suo Shu, it is characterized in that: the thickness of film is 0.04～0.05mm, the ratio of the thickness of the first surface layer film, internal layer membrane, the second surface layer film is 1: (1～3): (0.9～1.1).
7. anti-adhesion medical composite film according to claim 1, it is characterized in that: it be by be used to form the first surface layer film feed particles shape containing 46～59 parts of the LDPE: Low-density polyethylene plastics masterbatch of slipping agent, 5～8 parts of granular 36～49 parts of the LLDPE plastic matrixs containing slipping agent and granular silica containing opening master batches; Be used to form 20～70 parts of the low density polyethylene (LDPE)s of the feed particles shape of internal layer membrane, 30～80 parts of granular medium density polyethylenes and be used to form the second surface layer film feed particles shape containing 46～59 parts of the LDPE: Low-density polyethylene plastics masterbatch of slipping agent, 5～8 parts of granular 36～49 parts of LLDPE plastic matrixs containing slipping agent and granular silica containing opening master batches respectively stirrer for mixing evenly after, extrude in unit hopper for No. 1, No. 2, No. 3 that are transferred to respectively three-layer co-extruded blow molding machine;
Described the granular of the first surface layer film and the second surface layer film that be used to form contains in the LLDPE plastic matrix of slipping agent, and the content of slipping agent is 400～600mg/kg, and described slipping agent is erucyl amide or oleamide; The described granular silica containing opening master batch that is used to form the first surface layer film and the second surface layer film, is made up of the silica of 8～15wt% and the low density polyethylene (LDPE) of 85～92wt%;
Control and extrude barrel that unit hopper is connected for No. 1 and be 155～160 ℃ with the temperature of extruding the barrel that unit hopper is connected for No. 3, control is 175～180 ℃ with the temperature of extruding the barrel that unit hopper is connected for No. 2, makes the material melting in each barrel;
Start No. 1 simultaneously, No. 2, extrude unit No. 3 and extrude operation, controlling the extruded velocity of extruding unit for No. 2 is to extrude 1～3 times of unit No. 1 and No. 3, extrude unit and mold membrane pipe inflation and form first surface layer film of arranging successively according to order from top to bottom through each, internal layer membrane and the second surface layer film, again three-layer thin-film is passed through to vane successively cooling, herringbone retraction rack is guided into traction nip rolls and makes that three-layer thin-film is superimposed to be overlayed together, hot adhesion and form laminated film, pass through again lower traction nip rolls, metering, double rubs winding process and obtains the anti-adhesion medical composite film of rolling.
8. anti-adhesion medical composite film according to claim 1, it is characterized in that: it is to be used to form 46～58 parts of the LDPE: Low-density polyethylene plastics masterbatch of feed particles shape of the first surface layer film, 36～49 parts of granular LLDPE plastic matrixs, 0.4～0.8 part of 5～8 parts of granular silica containing opening master batches and granular smooth master batch containing slipping agent; Be used to form 20～70 parts of the low density polyethylene (LDPE)s of the feed particles shape of internal layer membrane, 30～80 parts of granular medium density polyethylenes and be used to form 46～58 parts of the LDPE: Low-density polyethylene plastics masterbatch of the feed particles shape of the second surface layer film, 36～49 parts of granular LLDPE plastic matrixs, 0.4～0.8 part of 5～8 parts of granular silica containing opening master batches and granular smooth master batch containing slipping agent, after stirrer for mixing is even, extrude in unit hopper for No. 1, No. 2, No. 3 that are transferred to respectively three-layer co-extruded blow molding machine respectively;
The described granular smooth master batch containing slipping agent that is used to form the first surface layer film and the second surface layer film is made up of the slipping agent of 8～15wt% and the low density polyethylene (LDPE) of 85～92wt%, and described slipping agent is erucyl amide or oleamide; The described granular silica containing opening master batch that is used to form the first surface layer film and the second surface layer film, is made up of the silica of 8～15wt% and the low density polyethylene (LDPE) of 85～92wt%;
Control and extrude barrel that unit hopper is connected for No. 1 and be 155～160 ℃ with extruding the barrel temperature that unit hopper is connected for No. 3, the temperature of controlling the barrel of extruding the connection of unit hopper for No. 2 is 175～180 ℃, makes the material melting in each barrel;
Start No. 1 simultaneously, No. 2, extrude unit No. 3 and extrude operation, controlling the extruded velocity of extruding unit for No. 2 is to extrude 1～3 times of unit No. 1 and No. 3, extrude unit and mold membrane pipe inflation and form first surface layer film of arranging successively according to order from top to bottom through each, internal layer membrane and the second surface layer film, again three-layer thin-film is passed through to vane successively cooling, herringbone retraction rack is guided into traction nip rolls and makes that three-layer thin-film is superimposed to be overlayed together, hot adhesion and form laminated film, pass through again lower traction nip rolls, metering, double rubs winding process and obtains the anti-adhesion medical composite film of rolling.
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| CN201110080911.6A CN102218875B (en) | 2011-03-31 | 2011-03-31 | Anti-adhesion medical composite film |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102504422B (en) * | 2011-11-09 | 2016-02-10 | 新乐华宝塑料薄膜有限公司 | A kind of polyethylene film and preparation method thereof |
| CN103263707B (en) * | 2013-05-25 | 2015-09-09 | 芜湖道润药业有限责任公司 | The adherence preventing material of doubly-linked PVC medicinal liquid storage bag and operating procedure |
| CN104924561A (en) * | 2015-06-15 | 2015-09-23 | 青岛正大环保科技有限公司 | Production process of three-layer co-extrusion film |
| CN104985893A (en) * | 2015-07-01 | 2015-10-21 | 常州高创塑业有限公司 | Anti-bacterial medical protective film and preparation method thereof |
| CN105559893A (en) * | 2015-12-18 | 2016-05-11 | 长沙汇一制药机械有限公司 | Medical composite anti-adhesive film |
| CN105536074A (en) * | 2015-12-18 | 2016-05-04 | 长沙汇一制药机械有限公司 | Medical complex anti-adhesion film |
| CN108068421A (en) * | 2017-12-26 | 2018-05-25 | 常州市华健药用包装材料股份有限公司 | Medicinal high-speed packaging polyethylene film |
| CN109350363B (en) * | 2018-11-23 | 2021-04-20 | 武汉维斯第医用科技股份有限公司 | Manufacturing process of sealed negative-pressure drainage wet sponge |
| CN116082734A (en) * | 2022-12-30 | 2023-05-09 | 广东溢达纺织有限公司 | Easily-opened regenerated polyethylene packaging material free of slipping agent pollution and preparation method thereof |
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