CN102217954B - Biopsy device and biopsy sample storing assembly - Google Patents

Biopsy device and biopsy sample storing assembly Download PDF

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CN102217954B
CN102217954B CN 201110077184 CN201110077184A CN102217954B CN 102217954 B CN102217954 B CN 102217954B CN 201110077184 CN201110077184 CN 201110077184 CN 201110077184 A CN201110077184 A CN 201110077184A CN 102217954 B CN102217954 B CN 102217954B
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tissue
biopsy device
sample
vacuum
cutter
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CN 201110077184
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CN102217954A (en
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J·A·希布纳
W·D·哈伯斯蒂克
K·E·霍格
T·W·V·斯皮格
M·达坎格洛
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伊西康内外科公司
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Priority to US60/874,792 priority
Priority to US11/952,405 priority patent/US8118755B2/en
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Priority to CN200710186190.02007.12.13 priority
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Abstract

本发明涉及活检装置和活检样本存储器,具体而言,涉及可以被用来获得和存储多份组织样本的活检装置,还涉及活检样本存储组件。 The present invention relates to a biopsy device and a biopsy sample memory, particularly to be used to obtain and store multiple biopsy apparatus the tissue sample, a biopsy sample storage assembly further relates. 所述活检装置容许组织样本以顺序的方式存储在大致透明的组织存储室内,所述组织存储室配置在活检装置的近端。 The biopsy tissue sample in the storage device allows a sequential manner in a generally transparent tissue storage chamber of the tissue storage chamber disposed at a proximal end of the biopsy device. 组织样本可以被存储在挠性的组织样本带上,所述组织样本带围绕设置在室内部的可旋转真空集合管的圆周设置。 The tissue sample may be a flexible tissue sample strip store, the tissue sample is provided with a circumferentially disposed around a rotatable inside the chamber of a vacuum manifold.

Description

活检装置和活检样本存储器 A biopsy device and a biopsy sample memory

[0001] 本申请是申请日为2007年12月13日、国家申请号为:200710186190.0、名称为 [0001] This application is filed December 13, 2007, the national application number: 200710186190.0, name

“活检装置和活检样本存储器”的专利申请的分案申请。 Divisional application "biopsy device and a biopsy sample memory" patent application.

[0002] 本申请要求2006年12月13日提交的美国临时申请60/869,736和2006年12月13日提交的美国临时申请60/874,792的优先权,这些文献通过引用结合入本文。 [0002] This application claims the benefit of US Provisional Application December 13, 2006, filed 60 / 869,736 and US 13 December 2006 Provisional Application No. 60 / 874,792, which are incorporated herein by reference .

技术领域 FIELD

[0003] 本发明总的涉及活检装置,尤其涉及能够将多个组织样本例如按间隔、顺序方式存储在活检装置的一部分中的活检装置。 [0003] Summary The present invention relates to biopsy devices, and more particularly can be a plurality of tissue samples at intervals of e.g., in a sequential manner biopsy device portion of a biopsy device in storage. 本发明还涉及活检样本存储组件。 The present invention further relates to a biopsy sample storage assembly.

背景技术 Background technique

[0004] 当通过诊察、超声、MR1、X射线成像等等在患者的胸部或其他区域发现了一个可疑的组织团块时,有必要进行活检程序从所述组织移取一个或多个样本以判断团块是否包含癌细胞。 [0004] When the through examination, ultrasound, MR1, X-ray imaging and the like discovered a suspicious tissue mass in the chest or other region of the patient, the need for a biopsy procedure pipetted from the tissue samples to one or more comprising determining whether a cancer cell pellet. 活检可以是通过开放式或经皮的方法来进行。 Biopsy may be done by an open or percutaneous method. 用于获得组织样本的医疗装置在活检领域是已知的,所述组织样本随后用于抽样和/或检测。 Obtaining a tissue sample for biopsy is a medical device are known in the art, the tissue sample for subsequent sampling and / or testing. 例如,Ethicon Endo-Surgery,Inc.的一种市售的商品名为ΜΑΜΜ0Τ0ΜΕ的活检器械可以在市场上买到,其用于获得乳房活检样本。 For example, Ethicon Endo-Surgery, Inc. Of a commercial trade name ΜΑΜΜ0Τ0ΜΕ biopsy instrument may be available on the market, for obtaining breast biopsy samples.

[0005] 开放式活检可以通过在乳房开一个大的切口并移取整个团块(称为切除式活检)、或大部分团块(被称为切取式活检)来进行。 [0005] The open biopsy in the breast can be opened by a large incision and pipetted entire agglomerates (called excisional biopsy), or most agglomerates (called cut biopsy) is performed. 开放式活检是可以在医院或外科中心以门诊手术进行的外科程序,可能涉及高成本和对患者的大程度损伤。 Open biopsy is a surgical procedure in a hospital or surgical center outpatient surgery carried out, may involve high costs and the large degree of injury to the patient. 与经皮活检相比,开放式活检可能带有相对较高的感`染和流血风险,并且由开放式活检引起的损形可能使将来的乳房X线照片难以辨认。 Compared with percutaneous biopsy, an open biopsy may carry relatively higher risk of bleeding and staining sense 'and disfigurement caused by an open biopsy may make future breast X-ray photographs illegible. 此外,患者对于损形的潜在危险的美观考虑也使开放式活检更不具有吸引力。 In addition, for patients with potentially dangerous loss of aesthetic considerations also shaped open biopsy even less appealing. 已经知道某些活检显示可疑组织团块不是癌,开放式活检程序的潜在的负面作用会导致所述方法在某些病例中是不恰当的。 Some have been known biopsy suspicious tissue mass is not cancerous, the potential negative effects of open biopsy procedure will result in some cases, the method is not appropriate.

[0006] 经皮活检比开放式活检具有较小的侵入性。 [0006] Percutaneous biopsy with less invasive than open biopsy. 经皮活检可以使用细针抽吸(FNA)、芯针活检或其他方式来进行。 Percutaneous biopsy may be used fine needle aspiration (FNA), core needle biopsy, or otherwise performed. 在FNA中,使用一个非常细的针来抽取可疑组织团块中的流体和细胞。 In FNA, a very thin needle to extract the suspicious tissue mass of fluid and cells. 这种方法带来的疼痛较小,因为低痛以致于不必总是使用局部麻醉剂,因为应用局部麻醉剂可能比细针抽吸本身还痛。 This method brings less pain, pain due to low so that the need to always use a local anesthetic, a local anesthetic because the application itself may also be painful than the fine needle aspiration. 然而,在某些FNA程序中,通过所述程序仅能获得少量细胞,因而在分析可疑组织的某些情况下不是很有效,并且如果发现样本是恶性时评估癌的发展阶段并不简单。 However, in some FNA procedures, only a small number of cells obtained by the procedure, thus not very effective in some cases analysis of suspicious tissue, and if the sample is found during the evaluation phase of development of malignant cancer is not easy.

[0007] 在某些芯针活检程序中,可移取一个小的组织样本用于组织的病理评价,包括评价发现的任意癌细胞的进展。 [0007] In some core needle biopsy procedures, a small removable take tissue samples for pathology evaluation of tissue, including cancer cells progress in any evaluation found.

[0008] 可以在市场上买到的Ethicon Endo-Surgery, Inc.的商品名为ΜΑΜΜ0Τ0ΜΕ的活检器械通常可在真空辅助下通过一次插入乳房组织中取得多份芯针活检样本。 [0008] commercially available in the market, Ethicon Endo-Surgery, Inc. under the trade name ΜΑΜΜ0Τ0ΜΕ biopsy instrument made in breast tissue may be generally more than one core biopsy sample is inserted through the vacuum assist. 具体而言,切割器管伸展到探头中以切取在真空辅助下脱垂入侧孔内的组织,随后在切割之间完全收回切割器管以提取样本。 Specifically, the cutting tube extends into the probe to cut tissue in a vacuum assisted prolapse into the side hole, then cut between the cutter tube is fully retracted to extract the sample.

[0009] 对于具有相对较长的切割冲程的装置,样本的提取率不仅受旋转或复位探头所需时间的限制,而且受平移切割器所需时间的限制。 [0009] For the cutting apparatus with a relatively long stroke, the extraction rate of the sample is only limited by the time required to rotate or reset of the probe, and time constraints required by translating cutter. 作为相对“长冲程”活检装置的替代,“短冲程”活检装置记载在下面共同受让的专利申请中:美国专利申请10/676,944,名称“Biopsy Instrument with Internal Specimen Collection Mechanism,,,申请日为2003年9月30日,申请人Hibner等,美国公开号为2005/0215921 ;和美国专利申请10/732,843,发明名称为“Biopsy Device with Sample Tube”,申请日为2003年12月10日,申请人Cicenas等,美国公开号为2004/0153003,上述两者通过参考结合入本文。切割器可以循环通过基本等于或稍微大于跨过侧孔距离的距离,以减少取样时间。 As an alternative relatively "long stroke" biopsy device, a "short stroke" biopsy device is described in the following commonly assigned patent applications: U.S. Patent Application No. 10 / 676,944, entitled "Biopsy Instrument with Internal Specimen Collection Mechanism ,,, Application date of September 30, 2003, the applicant Hibner et al., U.S. Publication No. 2005/0215921; and U.S. Patent application No. 10 / 732,843, entitled "Biopsy Device with Sample Tube", filed December 10, 2003 applicant Cicenas al., US Publication No. 2004/0153003, both of which is incorporated herein by reference. the cutter may be circulated through substantially equal to or slightly greater than the distance across the side aperture distance to reduce the sampling time.

[0010] 下述专利文件公开了多种活检装置,在此将它们全部通过引用结合入本文:2001年8月14日授权的US 6,273,862 ;2001年5月15日授权的US 6,231,522 ;2001年5月8日授权的US 6,228,055 ;2000年9月19日授权的US 6,120,462 ;2000年7月11日授权的US 6,086,544 ;2000年6月20日授权的US 6,077,230 ;2000年I月25日授权的US 6,017,316 ;1999年12月28日授权的US 6,007,497 ; 1999年11月9日授权的US 5,980,469 ;1999 年10 月12 日授权的US 5,964,716 ;1999 年7 月27 日授权的US5,928, 164 ; 1998 年7 月7 日授权的US 5, 775, 333 ; 1998 年6 月23 日授权的US 5, 769, 086 ;1997 年7 月22 日授权的US 5,649,547 ; 1996 年6 月18 日授权的US 5,526,822 ;和Hibner等的美国专利申请2003/0199753,公开于2003年10月23日。 [0010] The following patent documents disclose various biopsy devices, which are all hereby incorporated by reference herein: August 14, 2001 authorized US 6,273,862; US 15 May 2001 authorized 6 , 231,522; May 8, 2001 authorized US 6,228,055; September 19, 2000 authorized US 6,120,462; July 11, 2000 authorized US 6,086,544; June 20, 2000 authorized the US 6,077,230; on May 25, 2000 I authorized US 6,017,316; December 28, 1999 authorized US 6,007,497; November 9, 1999 authorized US 5,980,469; October 12, 1999 authorized US 5,964,716; July 27, 1999 authorized US5,928, 164; July 7, 1998 authorized the US 5, 775, 333; June 23, 1998 authorized the US 5, 769 , 086; 1997 July 22 authorized US 5,649,547; June 18, 1996 authorized US 5,526,822; and US Patent application 2003/0199753 Hibner, etc., published in October 2003 23rd. 上面通过参考结合入本文的美国专利5526852公开了一种组织样本盒,包括带传动的可旋转的样本盒。 The above incorporated by reference herein U.S. Patent 5,526,852 discloses a tissue sample cassette, including a rotatable sample cartridge tape drive. 其他组织样本存储组件公开于如下申请中:美国专利申请10/953,395,发明名称为“Biopsy Devicewith Sample Storage”、申请日为2004年9月29日,美国公开号为2006/0074343的专利申请;和美国专利申请11/198,558,申请日为2005年8月8日,发明名称为“Biopsy Devicewith Replaceable Probe and Incorporating Vibration Insertion Assist and StaticVacuum Source Sample Stacking Retrieval”,美国公开号为2007/0032741,它们都在此通过引用结合入本文。 Other tissue sample storage components are disclosed in the following applications: US Patent Application No. 10 / 953,395, entitled "Biopsy Devicewith Sample Storage", filed September 29, 2004, US Publication No. 2006/0074343 patent application ; and US Patent application No. 11 / 198,558, filed August 8, 2005, entitled "Biopsy Devicewith Replaceable Probe and Incorporating Vibration Insertion Assist and StaticVacuum Source Sample Stacking Retrieval", US Publication No. 2007/0032741, which are incorporated herein by reference herein.

发明内容 SUMMARY

[0011] 虽然已经制造和·使用了各种各样的活检装置,并且设计了各种各样的组织样本存储组件和技术,但是相信没有人在发明人之前制造或使用了如所附权利要求所述的活检系统。 [0011] Although the manufacture and use of a variety of · biopsy device, and various design and tissue sample storage assembly techniques, it is believed that no one manufacture or use as claimed in the appended claims prior to the inventors said biopsy system.

[0012] 更具体地说,本发明涉及了如下内容: [0012] More particularly, the present invention relates to the following:

[0013] (I)、一种活检装置,包括: [0013] (I), A biopsy device, comprising:

[0014] (a)从活检装置向远侧延伸的套管; [0014] (a) a cannula extending distally from the biopsy device;

[0015] (b)能够相对于所述套管平移的管状切割器,所述管状切割器具有近端和远端,所述切割器的远端用于切断接收在所述套管中的组织;和 [0015] (b) with respect to the tubular cutter translatable cannula, the tubular cutter having a proximal end and a distal end, the distal end of the cutter for severing tissue received in the cannula in ;with

[0016] (C)设置在所述管状切割器近侧的组织存储组件,所述组织存储组件用于接收被所述管状切割器切断的组织样本,所述组织存储组件包括: [0016] (C) tissue storage assembly disposed proximal of the tubular cutter, the tissue storage assembly for receiving tissue samples severed the tubular cutter, the tissue storage assembly comprising:

[0017] (i)设置在所述活检装置的近端的大致透明的盖罩, [0017] (i) provided at the proximal end of the biopsy device substantially transparent cover,

[0018] (ii)至少部分设置在所述大致透明的盖罩内的可旋转部件, [0018] (ii) at least partially disposed within the generally transparent cover member rotatable within the housing,

[0019]和 [0019] and

[0020] (iii)由所述可旋转部件可拆卸地承载的至少一个组织保持[0021] 架,所述组织保持架能够接收多个组织样本。 [0020] (iii) at least one tissue of the rotatable member carried removably hold the [0021] frame, the tissue holder is capable of receiving a plurality of tissue samples.

[0022] (2)、如第(I)项所述的活检装置,其中,所述可旋转部件包括用于将真空引导到所述组织保持架的一部分的集合管。 [0022] (2), as described in Section (I) according to item biopsy device, wherein the rotatable member includes means for directing a vacuum to the tissue holder part of the manifold.

[0023] (3)、如第(I)项所述的活检装置,其中,所述可旋转部件能够根据所述管状切割器的平移而旋转一个预定量。 [0023] (3), as described in Section (I) according to item biopsy device, wherein said predetermined amount can be rotated according to a translation of the tubular cutter rotating member.

[0024] (4)、如第(I)项所述的活检装置,其中,所述可旋转部件能够可选择地顺时针或者逆时针旋转。 The term [0024] (4), as described in Section (I) a biopsy device, wherein the rotatable member can be selectively clockwise or counterclockwise.

[0025] (5)、如第(I)项所述的活检装置,包括由所述可旋转部件可拆卸地承载的多个组织保持架,所述多个组织保持架的每个被配置成保持至少一个组织样本。 [0025] (5), as described in Section (I) according to item biopsy device, comprising a plurality of tissue by the rotatable member holder releasably carries a plurality of tissue holders being configured to each maintaining at least a tissue sample.

[0026] ¢)、如第(I)项所述的活检装置,其中,所述组织保持架包括多个凹槽,每个凹槽被配置成接收被切断的组织样本。 The biopsy device according to item) [0026] ¢), as described in Section (I, wherein the tissue holder comprises a plurality of grooves, each groove is configured to receive a severed tissue sample.

[0027] (7)、如第(6)项所述的活检装置,其中,所述组织保持架具有径向向内表面和径向向外表面,其中所述组织保持架包括由所述径向向外表面限定的多个凹槽。 [0027] (7), biopsy device as described in the item (6), wherein the tissue holder has a radially outer surface and a radially inwardly facing surface, wherein the tissue holder comprises a path a plurality of grooves defined outwardly of the surface.

[0028] (8)、如第(6)项所述的活检装置,其中,所述组织保持架具有径向向内表面和径向向外表面,其中所述组织保持架包括由所述径向向内表面限定的多个凹槽。 [0028] (8), biopsy device as described in the item (6), wherein the tissue holder has a radially outer surface and a radially inwardly facing surface, wherein the tissue holder comprises a path a plurality of recesses defined by the inwardly-facing surface.

[0029] (9)、如第(I)项所述的活检装置,其中,所述组织保持架包括至少一根挠性的组织样本带,所述组织样本带至少部分地围绕所述可旋转部件的圆周延伸。 [0029] (9), as described in Section (I) according to item biopsy device, wherein the tissue holder comprises at least one flexible tissue sample strip, the tissue sample with at least partially surrounding said rotatable circumferentially extending member.

[0030] (10)、如第⑴项所述的活检装置,包括至少三根挠性的组织样本带,每根所述组织样本带部分地围绕所述可旋转部件的圆周延伸。 [0030] (10), such as a biopsy apparatus according ⑴ item, comprising at least three flexible tissue sample strip, each of said tissue sample strip extending partially around the circumference of the rotatable member.

`[0031] (11)、如第(I)项所述的活检装置,其中,所述可旋转部件包括多个沿周向间隔开的径向延伸部。 `[0031] (11), as described in Section (I) according to item biopsy device, wherein the rotatable member includes a plurality of circumferentially spaced apart portions extending radially.

[0032] (12)、如第(11)项所述的活检装置,其中,所述组织保持架被成形为与所述可旋转部件的所述径向延伸部接合。 The biopsy device according to item [0032] (12) as (11), wherein the tissue holder is shaped to engage the radially extending portion of the rotatable member.

[0033] (13)、如第(11)项所述的活检装置,其中,所述组织保持架包括挠性的组织样本带,其中所述挠性组织样本带被成形为能提供设置在所述可旋转部件的相邻径向延伸部之间的组织样本凹槽。 [0033] (13), of biopsy device (11), wherein the tissue holder comprises a flexible tissue sample strip, wherein the flexible tissue sample strip is shaped to provide energy in the set said rotatable member adjacent radially extending groove between the tissue sample portion.

[0034] (14)、如第(I)项所述的活检装置,其中,所述组织保持架包括至少一根挠性的组织样本带,所述组织样本带包括多个组织样本凹槽,其中每个所述组织样本凹槽与延伸穿过所述挠性组织样本带的至少一个真空开口相关联。 [0034] (14), as described in Section (I) according to item biopsy device, wherein the tissue holder comprises at least one flexible tissue sample strip, the tissue sample strip comprising a plurality of tissue sample recesses, wherein the at least one opening of each said associated vacuum tissue sample recess extending through the flexible tissue sample strip.

[0035] (15)、一种与活检装置一起使用的组织样本存储组件,所述组织样本存储组件包括: [0035] (15), a tissue sample storage assembly for use with a biopsy device, the tissue sample storage assembly comprising:

[0036] (a)可拆卸的盖罩; [0036] (a) a removable cover;

[0037] (b)至少部分地设置在所述盖罩内的可旋转集合管,所述集合管具有至少一个真空通路;和 [0037] (b) at least partially disposed within said cover rotatable manifold, said manifold having at least one vacuum passageway; and

[0038] (C)设置在所述集合管外表面上并绕至少部分集合管外表面延伸的至少一根组织样本带。 [0038] (C) provided on the outer surface of the manifold and the manifold at least partially around the at least one tissue sample with an outer surface extending.

[0039] (16)、如第(15)项所述的组件,其中,所述可拆卸盖罩是大致透明的。 [0039] (16), as item (15) of said assembly, wherein said removable cover is substantially transparent.

[0040] (17)、如第(15)项所述的组件,还包括绕所述集合管的外表面设置的多根组织样本带,每根所述组织样本带被配置为保持至少一个组织样本。 [0040] (17), as described in item (15) assembly further comprising a plurality of tissue samples with an outer surface of the manifold around the set, each of said tissue sample strip is configured to hold at least one tissue sample. [0041] (18)、如第(15)项所述的组件,其中,所述至少一根组织样本带的至少一部分是可透射线的。 [0041] (18), as described in item (15) assembly, wherein the at least one tissue sample with at least a portion is radiopaque.

[0042] (19)、一种活检方法,包括如下步骤: [0042] (19) A biopsy method comprising the steps of:

[0043] (a)提供一种活检装置,所述活检装置具有套管、平移切割器和设置在所述切割器近侧的组织样本保持架,其中至少部分所述组织样本保持架是透明的,并且所述组织样本保持架提供多个组织存储室; [0043] (a) to provide a biopsy device, the biopsy device having a cannula, and translating cutter disposed in the cutter proximal tissue sample holder, wherein at least a portion of the tissue sample holder is transparent and the tissue sample holder provides a plurality of tissue storage chambers;

[0044] (b)将所述套管插入到待取样的组织团块中; [0044] (b) inserting the cannula into the tissue mass to be sampled;

[0045] (C)平移所述切割器,以从所述组织团块中切断第一组织样本; [0045] (C) translating the cutter, to cut from the tissue mass in a first tissue sample;

[0046] (d)将第一组织样本向近侧传送穿过所述切割器到达所述组织样本保持架内的第 [0046] (d) the first tissue samples through the cutter holder reaches the first tissue sample proximally within the transmitted frame

一存储室; A storage compartment;

[0047] (e)重新定位所述组织样本保持架,以给出空的第二存储室,用来收集第二组织样本; [0047] (e) repositioning the tissue sample holder to a second given empty storage compartment for collecting a second tissue sample;

[0048] (d)在不从组织团块移除所述套管的情况下使用所述切割器从组织团块切断第二组织样本;和 [0048] (d) using the cutter without removing the cannula from the tissue mass cut a second tissue sample from the tissue clumps; and

[0049] (e)将第二组织样本向近侧传送穿过所述切割器到达所述组织样本保持架内的第 [0049] (e) a second tissue sample proximally through the cutter reaches transmits the tissue sample holder of the rack

二存储室。 Two storage rooms.

[0050] (20)、如第(19)项所述的方法,其中,所述组织样本保持架的重新定位动作包括旋转所述组织样本保持架以使第二存储室与一个端口对准。 [0050] (20), as in the first (19) The method according to item, wherein the tissue sample holder frame repositioning operation comprises rotating the tissue sample holder such that a second port is aligned with the storage chamber. ·附图说明 · Brief Description

[0051] 虽然说明书以特别指出和明确要求保护本发明的权利要求书作为总结,但相信通过参考附图的下述描述将可更好的理解本发明,其中: [0051] While the specification particularly pointing out and distinctly claimed in the present invention is claimed as claims summary, it is believed by the following description with reference to the accompanying drawings will be better understanding of the invention, wherein:

[0052] 图1是本发明的一种实施方式的具有组织样本存储组件的活检装置的示意图; [0052] FIG. 1 is a schematic view of a biopsy device having a tissue sample storage assembly according to an embodiment of the present invention;

[0053]图2是本发明一种实施方式的具有组织样本存储组件的活检装置的示意图,其中活检装置的一些部分被移除,以便示出装置的内部构件,并且其中切割器处于缩回位置。 [0053] FIG. 2 is a schematic view of a biopsy device having a tissue sample storage assembly according to an embodiment of the present invention, with portions of the biopsy device removed to illustrate internal components of the apparatus, and wherein the cutter in a retracted position .

[0054] 图2A是沿图2中2A-2A剖面得到的截面示意图。 [0054] FIG. 2A is a schematic sectional view along 2A-2A in FIG. 2 a sectional obtained.

[0055] 图3是本发明一种实施方式的具有组织样本存储组件的活检装置的示意图,其中活检装置的局部被移除,以便示出装置的内部构件,并且其中切割器前进经过组织接收端□。 [0055] FIG. 3 is a schematic view of a biopsy device having a tissue sample storage assembly according to an embodiment of the present invention, wherein the biopsy device is partially removed to illustrate internal components of the device, and wherein the cutter advances through the tissue receiving end □.

[0056]图4是本发明一种实施方式的具有组织样本存储组件的活检装置的示意图,其中活检装置的局部被移除,以便示出装置的内部构件,并且显示了组织样本被存放在组织样本保持架上。 [0056] FIG. 4 is a schematic view of a biopsy device having a tissue sample storage assembly according to an embodiment of the present invention, wherein the local biopsy device removed to show the interior components of the apparatus, and shows the tissue samples are stored in tissue sample holder.

[0057]图5是本发明一种实施方式的具有组织样本存储组件的活检装置的示意图,其中活检装置的局部被移除,以便示出装置的内部构件,并且显示了切割器的缩回和组织样本保持架的转位(indexing)。 [0057] FIG. 5 is a schematic view of a biopsy device having a tissue sample storage assembly according to one embodiment of the present invention, wherein the local biopsy device removed to show the interior components of the apparatus, and shows a retracted cutter and a tissue sample holder indexing frame (indexing).

[0058] 图6提供了一种示例性组织存储组件的放大图。 [0058] FIG 6 provides an enlarged view of an exemplary tissue storage assembly.

[0059] 图7提供了图6所示的组织存储组件的构件的分解图。 [0059] Figure 7 provides an exploded view of the components of the tissue storage component shown in FIG. 6.

[0060] 图8提供了图6所示的组织存储组件的构件的剖视图。 [0060] FIG. 8 provides a cross-sectional view of the tissue storage assembly member shown in Fig.

[0061] 图9是具有径向延伸翼片和用于在相邻翼片之间传送真空的真空端口的集合管的示意图。 [0061] FIG. 9 is a schematic view of manifold having radially extending fins and vacuum ports for conveying vacuum between adjacent fins of.

[0062] 图10图示了组织保持架的另一种替代实施方式。 [0062] FIG. 10 illustrates a tissue holder of another alternative embodiment.

[0063] 图11图示了组织保持架的又一种替代实施方式。 [0063] FIG. 11 illustrates a tissue holder of yet another alternative embodiment.

[0064] 图1lA图示了处于相对扁平构造的图11的组织保持架。 [0064] FIG. 1lA relatively flat configuration illustrated in FIG. 11 of the tissue holder.

[0065] 图12图示了用于以端-端构型保持组织样本的组织保持架。 [0065] In FIG. 12 illustrates an end - the end configuration of the tissue sample holder tissue holder.

[0066] 图12A是沿图12的线12A-12A截取的截面示意图。 [0066] FIG. 12A is a schematic sectional view along the line 12A-12A 12 taken.

[0067] 图12B是沿着图12所示的组织样本保持架的长度的一部分得到的剖视图。 [0067] FIG. 12B is a cross-sectional view of a portion of the length of the shelf was kept along the tissue sample 12 shown in FIG.

[0068] 图13是示例性套管的远侧部分的示意图。 [0068] FIG. 13 is a schematic view of a distal portion of an exemplary sleeve.

[0069] 图14是当切割器在切割器腔中相对于组织接收孔前进和缩回时,在真空腔中提供的真空水平的示意图。 [0069] FIG. 14 when the tissue receiving aperture to advance and retract, providing a schematic view of vacuum level in the vacuum chamber with the cutter in the cutter lumen.

[0070] 图15是可与活检装置一起使用的气动控制结构的示意图。 [0070] FIG. 15 is a schematic view of a pneumatic control configuration that may be used with the biopsy device.

[0071] 图16显示了可以用于控制活检装置的多种控制状态。 [0071] Figure 16 shows a plurality of control states can be used to control biopsy device.

具体实施方式 Detailed ways

[0072] 图1显示了根据本发明一种实施方式的活检装置10。 [0072] Figure 1 shows a biopsy device 10 according to one embodiment of the present invention. 所述实施例的活检10包括一个手持件,总体标记为附图标记30。 Biopsy of the described embodiment includes a handpiece 10, the reference numeral 30 generally. 手持件30可以用单手舒服的握住,并可以使用单手操作。 The handpiece 30 with one hand can comfortably hold, and may be used one-handed operation. 活检装置10可以包括组织穿刺部分,例如套管100,其从手持件30向远侧伸出。 Biopsy device 10 can include a tissue piercing portion, such as a casing 100, which extends distally from the handpiece 30. 套管100可以包括远侧组织穿刺尖端110和与尖端110在近侧隔开的横向组织接收孔114。 Sleeve 100 may include a distal tissue piercing tip 110 and the tip 110 proximally spaced transverse tissue receiving aperture 114. 套管100可以插入到待取样的组织团块中。 Cannula 100 may be inserted into the tissue mass to be sampled. 然后被吸入孔114的组织可以被能够在套管100中平移的管状切割器120的远端122切断(图2)。 Then tissue is drawn into holes 114 may be translatable sleeve 100 in the distal end 122 of the tubular cutter 120 of the cutting (FIG. 2).

[0073] 该实施例的活检装置10还包括组织存储组件2000,其可以被放置在手持件30的近端,位于切割器120近侧。 [0073] The biopsy device 10 of this embodiment further comprises a tissue storage assembly 2000, which may be placed at the proximal end of the handpiece 30, proximal cutter 120 is located. 组织存储组件2000可以包括一个大致透明的盖罩2010,其可拆卸地连接到活检装置10例如手持件30的近端上。 Tissue storage assembly 2000 can include a generally transparent cover 2010, which is detachably connected to the proximal end of the biopsy device 30 of the handpiece 10, for example. 当然,盖罩2010可以大致半透明、不透明、透明和不透明结合,等等,或具有任意其他合适的性质。 Of course, the cover 2010 may be substantially translucent, opaque, transparent and opaque binding, and the like, or have any other suitable properties. 盖罩2010可以通过任意合适的连接机构或特征可拆卸地连接到手持件30的近端,包括但不限于通过卡扣配合、卡口配合、螺纹型配合,等等。 The cover 2010 may be detachably connected by any suitable attachment mechanism or feature to the proximal end of the handpiece 30, including but not limited to by snap fit, bayonet fitting, screw-type fitting, and the like. 在图1中,盖罩2010具有一个能与手持件30的近端可松开地卡扣配合的凸缘2012。 In Figure 1, the cover 2010 has a proximal end of the handpiece 30 can be releasably snap-fitted to the flange 2012.

[0074] 显示出的组织存储组件2000还包括设置在可拆卸盖罩2010内的至少一个组织保持架2200,保持架2200可松开地承载于一个可旋转构件上。 [0074] shows the tissue storage assembly 2000 further includes a cover removably disposed within the at least one tissue holder 2200 2010, holder 2200 may be releasably carried on a rotatable member. 在该实施例中,可旋转构件是集合管(manifold) 2300的形式(图7),但是也可以使用其它结构或构造。 In this embodiment, the rotatable member is a manifold (Manifold) form (FIG. 7) 2300, but may also be practiced using other structure or configurations. 集合管2300可以至少部分地放置在盖罩2010内。 Manifold 2300 may be at least partially disposed within the cover 2010. 组织样本保持架2200可以被成形或构造成能够容纳多个组织样本(总体用附图标记42表示),例如被切割器120切断的样本顺序间隔开地置于保持架2200上。 Tissue sample holder 2200 can be shaped or configured to be capable of accommodating a plurality of tissue samples (generally by reference numeral 42), for example, 120 samples are sequentially cut cutter disposed spaced apart holding frame 2200.

[0075] 该实施例的可旋转集合管2300和组织保持架2200可以是自动旋转的,例如每次组织样本42被切断时就转位一个预定角度增量,如下所述。 [0075] This embodiment of the rotatable manifold 2300 and the tissue holder 2200 may be automatically rotated, for example, every time a predetermined indexing organizations angular increment as the sample 42 is cut, as described below. 在用户希望“超驰(override) ”自动转位的情况下,可以提供一个手动旋钮2020以允许手动旋转集合管2300和组织保持架2200。 In the case where the user desires to "override (the override)" automatic indexing may be provided a manual knob 2020 to permit manual rotation of the manifold 2300 and the tissue holder 2200. 组织存储组件2000还可以包括致动器,例如控制杆2040,其用于选择在透明盖罩2010内的可旋转集合管2300和组织保持架2200转位的方向(顺时针或逆时针)。 Tissue storage assembly 2000 may further include an actuator, such as a control lever 2040 for selecting the transparent cover in a direction of the rotatable manifold 2300 and the tissue holder 2010 in the frame 2200 indexing (clockwise or counterclockwise). 当然,如在这里描述的其他的部件那样,旋钮2020和杆2040仅仅是可选择的,可以按照要求修改、替代、补充、或省略。 Of course, like other components described herein above, knob 2020 and lever 2040 is only optional, as required can be modified, substituted, supplemented, or omitted.

[0076] 根据本发明一种实施方式的采用组织存储组件2000的活检装置的操作顺序在图2至5中被说明。 [0076] The operation sequence using the biopsy apparatus the tissue storage assembly 2000 of one embodiment of the present invention is illustrated in FIGS. 2 to 5. 在图2至5中,通过移除盖罩2010来显示组织存储组件2000。 In FIGS. 2-5, by removing the cover 2010 to show the tissue storage assembly 2000. 图6、7和8更详细地图示了该实施例的组织存储组件2000。 6, 7 and 8 illustrate the tissue storage assembly 2000 of this embodiment in more detail.

[0077] 参照图2,其中显示了适合用于立体定向的示例性活检装置10的内部构件。 [0077] Referring to Figure 2, there is shown an exemplary inner member adapted for stereotactic biopsy device 10. 在图2中,显示出的套管100处于对应于套管100已经通过击发组件150穿入组织中的“击发”位置。 In FIG. 2, showing the position corresponding to the sleeve 100 the sleeve 100 has passed through the firing assembly 150 into tissue in the "firing" position. 该实施例的击发组件150包括击发叉架152,在用于击发的能量存储在击发弹簧158中时,击发叉架152可以处于准备击发状态(例如通过手动的准备击发器械或通过准备击发马达156)。 The firing assembly 150 of this embodiment includes a firing fork 152, storing energy in the firing spring 158 during firing, the firing fork 152 may be cocked state (e.g., by a manual cocking apparatus or by a cocking motor 156 ). 替代地,击发组件150可以具有任意其他合适的构造或可以省略。 Alternatively, firing assembly 150 may have any other suitable configuration or may be omitted.

[0078] 在该实施例中管状切割器120放置在套管100的切割器腔104内。 [0078] In this embodiment, the tubular cutter 120 is placed within the cutter lumen 104 of cannula 100. 在图2中,示出的切割器120处于缩回位置,切割器120的远侧切割末端122 (显示为虚线)刚好处于套管100中组织接收孔114的近侧位置。 In FIG. 2, shown in the retracted position of the cutter 120, the cutter 120 of the distal cutting tip 122 (shown in phantom) in the sleeve 100 just tissue receiving aperture 114 of proximal position. 在示例性工作模式下,当将套管100击发入组织后,切割器120缩回到图2所示的位置。 In an exemplary mode of operation, when firing the cannula 100 into tissue, the cutter 120 is retracted to the position shown in FIG.

[0079] 参照图2和图2A,套管100还可以包括设置在切割器腔104之下的真空腔108。 [0079] Referring to FIGS. 2 and 2A, the sleeve 100 may further include a cutter lumen 104 beneath the vacuum chamber 108. 当套管100被放置入组织,并且切割器120处于如图2所示的缩回位置时,该实施例的真空腔108通过多个通路107 (图13)将真空传递到恰好在端口或孔114之下的切割器腔104中,以帮助将组织吸入到端口114中。 When the cannula 100 is placed into tissue, and the cutter 120 is in the retracted position shown in FIG. 2, this embodiment of the vacuum chamber 108 to pass just vacuum ports or apertures by a plurality of passages 107 (FIG. 13) 104 below the cutter lumen 114 to aid in the tissue drawn into the port 114. 切割器120从远侧切割末端122延伸到切割器近端124。 Cutting the cutter 120 extends from the distal tip 122 to the cutter proximal end 124. 在远侧切割末端122和近端124中间,切割器120通过套管100的切割器腔104、真空集合管300、盐水/真空阀组件4080和切割器齿轮410。 The distal cutting tip 122 at the proximal end 124 and an intermediate cut 120 through cutter lumen 104 of cannula 100, a vacuum manifold 300, saline / vacuum valve assembly 4080 and a cutter gear 410.

[0080] 在该实施例中,切割器120的近端124与组织样本传输管2030的远端连接。 [0080] In this embodiment, the proximal end 124 of the cutter with the tissue sample transfer tube 120 is connected to the distal end 2030. 样本传输管2030可以是一个柔性管,通过滑配接头2028或允许切割器末端124相对于管2030作相对轴向运动和转动的其他合`适的连接件连接到切割器120的近端124。 Sample transfer tube 2030 can be a flexible tube, through the slip joint 2028, or allow the cutting tip 124 relative to the proximal tube 2030 for relative axial movement of the connecting member and the other engagement `suitable rotatably connected to the cutter 120 124. 样本传输管2030的近端连接到组织存储组件2000的近侧盖罩2050的组织样本端口2057上。 The proximal end of the sample transfer tube 2030 is connected to the tissue storage assembly 2000 of proximal cover 2050 of the tissue sample port 2057. 近侧盖罩2050包围组织存储组件2000的近端。 Proximal cover 2050 encloses the proximal end of the tissue storage assembly 2000. 近侧盖罩2050和基本透明的盖罩2010 —起形成了组织存储室,集合管2300和组织保持架2200至少部分地放置在组织存储室中。 The proximal cover 2050 and substantially transparent cover 2010 - formed from the tissue storage chamber, the manifold 2300 and the tissue holder 2200 is at least partially disposed in the tissue storage chamber. 端口2057和用于传递真空到集合管2300的真空端口2060可以与盖罩2050形成为一个整体。 And a port 2057 for communicating vacuum to the manifold vacuum port 20602300 2050 may be formed with the cover as a whole. 这里的教导是为了便于理解,然而,样本传输管2030可以根据需要被修改、替代、补充、或省略;并且其他各种构件或部件可以用来提供切割器120和组织存储组件2000之间的流体通道。 Teachings herein to facilitate understanding, however, the sample transfer tube 2030 may be modified as necessary, substituted, supplemented, or omitted; and various other members or parts 2000 may be used to provide fluid communication between cutter 120 and tissue storage assembly aisle.

[0081] 通过切割器120切取的组织样本42可以被运输通过切割器120,然后通过样本传输管2030,被放置在组织存储组件2000的组织存储室中。 [0081] tissue sample cut by the cutter 120 taken 42 can be transported through cutter 120, then through sample transfer tube 2030, to be placed in the tissue storage assembly 2000 of the tissue storage chamber. 通过在盖罩2050或其他位置的真空端口2060从真空源向组织存储组件2000提供真空。 Through vacuum port cover 2050 or 2060 is provided elsewhere in the vacuum from the vacuum source to the tissue storage assembly 2000. 在该实施例中,通过在盖罩2050上的端口2057进入组织存储室中的组织样本42放置在组织保持架2200上。 In this embodiment, the port 2057 on the cover 2050 by a tissue sample into the tissue storage chamber 42 is placed on the tissue holder 2200.

[0082] 近侧盖罩2050还可以包括进入开口2052,如图6所示。 [0082] The proximal cover 2050 can also include an access opening 2052, as shown in FIG. 集合管旋转齿轮2350的齿2354可以通过开口2052与分度棘爪2362啮合。 Manifold rotation gear 2350 engages the teeth 2354 through opening 2052 may be 2362 with the indexing pawl. 集合管旋转齿轮2350可以通过花键连接件或其他合适的连接件与集合管2300连接在一起,由此使齿轮2350的转动导致集合管2300也旋转。 Manifold rotation gear 2350 by spline connection or other suitable connection member 2300 connected to the manifold, whereby the rotation of the gear 2350 cause the manifold 2300 also rotates.

[0083] 在该实施例中,近侧盖罩2050包括可以被活检装置10主体的配合半部(未显示)捕获的凸缘2056,使盖罩2050可以绕组织存储组件2000的纵向轴线2055 (图6)旋转。 [0083] In this embodiment, the proximal cover 2050 includes a biopsy device may be fitted to the body halves 10 (not shown) to capture flange 2056, so that the cover 2050 may be rotated about the longitudinal axis 2055 of the tissue storage assembly 2000 ( FIG. 6) is rotated. 杆2040可以被用于使盖罩2050(和接触开口2052)从第一个点钟位置沿周向旋转到第二个点钟位置。 2040 may be used to lever the cover 2050 (and 2052 contact opening) from a first o'clock position to a second o'clock position is rotated to the circumferential direction. 当杆2040处于如图(例如,图1和6)所示的位置时,棘爪2362通过开口2052啮合齿2354。 When the lever 2040 is shown in FIG (e.g., FIGS. 1 and 6) in the position shown, the ratchet engaging the teeth 2354 through opening 2362 2052. 当杆2040被重新定位到活检装置外壳上的缝62的另外一端时(图1),盖罩2050和接触开口2052被旋转以使棘爪2364啮合齿2354。 When the other end of the lever 2040 is repositioned to the slit 62 of the biopsy device housing (FIG. 1), the cover 2050 and the opening 2052 are rotated to the contact pawl 2364 engages the teeth 2354. 棘爪2362提供了集合管2300绕轴线2055沿着一个方向的分度转位,而棘爪2364提供了集合管2300绕轴线2055沿着相反方向的分度转位。 Providing manifold pawl 2362 about axis 2300 2055 an indexing in one direction, the pawl 2364 and 2300 provided around the manifold 2055 an indexing axis in the opposite direction.

[0084] 在该实施例中通过改变杆2040的位置,组织样本42进入到组织存储组件2000的进入点也同时改变。 [0084] By changing the position of the rod 2040. In this embodiment, the tissue samples 42 into the tissue storage assembly 2000 is also the entry point to change. 当杆2040的位置改变时端口2057的位置沿周向运动,同时传输管2030适应这种运动。 Port location 2057 along the circumferential direction movement, while the transfer tube 2030 accommodate such movement when the position of lever 2040 is changed. 在实施方式中显示出的组织样本的进入点偏离12点钟(正上)位置。 In the embodiment shown the entry point of the tissue sample deviates from 12 o'clock (NOW) position. 杆2040可以用于选择组织进入点在大约2点钟或大约10点钟位置,因此,在立体定向的环境中,样本进入组件2000可以通过组织存储组件2000的透明盖罩2010被使用活检装置10的操作者看到,活检装置10的顶部可靠近立体定向工作台的下侧表面放置。 2040 bar may be used to select the tissue entry point or from about 10 o'clock to about 2 o'clock position, and therefore, in a stereotactic environment, sample enters the assembly 2000 can be transparent tissue storage assembly 2000 of the cover 2010 biopsy device 10 is used the operator sees the top of the biopsy device 10 may be close to the lower side surface of the stereotactic placement table.

[0085] 需要理解的是,任何其他合适的结构或装置可以被用于附加或替代杆2040来重新定位端口2057。 [0085] should be appreciated that any other suitable structures or devices may be used additionally or alternatively lever 2040 to reposition port 2057. 例如,一个或多个马达或传动器可以用于选择性的重新定位端口2057。 For example, one or more motors or actuators may be used to selectively reposition port 2057. 可选择的是,端口2057的周向或角度位置可以被基本上固定(例如,在12点钟位置等等)。 Alternatively, the circumferential or port 2057 may be substantially fixed angular position (e.g., at 12 o'clock, etc.). 类似的,棘爪2362、2364可以根据需要改变、替代、补充或省略。 Similarly, the pawl can be changed 2362,2364, substituted, supplemented, or omitted.

[0086] 仍参照图2,切割器导螺杆510支承在活检装置10上,由切割器马达500旋转。 [0086] Still referring to FIG 2, a cutter lead screw 510 is supported on the biopsy device 10, the motor 500 rotates by the cutter. 螺杆510的旋转导致切割器架螺母520根据螺杆510的旋转方向而在螺杆510上前进或缩回。 Rotation of the screw 510 causes the cutter holder nut 520 is advanced or retracted on the screw 510 depending on the direction of rotation of the screw 510. 螺母520可以安装到切割器架530上或与之一体形成。 Nut 520 can be mounted to the cutter holder 530 or formed integrally therewith. 在该实施例中切割器120被可旋转地支承在架530上,由此在切割器架平移切割器120时切割器120可以通过齿轮410被旋转。 In this embodiment the cutter 120 is rotatably supported on the frame 530, thereby translating the cutter holder 120 when the cutter the cutter 120 may be rotated by the gear 410. 螺母520在螺杆510上的运动导致架530和切割器120根据马达500和螺杆510的旋转方向朝近侧(缩回)或远侧(前进)轴向平移。 Moving nut 520 on the screw 530 and the rack 510 causes the cutter 120 proximally toward the direction of rotation of the motor 500 and the screw 510 (retract) or distally (advance) axial translation. 由于切割器旋转齿轮410与驱动齿轮512啮合,可通过齿轮410使切割器120绕自身轴线转动。 Since the cutter rotation gear 410 meshed with the drive gear 512, the cutter 410 may be via a gear 120 rotates about its own axis. 驱动齿轮512的转动还可以由马达500提供动力。 Rotation of the drive gear 512 may also be powered by a motor 500. 启动马达500可使切割器120同时旋转和平移。 A starter motor 500 of the cutter 120 can simultaneously rotate and translate. 在图2中,所示出的切割器架螺母520在它的近侧(缩回)位置,该位置对应于切割器120的正好位于孔114的近侧的远端122。 In FIG. 2, the illustrated cutter holder nut 520 in its proximal (retracted) position, which corresponds to the cutter positioned just proximal the distal end 114 of the aperture 122 120.

[0087] 仍参照图2,棘爪2362可枢转地安装在棘爪滑块2360上。 [0087] Still referring to Figure 2, pawl 2362 is pivotably mounted on the pawl slide 2360. 在图2中,显示出的棘爪滑块2360在它的最近侧位置。 In FIG. 2, showing the pawl slide 2360 in its proximal-most position. 滑块2360由切割器架螺母520上的凸片延伸部522推向近侧。 Tabs extending from the slider 2360 on the cutter holder 522 toward the nut 520 proximally. 滑块2360向近侧的运动压缩滑块弹簧2361。 2360 compression slider slider spring 2361 to proximal movement. 当螺母520和凸片延伸部522在导螺杆510上向远侧前进时,被压缩的滑块弹簧2361可以被用于将滑块2360推向远侧(使滑块前进)。 When the nut portion 520 and a tab extending distally advance on the lead screw 510 522, the compressed springs 2361 may be used to slide the slider 2360 advanced distally (advance the slider). 当然,如果需要,弹簧2361可以被省略、改变等等。 Of course, if desired, the spring 2361 may be omitted, changed, and so on.

[0088] 在图2中显示的位置,活检装置10准备获取组织样本42。 [0088] In the position shown in FIG. 2, the biopsy device 10 is ready to obtain a tissue sample 42. 真空控制模块5000 (图15)可将真空引导到真空腔108,以吸引组织到孔114中。 Vacuum control module 5000 (FIG. 15) may be directed into the vacuum chamber 108 a vacuum to draw tissue into the hole 114. 参照图3,切割器120已经前进到它的最远侧位置以切断组织样本42,并且示出的切割器120延伸穿过套管100的孔114且封闭该孔114。 Referring to Figure 3, the cutter 120 has been advanced to its distal-most position to sever a tissue sample 42, and the cutter 120 is shown extending through the aperture 114 of the sleeve 100 and the bore 114 is closed. 当切割器120从图2所示的位置前进到图3所示的位置时,切割器120还在切割器旋转齿轮410的作用下旋转,旋转齿轮410由驱动齿轮512旋转。 When the cutter 120 advances from the position shown in FIG. 2 to the position shown in FIG. 3, the cutter 120 also rotates under the action of cutter rotation gear 410, the gear 410 is rotated by the rotation of the drive gear 512. 在图3中,架530和切割器120已经通过螺杆510上的螺母520的平移而前进。 In Figure 3, the cutter holder 530 and 120 have been advanced by translation of nut 520 on screw 510. 当螺母520向远侧运动时,凸片延伸部522也向远侧运动,由于弹簧2361的展开而将棘爪滑块2360推向远侧。 When the nut 520 moving distally, tab extension 522 also moves distally to expand due to the spring 2361 and into the pawl slide 2360 distally. 在切割器120从图2所示的位置向远侧前进到图3所示的位置时,棘爪2362被松开,并“越过”集合管齿轮2350的齿2354。 When the cutter 120 advances from the position shown in FIG. 2 distally to the position shown in FIG. 3, the pawl 2362 is released, and "across" the manifold gear teeth 2350 2354. [0089] 参照图4,示出的切断的组织样本42正脱离样本传输管2030,被放置在组织保持架2200上。 [0089] Referring to Figure 4, illustrating the tissue sample 42 severed from the positive sample transfer tube 2030, it is placed on the tissue holder 2200. 为了从套管100传递切断的组织样本42到组织存储组件2000,在切割器120处于它的最远侧位置盖住组织接收孔114的同时,真空腔108中的真空被切断,并使用真空控制阀为真空腔108提供大气压力。 In order to cut the tissue sample 100 from the delivery cannula 42 to the tissue storage assembly 2000, the vacuum control at the same time the cutter 120 to its distal-most position covering the tissue receiving aperture 114 of the vacuum chamber 108 is cut off in a vacuum, and used a vacuum valve provided an atmospheric pressure chamber 108. 附加的,或可替代地,可以提供盐水。 Additionally, or alternatively, it may be provided with brine. 可以使用阀将盐水向远侧引导通过套管100的真空腔108流到一个或多个孔或通路107,所述的孔或通路107在切割器腔104和套管100远端的真空腔108之间提供流体连通。 Saline may be guided distally one or more apertures or flow path through the vacuum lumen 108 of cannula 100 using valve 107, the hole or passage 107 in the cutter lumen 104 and vacuum lumen 108 of the distal end of the cannula 100 providing fluid communication between the. 盐水流和/或大气压力向被切割器120切断的组织样本上提供指向近侧的力,其向位于切割器120远侧部分的被切断的组织样本提供指向近侧的“推力”。 Brine stream and / or the atmospheric pressure provide a proximally directed force on the tissue sample severed by cutter 120, which provides a proximally directed "push" the severed tissue sample positioned in the distal portion of the cutter 120.

[0090] 另外,可以使用组织存储真空源传送真空到真空端口2060。 [0090] Additionally, a tissue storage vacuum source using a vacuum to the vacuum port 2060. 在端口2060提供的真空通过样本传输管2030被传送通过组织存储组件2000到达切割器120。 Vacuum ports provided in 2060 through the sample transfer tube 2030 is transmitted through tissue storage assembly to the cutter 1,202,000. 因此,在端口2060提供的真空在切割器120中的被切断的组织样本上施加了指向近侧的“拉力”。 Accordingly, vacuum provided at port 2060 on the severed tissue sample in the cutter 120 is applied to a proximally directed "pull." 在被切断组织样本上的指向近侧的“推力”和“拉力”的结合用于传送组织样本42穿过切割器120(从切割器的远端122到切割器的近端124)、穿过样本传输管2030(其可以如图8所示地延伸穿过盖罩2050上的开口)、进入组织存储组件2000并被放置在组织保持架2200的与样本传输管2030对准的部分(例如凹槽或室)上。 Binding proximally directed on the tissue sample is cut "push" and "pull" for transferring the tissue sample 42 through the cutter 120 (from the proximal end to the distal end of the cutter 122 of the cutter 124), through sample transfer tube 2030 (shown in Figure 8 which can extend through an opening in the cover 2050), and enter the tissue storage assembly 2000 is placed in a portion of the tissue holder 2030 are aligned with the sample transfer tube 2200 (e.g., concave grooves or chambers) on. 在图4中显示组织样本42被放置在组织保持架2200上。 4 is shown in FIG tissue sample 42 is placed on the tissue holder 2200. 向真空端口2060提供的真空在整个样本切割周期内都可以保持“接通”,从而在中空切割器120的内部一直存在真空压力。 Vacuum port 2060 to provide a vacuum in the entire sample can be kept "on" inner cutting cycle, so that there has been a vacuum pressure in the hollow interior of the cutter 120. 替代地,提供到真空端口2060的真空可以根据预定程序循环接通和断开。 Alternatively, the vacuum provided to vacuum port 2060 can be cycled on and off according to a predetermined program. 考虑到这里的教导,本领域普通技术人员可以想到其他可以将组织样本42从切割器远端122输送到组织保持架2200的方式,包括可以使用的结构和装置及流体传递参数。 View of the teachings herein, those of ordinary skill in the art can envision other tissue sample 42 may be conveyed from the cutter distal end 122 to the tissue holder 2200 hold mode, and a fluid including structures and devices that may be used to pass parameters.

[0091] 参照图5,集合管2300和组织保持架2200在切割器120缩回期间可以被旋转移位(如箭头标记R指出的)。 [0091] Referring to Figure 5, the manifold 2300 and the tissue holder 2200 during retraction of the cutter 120 can be rotationally displaced (as indicated by arrow labeled R). 马达500为导螺杆510的旋转提供动力,以便使螺母520、切割器架530和切割器120向近侧平移,从而打开套管100上的组织孔114。 The motor 500 provides rotational force of the lead screw 510, so that the nut 520, the cutter holder 530 and the cutter 120 translate proximally, thereby opening tissue aperture 100 114 on the sleeve. 当螺母520向近侧行进时,凸片延伸部522向近侧方向推动棘爪滑块2360,导致棘爪2362啮合齿2354并“向上”推齿2354,导致集合管齿轮2350(和集合管2300)沿着图5所示的方向“R”旋转。 When the nut 520 travels proximally, the tab extension portion 522 pushing the pawl slide 2360 in the proximal direction, causing pawl 2362 engages the teeth 2354 and the "Up" push tooth 2354, causing manifold gear 2350 (and manifold 2300 ) in the direction shown in FIG. 5 "R" of rotation. 组织保持架2200与集合管2300 ·—起旋转,并且定位成使其空的凹槽或室与端口2057和样本传输管2030对准。 Tissue holder 2200 and manifold 2300 · - from rotating, and positioned so that an empty recess or compartment 2057 and the port 2030 and sample transfer tube is aligned.

[0092] 在一种替代实施方式中,不是使用棘爪机构来使集合管2300转位,而是使集合管2300和组织保持架2200根据组织接收孔114的转动位置被旋转。 [0092] In an alternative embodiment, the detent mechanism is not used to make the indexing manifold 2300, but to make the manifold 2300 and the tissue holder 2200 is rotated according to the rotational position of the tissue receiving aperture 114. 例如套管100可相对于活检装置旋转,以将孔114定位在所需的时钟位置,例如使用指轮。 For example the sleeve 100 with respect to the biopsy device may be rotated to the hole 114 positioned at a desired position of a clock, for example, a thumbwheel. 美国专利6,602,203 (在此通过引用结合入本文)公开了用于旋转组织接收孔的指轮。 U.S. Patent No. 6,602,203 (herein incorporated by reference herein) discloses a thumbwheel for rotating a tissue receiving aperture. 如果需要,集合管2300和组织保持架2200可以设置成随孔114 一起旋转,因此在组织保持架2200上的每个组织保持凹槽或室对应于在组织取样期间孔114的特定点钟位置。 If desired, the manifold 2300 and the tissue holder 2200 may be provided with apertures 114 rotate together, so that each tissue holding frame 2200 in the tissue holding recess or compartment corresponds to a specific o'clock position of the hole 114 during tissue sampling. 在另一种替代实施方式中,可以使用马达500或单独的马达旋转组织保持架2200和集合管2300。 In another alternative embodiment, the motor 500 may be used alone or tissue holder rotation motor 2200 and manifold 2300. 可选的是,集合管2300可以使用任何其它合适的构件、部件、装置、或技术来旋转。 Alternatively, manifold 2300 may use any other suitable means, components, devices, or techniques rotation.

[0093] 在切割器120平移、例如当切割器120前进或缩回时组织保持架2200可以补充或替换地旋转一个预定量,由此针对切割器120的每个冲程,可旋转集合管2300重新定位支承在集合管2300上的组织保持架2200,使组织保持架2200 “设定在所需时钟位置”,以便接收在该切割器120冲程中被切断的组织样本42。 [0093] 120 translate the cutter, for example when the tissue holder 120 advance or retract the cutter 2200 may additionally or alternatively rotate a predetermined amount, whereby for each cutter 120 stroke, the rotatable manifold 2300 re positioning support manifold tissue held on the rack 2300 2200, the tissue holder 2200 "is set in the desired position clock", in order to receive the tissue sample 42 in the stroke of the cutters 120 is cut. 在一种实施方式中,开关或杆(例如,杆2040)可以被用于允许选择可旋转集合管的旋转方向为顺时针或逆时针。 In one embodiment, the switch or lever (e.g., lever 2040) may be used to allow selection of the direction of rotation of the rotatable manifold is clockwise or counterclockwise. 通过移动杆,组织样本进入组织存储组件的进入点也可以改变。 By moving the lever, the entry point of the tissue sample into the tissue storage assembly can also be changed. 例如,组织样本的进入点可以偏离12点钟位置(正上)。 For example, the entry point of the tissue samples may be offset from the 12 o'clock position (NOW). 在一种实施方式中,杆可以被用于选择组织进入点在大约2点钟或大约10点钟位置,从而在立体定向的环境中样本进入组件可以通过组织存储组件2000的透明盖罩2010被使用活检装置10的操作者看到,在所述立体定向环境中,活检装置10可以放置在立体定向工作台的下侧表面上或其他地方。 In one embodiment, the rod may be used to select the tissue entry point at about 2 o'clock or 10 o'clock position about to enter the sample components may be stereospecific environment by a transparent cover 2000 of the tissue storage assembly 2010 is the operator using the biopsy device 10 is seen in a stereotactic environment, the biopsy device 10 may be placed on the lower side surface of the stereotactic table or elsewhere.

[0094] 图6提供了该实施例组织存储组件2000的放大示意图。 [0094] Figure 6 provides an enlarged view of the embodiment of the tissue storage assembly 2000 of the embodiment. 图7提供了组织存储组件2000的构件的分解图。 Figure 7 provides an exploded view of the components of the tissue storage assembly 2000. 图8提供了组织存储组件2000的构件的截面图。 Figure 8 provides a cross-sectional view 2000 of the tissue storage assembly member. 图9是具有径向延伸翼片2320和用于在相邻翼片之间传送真空的真空端口2324的集合管2300的示意图。 9 is a schematic radially extending fins 2320 and vacuum ports for conveying vacuum between adjacent fins 2324 of the manifold 2300 having.

[0095] 参照图6至8,该实施例中的组织存储组件2000可以包括多个组织保持架2200。 [0095] Referring to FIGS. 6-8, for example, the tissue storage assembly 2000 of the embodiment may include a plurality of tissue holder 2200. 在图7中,组织存储组件包括三个样本保持架,被标记为2200A、2200B和2200C。 In Figure 7, the tissue storage assembly comprises three sample holders, are labeled 2200A, 2200B, and 2200C. 组织保持架2200A-C由集合管2300可拆卸地承载。 Tissue holder 2200A-C from the manifold 2300 is detachably carried. 每个组织保持架2200可以在组织样本42保持就位在其上的情况下通过移除盖罩2010和从集合管2300升起或滑开保持架2200而从活检装置10上移除。 Each tissue holder 2200 may be held in place in the tissue sample 42 on which the case by removing the cover 2010 and the manifold 2300 rise from or slid holder 2200 is removed from the biopsy device 10.

[0096] 在图6至8所示的实施方式中,每个组织保持架2200A-C可以绕集合管2300的周长延伸大约120度。 [0096] In the embodiment shown in FIGS. 6-8, each tissue holder 2200A-C can be around the perimeter of the manifold 2300 extends about 120 degrees. 替换地,组织保持架2200A-C可以延伸到任何其他合适的范围(例如,大约90度,大约180度,大约360度等等)。 Alternatively, the tissue holder 2200A-C may extend to any other suitable range (e.g., about 90 degrees, about 180 degrees, about 360 degrees, etc.). 该实施例的每个组织保持架2200A-C被成形或形成为以间隔的、顺序的方式接收和容纳多个组织样本42。 This embodiment each tissue holder 2200A-C is shaped or formed as a spaced manner, in order to receive and contain a plurality of tissue samples 42. 在图7中,每个组织保持架2200A-C是挠性的组织样本带的形式,每个组织样本带包括多个凹槽2204,每个凹槽2204用于接收各自的组织样本42。 In Figure 7, each tissue holder 2200A-C is in the form of a flexible tissue sample strip, and each tissue sample strip includes a plurality of recesses 2204, each recess 2204 for receiving a respective tissue sample 42.

[0097] 参照图6至9,集合管2300可以包括多个径向延伸的突起,例如径向延伸的翼片2320。 [0097] Referring to FIGS. 6-9, the manifold 2300 may comprise a plurality of radially extending projections, such as radially extending fins 2320. 组织保持架2200A-C可以被成形或以其它方式形成为与翼片2320接合,使翼片2320防止保持架2200A-C相对于集合管2300作周向运动,并且翼片2320保持三个组织保持架2200A-C在集合管2300上适当的位置。 Tissue holder 2200A-C can be shaped or otherwise formed to engage the fins 2320 and the flap 2320 preventing the holders 2200A-C relative to the manifold 2300 for circumferential movement, and holding the flap 2320 remains three tissue holder 2200A-C in the manifold 2300 on an appropriate position. 当组织保持架2200A-C位于集合管2300上时,每个凹槽2204可以被放置在集合管2300的一对相邻翼片2320之间。 When the tissue holders 2200A-C is positioned on the tube set 2300, each recess 2204 can be positioned between a pair of adjacent fins 2300 of the manifold 2320. 替换地,也可以通过集合管2300提供除翼片2320以外的径向延伸或其他方式的任意合适的结构或部件。 Alternatively, 2300 may be provided by manifold or other structural components extending radially or in any other manner suitable than 2320 flaps.

[0098] 组织样本保持架2200A-C可以由薄的聚合物板材形成或使用其他材料、结构和方法形成。 [0098] tissue sample holders 2200A-C can be formed from a thin polymer sheet or formed using other materials, structures and methods. 如果需要,组织样本保持架2200A-C可以使用大致可透射线的(大致可透过X射线的)材料形成。 If desired, the tissue sample holders 2200A-C can be substantially radiopaque (roughly rays through X) material. 在一种实施方式中,样本保持架2200A-C可以由厚度大约为0.015英寸或任意其他合适厚度的聚丙烯形成。 In one embodiment, the sample holders 2200A-C can be a thickness of about or any other suitable thickness of 0.015 inches is formed of polypropylene. 样本保持架2200A-C可以具有径向向内的表面2203和径向向外的表面2205 (图8)。 Sample holders 2200A-C can have a radially inwardly facing surface 2205 and a radially outward surface 2203 (FIG. 8). 样本保持架2200A-C可以被形成(例如通过模制、真空成型、或冲压等等)为在带的径向向外表面2205上具有组织接收凹槽2204,每个凹槽2204具有基底2205、径向向外延伸侧壁2206和近侧后壁2208。 Sample holders 2200A-C can be formed (e.g. by molding, vacuum forming, stamping, or the like) is radially outward with the upper surface 2205 having a tissue receiving recesses 2204, each recess 2204 having a substrate 2205, a radially outwardly extending side wall 2206 and rear wall 2208 proximally. 当样本保持架2200A-C位于集合管2300上时,每个凹槽2204可以被放置在集合管的一对相邻翼片2320之间。 When the sample holder 2200A-C is positioned on the collection manifold 2300, each recess 2204 can be positioned between a pair of adjacent manifold fins 2320. 每个样本保持架2200A-C还可以包括向远侧延伸的唇缘2260。 Each sample holders 2200A-C can further include a lip 2260 extending distally.

[0099] 替换地,样本保持架2200A-C可以被成形为在样本保持架2200A-C的径向向内表面2203上或以其它适宜的方式接收组织样本。 [0099] Alternatively, the sample holders 2200A-C can be shaped Radial 2200A-C is maintained at the sample received on the inwardly facing surface 2203 or to another tissue sample suitable manner.

[0100] 真空开口2212、2214(例如是孔或槽的形式)可以设置于样本保持架2200A-C中,以便将真空从集合管2300传送通过样本保持架2200A-C,从而将组织样本42从样本传输管2030传送到凹槽2204。 [0100] Vacuum openings 2212, 2214 (e.g., in the form of holes or slots) may be provided in the sample holders 2200A-C in vacuum in order to transfer 2300 holders 2200A-C from the manifold through the sample, so that the tissue sample 42 from sample transfer tube 2030 into the recess 2204 transfer. 例如,真空开口2214可以延伸穿过侧壁2206,真空开口2212可以延伸穿过基底2205。 For example, vacuum openings 2214 can extend through the sidewalls 2206, 2212 may extend through the substrate 2205 vacuo opening. 替换地,在任意合适位置的任意其他结构可以被用来允许流体传送通过样本保持架2200A-C。 Alternatively, any other structures in any suitable location may be used to allow fluid delivery through the sample holders 2200A-C.

[0101] 参照图8和9,集合管2300可以包括从大致圆盘形的远端板2310延伸的翼片2320。 [0101] Referring to FIGS. 8 and 9, 2300 may include a set of fins extending from the distal end 2310 is substantially disc-shaped plate 2320. 端板2310的远侧面包括花键部件2314,用于与集合管齿轮2350上互补的凹槽(未显示)配合。 Distal face of the end plate 2310 includes a spline member 2314, a gear 2350 with a complementary recess on the manifold (not shown) fit. 端板2310还包括延伸通过端板2310的多个真空端口2324,每个端口2324被放置成用于在相邻的一对翼片2320之间引导真空。 End plate 2310 extending through the end plate further comprises a plurality of vacuum ports 2324 to 2310, each port 2324 is placed between a pair of adjacent guiding fins 2320 vacuo.

[0102] 由真空源(例如,来自如下所述的真空泵4010)提供和传送到近侧盖罩2050的真空端口2060的真空被引导通过盖罩2050,到达延伸穿过齿轮2350的多个通路2352中的一个。 [0102] and transmitted to provide a vacuum port proximal cover 20602050 by the vacuum source (e.g., from vacuum pump 4010 as described below) is directed through a vacuum cap 2050, 2350 reaches extending through a plurality of passages gear 2352 one of the. 当花键部件2314与集合管齿轮2350配合时,每个贯穿集合管齿轮2350延伸的通路2352可以与集合管端板2310上的相关的真空端口2324对准。 When the spline members 2314 and 2350 with gear manifold, each passageway through the manifold gear 23522350 extending associated vacuum port 2324 can align the manifold end plate 2310. 因此,在端口2060提供的真空被引导通过盖罩2050到达齿轮2350中的一个通路,然后通过集合管2300中的真空端口2324,被引导到一对相邻的翼片2320之间。 Thus, the vacuum port 2060 to provide the cover 2050 is directed through a passageway reaching the gears 2350, 2324 and the port 2300 by vacuum manifold, it is guided to between 2320 a pair of adjacent flaps. 样本存储真空源提供的气流的方向在图8中用箭头示出。 The direction of airflow provided by the sample storage vacuum source is shown by arrows in FIG. 8.

[0103] 在上述实施方式中,组织保持架2200包括多个样本保持架2200A-C。 [0103] In the above embodiment, the tissue holder 2200 comprises a plurality of sample holders 2200A-C. 替换地,组织保持架2200可以包含一个单独的零件,例如围绕集合管2300延伸的三百六十度的连续环的形式,或围绕集合管基本上延伸三百六十度的单根带的形式。 Alternatively, the tissue holder 2200 can comprise a separate part, for example in the form of a continuous ring extending three hundred and sixty degrees around the manifold 2300, the manifold substantially surrounds or extends in the form of 360-degree single band . 替换地,任意其他合适的结构、部件或装置可以被用来保持组织样本42。 Alternatively, any other suitable structures, components or devices may be used to hold tissue samples 42.

[0104] 图10图示了组织样本保持架2200的一种替代实施方式。 [0104] FIG. 10 illustrates a tissue sample holder 2200 of an alternative embodiment. 在图10中,样本保持架2200包括单根带,所述带包括四个区段2201A-D,区段2201A-D的相邻一对区段通过挠性铰链2203连接在一起。 In FIG 10, a sample holder 2200 comprises a single band, said band adjacent pair of segments comprising four segments 2201A-D, segments 2201A-D are connected together by a flexible hinge 2203. 每个区段220IA-D可以具有环绕大约90度的大致弓形,其中大致凸形的外表面具有多个凹槽,每个凹槽用于保持组织样本。 Each segment may have 220IA-D surround substantially arcuate about 90 degrees, wherein the generally convex outer surface having a plurality of recesses, each recess for holding a tissue sample.

[0105] 在组织样本42以间隔地、顺序排列地保持在组织保持架2200上的情况下,该实施例可透射线的或具有其他性质的保持架2200可以被从组织存储组件2000上移除。 [0105] in the tissue sample 42 at intervals, in order to held the case of tissue holding frame 2200, this embodiment may be radio-opaque or have other properties holder 2200 may be removed from the tissue storage assembly 2000 . 不用将样本42从保持架2200移除,也不打乱样本42的顺序和/或不接触单个样本42,样本42就可以被检测和/或准备好检测,例如通过将样本42和保持架2200放置在任何合适的检测设备或放置在合适的检测制备流体中。 42 without the sample 2200 is removed from the holder, not disrupt the order and / or not in contact with a single sample 42, sample 42 can be detected and / or the test sample 42 is ready, for example, by the sample holder 42 and 2200 placed in any suitable test equipment or in a suitable place in the preparation of fluid detection.

[0106] 例如,如果检查患者的微钙化,在样本42被放置在组织保持架2200上时就可以在样本42上进行样本的射线照相。 [0106] For example, if examination of the patient microcalcifications, the sample 42 is placed on the tissue holder 2200 holding radiographing can sample 42 on the sample. 获得的样本射线照片用于检查微钙化。 Radiographs obtained samples for examination microcalcifications. 如果需要,在组织保持架2200上的那些显示微钙化的样本42可以从组织保持架2200上移除。 If desired, the tissue holding microcalcifications those samples displayed on holder 42 may be removed from the tissue 2200 holding frame 2200. 组织保持架2200、任何保持在组织保持架2200上的组织样本42和任何包含微钙化的组织样本42可以被一起浸入福尔马林液体中制备病理学样本。 Tissue holder 2200, any tissue samples held in the tissue holding frame 2200, and any tissue samples 42 contained microcalcifications 42 may be immersed in formalin and pathological samples prepared with a liquid. 替换地,组织保持架2200与保持在组织保持架2200上的组织样本42可以一起被浸入盐水或合适的液体制剂中。 Alternatively, the tissue holder 2200 with the tissue held in the tissue sample holder 2200 on the holder 42 may be immersed together in saline or a suitable liquid formulation. 当然,组织样本42可以在仍然在组织保持架2200上或不在的条件下使用任意其他合适的步骤处理。 Of course, tissue samples 42 may or may not remain in the tissue under conditions of holding the holder 2200 using any other suitable process step.

[0107] 图11和IlA图示了组织样本保持架2200的另一种实施方式。 [0107] FIGS. 11 and IlA illustrate a tissue sample holder 2200 of another embodiment. 在图11中,样本保持架2200包括从毂2270径向伸出的多个臂2272。 In FIG 11, a sample holder 2200 comprises a plurality of arms extending radially from the hub 2270 2272. 彀2270可以具有大致圆柱形,并且其尺寸使其可以装配在集合管2300的一端上。 Dice 2270 may have a substantially cylindrical shape, and is sized so that it may be fitted on the end 2300 of the manifold. 臂2272的尺寸和间隔能够装配在集合管2300的相邻翼片2320之间。 The size and spacing of the arm 2272 can fit between adjacent fins 2300 of the manifold 2320. 每个臂2272可以包括组织接收室2274,组织接收室2274可以被一体地形成在臂2272自身上,或是连接到臂2272上的单独的零件。 Each arm 2272 can include a tissue receiving compartment 2274, a tissue receiving compartment 2274 may be integrally formed in the arm 2272 itself, or is linked to the individual parts on the arm 2272. 尽管在该实施例中组织接收室2274使用一个杯形的或凹槽形的结构,但是其他构造也可以使用。 Although this embodiment uses a tissue receiving chamber 2274 of the cup-shaped or groove-shaped configuration in this embodiment, but other configurations may also be used. 每个臂2272可以包括一个或多个真空开口,用于将真空从集合管2300传递到组织接收室2274。 Each arm 2272 can include one or more vacuum openings for the vacuum transmitted from the manifold 2300 to the tissue receiving chamber 2274.

[0108] 每个臂2272可以通过铰链2275连接到彀。 [0108] Each arm 2272 may be connected by a hinge to the dice 2275. 每个铰链2275可以是挠性的“活动”铰链,其例如由形成臂2272的材料的薄的挠性带形成。 Each hinge 2275 can be a flexible "active" hinge, for example, from a thin flexible material formed with the arm 2272 is formed. 替换地,其他构造可以被使用。 Alternatively, other configurations may be used. 当保持架2200被放置在组织存储组件2000上时,该实施例中的挠性铰链2275允许将臂2272径向向内折叠,与彀2270的纵向轴线2271大致平行地延伸。 When the holder 2200 is placed on the tissue storage assembly 2000, the flexible hinge example embodiment 2275 allows the arm 2272 is folded radially inwardly extending longitudinal axis 2271 2270 enough substantially parallel. 当保持架2200被从组织存储组件2000上移除时,该实施例中的挠性铰链2275容许臂2272径向向外折叠成扁平构型,例如图1lA所示。 When 2200 is removed from the holder tissue storage assembly 2000, the flexible hinge in the embodiment of the embodiment 2275 2272 allowable arms radially outwardly into a flat folded configuration, as shown in FIG 1lA.

[0109] 组织保持架2200可以包括可见的和/或不透射线的标记(例如字母、数字、符号等等)。 [0109] tissue holder 2200 can comprise visible and / or radiopaque markers (e.g. letters, numbers, symbols, etc.). 例如,标记可以被用于识别在组织保持架2200上的每个单独的组织保持凹槽或室2274。 For example, the marker may be used to identify each individual tissue holding frame 2200 on the tissue holding recess or compartment 2274. 每个凹槽或室2274可以具有一个与其相关的唯一的数字或符号,其中数字或符号是形成或打印在保持架2200上肉眼可见和/或不透射线的。 Each recess or compartment 2274 can have a unique number or symbol associated therewith, wherein the number or symbol is formed or printed on the holder 2200 visible and / or radiopaque. 因此,当组织保持架2200从活检装置10缩回时,单独的组织样本42可以在保持架2200上通过目视和/或在X射线下被唯一地识别。 Therefore, when the tissue holder 2200 is retracted from the biopsy device 10, the individual tissue samples 42 can be visually and / or is uniquely identified in the X-ray on the holder 2200.

[0110] 如果需要,活检装置10可以包括显示装置(未显示),用于标识出在活检装置10操作过程中被切割的样本42的数字。 [0110] If desired, the biopsy device 10 may include a display device (not shown), for identifying a digital during the biopsy device 10 in the sample 42 is cut. 例如,活检装置10或控制单元5000可以包括显示装置,例如发光二极管(LED)显示装置,其标识出已经切割和存储的组织样本42的数字。 For example, the biopsy device 10 or the control unit 5000 may include a display device, a light emitting diode (LED) display device, which identifies the tissue sample has been cut 42 and stored digital. 另夕卜,发光二极管显示装置可以包括图表显示装置,用于标识每个样本42相对于基准位置被提取的位置。 Another Bu Xi, light emitting diode display device may include a graph display means for identifying each sample location with respect to the reference position 42 is extracted. 例如,显示装置可以标识每个样本42被提取的位置相对于组织孔114的初始12点钟(正上)位置的“点钟”位置。 For example, the display device 42 may identify each sample extracted position "o'clock" position relative to the original tissue aperture 114 at the 12 o'clock (NOW) position. 替换地,发光二极管显示装置可以标识在组织保持架2200上的每个室或凹槽2274的位置,并且其中发光二极管显示装置标识组织样本42是否已经被存放在特定室或凹槽2274中,或在围绕组织保持架2200圆周的特定位置。 Alternatively, light emitting diode display device may identify the position of each tissue holding recess or compartment on the shelf 22002274, and wherein the light emitting diode display device 42 identifies whether the tissue sample has been deposited in a particular compartment or recess 2274, or in in keeping organized around a specific location circumference frame 2200. 替代地,显示装置可以与活检装置10`以任意其他合适的方式在任意其他合适的位置结合,并可以显不任意需要的ί目息。 Alternatively, the display device 10 'in the biopsy device may be any other suitable manner in conjunction with any other suitable position, and may not be any significant information required ί purposes.

[0111] 图12示出了一种替代的组织存储组件2700,其可以被用于以端-端构型保持样本42。 [0111] FIG. 12 illustrates an alternative tissue storage assembly 2700, which may be used to end - the end configuration 42 hold the sample. 图12Α是沿线12Α-12Α得到的剖视图。 FIG 12 [alpha] is a sectional view along line 12Α-12Α obtained. 图12Β是沿部分存储组件2700的一段长度得到的剖面图。 FIG 12Β is a sectional view along a length portion of the storage assembly 2700 is obtained. 该实施例中的存储组件2700包括挠性的、盘绕的组织样本保持架2710,其可以由薄壁的挠性管例如挤压管形成。 Examples of the storage assembly 2700 includes a flexible, coiled tissue sample holder 2710, which may, for example an extruded tube is formed of thin-walled flexible tube. 组织样本保持架2710包括三个腔2712、2714、2716,它们沿着盘绕的组织样本保持架2710的长度相互并排延伸。 Tissue sample holder 2710 includes three chambers 2712,2714,2716, 2710 are maintained along the length of the tissue sample holder extends coiled alongside each other.

[0112] 该实施例的样本保持架2710包括用于以端-端顺序接收组织样本42的组织样本腔2712、真空供应腔2714以及位于腔2712和腔2714之间且与它们相互并排延伸的真空控制腔2716。 [0112] The sample embodiment includes a retainer 2710 to the end - the tissue sample the tissue sample receiving chamber 42 end of the sequence between 2712 and 2714 located in the vacuum chamber supply chamber 2712 and the cavity 2714 and which extend parallel to one another and in vacuo control chamber 2716. 挠性的细长控制构件2718被放置在控制腔2716中。 A flexible elongated control member 2718 is disposed in the control chamber 2716. 当细长的控制构件2718完全插入到控制腔2716中时,控制构件2718用于堵塞一系列的交叉流端口2719,这些端口2719沿真空控制腔2716的长度间隔地布置。 When the elongated control member 2718 is fully inserted into the control chamber 2716, the control means 2718 for plugging a series of cross-flow port 2719, which port 2719 is arranged along the length of the vacuum chamber 2716 control intervals. 交叉流端口2719可以沿真空控制腔2716的长度间隔一定距离放置,所述距离大致等于或稍大于被活检装置10的切割器120切断的组织样本42的最大长度。 The maximum length of the cross flow ports 2719 can be placed at a distance along the length of the vacuum chamber 2716 to control the distance substantially equal to or slightly larger than the cutter 120 cutting the biopsy device 10 of the tissue sample 42. 控制构件2718可以从腔2716按显示的方向逐渐缩回,以允许真空供应腔2714内的真空传递到样本腔2712。 Direction control member 2718 may be displayed progressively from the cavity 2716 is retracted, to allow the vacuum in vacuum supply lumen 2714 is transmitted to the sample chamber 2712. 每次控制构件2718逐渐缩回时,真空控制腔2716中的一对交叉流端口2719被暴露,从而为样本腔2712提供真空。 Each time the control member 2718 is gradually retracted, a pair of cross flow ports 2716 in vacuum control lumen 2719 is exposed, so as to provide a vacuum sample chamber 2712. 替换地,可以使用任意其他合适的结构、部件、装置或方法有选择地传递真空到样本腔2712。 Alternatively, any other suitable structures, components, apparatus or method for selectively transferred to the sample chamber 2712 in vacuo.

[0113] 在该实施例中,组织样本腔2712可以被直接地或间接地连接到样本传输管2030。 [0113] In this embodiment, the tissue sample chamber 2712 may be connected directly or indirectly to the sample transfer tube 2030. 腔2714可以被连接到真空源(例如,真空控制模块5000)。 Cavity 2714 may be connected to a vacuum source (e.g., vacuum control module 5000). 控制构件2718可以被手动缩回,或替换地,可以通过与活检装置10相联的卷绕机构(未显示)被自动地缩回。 Control member 2718 may be retracted manually, or alternatively, may be automatically retracted by winding mechanism associated with the biopsy device 10 (not shown).

[0114] 图13提供了套管100的远侧部分的示意图,图14提供了当切割器120在切割器腔104内相对于组织接收孔114前进和缩回时,在真空腔108中提供的真空水平的示意图。 [0114] Figure 13 provides a schematic illustration of a distal portion of the cannula 100, FIG. 14 is provided when the cutter 120 within the cutter lumen 104 to the tissue receiving aperture 114 to advance and retract, provided in the vacuum chamber 108 a schematic view of vacuum level. 图13示出了可以设置在套管100内部结构中用于在真空腔108和切割器腔104之间提供流体连通的通路。 FIG 13 shows may be provided for the internal structure of cannula 100 to provide fluid communication passage between the vacuum chamber 108 and the cutter lumen 104. 通路107通常设置在孔114之下,通路109设置在孔114的远侧。 Passageway 107 is generally disposed below the hole 114, 109 provided at the distal passage hole 114.

[0115] 图15是可以用于该实施例中活检装置10的气动结构的示意图。 [0115] FIG. 15 is a schematic view of a pneumatic structure of the biopsy device 10 in this embodiment. 所述气动系统可以包括真空泵4010、调节器4020、真空罐/容器4030、主控制阀4060和盐水/真空阀4080。 The pneumatic system may include a vacuum pump 4010, a regulator 4020, a vacuum canister / container 4030, the master control valve 4060 and saline / vacuum valve 4080.

[0116] 由真空泵4010提供的真空可以不使用阀而被引导通过真空管4012、通过组织存储组件2000、到达切割器120和切割器腔104,当真空泵4010工作时,提供到切割器120内部和套管100的切割器腔104的真空一直处于“接通”的状态。 [0116] vacuum provided by the vacuum pump 4010 may not use the valve is guided by a vacuum 4012, through tissue storage assembly 2000, reaches the cutter 120 and cutter lumen 104, when the vacuum pump 4010 work, is supplied to the cutter 120 inside and the sleeve vacuum cutter lumen 104 of tube 100 has been in a state "ON". 替换地,可以沿着这样的流体通路设置一个或多个阀或其他的部件或机构。 Alternatively, one or more valves may be provided, or other components or mechanisms along such a fluid passage. 用于真空腔108的气动回路包括两个阀4060,4080ο阀4080可以包括两位三通阀,其具有两个输入端口。 The pneumatic circuit for vacuum lumen 108 includes two valves 4080 may include valves 4060,4080ο 2-way valve having two input ports. 一个输入端口可以连接到真空管4012,另一个输入端口可以连接到盐水源4016(或替代地通过过滤器4018与大气压力通气)。 An input port may be connected to vacuum line 4012, the other input port may be connected to a source of saline 4016 (or alternatively 4018 plenum to atmosphere through the filter). 阀4080的输出端口与主阀4060的进入端口连接。 The output port of valve 4080 and the inlet port of the main valve 4060 is connected.

[0117] 阀4080的位置根据切割器120的位置配置。 Position [0117] Valve 4080 is disposed according to the position of the cutter 120. 当切割器120向近侧缩回(例如,导致组织孔114打开)时,阀4080传送真空到主控制阀4060。 When the cutter 120 is retracted proximally (e.g., resulting in tissue aperture 114 is open), the transfer valve 4080 to a main vacuum control valve 4060. 当切割器120向远侧前进(例如,导致组织接收孔114关闭)时,阀4080传送盐水到主控制阀4060。 When the cutter 120 is advanced distally (e.g., resulting in tissue receiving aperture 114 closed), the valve 4080 transmits to the master control valve 4060 brine. 替换地,如果盐水不可用,或不需要,阀4080通过过滤器4018传送大气到主控制阀4060。 Alternatively, if saline is not available, or not required, the valve 4080 transmits the atmosphere through a filter 4018 to the master control valve 4060. 阀4080可以使用任意合适的方法开启,包括使用电磁线圈、马达、通过连接到切割器120的机械连杆或其它方法开启。 Valve 4080 may be opened using any suitable method, including a solenoid, a motor, a mechanical linkage connected to the open, or by other methods of the cutter 120. 阀4080可以被弹性加载到一个位置,切割器120的运动(例如切割器120向远侧位置的运动)可以用于改变阀4080的位置。 Valve 4080 can be loaded elastically into a position, motion of cutter 120 (e.g., movement of the cutter 120 to the distal position) can be used to change the position of the valve 4080.

[0118] 主控制阀4060可以包含三位三通阀。 [0118] The main control valve 4060 may comprise a three-way valve. 一个输入端口可以被连接到阀4080的输出端口。 One input port of the valve 4080 may be connected to the output port. 第二个输入端口可以与过滤的大气通气。 The second input port can ventilation and air filtration. 阀4060的输出端口可以被连接到套管100的真空腔108的近端。 The output port of valve 4060 can be connected to the proximal end of vacuum lumen 108 of cannula 100. 阀4060的位置可以由活检装置10的操作者使用一个或多个用户控制接口来控制,例如列在图16上的控制按钮。 Position of the valve 4060 may be used by an operator of the biopsy device 10 controls one or more user interface controls, for example, listed in Figure 16 the control buttons. 控制按钮(在设备10上未显示)可以位于活检装置10主体上的任何方便的位置,包括例如在手持件30上,或其他位置(例如,在真空控制模块5000上)。 Control button (not shown on device 10) may be located at any convenient location on the body of the biopsy device 10, including, for example on the handpiece 30, or elsewhere (e.g., on vacuum control module 5000). 阀4060可以通过电磁线圈、马达、借助连接到切割器120的连杆或其他方法来开启。 By a solenoid valve 4060, a motor, is connected by means of a link to the cutter 120, or other methods to open.

[0119] 当然,图15显示的气动回路仅仅是说明性的,任意其他合适的回路,包括不同构件、构件的布置和构件的操作也可以使用。 [0119] Of course, the pneumatic circuit shown in Figure 15 is merely illustrative, any other suitable circuit, including different components, arrangements and operating member member may also be used.

[0120] 图16显示了可以用于控制活检装置10的多种控制状态。 [0120] Figure 16 shows a plurality of control states can be used to control biopsy device 10. 参照图16并且参照图8,活检装置10的“就绪状态”对应于切割器120被前进到其最远侧位置并且组织孔114被关闭。 Referring to FIG. 16 and 8, the "Ready State" of biopsy device 10 corresponds to the cutter 120 being advanced to its distal most position and tissue aperture 114 being closed. 在就绪状态,阀4080传送盐水到主控制阀4060,并且主控制阀处于封闭(关闭)它的其他端口的位置,包括与真空腔108连通的输出端口。 In the ready state, the valve 4080 transmits to the master control valve 4060 with brine, and the main control valve is in the closed (OFF) position to its other ports, including the output port communicating with the vacuum chamber 108. 通过在就绪状态时关闭到侧面的腔108的端口,通过该装置的气流可以被最小化,这样可以允许泵4010更容易地保持真空罐4030内的所需真空水平。 By closing the port to the ready state when the side of the chamber 108, can be minimized by means of the gas flow, which may allow the pump 4010 to more easily maintain the desired vacuum level in the vacuum tank 4030. [0121] 在该实施例中当操作者压下“样本”按钮170时,切割器马达被激活,导致切割器120向近侧缩回。 [0121] When the operator in this embodiment, the pressure "Sample" button 170, the cutter motor is activated, causing the cutter 120 is retracted proximally. 当切割器缩回时,阀4080改变位置以传送真空到主控制阀4060。 When the cutter retracts, the valve 4080 changes position to communicate vacuum to the master control valve 4060. 同时,主控制阀改变位置,以传送真空到真空腔108。 Meanwhile, the master control valve changes position to communicate vacuum to the vacuum chamber 108. 在组织孔114打开的条件下,来自真空泵4010的真空被用于切割器120 (例如借助组织存储组件2000)和切割器腔104 (借助切割器120)以及真空腔108 (借助阀4080和4060)。 Under conditions of tissue aperture 114 open, vacuum from vacuum pump 4010 is used for the cutter 120 (e.g., via the tissue storage assembly 2000) and cutter lumen 104 (via the cutter 120) and a vacuum chamber 108 (by means of valves 4080 and 4060) . 应用于切割器腔104和真空腔108的真空帮助组织脱垂进入套管100的孔114。 Applied to cutter lumen 104 and vacuum chamber 108 of the vacuum assisted tissue prolapsing into aperture 114 of the sleeve 100.

[0122] 在维持这种真空状态一秒或更长时间以保证组织已经脱垂进入孔114以后,切割器120向远侧前进(并同时旋转)以关闭孔114,并且切断在中空切割器120的远侧部分的组织样本42。 [0122] In this vacuum state is maintained for one second or more to ensure tissue has prolapsed into the subsequent hole 114, the cutter 120 advances distally (and simultaneously rotated) to close the hole 114, and cuts off the hollow cutter 120 the distal portion of tissue sample 42. 当切割器120向远侧前进时,切割器120可以接触或通过其他方式开启阀4080,以改变阀位置来传送盐水到主控制阀4060。 When the cutter 120 advances distally, the cutter 120 may contact or otherwise opening the valve 4080 to change the valve position is transmitted to the master control valve 4060 brine. 并且,当切割器120前进时,可以使用微处理器改变主控制阀4060的位置以传送过滤的大气到真空腔108中,然后又被通过通路107,109传送到达位于中空切割器120远侧部分的切断的组织样本42的远侧面。 Then, when the cutter 120 advances, a microprocessor can be used to change the master control valve 4060 position to communicate filtered air to the vacuum chamber 108, and then is transferred by the cutting path 107, 109 of the hollow cutter 120 reaches the distal portion the far side of the tissue sample 42. 在组织样本远侧面的大气提供作用于组织样本42的向近侧的推力,同时切割器120中的真空(借助组织存储组件2000)提供了作用于切断的组织样本42上的向近侧的拉力。 42 proximally pulling force on the tissue sample to provide a role in the far side of the tissue sample atmospheric thrust proximally to 42, while the cutter 120 is provided acting on the vacuum cutting (via the tissue storage assembly 2000) of the tissue sample . 在组织样本42上最终的向近侧的力输送组织样本42通过中空切割器120进入组织存储组件2000。 The final tissue sample transporting force on the tissue sample proximally into tissue storage assembly 4242 through hollow cutter 120 2000. 当然,任意其他合适的结构或方法可以用于捕获组织样本42并传送它到组织存储组件2000。 Of course, any other suitable structures or methods may be used to capture a tissue sample 42 and transmits it to the tissue storage assembly 2000.

[0123] 在一种替代实施方式中,可以使用微处理器改变主控制阀4060的位置以在预定时间段首先传送盐水到真空腔108中,然后改变阀的位置传送大气到腔108中。 [0123] In an alternative embodiment, the microprocessor may be used to change the position of master control valve 4060 to first transmit saline to vacuum lumen 108 for a predetermined period of time, and then change the atmosphere into the transfer position of the valve cavity 108. 由此,固定量的盐水可以通过通路107、109被传递到中空切割器120的远端,从而帮助切断的组织样本向近侧移动通过中空切割器120到达组织存储组件2000。 Thus, a fixed amount of brine may be passed to the distal end of hollow cutter 120 through passages 107, 109, to help reach the tissue sample severed tissue storage assembly 120 through hollow cutter 2000 move proximally. 控制系统可以被编程,在预定时间段(一秒或多秒)后回复到就绪状态。 The control system may be programmed, at a predetermined period of time (one or more seconds) after the return to the ready state.

[0124] 当处于就绪状态时(例如,已经操作过“样本”按钮170切断组织之后),活检装置操作者可以压下“清理探头”按钮172,用于产生一个微处理机控制,使得切割器120略微往复运动以打开和关闭孔114几分之一英寸(例如0.2英寸)或任意合适幅度。 (For example, after the operation has been the "Sample" button 170 to sever tissue) [0124] When in the ready state, biopsy device operator can depress a "clear probe" button 172, for generating a control microprocessor, so that the cutter 120 to reciprocate slightly to open and close the aperture 114, one fraction of an inch (e.g. 0.2 inches), or any suitable amplitude. 切割器120的这种往复运动可以有效的移动·组织样本42或以其他方式释放样本42,从而使样本42可以自由地移动通过中空切割器120。 This reciprocation of cutter 120 can effectively move the tissue sample 42 · 42 or otherwise release the sample so that the sample 42 can move freely through hollow cutter 120. 在切割器120往复运动的同时,真空控制阀4060可以被重新定位以传送盐水到真空腔108和通过通路107、109,以向组织样本42的远侧面提供推力。 In the cutter 120 while reciprocating, the vacuum control valve 4060 can be repositioned to communicate saline to the vacuum chamber through the passages 107, 109 and 108, to provide thrust to the distal side 42 of the tissue sample. 在预定的时间段之后,微处理器可以回复气动系统到就绪状态。 After a predetermined period of time, the microprocessor can return the pneumatic system to the Ready state.

[0125] 当装置处于就绪状态时,操作者可以压下和释放“抽吸/插入”按钮174,以将药物或组织标记插入到被取样的组织中或组织样本已经或将要被采集的位置处。 [0125] When the apparatus is in a ready state, the operator can depress and release the "Aspirate / Insert" button 174 at a position to insert the drug into the tissue or tissue marker or the sampled tissue sample has been or will be collected . 在该例子中当按钮174被压下时,切割器120向近侧平移以打开孔114。 When the button 174 is depressed in this example, the cutter 120 translating proximally to open aperture 114. 主控制阀4060的位置被改变以传送大气到真空腔108。 The position of master control valve 4060 is changed to communicate atmospheric chamber 108 to the vacuum. 压下“抽吸/插入”按钮174也切断真空(例如通过关闭泵4010或打开调节器4020使泵4010出口通向大气,等等)。 Pull-down "suction / Insert" button 174 is also cut off in vacuo (e.g. by turning off the pump 4020 so that 4010 or 4010 opens the regulator of the pump outlet to atmosphere, etc.). 组织标记(或药物)施放器可以通过中空切割器120被放置到套管100的近端,例如通过组织存储组件2000或其他方式,标记(或药物)随后通过套管100上的打开的孔114被应用。 Tissue marker (or medication) applicator 120 may be placed through the cannula to the proximal end of hollow cutter 100, such as by tissue storage assembly 2000 or otherwise labeled (or drugs) followed hole 100 is opened by the cannula 114 be utilized. 在标记或药物已经被应用之后,用户可以按下任意按钮,其可以在主控制阀4060朝上定位的状态下前进切割器120,回复到就绪状态。 After the marker or medication has been applied, the user may press any button, which may advance the cutter 120 in a state where the master control valve 4060 positioned up, returns to the ready state.

[0126] 操作者可以压下和保持“抽吸/插入”按钮174以吸出在孔114附近的流体。 [0126] The operator can depress and hold "Aspirate / Insert" button 174 to aspirate fluid in the vicinity of the hole 114. 在该实施例中当操作者压下按钮174时,切割器120移向近侧以打开孔114。 In this embodiment, when the operator depresses button 174, the cutter 120 moves proximally to open aperture 114. 当切割器处于近侧位置时,阀4080传送真空到主控制阀4060,主控制阀4060定位成传递真空到真空腔108。 When the cutter is in a proximal position, the valve 4080 transmits to the main vacuum control valve 4060, the master control valve 4060 is positioned to deliver vacuum to the vacuum chamber 108. 因此,真空被用于腔108和切割器腔104两个腔内(因为在该实施例中当泵4010工作时,真空被连续地通过切割器120提供到腔104)。 Thus, the vacuum chamber 108 is used to cutter lumen 104 and two cavities (because in the embodiment when the pump 4010 work in this embodiment, vacuum is provided continuously through cutter 104 to lumen 120). 提供到腔104和腔108的真空抽吸孔114附近的任何液体。 Any liquid supplied to the chamber 104 near the cavity 108 and the vacuum suction holes 114. 当释放抽吸/插入按钮174时,控制气动系统回复到就绪状态。 When releasing the suction / Insert button 174, the control pneumatic system returns to the ready state. 前进切割器120以关闭孔114。 Advancing the cutter 120 to close the hole 114. 在该实施例中当切割器120被前进时,主控制阀4060被定位成将过滤的大气传送到真空腔108。 In this embodiment, when the cutter 120 is advanced is, the master control valve 4060 is positioned to transmit the filtered air to the vacuum chamber 108. 一旦孔114被关闭,主控制阀4060被定位成关闭其所有端口以处于就绪状态。 Once the hole 114 is closed, the master control valve 4060 is positioned to close all its ports to the ready state. 如同这里描述的其它操作顺序一样,上述操作顺序仅仅是说明性的,任意其他合适的操作顺序可以被用于补充或替代这里明确描述的操作顺序。 As with the other sequence of operations as described herein, the above-described sequence of operations merely illustrative, any other suitable sequence of operations may be used to supplement or substitute the sequence of operations described herein explicitly.

[0127] 为了适应活检装置10在手术室内的移动,或由于在磁共振成像环境中控制模块5000的位置受限制,从容纳真空泵4010的控制模块5000到活检装置10的真空管4012的长度可以相对较长(可多达20英尺或有时更长)。 [0127] In order to accommodate movement of the biopsy device 10 in the operating room, or due to the control module in the magnetic resonance imaging environment position 5000 is limited, the length of the vacuum means 10 of the vacuum pump 4012 from receiving control module 5000 to 4010 can be relatively biopsy long (up to 20 feet or sometimes longer). 当然,真空管4012可以是任意需要的长度。 Of course, vacuum line 4012 may be of any desired length. 在该实施例中,真空管4012可以用于在组织孔114打开时需要通过真空泵4010和真空罐4030供给或维持的流体体积的相当大的部分。 In this embodiment, the vacuum line 4012 may be used when the tissue aperture 114 is open needed to maintain a substantial portion of the volume of fluid supplied by a vacuum pump and vacuum canister 4030 or 4010. 将盐水/真空阀4080和主控制阀4060放置在真空管4012的远端(与活检装置10相应的端部)而不是放置在活检真空控制单元5000内,这意味着可以使用较小的真空泵4010和较小的真空罐4030。 The saline / vacuum valve 4080 and the master control valve 4060 disposed at the distal end (10 biopsy apparatus corresponding end portion) instead of being placed in the biopsy vacuum control unit 5000 of the vacuum tube 4012, which means that a smaller vacuum pump 4010 and smaller vacuum canister 4030. 在某些传统的活检装置中,阀可以被放置在包括真空泵的控制单元中,并且由于控制单元的重量和尺寸可以为其配备轮子。 In some conventional biopsy devices, the valve may be placed in a vacuum pump comprising a control unit, and since the control unit weight and size may be provided for the wheels. 在图16中显示出的阀4060、4080放置在活检装置10中。 It shows the valve 16 in FIG 4060,4080 placed in the biopsy device 10. 阀4060、4080可以被放置在包括套管100和切割器120 (例如手持件30)的一次性探头部分中和/或设置在该活检装置10的非一次性部分(例如机架)中。 4060,4080 valve may be placed in a disposable probe portion (e.g., handpiece 30) of the cannula 100 and cutter 120 and / or disposed in a non-disposable portion of the biopsy device 10 (e.g., a rack) in the. 与需要超过80升/分钟的流速的传统泵和阀布置相比,这样的阀设置可以允许使用重量相对低的流速为大约18升/分钟的隔膜真空泵4010。 Compared with the need to more than 80 l / min flow rate of a conventional pump and valve arrangement, so that the valve is provided may allow a relatively low flow rate by weight of about 18 liters / minute diaphragm vacuum pump 4010. 当然,具有任意期望性质的任意期望的真空泵可以被使用。 Of course, any desired vacuum pump having any desired properties may be used.

[0128] 类似的,与具有1200立方厘米或以上的体积存储容量的传统真空罐相比,真空罐4030可以相对较小,具有小于大约300立方厘米的体积。 [0128] Similarly, the conventional vacuum canister having a 1200 cm3 or more as compared to the volume of storage capacity, vacuum canister 4030 can be relatively small, having a volume of less than about 300 cubic centimeters. 因此,可以使用一个相对轻质、便携式真空控制模块5000。 Thus, it is possible to use a relatively lightweight, portable vacuum control module 5000. 真空控制模块5000(图15)的重量可以小于25磅,可以由单手携带,可以具有均小于大约1.5英尺的高度、宽度和长度。 5000 (FIG. 15) of the weight of vacuum control module may be less than 25 lbs, may be carried by a single hand, may have less than about 1.5 feet in height, width and length. 替代地,真空罐4030和控制模块5000可以具有任意其他合适的容量、大小、重量和其他性质。 Alternatively, vacuum canister 4030 and control module 5000 may have any other suitable capacity, size, weight and other properties.

[0129] 如果需要,可以使用脚踏开关(未显示)或遥控键盘(未显示)来提供直接控制输入或指令到活检装置10和/或到真空控制模块5000。 [0129] If desired, foot switch (not shown) or remote keypad (not shown) to provide control input or instructions directly to the biopsy device 10 and / or to the vacuum control module 5000. 脚踏开关和遥控键盘可以是有线连接的(例如,具有从脚踏开关/键盘延伸到真空控制模块5000的一根或多根电线,等等)。 Foot switch and remote keypad can be wired connection (e.g., extending from the foot switch / keypad to the vacuum control module 5000 of one or more wires, etc.). 替代地,可以在脚踏开关/键盘和真空控制模块5000和/或活检装置10之间使用“无线”通信。 Alternatively, use the "wireless" communication between the foot switch / keypad and a vacuum control module 5000 and / or the biopsy device 10. 例如,无线“蓝牙”通信和相关硬件和软件可以被用来为真空控制模块5000和/或活检装置10提供无线电控制信号,而不再需要用于信号发送和接收的“可见的线”。 For example, wireless "Bluetooth" communication and associated hardware and software can be used to vacuum control module 10 provides a radio control signal 5000 and / or the biopsy device without the need for signal transmission and reception of the "visible line." 替代地,红外发射器和接收器可以用于发射和接收控制信号。 Alternatively, the infrared transmitter and receiver may be used to transmit and receive control signals. 鉴于这里的教导,本领域普通技术人员可以清楚,在活检系统构件之间(例如在脚踏开关/键盘和控制模块5000之间)使用其他方法通信,有线、无线或其他方式。 Given the teachings herein, those of ordinary skill in the art may be apparent between the biopsy system components (e.g., between the foot switch / keypad and control module 5000) using other methods of communication, wired, wireless or otherwise.

[0130] 虽然本发明的优选实施例已经在这里被显示和说明,显然对本领域技术人员来说这些实施例仅仅是用来举例说明的。 [0130] Although the preferred embodiments of the present invention have been shown and described herein, be apparent to those skilled in the art for these embodiments are merely illustrative. 对本领域技术人员来说不偏离附加权利要求的精神和范围可以产生很多变化、改变和置换。 The appended claims without departing from the spirit and scope of the present can produce many variations of skill in the art, changes and substitutions. 另外,涉及发明的每个描述的元件可以用现有的具有执行该元件功能的手段替换。 Further, each of the elements described can be used, in the invention has a conventional means for performing the functions of the replaced element.

Claims (11)

1.一种活检装置,其具有用于活检装置的组织样本存储组件,所述活检装置包括: (a)套管,其从所述活检装置向远侧延伸; (b)管状切割器,其能够相对于所述套管平移,所述管状切割器具有近端和远端,所述远端能够切断所述套管接收的组织;以及(c)组织样本存储组件,其包括: (i)可旋转构件, (ϋ)由所述可旋转构件可拆卸地承载的组织保持架,其中组织保持架包括多个凹槽,每个凹槽能够接收被切断的组织样本,和(iii)盖罩,其中所述可旋转构件与所述组织保持架至少部分地设置在所述盖罩中。 A biopsy device having a tissue sample storage assembly for a biopsy device, the biopsy device comprising: (a) a cannula extending distally from the biopsy device; (b) a tubular cutter, which translating with respect to the cannula, the tubular cutter having a proximal end and a distal end, said distal end capable of cutting tissue received in the cannula; and (c) a tissue sample storage assembly comprising: (i) rotatable member, (ϋ) organized by the rotatable member carried removably holder, wherein the tissue holder comprises a plurality of grooves, each groove capable of receiving the severed tissue sample, and (iii) cover wherein the rotatable member and the tissue holder disposed at least partially in the cover.
2.根据权利要求1所述的活检装置,包括近侧盖罩,其中所述近侧盖罩包括样本端口和真空端口。 2. The biopsy device of claim 1, comprising a proximal cover, wherein the proximal cover includes a sample port and a vacuum port.
3.根据权利要求2所述的活检装置,其中所述样本端口能够与所述套管流体连通,且所述样本端口能够与所述多个凹槽中的至少一个流体连通。 3. The biopsy device of claim 2, wherein said sample port capable of fluid communication with the cannula, and the sample port capable of fluid communication with at least one of said plurality of grooves.
4.根据权利要求3所述的活检装置,其中所述套管具有中央轴线且所述样本端口具有中央轴线,且其中所述套管的中央轴线与所述样本端口的中央轴线同轴。 4. The biopsy device of claim 3, wherein said sleeve has a central axis and the sample port has a central axis and a central axis coaxial with the sleeve wherein the sample port to the central axis.
5.根据权利要求2所述的活检装置,其中所述真空端口能够与真空源流体连通,且所述真空端口能够与所述凹槽中的至少一个流体连通。 The biopsy device of claim 2, wherein said vacuum port capable of communication with a vacuum source in fluid communication with, and capable of communication with the vacuum port of said at least one fluid groove.
6.根据权利要求1所述的活检装置,其中所述凹槽还包括多个真空开口。 6. The biopsy device of claim 1, wherein said recess further comprises a plurality of vacuum ports.
7.根据权利要求6所述的活检装置,其中所述多个真空开口是多个孔。 7. The biopsy device of claim 6, wherein said plurality of openings is a plurality of vacuum holes.
8.根据权利要求1所述的活检装置,包括能够联接至所述可旋转构件的可旋转构件齿轮,其中所述可旋转构件齿轮联接至马达。 8. The biopsy device of claim 1, comprising a rotatable member can be coupled to the rotatable gear member, wherein the rotatable member is coupled to the motor gear.
9.根据权利要求8所述的活检装置,其中所述可旋转构件齿轮包括带键的连接件。 9. The biopsy device of claim 8, wherein the rotatable member comprises a gear keyed connector.
10.根据权利要求1所述的活检装置,其中所述组织保持架还包括唇缘。 10. The biopsy device of claim 1, wherein said tissue holder further comprises a lip.
11.根据权利要求1所述的活检装置,其中所述组织样本存储组件可拆下地连接至所述活检装置。 11. The biopsy device of claim 1, wherein the tissue sample storage assembly detachably connected to the biopsy device.
CN 201110077184 2006-12-13 2007-12-13 Biopsy device and biopsy sample storing assembly CN102217954B (en)

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