CN102210856B - Collagen eye drops and preparation method thereof - Google Patents
Collagen eye drops and preparation method thereof Download PDFInfo
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- CN102210856B CN102210856B CN201110147418A CN201110147418A CN102210856B CN 102210856 B CN102210856 B CN 102210856B CN 201110147418 A CN201110147418 A CN 201110147418A CN 201110147418 A CN201110147418 A CN 201110147418A CN 102210856 B CN102210856 B CN 102210856B
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Abstract
The invention relates to collagen eye drops and a preparation method thereof. The type of the conventional antifatigue eye drops is mainly divided into a type of ocular tissue similar objects and a type of traditional Chinese medicines, the main raw material of the eye drops in type of the ocular tissue similar objects is sodium hyaluronate which has large molecular weight and is not easy to be absorbed; and the eye drops in type of the traditional Chinese medicines has bad histocompatibility with human eyes, and generates a stimulation effect on the eyes when used for a long time. The collagen eye drops disclosed by the invention is prepared by adding auxiliary materials, such as a retina growth facilitating auxiliary material, a vitamin auxiliary material, an angiotonics auxiliary material, an antihistamine auxiliary material and a preservative auxiliary material, to collagen and an isotonic solution. The collagen eye drops has excellent biological functions, high adhesivity and hydrophily, and can play the roles of supporting and lubricating during cell migration; meanwhile, various necessary elements required by the eyes can be met, the surviving environment of ocular cells can be improved, and the metabolism of the eyes can be facilitated, and the purpose of nutrition is realized; in addition, the collagen eye drops has excellent moistening and lubricating curative effects and also has excellent curative effects on xerophthalmus and asthenopia.
Description
Technical field
The invention belongs to field of medicine producing technology, be specifically related to a kind of collagen eye drops and preparation method thereof.
Background technology
Because the continuous increase of work, learning pressure, most of people have in various degree eyestrain, dry and astringent, malnutrition and capillary hemorrhage malaise symptoms such as break.Existing resisting fatigue eye drop mainly is divided into two kinds: ocular tissue's homologue class eye drop and Chinese medicine class eye drop; The primary raw material of ocular tissue's homologue class eye drop is a hyaluronate sodium; And the hyaluronate sodium molecular weight is about 500000-730000 dalton, and molecular weight is big, is difficult for being absorbed; The histocompatibility of Chinese medicine class eye drop and human eye is relatively poor, and life-time service can produce stimulation to eyes, and drug effect is comparatively single.
Summary of the invention
The purpose of this invention is to provide a kind of can alleviating asthenopia, increase eye nutrition, keep moistening collagen eye drops of eyeball and preparation method thereof, prevent and treat symptoms such as eyestrain that long-time excess eye-using causes, dry and astringent, malnutrition and capillary hemorrhage break.
The technical scheme that the present invention adopted is:
A kind of collagen eye drops is characterized in that:
Per 100 milliliters collagen eye drops is made up of the component of following mass fraction:
Collagen protein 50-200 milligram;
Short retina growth stimulator 100-200 milligram;
Vitamin 5-15 milligram;
Vasoconstrictor 1-2 milligram;
Hydryllin 10-20 milligram;
Antiseptic 30-50 milligram;
All the other are 0.9% sodium chloride isotonic solution.
Described collagen protein is animal sources collagen protein or Human-like Collagen;
Described short retina growth stimulator is a taurine;
Described vitamin is a vitamin B
6, vitamin B
12, a kind of in the vitamin E;
Described vasoconstrictor is a kind of in Naphazoline Chloridum, the hydrochloric acid hydroxymethyl thiazole woods;
Described hydryllin is a chlorphenamine maleate;
Described antiseptic is a kind of in ethyl hydroxybenzoate, benzalkonium bromide, levofloxacin, the propyl p-hydroxybenzoate.
Method for preparing like described a kind of collagen eye drops is characterized in that:
Realize by following steps:
Step 1: with 50-200 milligram collagen protein, the short retina growth stimulator of 100-200 milligram, 5-15 milligram vitamin, 1-2 milligram vasoconstrictor, 10-20 milligram hydryllin and 30-50 milligram antiseptic; Be dissolved in 0.9% the sodium chloride isotonic solution; Be mixed with 100 milliliters mixed liquor; PH value is adjusted between the 6.5-7.5 40 ℃ of water bath heat preservations 30 minutes;
Step 2: degerming while hot in sterile working's platform, the method for degerming are filtering with microporous membrane, and employed microporous filter membrane is the hydrophilic filter membrane of aperture 0.22 μ m, and packing obtains collagen eye drops.
Collagen protein in the described step 1 is animal sources collagen protein or Human-like Collagen;
Short retina growth stimulator in the described step 1 is a taurine;
Vitamin in the described step 1 is a vitamin B
6, vitamin B
12, a kind of in the vitamin E;
Vasoconstrictor in the described step 1 is a kind of in Naphazoline Chloridum, the hydrochloric acid hydroxymethyl thiazole woods;
Hydryllin in the described step 1 is a chlorphenamine maleate;
Antiseptic in the described step 1 is a kind of in ethyl hydroxybenzoate, benzalkonium bromide, levofloxacin, the propyl p-hydroxybenzoate.
The method for preparing of described a kind of collagen eye drops is characterized in that:
Realize by following steps:
Step 1: with 100 milligrams of animal sources collagen protein, 150 milligrams of taurines, 10 milligrams of vitamin Bs
12, 1 milligram of Naphazoline Chloridum, 15 milligrams of chlorphenamine maleate and 40 milligrams of benzalkonium bromides, be dissolved in 0.9% the sodium chloride isotonic solution, be mixed with 100 milliliters mixed liquor, pH value is adjusted between 7.0 40 ℃ of water bath heat preservations 30 minutes;
Step 2: degerming while hot in sterile working's platform, the method for degerming are filtering with microporous membrane, and employed microporous filter membrane is the hydrophilic filter membrane of aperture 0.22 μ m, and packing obtains collagen eye drops.
The present invention has the following advantages:
The present invention adds short retina growth class, vitamins, vasoconstrictor class, antihistaminic and antiseptic kind adjuvant in collagen protein and isotonic solution, be configured to collagen eye drops, has good biological function; Has a large amount of hydrophilic groups; Make it to have the adhesiveness and the hydrophilic of height, when cell migration, can play a part to support and lubricate, can give eye required various neccessary compositions simultaneously; Improve the living environment and the metabolism that promotes eye of eye cell; To reach the purpose of nutrition, have the excellent lubricating effect of preserving moisture in addition, xerophthalmia and eyestrain there are better curative effect.
The specific embodiment
Below in conjunction with the specific embodiment the present invention is carried out detailed explanation.
Collagen protein is that the vertebrates in-vivo content is the abundantest, one group of scleroprotein of most widespread.Have many biological characteristics and functions such as reduced immunogenicity, biodegradable and promoting growth of cell; Can be used as pharmaceutical carrier clinically and treat various oculopathy; And can promote the reparation of cornea epithelial damage; The growth of corneal epithelial cell and the healing of corneal wound are a kind of good eye medicinal preparations.But the collagen protein great majority that use at present come from the extract of animal tissue, skin etc., have communicate illness, cause rejection, water insoluble etc. defective.Collagen protein of the present invention is animal collagen or adopts genetic engineering and the Human-like Collagen of biological engineering method production; Except that good characteristic with animal collagen; Also have safe, virus-free hidden danger, molecular weight is less; Soluble in water, have the characteristics of good osmotic absorption property.
Collagen eye drops of the present invention is a colourless clear liquid; In per 100 milliliters of eye drops; Be added with 50-200 milligram collagen protein, the short retina growth stimulator of 100-200 milligram, 5-15 milligram vitamin, 1-2 milligram vasoconstrictor, 10-20 milligram hydryllin and 30-50 milligram antiseptic, all the other are 0.9% sodium chloride isotonic solution.Wherein, short retina growth stimulator is a taurine, and vitamin is a vitamin B
6, vitamin B
12, a kind of in the vitamin E, vasoconstrictor is a kind of in Naphazoline Chloridum, the hydrochloric acid hydroxymethyl thiazole woods, hydryllin is a chlorphenamine maleate, antiseptic is a kind of in ethyl hydroxybenzoate, benzalkonium bromide, levofloxacin, the propyl p-hydroxybenzoate.
The method for using of collagen eye drops of the present invention: adult's every day, every eyes were 4-6 time, and each 1-2 drips.Child's using dosage dosage of being grown up relatively reduces in right amount.
Below be the specific embodiment of collagen eye drops method for preparing:
Embodiment one:
Step 1: with 50 milligrams of animal sources collagen protein, 100 milligrams of taurines, 5 milligrams of vitamin Bs
6, 1 milligram of Naphazoline Chloridum, 10 milligrams of chlorphenamine maleate and 30 milligrams of ethyl hydroxybenzoates, be dissolved in 0.9% the sodium chloride isotonic solution, be mixed with 100 milliliters mixed liquor, pH value is adjusted between 6.5 40 ℃ of water bath heat preservations 30 minutes;
Step 2: degerming while hot in sterile working's platform, the method for degerming are filtering with microporous membrane, and employed microporous filter membrane is the hydrophilic filter membrane of aperture 0.22 μ m, and packing obtains collagen eye drops.
This routine collagen eye drops is tested through following:
The large ear rabbit of 15 health, body weight 2.0 ± 0.2kg is divided into three groups of A, B, C at random, and 5 every group, use the irradiate light of intensity as 4000-5000liux, light application time is 5 days, then every lagophthalmos is carried out tired index marking.The A group drips this routine collagen eye drops, and the B group drips certain commercially available resisting fatigue eye drop, and the C group drips 0.9% sodium chloride solution.Every day, each eye drip was 5 times, and each 2, make lagophthalmos moistening fully, arrangement of time is: 8:00,11:00,14:00,17:00,20:00, eye drip 3-8 days continuously, observe the variation of the tired index of lagophthalmos each item every day, and give a mark and record.
The result shows: the cornea of A group rabbit is fuzzy to recover clearly that be 3 days average time, and iris is congested, be 3 days the recovery time of swelling, and be 4 days the recovery time of conjunctival congestion.The cornea of B group rabbit is fuzzy to recover clearly that be 4 days average time, and iris is congested, be 3 days the recovery time of swelling, and be 4 days the recovery time of conjunctival congestion.The cornea of C group rabbit is fuzzy to recover clearly that be 7 days average time, and iris is congested, be 6 days the recovery time of swelling, and be 8 days the recovery time of conjunctival congestion.Therefore, the resisting fatigue effect of this routine collagen eye drops is remarkable, and recovery time is fast, has good capillary rupture repair.
Embodiment two:
Step 1: with 100 milligrams of animal sources collagen protein, 150 milligrams of taurines, 10 milligrams of vitamin Bs
12, 1 milligram of Naphazoline Chloridum, 15 milligrams of chlorphenamine maleate and 40 milligrams of benzalkonium bromides, be dissolved in 0.9% the sodium chloride isotonic solution, be mixed with 100 milliliters mixed liquor, pH value is adjusted between 7.0 40 ℃ of water bath heat preservations 30 minutes;
Step 2: degerming while hot in sterile working's platform, the method for degerming are filtering with microporous membrane, and employed microporous filter membrane is the hydrophilic filter membrane of aperture 0.22 μ m, and packing obtains collagen eye drops.
This routine collagen eye drops is tested through following:
The large ear rabbit of 15 health, body weight 2.0 ± 0.2kg is divided into three groups of A, B, C at random, and 5 every group, use the irradiate light of intensity as 4000-5000liux, light application time is 5 days, then every lagophthalmos is carried out tired index marking.The A group drips this routine collagen eye drops, and the B group drips certain commercially available resisting fatigue eye drop, and the C group drips 0.9% sodium chloride solution.Every day, each eye drip was 5 times, and each 2, make lagophthalmos moistening fully, arrangement of time is: 8:00,11:00,14:00,17:00,20:00, eye drip 3-8 days continuously, observe the variation of the tired index of lagophthalmos each item every day, and give a mark and record.
The result shows: the cornea of A group rabbit is fuzzy to recover clearly that be 3 days average time, and iris is congested, be 3 days the recovery time of swelling, and be 3 days the recovery time of conjunctival congestion.The cornea of B group rabbit is fuzzy to recover clearly that be 4 days average time, and iris is congested, be 3 days the recovery time of swelling, and be 4 days the recovery time of conjunctival congestion.The cornea of C group rabbit is fuzzy to recover clearly that be 7 days average time, and iris is congested, be 6 days the recovery time of swelling, and be 8 days the recovery time of conjunctival congestion.Therefore, the resisting fatigue effect of this routine collagen eye drops is remarkable, and recovery time is fast, has good capillary rupture repair.
Embodiment three:
Step 1: with 150 milligrams of Human-like Collagens, 150 milligrams of taurines, 10 milligrams of vitamin Bs
12, 2 milligrams of hydrochloric acid hydroxymethyl thiazole woodss, 15 milligrams of chlorphenamine maleate and 40 milligrams of levofloxacin, be dissolved in 0.9% the sodium chloride isotonic solution, be mixed with 100 milliliters mixed liquor, pH value is adjusted between 7.0 40 ℃ of water bath heat preservations 30 minutes;
Step 2: degerming while hot in sterile working's platform, the method for degerming are filtering with microporous membrane, and employed microporous filter membrane is the hydrophilic filter membrane of aperture 0.22 μ m, and packing obtains collagen eye drops.
This routine collagen eye drops is tested through following:
The large ear rabbit of 15 health, body weight 2.0 ± 0.2kg is divided into three groups of A, B, C at random, and 5 every group, use the irradiate light of intensity as 4000-5000liux, light application time is 5 days, then every lagophthalmos is carried out tired index marking.The A group drips this routine collagen eye drops, and the B group drips certain commercially available resisting fatigue eye drop, and the C group drips 0.9% sodium chloride solution.Every day, each eye drip was 5 times, and each 2, make lagophthalmos moistening fully, arrangement of time is: 8:00,11:00,14:00,17:00,20:00, eye drip 3-8 days continuously, observe the variation of the tired index of lagophthalmos each item every day, and give a mark and record.
The result shows: the cornea of A group rabbit is fuzzy to recover clearly that be 3 days average time, and iris is congested, be 3 days the recovery time of swelling, and be 3 days the recovery time of conjunctival congestion.The cornea of B group rabbit is fuzzy to recover clearly that be 4 days average time, and iris is congested, be 3 days the recovery time of swelling, and be 4 days the recovery time of conjunctival congestion.The cornea of C group rabbit is fuzzy to recover clearly that be 7 days average time, and iris is congested, be 6 days the recovery time of swelling, and be 8 days the recovery time of conjunctival congestion.Therefore, the resisting fatigue effect of this routine collagen eye drops is remarkable, and recovery time is fast, has good capillary rupture repair.
Embodiment four:
Step 1: with 200 milligrams of Human-like Collagens, 200 milligrams of taurines, 15 milligrams of vitamin Es, 2 milligrams of hydrochloric acid hydroxymethyl thiazole woodss, 20 milligrams of chlorphenamine maleate and 50 milligrams of propyl p-hydroxybenzoate; Be dissolved in 0.9% the sodium chloride isotonic solution; Be mixed with 100 milliliters mixed liquor; PH value is adjusted between 7.5 40 ℃ of water bath heat preservations 30 minutes;
Step 2: degerming while hot in sterile working's platform, the method for degerming are filtering with microporous membrane, and employed microporous filter membrane is the hydrophilic filter membrane of aperture 0.22 μ m, and packing obtains collagen eye drops.
This routine collagen eye drops is tested through following:
The large ear rabbit of 15 health, body weight 2.0 ± 0.2kg is divided into three groups of A, B, C at random, and 5 every group, use the irradiate light of intensity as 4000-5000liux, light application time is 5 days, then every lagophthalmos is carried out tired index marking.The A group drips this routine collagen eye drops, and the B group drips certain commercially available resisting fatigue eye drop, and the C group drips 0.9% sodium chloride solution.Every day, each eye drip was 5 times, and each 2, make lagophthalmos moistening fully, arrangement of time is: 8:00,11:00,14:00,17:00,20:00, eye drip 3-8 days continuously, observe the variation of the tired index of lagophthalmos each item every day, and give a mark and record.
The result shows: the cornea of A group rabbit is fuzzy to recover clearly that be 3 days average time, and iris is congested, be 4 days the recovery time of swelling, and be 3 days the recovery time of conjunctival congestion.The cornea of B group rabbit is fuzzy to recover clearly that be 4 days average time, and iris is congested, be 3 days the recovery time of swelling, and be 4 days the recovery time of conjunctival congestion.The cornea of C group rabbit is fuzzy to recover clearly that be 8 days average time, and iris is congested, be 7 days the recovery time of swelling, and be 8 days the recovery time of conjunctival congestion.Therefore, the resisting fatigue effect of this routine collagen eye drops is remarkable, and recovery time is fast, has good capillary rupture repair.
Claims (3)
1. collagen eye drops is characterized in that:
Per 100 milliliters collagen eye drops is made up of the component of following mass fraction:
Collagen protein 50-200 milligram;
Short retina growth stimulator 100-200 milligram;
Vitamin 5-15 milligram;
Vasoconstrictor 1-2 milligram;
Hydryllin 10-20 milligram;
Antiseptic 30-50 milligram;
All the other are 0.9% sodium chloride isotonic solution;
Wherein:
Described collagen protein is animal sources collagen protein or Human-like Collagen;
Described short retina growth stimulator is a taurine;
Described vitamin is a vitamin B
6, vitamin B
12, a kind of in the vitamin E;
Described vasoconstrictor is a kind of in naphcon, the oxymetazoline hydrochloride;
Described hydryllin is a chlorphenamine maleate;
Described antiseptic is a kind of in ethyl hydroxybenzoate, benzalkonium bromide, levofloxacin, the propyl p-hydroxybenzoate.
2. the method for preparing of a kind of collagen eye drops as claimed in claim 1 is characterized in that:
Realize by following steps:
Step 1: with 50-200 milligram collagen protein, the short retina growth stimulator of 100-200 milligram, 5-15 milligram vitamin, 1-2 milligram vasoconstrictor, 10-20 milligram hydryllin and 30-50 milligram antiseptic; Be dissolved in 0.9% the sodium chloride isotonic solution; Be mixed with 100 milliliters mixed liquor; PH value is adjusted between the 6.5-7.5 40 ℃ of water bath heat preservations 30 minutes;
Step 2: degerming while hot in sterile working's platform, the method for degerming are filtering with microporous membrane, and employed microporous filter membrane is the hydrophilic filter membrane of aperture 0.22 μ m, and packing obtains collagen eye drops.
3. the method for preparing of a kind of collagen eye drops according to claim 2 is characterized in that:
Realize by following steps:
Step 1: with 100 milligrams of animal sources collagen protein, 150 milligrams of taurines, 10 milligrams of vitamin Bs
12, 1 milligram of naphcon, 15 milligrams of chlorphenamine maleate and 40 milligrams of benzalkonium bromides, be dissolved in 0.9% the sodium chloride isotonic solution, be mixed with 100 milliliters mixed liquor, pH value is adjusted to 7.0,40 ℃ of water bath heat preservations 30 minutes;
Step 2: degerming while hot in sterile working's platform, the method for degerming are filtering with microporous membrane, and employed microporous filter membrane is the hydrophilic filter membrane of aperture 0.22 μ m, and packing obtains collagen eye drops.
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102492033A (en) * | 2011-11-16 | 2012-06-13 | 陕西巨子生物技术有限公司 | Human-like collagen and human-like collagen composite sodium hyaluronate hydrogel |
| CN109453151B (en) * | 2018-12-18 | 2021-03-26 | 湖北远大天天明制药有限公司 | Pharmaceutical composition for eyes, preparation method and application thereof |
| CN111420036A (en) * | 2020-04-30 | 2020-07-17 | 广州市醒目医药科技有限公司 | Compound containing type I collagen and salvia miltiorrhiza extract, preparation and application |
| CN111450044B (en) * | 2020-04-30 | 2021-06-25 | 云南生物谷药业股份有限公司 | Ophthalmic preparation containing scutellarin, preparation method and application thereof |
| CN114748611A (en) * | 2022-03-14 | 2022-07-15 | 深圳中科欣扬生物科技有限公司 | Composition with antioxidant, moisturizing and lubricating effects and application thereof |
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| CN1927392A (en) * | 2005-09-08 | 2007-03-14 | 佟刚 | Composite collagen eye drops |
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| CN1927392A (en) * | 2005-09-08 | 2007-03-14 | 佟刚 | Composite collagen eye drops |
| CN1927391A (en) * | 2005-09-08 | 2007-03-14 | 佟刚 | Collagen eye drops |
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Application publication date: 20111012 Assignee: XI'AN GIANT BIOGENE TECHNOLOGY CO., LTD. Assignor: Shaanxi Giant Biogene Technology Co., Ltd. Contract record no.: 2014610000121 Denomination of invention: Collagen eye drops and preparation method thereof Granted publication date: 20121003 License type: Exclusive License Record date: 20140827 |
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Effective date of registration: 20170406 Address after: 710077 Xi'an high tech Zone, Jin Industrial Road, No., No. C Venture Park, No. 20, Patentee after: XI'AN GIANT BIOGENE TECHNOLOGY CO., LTD. Address before: 710077 Xi'an high tech Zone, Jin Industrial Road, No., No. C Venture Park, No. 20, Patentee before: Shaanxi Giant Biogene Technology Co., Ltd. |
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Assignee: XI'AN GIANT BIOGENE TECHNOLOGY CO., LTD. Assignor: Shaanxi Giant Biogene Technology Co., Ltd. Contract record no.: 2014610000121 Date of cancellation: 20181204 |