CN102206888B - Integrally formed three-layer woven simulation artificial blood vessel - Google Patents
Integrally formed three-layer woven simulation artificial blood vessel Download PDFInfo
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- CN102206888B CN102206888B CN2011101426050A CN201110142605A CN102206888B CN 102206888 B CN102206888 B CN 102206888B CN 2011101426050 A CN2011101426050 A CN 2011101426050A CN 201110142605 A CN201110142605 A CN 201110142605A CN 102206888 B CN102206888 B CN 102206888B
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Abstract
The invention relates to an integrally formed three-layer woven simulation artificial blood vessel, which is characterized by comprising an outer layer weaving structure, a middle layer weaving structure and an inner layer weaving structure which are connected together. The integrally formed three-layer woven simulation artificial blood vessel has a structure similar to that of a blood vessel of a human body, an outer layer, a middle layer and an inner layer are connected with one another through two groups of binding yarns to form a complete pipe wall structure which is similar to the pipe wall structure of an arterial blood vessel of the human body and has high pipe wall elasticity and bulkiness, and the artificial blood vessel is favorable for growing nutrition blood vessels and the like of the human body after being implanted into the human body, is more similar to the three-layer blood vessel wall of the human body compared with the common single-layer or double-layer artificial blood vessel, and can be implanted for a long time.
Description
Technical field
The present invention relates to a kind of one-body molded three layers of woven emulation artificial blood vessel, belong to bio-medical textile fabrics technical field.
Background technology
Blood vessel transplantation is the effective means of treating vascular defects property disease at present.Current, the blood vessel succedaneum that is used for blood vessel transplantation has from blood vessel and other pipeline group from body or allosome to be knitted, and directly or through taking off processing backs such as cell uses; The artificial blood vessel that also has other to utilize woven, knitting or non-organization method to process.Now Weave type artificial blood vessel is in the extensive use of blood vessel transplantation field and obtained good effect.But; Though obtained clinically using widely; Because to take into account mechanical strength, tube wall elasticity simultaneously, tube wall leaks blood and promotes cell tissue function such as grow into when preventing to perform the operation, seek the textile structural that approaches the human vas structure most and seem particularly important.
The human body artery vascular wall mainly is made up of for three layers adventitia, middle film, inner membrance, contains elastic fiber and collagen fiber in the middle film, and elastic fiber has the effect of the blood vessel retraction of the expansion of making, and collagen fiber play keeps tensile effect, has support function.The thickness of film is bigger in general, wherein is distributed with a considerable amount of little blood vessels (below the 1mm), is branched off into blood capillary after these little blood vessels get into adventitia, is distributed to adventitia and middle film.Nutrient vessel has a very important role in vessel growth.If do not have corresponding structure and enough spaces, nutrient vessel just can't be grown into, and growth of artificial blood vessel inner tissue etc. just can not get nutrition supply so, can influence blood vessel in the intravital long-term existence of people.
Conventional monolayers or double-deck artificial blood vessel be not owing to have and the corresponding three-decker of artificial blood vessel; Implant the back and just competent space and nutrition can not be provided for the growth of nutrient vessel; Tunica adventitia and middle film can not get enough nutrition supplies, are unfavorable for long-term existence in vivo; And conventional monolayers or double-deck artificial blood vessel material therefor generally are nondegradable, and long-term its structure of back of implanting might produce inhibition to the growth of human body self tissue, is unfavorable for long-term implantation.
Existing Weave type artificial blood vessel mainly contains following several kinds: the monolayer artificial blood vessel of (1) Weave type; (publication number CN 1565394A and grant number CN20134972Y) is described like Chinese patent; Utilize the variation of basic organization to realize the requirement of artificial blood vessel; But the water permeability of monolayer tube wall etc. need be controlled through the thickness through weft count and yarn of tissue; Tube wall elasticity and water permeability are difficult to reach requirement simultaneously, and the tube wall hole may not reach requirement, and growing into of back cell is implanted in influence; (2) through the weave method of coating collagen protein on the basic artificial blood vessel, fibroin albumen or collagen fibroin blend film of monolayer; Like Chinese patent (grant number 100364620C; Grant number 100364621C and publication number 100364619C), reduce the hole on the tube wall, oozing of blood when avoiding performing the operation; But its tube wall elasticity and thickness are limited, and the uniformity of coating etc. still need be probed into; (3) utilize knitting, woven or itself and the bonded method of additive method obtain double-deck Weave type artificial blood vessel; Like Chinese patent (grant number CN101069756B; Publication number CN101069757B and publication number 101066476A); But double-deck artificial blood vessel structurally still has the structural pipe wall that differs from human vas, is unfavorable for long-term implantation.
Summary of the invention
Technical problem to be solved by this invention provides a kind of one-body molded three layer woven emulation artificial blood vessel similar with the human vas structural pipe wall; Make artificial blood vessel structurally farthest near the structure of human body artery blood vessel, the artificial blood vessel tube wall has better elastic and bulkiness.
In order to solve the problems of the technologies described above; The invention provides a kind of one-body molded three layers of woven emulation artificial blood vessel; It is characterized in that; Comprise outer machine-knitted structure, middle level machine-knitted structure and internal layer machine-knitted structure, outer machine-knitted structure, middle level machine-knitted structure and internal layer machine-knitted structure link together through binder yarn.
Preferably, described outer machine-knitted structure adopts twill or satin weave, and warp thread adopts the 30D-50D polyester multifilament, and weft yarn adopts the 30D-50D polyester multifilament; Described middle level machine-knitted structure employing twill-weave, warp thread all adopts the terylene textured filament of 30D-50D and degradation material plying institute to become yarn with weft yarn; Described internal layer machine-knitted structure adopts plain weave, and warp thread adopts the 30D-50D polyester monofilament, and weft yarn adopts the 20D-30D polyester monofilament.
Preferably, the warp count of described outer machine-knitted structure is that 300-500 root/10cm, weft count are 400-500 root/10cm; The warp count of middle level machine-knitted structure is that 500-600 root/10cm, weft count are 400-500 root/10cm; The warp count of internal layer machine-knitted structure is that 800-1000 root/10cm, weft count are 1000-1500 root/10cm.
Preferably, described degradation material is collagen, chitin, polyvinyl alcohol, polycaprolactone, gathers Acetic acid, hydroxy-, bimol. cyclic ester, PPDO, polylactic acid, poly (glycolide-lactide) or gather dioxanone.
Preferably, the water permeability of described outer machine-knitted structure is 800-1500ml/cm
2Min, the water permeability of middle level machine-knitted structure (2) is 400-700ml/cm
2Min, the water permeability of internal layer machine-knitted structure are 100-300ml/cm
2Min, the whole water permeability of outer machine-knitted structure, middle level machine-knitted structure and internal layer machine-knitted structure is 100-200ml/cm
2Min, compliance are 2.2%/100mmHg-3.28%/100mmHg.
Preferably, connect through back warp access node method, associating access node method or binding pick access node method between described outer machine-knitted structure, middle level machine-knitted structure and the internal layer machine-knitted structure.
The present invention has following beneficial effect:
(1), one-body molded three layers of woven emulation artificial blood vessel of the present invention and human vas structural similarity; Through two groups of binder yarn; Outward, in, interior three layers interconnect, constitute complete structural pipe wall close with human body artery vascular wall structure, that have good tube wall elasticity and bulkiness, help the growth of human nutrition blood vessel etc. after implanting; Compare with the general monolayer or double-deck artificial blood vessel more near three layers of blood vessel wall of human body, more help the long-term implantation of artificial blood vessel.
(2), the outer tissue density of one-body molded three layers of woven emulation artificial blood vessel of the present invention is less, hole is bigger between yarn, is beneficial to growing into of cell, tissue; The middle level structure is fluffy, has elasticity preferably, and hole is moderate, the space that elasticity preferably is provided and the nutrient vessel growth is provided for blood vessel wall; Internal layer tissue density is bigger, and hole is less, and tube wall is level and smooth, is beneficial to blood flow, can effectively prevent the oozing of blood of tube wall when textile artificial blood vessel is transplanted, and thinner monofilament helps the growth of endotheliocyte in the multifilament.
(3), adopted degradation material in the middle level of one-body molded three layers of woven emulation artificial blood vessel of the present invention; Degradation material degraded in the artificial blood vessel behind the implantation certain hour; Make cells in vivo organize the formation endothelial layer of growing into smoothly; It forms more fluffy middle level structure, can more competent space be provided for the growth of human tissue cell and nutrient vessel etc.
Description of drawings
Fig. 1 three layers of woven emulation artificial blood vessel structural representation that are formed in one; 1 is outer blood vessel wall, and 2 is the middle level blood vessel wall, and 3 is the internal layer blood vessel wall.
Fig. 2 is outer tissue structure organization figure; 4 is through interlacing point, and 5 is the latitude interlacing point;
Fig. 3 is a middle level organizational structure organization charts; 4 is through interlacing point, and 5 is the latitude interlacing point;
Fig. 4 is an internal layer organizational structure organization charts; 4 is through interlacing point, and 5 is the latitude interlacing point;
Fig. 5 is a broadwise the sectional view outer and middle level; 1.~4. be outer warp thread;
~
is the middle level warp thread; 6 is outer weft yarn, and 7 is the middle level weft yarn.
Fig. 6 is the broadwise sectional view of middle level and internal layer;
~
is the middle level warp thread;
and
is the internal layer warp thread; 7 is the middle level weft yarn, and 8 is the internal layer weft yarn.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in the restriction scope of the present invention.In addition, after having read content of the present invention, those skilled in the art can do various changes or modification to the present invention, and these equivalent form of values fall within the application's appended claims institute restricted portion equally.
As shown in Figure 1; Three layers of woven emulation artificial blood vessel structural representation are formed in one; Described a kind of one-body molded three layers of woven emulation artificial blood vessel comprise outer machine-knitted structure 1, middle level machine-knitted structure 2 and internal layer machine-knitted structure 3; Adopt back warp access node method to connect between outer machine-knitted structure 1 and the middle level machine-knitted structure 2, the same back warp access node method that adopts connects between middle level machine-knitted structure 2 and the internal layer machine-knitted structure 3.
As shown in Figure 2, be the outer tissue structural representation, outer machine-knitted structure 1 is 2/2 twill-weave; Warp thread and weft yarn all adopt the 30D/12f polyster fibre; As shown in Figure 3, be middle level organizational structure sketch map, middle level machine-knitted structure 2 is 3/1 twill-weave; It is 30D/12f that warp thread all adopts the terylene textured filament to become yarn, specification with the chitin fiber plying with weft yarn; As shown in Figure 4, be internal layer organizational structure sketch map, internal layer machine-knitted structure 3 is 1/1 plain weave, and warp thread adopts the 30D/1f polyster fibre, and weft yarn adopts the 20D/12f polyster fibre.Adopt back warp access node method to connect (when being nonwoven outer, the corresponding warp thread in middle level is mentioned with outer weft yarn and interweaved) between outer machine-knitted structure 1 and the middle level machine-knitted structure 2, as shown in Figure 5, be broadwise the sectional view outer and middle level; Connect (when promptly weaving the middle level, the corresponding warp thread of internal layer is mentioned with the middle level weft yarn and interweaved) through back warp access node method between middle level machine-knitted structure 2 and the internal layer machine-knitted structure 3, as shown in Figure 6, be the broadwise sectional view of middle level and internal layer.By binder yarn outer machine-knitted structure 1, middle level machine-knitted structure 2, internal layer machine-knitted structure 3 are connected into the structural pipe wall of an integral body, as shown in Figure 7, be tube wall broadwise sectional view.The blood vessel intended diameter is 6mm.
Three layers of tubing of the system that weaves on looms, outer machine-knitted structure 1 warp count is that 500/10cm, weft count are 400/10cm; Machine-knitted structure 2 warp counts in middle level are that 500/10cm, weft count are 500/10cm; Internal layer machine-knitted structure 3 warp counts are that 1000/10cm, weft count are 1500/10cm.
The water permeability of outer machine-knitted structure 1 is 1000ml/cm
2Min, the water permeability of middle level machine-knitted structure 2 are 700ml/cm
2Min, the water permeability of internal layer machine-knitted structure 3 are 180ml/cm
2Min, the whole water permeability of outer machine-knitted structure 1, middle level machine-knitted structure 2 and internal layer machine-knitted structure 3 is 180ml/cm
2Min, compliance are 2.8%/100mmHg.
The artificial blood vessel porosity is 65%.
The blood vessel that weaves is cut into the disk of 1cm2, places 96 orifice plates, and the commercially available monolayer dacron-made artificial blood vessel of preparing identical size places another hole of 96 orifice plates as contrast, marked, and use ethylene oxide sterilizing.L929 fibroblast and the MTT (tetrazolium bromide) that configures are equipped with in the hole of sample with the adding of high glycoform DMEM (culture medium that contains each seed amino acid and glucose) culture medium, in incubator, cultivate 4h.Add DMSO (dimethyl sulfoxide) after removing culture medium behind the 4h, low speed shakes 15-20min on shaking table, goes out to measure the absorption photometric value in two holes at OD490nm.One-body molded three layers of woven emulation artificial blood vessel OD value are 1.5; Commercial monolayer dacron-made artificial blood vessel OD value is 1.0; One-body molded three layers of woven emulation artificial blood vessel OD value prove that greater than commercial monolayer dacron-made artificial blood vessel this three-decker artificial blood vessel helps the cell growth.
A kind of one-body molded three layers of woven emulation artificial blood vessel comprise outer machine-knitted structure 1, middle level machine-knitted structure 2 and internal layer machine-knitted structure 3; Be interweaved through the broadwise binder yarn that adds between outer machine-knitted structure 1 and the middle level machine-knitted structure 2, be interweaved through the broadwise binder yarn that adds between middle level machine-knitted structure 2 and the internal layer machine-knitted structure 3.
Outer machine-knitted structure 1 is 5/2 satin weave, all adopts the 50D/36f polyster fibre through weft yarn; Middle level machine-knitted structure 2 is 3/1 twill, and it is 40D/12f that warp thread, weft yarn all adopt the terylene textured filament to become yarn, specification with poly (glycolide-lactide) (PLGA) plying; Internal layer machine-knitted structure 3 is 1/1 plain weave, and warp thread adopts the 40D/1f polyster fibre, and weft yarn adopts the 30D/12f polyster fibre.Introduce stitching weft in the weaving process, introduce the 40D/36f polyster fibre between its ectomesoderm machine-knitted structure 1 and the middle level machine-knitted structure 2 as stitching weft, with in the weaving process outer machine-knitted structure 1 being connected with middle level machine-knitted structure 2 tube walls; Introduce the 40D/12f polyster fibre between middle level machine-knitted structure 2 and the internal layer machine-knitted structure 3 as stitching weft.Outer machine-knitted structure 1, middle level machine-knitted structure 2, internal layer machine-knitted structure 3 are connected into the structural pipe wall of an integral body by binder yarn.Intended diameter is 18mm.
Three layers of tubing of weaving on loom, outer machine-knitted structure 1 warp count are that 400/10cm, weft count are 500/10cm; Machine-knitted structure 2 warp counts in middle level are that 600/10cm, weft count are 400/10cm; Internal layer machine-knitted structure 3 warp counts are that 800/10cm, weft count are 1500/10cm.
The water permeability of outer machine-knitted structure 1 is 1200ml/cm
2Min, the water permeability of middle level machine-knitted structure 2 are 600ml/cm
2Min, the water permeability of internal layer machine-knitted structure 3 are 200ml/cm
2Min, the whole water permeability of outer machine-knitted structure 1, middle level machine-knitted structure 2 and internal layer machine-knitted structure 3 is 175 ml/cm
2Min, compliance are 3.1%/100mmHg.
The artificial blood vessel porosity is 68%.
The blood vessel that weaves is cut into the disk of 1cm2, places 96 orifice plates, and the commercially available monolayer dacron-made artificial blood vessel of preparing identical size places another hole of 96 orifice plates as contrast, marked, and use ethylene oxide sterilizing.L929 fibroblast and the MTT (tetrazolium bromide) that configures are equipped with in the hole of sample with the adding of high glycoform DMEM (a kind of culture medium that contains each seed amino acid and glucose) culture medium, in incubator, cultivate 4h.Add DMSO (dimethyl sulfoxide) after removing culture medium behind the 4h, low speed shakes 15-20min on shaking table, goes out to measure the absorption photometric value in two holes at OD490nm.One-body molded three layers of woven emulation artificial blood vessel OD value are 1.45; Commercial monolayer dacron-made artificial blood vessel OD value is 0.94; One-body molded three layers of woven emulation artificial blood vessel OD value prove that greater than commercial monolayer dacron-made artificial blood vessel this three-decker artificial blood vessel helps the cell growth.
A kind of one-body molded three layers of woven emulation artificial blood vessel comprise outer machine-knitted structure 1, middle level machine-knitted structure 2 and internal layer machine-knitted structure 3; Tongli connects through the access node method between outer machine-knitted structure 1 and the middle level machine-knitted structure 2, connects through the access node method through table between middle level machine-knitted structure 2 and the internal layer machine-knitted structure 3.
Outer machine-knitted structure 1 is 2/2 twill-weave, all adopts the 40D/12f polyster fibre through weft yarn; Middle level machine-knitted structure 2 is 2/2 twill, and it is 40D/12f that warp thread, weft yarn all adopt the terylene textured filament to become yarn, specification with polylactic acid (PLA) plying; Internal layer machine-knitted structure 3 is 1/1 plain weave, and warp thread adopts the 20D/1f polyster fibre, and weft yarn adopts the 50D/12f polyster fibre.Adopt back warp access node method to connect (when being nonwoven outer between outer machine-knitted structure 1 and the middle level machine-knitted structure 2; The corresponding warp thread in middle level is mentioned with outer weft yarn and is interweaved); Connect (when promptly weaving internal layer, the middle level warp thread descends and the internal layer weft yarn interweaves) through table through the access node method between middle level machine-knitted structure 2 and the internal layer machine-knitted structure 3.Outer machine-knitted structure 1, middle level machine-knitted structure 2, internal layer machine-knitted structure 3 are connected into the structural pipe wall of an integral body by binder yarn.Intended diameter is 42mm.
Three layers of tubing of weaving on loom, outer machine-knitted structure 1 warp count are that 450/10cm, weft count are 500/10cm; Machine-knitted structure 2 warp counts in middle level are that 550/10cm, weft count are 450/10cm; Internal layer machine-knitted structure 3 warp counts are that 900/10cm, weft count are 1400/10cm.
The water permeability of outer machine-knitted structure 1 is 1400ml/cm
2Min, the water permeability of middle level machine-knitted structure 2 are 600ml/cm
2Min, the water permeability of internal layer machine-knitted structure 3 are 195ml/cm
2Min, the whole water permeability of outer machine-knitted structure 1, middle level machine-knitted structure 2 and internal layer machine-knitted structure 3 is 185 ml/cm
2Min, compliance are 2.6%/100mmHg.The artificial blood vessel porosity is 63%.
The blood vessel that weaves is cut into the disk of 1cm2, places 96 orifice plates, and the commercially available monolayer dacron-made artificial blood vessel of preparing identical size places another hole of 96 orifice plates as contrast, marked, and use ethylene oxide sterilizing.L929 fibroblast and the MTT (tetrazolium bromide) that configures are equipped with in the hole of sample with the adding of high glycoform DMEM (a kind of culture medium that contains each seed amino acid and glucose) culture medium, in incubator, cultivate 4h.Add DMSO (dimethyl sulfoxide) after removing culture medium behind the 4h, low speed shakes 15-20min on shaking table, goes out to measure the absorption photometric value in two holes at OD490nm.One-body molded three layers of woven emulation artificial blood vessel OD value are 1.48; Commercial monolayer dacron-made artificial blood vessel OD value is 0.97; One-body molded three layers of woven emulation artificial blood vessel OD value prove that greater than commercial monolayer dacron-made artificial blood vessel this three-decker artificial blood vessel helps the cell growth.
Claims (5)
1. one-body molded three layers of woven emulation artificial blood vessel; It is characterized in that; Comprise outer machine-knitted structure (1), middle level machine-knitted structure (2) and internal layer machine-knitted structure (3), outer machine-knitted structure (1), middle level machine-knitted structure (2) and internal layer machine-knitted structure (3) link together through binder yarn, and described outer machine-knitted structure (1) adopts twill or satin weave; Warp thread adopts the 30D-50D polyester multifilament, and weft yarn adopts the 30D-50D polyester multifilament; Described middle level machine-knitted structure (2) employing twill-weave, warp thread all adopts the terylene textured filament of 30D-50D and degradation material plying institute to become yarn with weft yarn; Described internal layer machine-knitted structure (3) adopts plain weave, and warp thread adopts the 30D-50D polyester monofilament, and weft yarn adopts the 20D-30D polyester monofilament.
2. one-body molded three layers of woven emulation artificial blood vessel as claimed in claim 1 is characterized in that the warp count of described outer machine-knitted structure (1) is that 300-500 root/10cm, weft count are 400-500 root/10cm; The warp count of middle level machine-knitted structure (2) is that 500-600 root/10cm, weft count are 400-500 root/10cm; The warp count of internal layer machine-knitted structure (3) is that 800-1000 root/10cm, weft count are 1000-1500 root/10cm.
3. one-body molded three layers of woven emulation artificial blood vessel as claimed in claim 1; It is characterized in that described degradation material is collagen, chitin, polyvinyl alcohol, polycaprolactone, gather Acetic acid, hydroxy-, bimol. cyclic ester, PPDO, polylactic acid, poly (glycolide-lactide) or gather dioxanone.
4. one-body molded three layers of woven emulation artificial blood vessel as claimed in claim 1 is characterized in that the water permeability of described outer machine-knitted structure (1) is 800-1500ml/cm
2Min, the water permeability of middle level machine-knitted structure (2) is 400-700ml/cm
2Min, the water permeability of internal layer machine-knitted structure (3) is 100-300ml/cm
2Min, the whole water permeability of outer machine-knitted structure (1), middle level machine-knitted structure (2) and internal layer machine-knitted structure (3) is 100-200ml/cm
2Min, compliance are 2.2%/100mmHg-3.28%/100mmHg.
5. one-body molded three layers of woven emulation artificial blood vessel as claimed in claim 1; It is characterized in that described outer machine-knitted structure (1), middle level machine-knitted structure (2) and internal layer machine-knitted structure (3) are connected through back warp access node method, associating access node method or binding pick access node method.
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CN102920531A (en) * | 2012-11-08 | 2013-02-13 | 东华大学 | Production method of woven artificial blood vessel |
WO2014175301A1 (en) * | 2013-04-26 | 2014-10-30 | 東レ株式会社 | Artificial blood vessel |
CN105873622B (en) * | 2013-12-16 | 2019-12-31 | 卫材R&D管理有限公司 | Vascular reconstruction graft material |
CN108186162A (en) * | 2017-12-06 | 2018-06-22 | 江苏百优达生命科技有限公司 | A kind of three-decker composite artificial blood vessel |
CN109106468B (en) * | 2018-08-14 | 2023-12-01 | 江苏百优达生命科技有限公司 | Artificial blood vessel structure capable of improving compliance |
CN110755175B (en) * | 2019-10-15 | 2021-08-27 | 东华大学 | Integrally-formed gradient-degradable woven artificial ligament and preparation method thereof |
CN116672126B (en) * | 2023-07-28 | 2023-10-03 | 上海威高医疗技术发展有限公司 | Artificial blood vessel with adjustable cavity content under pressure |
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CN101069757A (en) * | 2007-05-25 | 2007-11-14 | 东华大学 | Two-lay machine-knitted structure textile type artificial blood vessel |
CN101803964A (en) * | 2009-10-23 | 2010-08-18 | 东华大学 | Textile artificial blood vessel capable of improving radial compliance |
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