CN102198211B - Traditional Chinese medicine composition for treating neurasthenia, and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating neurasthenia and a preparation method thereof. , Ophiopogon japonicus, tortoise shell, fried jujube kernel, schisandra, polygala, rehmannia glutinosa, cocklebur, a total of sixteen traditional Chinese medicines; the medicine has the effect of nourishing and strengthening, calming and calming the nerves; it is mainly used for neurasthenia, headache, dizziness , forgetfulness, insomnia, tinnitus embolism. Compared with the prior art, the technique of the medicine is more reasonable, and its clinical pharmacodynamic test effect is significantly improved; the bioavailability is high, the medicine stability is good, and there is no toxic or side effect.

Description

A preparation method of traditional Chinese medicine composition for treating neurasthenia

technical field

The invention relates to a traditional Chinese medicine composition for treating neurasthenia and a preparation method thereof, belonging to the technical field of pharmacy. the

technical background

Neurasthenia is a class of neurotic disorders characterized by easy excitement and mental fatigue, emotional troubles and psychological symptoms. Neurasthenia is often accompanied by dizziness, headache, vertigo, tinnitus, palpitations, irritability and irritation, difficulty falling asleep, anxiety and depression, and impotence, premature ejaculation or menstrual disorders. the

With the rapid development of society and the continuous acceleration of people's life rhythm, people's life, study, and work pressure are increasing, and people are prone to mental weakness, which seriously affects people's health.

At present, Western medicine mainly treats neurasthenia by taking sleeping pills, but clinical addiction and drug resistance are prone to occur. Traditional Chinese medicine has a lot of Chinese patent medicines in the treatment of neurasthenia, but the curative effect is not ideal enough. "Jiannao Anshen Tablet" under the item WS ₃ -B-2407-97 of the twelfth volume of "Prescriptions of Traditional Chinese Medicine" issued by the Ministry of Standards is a pure traditional Chinese medicine preparation. Certain curative effect, but in the middle of clinical application we find that its curative effect is not ideal enough, there is low cure rate, easy to relapse; for sugar-coated tablets, diabetes patients take etc. can not be ignored shortcomings.

The volatile oil in Suanzaoren has a very good sedative and tranquilizing effect, but it is a pity that the volatile oil in Suanzaoren has not been extracted during the extraction process of the preparation process of "Jiannao Anshen Tablets", and the loss is relatively large. the

In order to solve the defects of the existing technology, in recent years, we have explored the rich resources of traditional Chinese medicine in the motherland, combined with a large number of clinical pharmacodynamic studies, and based on the original "Jiannao Anshen Tablet" technology , Through a large number of experiments and explorations, it was found that in the original process, the "broken wild jujube kernels and cooked rehmannia glutinosa, Ophiopogon japonicus, Polygonatum, Polygala, and jujube were decocted twice, each time for 4 hours" into "fried jujube kernels, broken and cooked rehmannia glutinosa. Huang, Ophiopogon japonicus, Steamed Polygonatum, Polygala, Pitted Jujube Add water and decoct twice, each time for 4 hours, collect the distilled oil-water mixture during the decoction to separate the volatile oil; extract the volatile oil from the jujube seed, and spray it into the granules After being made into tablets, capsules and granules", the effect of the clinical pharmacodynamic experiment was significantly improved without any toxic and side effects; we made it according to the conventional process: tablets, capsules and granules. the

Contents of the invention

The object of the present invention is to provide a traditional Chinese medicine composition for treating neurasthenia and a preparation method thereof. the

In order to achieve the above object, the technical scheme adopted in the present invention is:

Formula ratio:

The preparation method of the present invention is:

1. Tablets:

The above sixteen flavors, 10g red ginseng, 4g antler, 10g antler gum, 25g antler cream and 40g poria cocos are crushed into fine powder, sieved and mixed; Add 50% ethanol for reflux extraction twice, add 13 times the amount for the first time, reflux for 2 hours, add 11 times the amount for the second time, reflux for 1.5 hours, filter, combine the filtrates, and recover ethanol, at -0.07～-0.08mpa Thick paste with a relative density of 1.31 to 1.32 when concentrated under reduced pressure to 80°C; 40g of fried jujube kernels, broken, and 40g of Rehmannia glutinosa, 40g of Radix Radix Radix, 235g of steamed Polygonatum, 80g of Polygala, 80g of pitted jujube, and decocted with water For the second time, add 12 times the amount for the first time, decoct for 4 hours, add 10 times the amount for the second time, and decoct for 4 hours, collect the distilled oil-water mixture during the two decoctions to separate the volatile oil, filter the decoction, and combine The filtrate is concentrated under reduced pressure at -0.07～-0.08mpa to a thick paste with a relative density of 1.31～1.32 at 80°C; the tortoise shell is decocted twice, adding 9 times the amount for the first time, decocting for 3 hours, and decocting for the second time. Add 7 times the amount for the second time, decoct for 3 hours, filter, combine the filtrates, concentrate under reduced pressure under the condition of -0.07 ~ -0.08mpa to a thick paste with a relative density of 1.31 ~ 1.32 at 80°C, and the residue is dried and crushed into Fine powder, sieve; combine the above thick paste, add appropriate amount of the above fine powder and starch, mix well, granulate, dry at 65-75°C, spray with volatile oil, press into 1000 tablets, coat with film to obtain tablets. the

2. Capsules:

The above sixteen flavors, 10g red ginseng, 4g antler, 10g antler gum, 25g antler cream and 40g poria cocos are crushed into fine powder, sieved and mixed; Add 50% ethanol for reflux extraction twice, add 13 times the amount for the first time, reflux for 2 hours, add 11 times the amount for the second time, reflux for 1.5 hours, filter, combine the filtrates, and recover ethanol, at -0.07～-0.08mpa Thick paste with a relative density of 1.31 to 1.32 when concentrated under reduced pressure to 80°C; 40g of fried jujube kernels, broken, and 40g of Rehmannia glutinosa, 40g of Radix Radix Radix, 235g of steamed Polygonatum, 80g of Polygala, 80g of pitted jujube, and decocted with water For the second time, add 12 times the amount for the first time, decoct for 4 hours, add 10 times the amount for the second time, and decoct for 4 hours, collect the distilled oil-water mixture during the two decoctions to separate the volatile oil, filter the decoction, and combine The filtrate is concentrated under reduced pressure at -0.07～-0.08mpa to a thick paste with a relative density of 1.31～1.32 at 80°C; the tortoise shell is decocted twice, adding 9 times the amount for the first time, decocting for 3 hours, and decocting for the second time. Add 7 times the amount for the second time, decoct for 3 hours, filter, combine the filtrates, concentrate under reduced pressure under the condition of -0.07 ~ -0.08mpa to a thick paste with a relative density of 1.31 ~ 1.32 at 80°C, and the residue is dried and crushed into Fine powder, sifted; combine the above thick paste, add appropriate amount of the above fine powder and starch, mix well, granulate, dry at 65-75°C, spray into volatile oil, and make 1000 capsules to obtain capsules. the

3. Granules:

The above sixteen flavors, 10g red ginseng, 4g antler, 10g antler gum, 25g antler cream and 40g poria cocos are crushed into fine powder, sieved and mixed; Add 50% ethanol for reflux extraction twice, add 13 times the amount for the first time, reflux for 2 hours, add 11 times the amount for the second time, reflux for 1.5 hours, filter, combine the filtrates, and recover ethanol, at -0.07～-0.08mpa Thick paste with a relative density of 1.31 to 1.32 when concentrated under reduced pressure to 80°C; 40g of fried jujube kernels, broken, and 40g of Rehmannia glutinosa, 40g of Radix Radix Radix, 235g of steamed Polygonatum, 80g of Polygala, 80g of pitted jujube, and decocted with water For the second time, add 12 times the amount for the first time, decoct for 4 hours, add 10 times the amount for the second time, and decoct for 4 hours, collect the distilled oil-water mixture during the two decoctions to separate the volatile oil, filter the decoction, and combine The filtrate is concentrated under reduced pressure at -0.07～-0.08mpa to a thick paste with a relative density of 1.31～1.32 at 80°C; the tortoise shell is decocted twice, adding 9 times the amount for the first time, decocting for 3 hours, and decocting for the second time. Add 7 times the amount for the second time, decoct for 3 hours, filter, combine the filtrates, concentrate under reduced pressure under the condition of -0.07 ~ -0.08mpa to a thick paste with a relative density of 1.31 ~ 1.32 at 80°C, and the residue is dried and crushed into Fine powder, sieve; combine the above thick paste, add appropriate amount of the above fine powder and dextrin, mix, granulate, dry at 65-75°C, granulate, spray into volatile oil, and make 1000g of granules to obtain granules. the

The scheme of the present invention is concluded through repeated experiments by the inventor, continuous improvement and adjustment. The preparation method of the above-mentioned traditional Chinese medicine composition drug is the best preparation method, and the effect of clinical pharmacodynamic experiments is significantly improved. the

Below, "Jiannao Anshen Tablet" under the item of the capsule prepared by the present invention is compared with the ministerial standard "Preparation of Traditional Chinese Medicine" twelfth volume WS ₃ -B-2407-97, illustrating its main pharmacodynamics:

The main pharmacodynamic experiment

Experimental purpose: Through the pharmacological experimental research of the capsules of the present invention and Jiannao Anshen Tablets on sedation, hypnosis, memory improvement, anti-convulsions, hypoxia resistance, anti-fatigue, etc., compare the capsules of the present invention with Jiannao Anshen Tablets, and observe their pharmacological effects strength. the

Test method: the influence of capsules of the present invention and Jiannao Anshen tablet on the spontaneous activity of mice; the influence of sleep time of mice; the influence of memory of mice; the influence of anticonvulsant effect of mice; The effect of; the effect on the anti-fatigue effect of mice. the

Experimental Materials

1.1 Instruments

XZC-4A small animal autonomous activity instrument; water maze automatic control instrument LW-I type. the

1.2 Reagents

Pentobarbital Sodium (Foshan Chemical Experimental Factory); Strychnine Nitrate Injection (Shanghai Tianfeng Pharmaceutical Factory)

Soda lime (Shanghai Wusi Chemical Reagent Factory); Scopolamine (Beijing Pharmaceutical Industry Research Institute)

1.3 Animals

Kunming mice, both male and female, weighing 18-22g, were fed with standard feed. Animal certificate: SCXK (Shaanxi) 2008-018, provided by the Experimental Animal Center of Xi'an Jiaotong University School of Medicine. the

1.4 Drugs

Brain-invigorating and tranquilizing tablets group: 5 tablets each time, 2 times a day. the

Large, medium and small dosage groups of capsules of the present invention: 1 capsule twice a day. the

Content: daily dose of crude drug 2.418g/day

Human daily dosage: Human daily dosage is 0.035 crude drug/kg (body weight is calculated as 70kg)

Daily dosage for animals: the daily dosage for mice is 0.314g crude drug/kg

1. The effect on the spontaneous activity of mice

Experimental Materials

1. Animals: Kunming mice, weighing 18-22 g. the

2. Drugs: 0.2418g crude drug/tablet for Jiannao Anshen Tablets; 0.6045g crude drug/granule for the large, medium and small dosage groups of the capsules of the present invention. The drug was prepared with distilled water before the experiment and administered by intragastric administration. the

experimental method

Fifty Kunming mice, half male and half male, weighing 18-22 g, were randomly divided into 5 groups, 10 mice in each group. The control group was gavaged with the same volume of normal saline; the capsule group of the present invention was gavaged with 0.8, 0.4, and 0.2 g crude drug/kg; the Jiannao Anshen tablet group was gavaged with 0.8 g crude drug/kg. The administration was continued for 7 days, and 1 hour after the last administration, the mice were placed in the spontaneous activity instrument for 3 minutes to adapt, and then the number of spontaneous activities of the mice within 5 minutes was measured. the

Experimental results: see Table 1

Table 1 Effects on spontaneous activity in mice

Compared with the control group **P<0.01; compared with the Jiannao Anshen tablet group ΔP<0.05. the

The result shows: the capsule group of the present invention and Jiannao Anshen Tablet group can obviously reduce the number of spontaneous activities of mice, and compared with the matched group, there is a very significant difference (P＜0.01); There was a significant difference (P<0.05) compared with the film group. It can be seen that the sedative effect of the capsule group of the present invention is stronger than that of the Jiannao Anshen tablet group. the

2. Effect on sleep time of mice

Experimental Materials

1. Animals: Kunming mice, weighing 18-22 g. the

2. Drugs: 0.2418g crude drug/tablet for Jiannao Anshen Tablets; 0.6045g crude drug/granule for the large, medium and small dosage groups of the capsules of the present invention. The drug was prepared with distilled water before the experiment and administered by intragastric administration. the

experimental method

Fifty Kunming mice, half male and half male, weighing 18-22 g, were randomly divided into 5 groups, 10 mice in each group. The control group was gavaged with the same volume of normal saline; the capsule group of the present invention was gavaged with 0.8, 0.4, and 0.2 g crude drug/kg; the Jiannao Anshen tablet group was gavaged with 0.8 g crude drug/kg. Continuous administration for 7 days, 1 hour after the last administration, intraperitoneal injection of pentobarbital sodium 45mg/kg, observe the disappearance and recovery time of the righting reflex of the mice, record the sleep duration, and observe for a total of 2 hours. If the sleep time exceeds 2 hours, it will be counted as 2 hours. . Experimental results: see Table 2

Table 2 Effects on sleep time of mice

Compared with the control group **P<0.01; compared with the Jiannao Anshen tablet group ΔP<0.05. the

The result shows: capsule group of the present invention and Jiannao Anshen Tablet group can obviously prolong the sleep time of mouse, compares with matched group and has very significant difference (P＜0.01); There was a significant difference between the groups (P<0.05). It can be seen that the hypnotic effect of the capsule group of the present invention is stronger than that of the Jiannao Anshen tablet group. the

3. The effect on the memory of mice

Experimental Materials

1. Animals: Kunming mice, weighing 18-22 g. the

2. Drugs: 0.2418g crude drug/tablet for Jiannao Anshen Tablets; 0.6045g crude drug/granule for the large, medium and small dosage groups of the capsules of the present invention. The drug was prepared with distilled water before the experiment and administered by intragastric administration. the

experimental method

Fifty Kunming mice, half male and half male, weighing 18-22 g, were randomly divided into 5 groups, 10 mice in each group. The control group was gavaged with the same volume of normal saline; the capsule group of the present invention was gavaged with 0.8, 0.4, and 0.2 g crude drug/kg; the Jiannao Anshen tablet group was gavaged with 0.8 g crude drug/kg. Continuous administration for 7 days, 1 hour after the second administration, intraperitoneal injection of 5 mg/kg of scopolamine solution, 10 minutes later, put the mice into the water maze automatic recorder, observe the time for the mice to step on the stage from the starting point to the end point, repeat 4 times, Each interval was 20s, and the average value was taken for statistical analysis. the

Experimental results: see Table 3

Table 3 Effects on the memory of mice

Compared with the control group **P<0.01; compared with the Jiannao Anshen tablet group ΔP<0.05. the

The result shows: capsule group of the present invention and Jiannao Anshen tablet group have the effect of repairing memory to the memory impairment model mouse that scopolamine causes, compare with matched group and have extremely significant difference (P＜0.01); Capsule large dose group of the present invention and Compared with the Jiannao Anshen Tablets group, there was a significant difference (P<0.05). It can be seen that the capsule group of the present invention has a stronger effect on improving memory than the Jiannao Anshen tablet group. the

4. Effect on anticonvulsant effect in mice

Experimental Materials

1. Animals: Kunming mice, weighing 18-22 g. the

2. Drugs: 0.2418g crude drug/tablet for Jiannao Anshen Tablets; 0.6045g crude drug/granule for the large, medium and small dosage groups of the capsules of the present invention. The drug was prepared with distilled water before the experiment and administered by intragastric administration. the

experimental method

Fifty Kunming mice, half male and half male, weighing 18-22 g, were randomly divided into 5 groups, 10 mice in each group. The control group was gavaged with the same volume of normal saline; the capsule group of the present invention was gavaged with 0.8, 0.4, and 0.2 g crude drug/kg; the Jiannao Anshen tablet group was gavaged with 0.8 g crude drug/kg. Continuous administration for 7 days, 1 hour after the last administration, intraperitoneal injection of strychnine nitrate injection 2mg/kg. The convulsion latency period of the mice (the time from injection of strychnine nitrate to the occurrence of convulsion) was recorded. the

Experimental results: see Table 4

The impact of table 4 on the anticonvulsant effect of mice

Compared with the control group **P<0.01; compared with the Jiannao Anshen tablet group ΔP<0.05. the

The result shows: capsule group of the present invention and Jiannao Anshen Tablet group all can prolong strychnine and cause the latent period that mouse convulsion takes place, compare with matched group and have extremely significant difference (P＜0.01); Compared with the Nao Anshen Tablets group, there was a significant difference (P<0.05). It can be seen that the anticonvulsant effect of the capsule group of the present invention is stronger than that of the Jiannao Anshen tablet group. the

5. The effect on the hypoxia resistance of mice

Experimental Materials

1. Animals: Kunming mice, weighing 18-22 g. the

2. Drugs: 0.2418g crude drug/tablet for Jiannao Anshen Tablets; 0.6045g crude drug/granule for the large, medium and small dosage groups of the capsules of the present invention. The drug was prepared with distilled water before the experiment and administered by intragastric administration. the

experimental method

Fifty Kunming mice, half male and half male, weighing 18-22 g, were randomly divided into 5 groups, 10 mice in each group. The control group was gavaged with the same volume of normal saline; the capsule group of the present invention was gavaged with 0.8, 0.4, and 0.2 g crude drug/kg; the Jiannao Anshen tablet group was gavaged with 0.8 g crude drug/kg. Continuous administration for 7 days, once a day, 0.5 hours after the last administration, each mouse was subcutaneously injected with 10% norepinephrine 0.1ml/only, and immediately after the injection, the mice were put into a 250ml aquarium filled with 5g of soda lime. The hypoxia resistance test was carried out in the mouth bottle. Coat the mouth of the jar with vaseline, put one mouse in each jar, seal it with a cap, and start timing immediately. The time when the mice died due to hypoxia was recorded by taking the breath stop of the mice as an indicator. the

Experimental results: see Table 5

Table 5 Effects on Mice's Resistance to Hypoxia

Compared with the control group **P<0.01; compared with the Jiannao Anshen tablet group ΔP<0.05. the

The result shows: the capsule group of the present invention and the Jiannao Anshen Tablet group can prolong the survival time of mice in the hypoxic environment, and compared with the matched group, there is a very significant difference (P＜0.01); Compared with the Nao Anshen Tablets group, there was a significant difference (P<0.05). It can be seen that the capsule group of the present invention has a stronger hypoxia-resistant effect than the Jiannao Anshen tablet group. the

6. Effect on the anti-fatigue effect of mice

Experimental Materials

1. Animals: Kunming mice, weighing 18-22 g. the

2. Drugs: 0.2418g crude drug/tablet for Jiannao Anshen Tablets; 0.6045g crude drug/granule for the large, medium and small dosage groups of the capsules of the present invention. The drug was prepared with distilled water before the experiment and administered by intragastric administration. the

experimental method

Fifty Kunming mice, half male and half male, weighing 18-22 g, were randomly divided into 5 groups, 10 mice in each group. The control group was gavaged with the same volume of normal saline; the capsule group of the present invention was gavaged with 0.8, 0.4, and 0.2 g crude drug/kg; the Jiannao Anshen tablet group was gavaged with 0.8 g crude drug/kg. Continuous administration for 7 days, once a day, 1 hour after the last administration, 2 g of lead was bundled at the base of the tail of the mice, and the mice were placed in glass tanks to swim at a water depth of 20 cm and a water temperature of 25±0.5°C, and the swimming time was recorded. When the head of the mouse submerges in the water for 10 seconds and fails to surface, it is considered to be physically exhausted, and the swimming time of the mouse is counted immediately. the

Experimental results: see Table 6

The influence of table 6 on the anti-fatigue effect of mice

Compared with the control group **P<0.01; compared with the Jiannao Anshen tablet group ΔP<0.05. the

The results show that: the capsule group of the present invention and the Jiannao Anshen Tablet group can obviously prolong the weight-bearing swimming time of mice, and there is a very significant difference (P＜0.01) compared with the matched group; There was a significant difference (P<0.05). It can be seen that the anti-fatigue effect of the capsule group of the present invention is stronger than that of the Jiannao Anshen tablet group. the

Experimental results: capsules of the present invention and Jiannao Anshen Tablets can significantly reduce the number of spontaneous activities of mice; can obviously prolong the sleep time of mice; have the effect of repairing memory on mice with memory impairment; The incubation period of convulsions in mice; it can prolong the survival time of mice in hypoxic environment: it can significantly prolong the weight-bearing swimming time of mice. the

Conclusion: the capsules of the present invention are stronger than Jiannao Anshen Tablets in pharmacological effects such as sedation, hypnosis, memory improvement, anticonvulsion, hypoxia resistance, anti-fatigue, etc. Good clinical curative effect such as forgetfulness and insomnia. the

Toxicology experiment:

Acute toxicity test results show that: the maximum concentration and maximum volume of the capsules of the present invention are given by intragastric administration, and the capsules are administered continuously for 3 times within 24 hours, with an interval of 4 hours each time. 347 times. Within 7 days after administration, the mice's activities, food intake, and excretion were all normal, their growth was good, their coat color was bright, and their average body weight increased with the prolongation of the test time. After the 8th day of death, each mouse was dissected to observe the heart, liver, spleen, lung, kidney, brain, thymus, stomach and intestine with naked eyes, and no abnormal color and shape were found, and the LD ₅₀ could not be measured. Show that capsule of the present invention has no acute toxicity reaction.

Long-term toxicity test results show that: the capsule components of the present invention have low, medium and high doses of 1, 2, and 4 g of crude drug/kg/d, which are equivalent to 29.0, 57.9, and 115.8 times the clinical dose. , the capsule of the present invention has no significant impact on the general condition, hematology index, and blood biochemical index of the animal, and no abnormal pathological changes have been found in system anatomy, organ coefficients, and histopathological examination. There was no significant change after stopping the drug for 2 weeks. In the long-term toxicity test of the capsule of the present invention, no obvious toxic reaction and delayed toxic reaction are found. It can be seen that the capsule of the present invention has no toxic reaction, and the long-term medication is safe and reliable. the

Specific embodiments of the present invention:

Embodiment 1 of the present invention:

Formula ratio:

Tablet preparation method:

The above sixteen flavors, 10g red ginseng, 4g antler, 10g antler gum, 25g antler cream and 40g poria cocos are crushed into fine powder, sieved and mixed; Add 50% ethanol for reflux extraction twice, add 13 times the amount for the first time, reflux for 2 hours, add 11 times the amount for the second time, reflux for 1.5 hours, filter, combine the filtrates, and recover ethanol, at -0.07～-0.08mpa Thick paste with a relative density of 1.31 to 1.32 when concentrated under reduced pressure to 80°C; 40g of fried jujube kernels, broken, and 40g of Rehmannia glutinosa, 40g of Radix Radix Radix, 235g of steamed Polygonatum, 80g of Polygala, 80g of pitted jujube, and decocted with water For the second time, add 12 times the amount for the first time, decoct for 4 hours, add 10 times the amount for the second time, and decoct for 4 hours, collect the distilled oil-water mixture during the two decoctions to separate the volatile oil, filter the decoction, and combine The filtrate is concentrated under reduced pressure at -0.07～-0.08mpa to a thick paste with a relative density of 1.31～1.32 at 80°C; the tortoise shell is decocted twice, adding 9 times the amount for the first time, decocting for 3 hours, and decocting for the second time. Add 7 times the amount for the second time, decoct for 3 hours, filter, combine the filtrates, concentrate under reduced pressure under the condition of -0.07 ~ -0.08mpa to a thick paste with a relative density of 1.31 ~ 1.32 at 80°C, and the residue is dried and crushed into Fine powder, sieve; combine the above thick paste, add appropriate amount of the above fine powder and starch, mix well, granulate, dry at 65-75°C, spray with volatile oil, press into 1000 tablets, coat with film to obtain tablets. the

Embodiment 2 of the present invention:

Formula ratio:

Capsule preparation method:

The above sixteen flavors, 10g red ginseng, 4g antler, 10g antler gum, 25g antler cream and 40g poria cocos are crushed into fine powder, sieved and mixed; Add 50% ethanol for reflux extraction twice, add 13 times the amount for the first time, reflux for 2 hours, add 11 times the amount for the second time, reflux for 1.5 hours, filter, combine the filtrates, and recover ethanol, at -0.07～-0.08mpa Thick paste with a relative density of 1.31 to 1.32 when concentrated under reduced pressure to 80°C; 40g of fried jujube kernels, broken, and 40g of Rehmannia glutinosa, 40g of Radix Radix Radix, 235g of steamed Polygonatum, 80g of Polygala, 80g of pitted jujube, and decocted with water For the second time, add 12 times the amount for the first time, decoct for 4 hours, add 10 times the amount for the second time, and decoct for 4 hours, collect the distilled oil-water mixture during the two decoctions to separate the volatile oil, filter the decoction, and combine The filtrate is concentrated under reduced pressure at -0.07～-0.08mpa to a thick paste with a relative density of 1.31～1.32 at 80°C; the tortoise shell is decocted twice, adding 9 times the amount for the first time, decocting for 3 hours, and decocting for the second time. Add 7 times the amount for the second time, decoct for 3 hours, filter, combine the filtrates, concentrate under reduced pressure under the condition of -0.07 ~ -0.08mpa to a thick paste with a relative density of 1.31 ~ 1.32 at 80°C, and the residue is dried and crushed into Fine powder, sifted; combine the above thick paste, add appropriate amount of the above fine powder and starch, mix well, granulate, dry at 65-75°C, spray into volatile oil, and make 1000 capsules to obtain capsules. the

Embodiment 3 of the present invention:

Formula ratio:

Preparation method of granules:

The above sixteen flavors, 10g red ginseng, 4g antler, 10g antler glue, 25g antler cream and 40g poria cocos are crushed into fine powder, sieved and mixed; Add 50% ethanol for reflux extraction twice, add 13 times the amount for the first time, reflux for 2 hours, add 11 times the amount for the second time, reflux for 1.5 hours, filter, combine the filtrates, and recover ethanol, at -0.07～-0.08mpa Thick paste with a relative density of 1.31 to 1.32 when concentrated under reduced pressure to 80°C; 40g of fried jujube kernels, broken, and 40g of Rehmannia glutinosa, 40g of Radix Radix Radix, 235g of steamed Polygonatum, 80g of Polygala, 80g of pitted jujube, and decocted with water For the second time, add 12 times the amount for the first time, decoct for 4 hours, add 10 times the amount for the second time, and decoct for 4 hours, collect the distilled oil-water mixture during the two decoctions to separate the volatile oil, filter the decoction, and combine The filtrate is concentrated under reduced pressure at -0.07～-0.08mpa to a thick paste with a relative density of 1.31～1.32 at 80°C; the tortoise shell is decocted twice, adding 9 times the amount for the first time, decocting for 3 hours, and decocting for the second time. Add 7 times the amount for the second time, decoct for 3 hours, filter, combine the filtrates, concentrate under reduced pressure under the condition of -0.07 ~ -0.08mpa to a thick paste with a relative density of 1.31 ~ 1.32 at 80°C, and the residue is dried and crushed into Fine powder, sieve; combine the above thick paste, add appropriate amount of the above fine powder and dextrin, mix, granulate, dry at 65-75°C, granulate, spray into volatile oil, and make 1000g of granules to obtain granules. the

Claims (1)

1. a preparation method of a Chinese medicine composition for the treatment of neurasthenia, characterized in that: the raw material proportioning of said Chinese medicine composition is:

The preparation method is: The above sixteen flavors, 10g red ginseng, 4g antler, 10g antler gum, 25g antler cream and 40g poria cocos are crushed into fine powder, sieved and mixed; Add 50% ethanol for reflux extraction twice, add 13 times the amount for the first time, reflux for 2 hours, add 11 times the amount for the second time, reflux for 1.5 hours, filter, combine the filtrates, and recover ethanol, at -0.07～-0.08mpa Thick paste with a relative density of 1.31 to 1.32 when concentrated under reduced pressure to 80°C; 40g of fried jujube kernels, broken, and 40g of Rehmannia glutinosa, 40g of Radix Radix Radix, 235g of steamed Polygonatum, 80g of Polygala, 80g of pitted jujube, and decocted with water For the second time, add 12 times the amount for the first time, decoct for 4 hours, add 10 times the amount for the second time, and decoct for 4 hours, collect the distilled oil-water mixture during the two decoctions to separate the volatile oil, filter the decoction, and combine The filtrate is concentrated under reduced pressure at -0.07～-0.08mpa to a thick paste with a relative density of 1.31～1.32 at 80°C; the tortoise shell is decocted twice, adding 9 times the amount for the first time, decocting for 3 hours, and decocting for the second time. Add 7 times the amount for the second time, decoct for 3 hours, filter, combine the filtrates, concentrate under reduced pressure under the condition of -0.07 ~ -0.08mpa to a thick paste with a relative density of 1.31 ~ 1.32 at 80°C, and the residue is dried and crushed into Fine powder, sifted; combine the above thick paste, add appropriate amount of the above fine powder and starch, mix well, granulate, dry at 65-75°C, spray into volatile oil, and make 1000 capsules to obtain capsules.