CN102139126A - Tectorial membrane stent and membraneous material - Google Patents
Tectorial membrane stent and membraneous material Download PDFInfo
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- CN102139126A CN102139126A CN2010101038845A CN201010103884A CN102139126A CN 102139126 A CN102139126 A CN 102139126A CN 2010101038845 A CN2010101038845 A CN 2010101038845A CN 201010103884 A CN201010103884 A CN 201010103884A CN 102139126 A CN102139126 A CN 102139126A
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- eptfe
- overlay film
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- tectorial membrane
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Abstract
The invention provides a tectorial membrane stent. The tectorial membrane stent comprises a stent section and a tectorial membrane coated on the stent section, wherein the tectorial membrane consists of at least two layers of incongruously compound expanded polytetrafluoroethylene (ePTFE). The invention also provides a membraneous material, which comprises at least two layers of incongruously compound ePTFE. Compared with the prior art, the tectorial membrane of the tectorial membrane stent provided by the invention consists of the at least two layers of incongruously compound ePTFE; and the pore spaces of all the layers of ePTFE have different sizes and directions. When the tectorial membrane stent is released, nodes of all the layers of ePTFE are radioactively extended towards different directions, and the defect of shortened filamentary fibers among the nodes is overcome, so that the tectorial membrane stent of the tectorial membrane formed by more layers of ePTFE are radioactively expended towards multiple directions, the phenomenon of radial shortening can be prevented, and treatment effects can be improved.
Description
Technical field
The present invention relates to a kind of Wicresoft and hinder the interventional medical device product, relate in particular to a kind of overlay film frame and membrane material.
Background technology
The traditional method of aneurysm treatment is to close and remove aneurysm by driving cranium microsurgery folder, but this surgical operation is traumatic and has high risk.And in the blood vessel interventional therapy have that wound is little, complication is few, safe, advantage such as the patient suffering is few, become the aneurysmal main method of treatment gradually.
Prior art discloses interventional therapy method in the multiple blood vessel, and wherein, the overlay film frame method is a kind of method commonly used.The overlay film frame method mainly is that the overlay film frame that is in compressive state is sent to the vascular lesion position, accurately behind the location, with its release, overlay film frame after the expansion can cover lesion vessels, isolated vascular lesion position also forms new channel of blood flow, thereby make aneurysm forfeiture blood supply, reach therapeutic purposes.Because overlay film frame needs implantable intravascular inside, the effect of performance blood channel, therefore, the overlay film of overlay film frame need satisfy following requirement: excellent biological compatibility and certain expansion plasticity and mechanical endurance are arranged.Prior art discloses the overlay film of multiple material as overlay film frame, and that commonly used is expanded PTFE (ePTFE), and ePTFE has good antithrombotic, certain expansion plasticity and mechanical endurance.
But the pore structure of monolayer ePTFE is comparatively single, and referring to Fig. 1, Fig. 1 is the microstructure sketch map of monolayer expanded PTFE.By 1 as can be known, ePTFE is made up of knot 1 and filament shape cross-bridges fiber (filamentary fibers) 2, knot with tie between form hole, continuous by filamentary fibers.When overlay film frame is released, the ePTFE expansion, at this moment, the knot 1 of ePTFE forms radioactivity elongation, then shortening of filamentary fibers 2.Monolayer ePTFE can only become the characteristics of footpath radiotropism expansion, when causing overlay film frame to be released expansion in blood vessel the phenomenon of radially cripetura can take place, thereby can not cover lesion vessels fully, influences therapeutic effect.
Summary of the invention
In view of this, the technical problem to be solved in the present invention is to provide a kind of overlay film frame and membrane material, and overlay film frame provided by the present invention radially cripetura phenomenon can not take place, and can improve therapeutic effect.
The invention provides a kind of overlay film frame, comprise brace sections and the overlay film that is coated on the described brace sections;
Described overlay film is made of two-layer at least, incorgruous compound expanded PTFE.
Preferably, in the described overlay film, adjacent eptfe layer is compound in the scope of 0 degree angle-an angle of 90 degrees.
Preferably, in the described overlay film, the hole of innermost layer expanded PTFE is less than the hole of outermost layer expanded PTFE.
Preferably, the hole of described innermost layer expanded PTFE is 0.1 μ m-40 μ m.
Preferably, the hole of described innermost layer expanded PTFE is 25 μ m-35 μ m.
Preferably, the hole of described outermost layer expanded PTFE is greater than 40 μ m.
Preferably, the hole of described outermost layer expanded PTFE is 50 μ m-100 μ m.
Preferably, described overlay film compoundly constitutes by 3 layers of expanded PTFE is incorgruous.
The present invention also provides a kind of membrane material, comprises two-layer at least, incorgruous compound expanded PTFE.
Preferably, adjacent eptfe layer is compound in the scope of 0 degree angle-an angle of 90 degrees.
Compared with prior art, the overlay film of overlay film frame provided by the invention is made of two-layer at least, incorgruous compound expanded PTFE, the hole of each layer ePTFE has different size and Orientations, when overlay film frame is released, the knot of each layer ePTFE remedies the defective that the filamentary fibers between finishing shortens to the elongation of different directions radioactivity, thereby makes multilamellar ePTFE constitute the multi-direction radioactivity expansion of overlay film frame of overlay film, radially cripetura phenomenon can not take place, can improve therapeutic effect.
Description of drawings
In order to be illustrated more clearly in the embodiment of the invention or technical scheme of the prior art, to do to introduce simply to the accompanying drawing of required use in embodiment or the description of the Prior Art below, apparently, accompanying drawing in describing below only is some embodiments of the present invention, for those of ordinary skills, under the prerequisite of not paying creative work, can also obtain other accompanying drawing according to these accompanying drawings.
Fig. 1 is the microstructure sketch map of monolayer expanded PTFE;
The structural representation of the overlay film frame that Fig. 2 provides for the embodiment of the invention;
The two-layer expanded PTFE that Fig. 3 provides for the embodiment of the invention is compound sketch map when an angle of 90 degrees;
The two-layer expanded PTFE that Fig. 4 provides for the embodiment of the invention is compound sketch map when miter angle.
The specific embodiment
The invention provides a kind of overlay film frame, comprise brace sections and the overlay film that is coated on the described brace sections; Wherein, described overlay film is made of two-layer at least, incorgruous compound expanded PTFE.
According to the present invention, described overlay film frame comprises brace sections and the overlay film that is coated on the described brace sections.The present invention does not have particular restriction to the shape of described overlay film frame, is preferably shape well known to those skilled in the art, includes but not limited to straight pipe type overlay film frame, webmaster type overlay film frame and has ramose overlay film frame.The present invention does not have particular restriction to the material of described brace sections, is preferably material well known to those skilled in the art, includes but not limited to metal and high molecular polymer.The present invention does not have particular restriction to the coating mode of described overlay film and brace sections, be preferably coating mode well known to those skilled in the art, include but not limited to described overlay film is sewn on the described brace sections and described overlay film is made tubular structure be enclosed within the brace sections outside.
The overlay film of overlay film frame provided by the invention is made of two-layer at least, incorgruous compound expanded PTFE (ePTFE).The structure of monolayer ePTFE is referring to Fig. 1, and Fig. 1 is the microstructure sketch map of monolayer expanded PTFE, and as shown in Figure 1, ePTFE is made up of knot 1 and filament shape cross-bridges fiber (filamentary fibers) 2, forms hole between knot and the knot, links to each other by filamentary fibers.Average distance between two knots is called the knot spacing, is the measurement index of hole.When overlay film frame is released, the ePTFE expansion, knot presents the radioactivity elongation, thereby realizes cutting off the blood flow of diseased region.
The present invention is incorgruous compound with two-layer at least ePTFE, makes the knot of each layer ePTFE realize the radioactivity elongation in different directions.
The present invention does not have particular restriction to the complex method of described each layer ePTFE, is preferably method well known to those skilled in the art.
The present invention does not have particular restriction to the compound direction of described each layer ePTFE, can be all inequality for each layer ePTFE direction, also can be one or more layers direction difference wherein, and be preferably adjacent two layers ePTFE direction difference.
Direction of the present invention is meant the angle that the filamentary fibers of each layer ePTFE forms, and the preferred adjacent two layers ePTFE of the present invention is compound in the scope of 0 degree angle-an angle of 90 degrees.
According to the present invention, the number of plies of described ePTFE is preferably more than 3 layers, more preferably the 3-5 layer.
Because overlay film frame is used for interventional therapy in the blood vessel, described overlay film will directly contact with blood vessel wall and blood, and the present invention preferably makes described overlay film meet the following conditions: the hole of innermost layer expanded PTFE is less than the hole of outermost layer expanded PTFE.The ePTFE layer that described innermost layer ePTFE is meant when overlay film frame is in compressive state and brace sections is the most approaching.After overlay film frame was released, innermost layer ePTFE will directly contact with blood, and less hole can intercept blood flow, prevent seepage, can hinder proliferation of smooth muscle to intravascular space simultaneously.
According to the present invention, the hole of described innermost layer expanded PTFE is 0.1 μ m-40 μ m, and more preferably 10 μ m-35 μ m most preferably are 25 μ m-35 μ m.Described outermost layer ePTFE is meant when overlay film frame is in compressive state and brace sections distance ePTFE layer farthest.After overlay film frame was released, outermost layer ePTFE directly contacted with blood vessel wall, and bigger hole can stimulate myofibroblast to grow between hole, quickened the healing of overlay film and blood vessel wall.
According to the present invention, the hole of described outermost layer expanded PTFE is preferably more than 40 μ m, and more preferably 50 μ m-150 μ m most preferably are 50 μ m-100 μ m.
The present invention also provides a kind of membrane material, comprises two-layer at least, incorgruous compound expanded PTFE.
The present invention is incorgruous compound with two-layer at least ePTFE, makes each layer ePTFE realize the radioactivity elongation in different directions.
The present invention does not have particular restriction to the complex method of described each layer ePTFE, is preferably method well known to those skilled in the art.
The present invention does not have particular restriction to the compound direction of described each layer ePTFE, can be all inequality for each layer ePTFE direction, also can be one or more layers direction difference wherein, and be preferably adjacent two layers ePTFE direction difference.
Direction of the present invention is meant the angle that the filamentary fibers of each layer ePTFE forms, and the preferred adjacent two layers ePTFE of the present invention is compound in the scope of 0 degree angle-an angle of 90 degrees.
According to the present invention, the number of plies of described membrane material is preferably more than 3 layers, more preferably the 3-5 layer.Compared with prior art, the overlay film of overlay film frame provided by the invention is made of two-layer at least, incorgruous compound expanded PTFE, the hole of each layer ePTFE has different size and Orientations, when overlay film frame is released, the knot of each layer ePTFE remedies the defective that the filamentary fibers between finishing shortens to the elongation of different directions radioactivity, thereby makes multilamellar ePTFE constitute the multi-direction radioactivity expansion of overlay film frame of overlay film, radially cripetura phenomenon can not take place, improved therapeutic effect.
Below in conjunction with accompanying drawing overlay film frame provided by the invention is described.
Referring to Fig. 2, the structural representation of the overlay film frame that Fig. 2 provides for the embodiment of the invention.
As shown in Figure 2, described overlay film frame comprises brace sections 3 and is coated on outside the brace sections, piped overlay film 4.Described overlay film is made of two-layer ePTFE, and described two-layer ePTFE can be compound in an angle of 90 degrees direction, and referring to Fig. 3, the two-layer expanded PTFE that Fig. 3 provides for the embodiment of the invention is compound sketch map when an angle of 90 degrees.As shown in Figure 3, ePTFE411 is with after 412 one-tenth an angle of 90 degrees are compound, and described overlay film has the knot and the filamentary fibers of different directions.After described overlay film frame is released, the knot of two-layer ePTFE is respectively in 0 degree angular direction and the elongation of an angle of 90 degrees direction dilatancy, filamentary fibers shortens in an angle of 90 degrees direction and 0 degree angular direction respectively, the making a concerted effort of two-layer ePTFE described overlay film can not shortened, and the whole film covering support can not shorten yet.Described two-layer ePTFE can be compound in the miter angle direction, and referring to Fig. 4, the two-layer expanded PTFE that Fig. 4 provides for the embodiment of the invention is compound sketch map when miter angle.As shown in Figure 4, ePTFE421 is with after 422 one-tenth miter angles are compound, and described overlay film has the knot and the filamentary fibers of different directions.After described overlay film frame is released, the knot of two-layer ePTFE is respectively in 0 degree angular direction and the elongation of miter angle direction dilatancy, filamentary fibers shortens in miter angle direction and 0 degree angular direction respectively, the making a concerted effort of two-layer ePTFE described overlay film can not shortened, and the whole film covering support can not shorten yet.
The explanation of above embodiment just is used for helping to understand method of the present invention and core concept thereof.Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of claim of the present invention.
Claims (10)
1. an overlay film frame is characterized in that, comprises brace sections and the overlay film that is coated on the described brace sections;
Described overlay film is made of two-layer at least, incorgruous compound expanded PTFE.
2. support according to claim 1 is characterized in that, in the described overlay film, adjacent eptfe layer is compound in the scope of 0 degree angle-an angle of 90 degrees.
3. support according to claim 1 is characterized in that, in the described overlay film, the hole of innermost layer expanded PTFE is less than the hole of outermost layer expanded PTFE.
4. support according to claim 3 is characterized in that, the hole of described innermost layer expanded PTFE is 0.1 μ m-40 μ m.
5. support according to claim 4 is characterized in that, the hole of described innermost layer expanded PTFE is 25 μ m-35 μ m.
6. support according to claim 3 is characterized in that, the hole of described outermost layer expanded PTFE is greater than 40 μ m.
7. support according to claim 6 is characterized in that, the hole of described outermost layer expanded PTFE is 50 μ m-100 μ m.
8. according to any described support of claim 1-7, it is characterized in that described overlay film is made of 3 layers of incorgruous compound expanded PTFE.
9. a membrane material is characterized in that, comprises two-layer at least, incorgruous compound expanded PTFE.
10. membrane material according to claim 9 is characterized in that, adjacent eptfe layer is compound in the scope of 0 degree angle-an angle of 90 degrees.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101038845A CN102139126A (en) | 2010-02-01 | 2010-02-01 | Tectorial membrane stent and membraneous material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101038845A CN102139126A (en) | 2010-02-01 | 2010-02-01 | Tectorial membrane stent and membraneous material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102139126A true CN102139126A (en) | 2011-08-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101038845A Pending CN102139126A (en) | 2010-02-01 | 2010-02-01 | Tectorial membrane stent and membraneous material |
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| CN (1) | CN102139126A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287048A (en) * | 2014-07-03 | 2016-02-03 | 上海理工大学 | Filming support |
| CN109260527A (en) * | 2013-03-15 | 2019-01-25 | W.L.戈尔及同仁股份有限公司 | With fibril micro-structure and the porous material that coating can be broken |
| US11229540B2 (en) | 2013-03-14 | 2022-01-25 | W. L. Gore & Associates, Inc. | Inflatable balloon and cove |
-
2010
- 2010-02-01 CN CN2010101038845A patent/CN102139126A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11229540B2 (en) | 2013-03-14 | 2022-01-25 | W. L. Gore & Associates, Inc. | Inflatable balloon and cove |
| US11883311B2 (en) | 2013-03-14 | 2024-01-30 | W. L. Gore & Associates, Inc. | Inflatable balloon and cover |
| US11903855B2 (en) | 2013-03-14 | 2024-02-20 | W. L. Gore & Associates, Inc. | Inflatable balloon and cover |
| CN109260527A (en) * | 2013-03-15 | 2019-01-25 | W.L.戈尔及同仁股份有限公司 | With fibril micro-structure and the porous material that coating can be broken |
| CN109260527B (en) * | 2013-03-15 | 2021-11-05 | W.L.戈尔及同仁股份有限公司 | Porous material with fibrillar microstructure and fracturable coating |
| CN105287048A (en) * | 2014-07-03 | 2016-02-03 | 上海理工大学 | Filming support |
| CN105287048B (en) * | 2014-07-03 | 2017-06-23 | 上海理工大学 | Overlay film frame |
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Address after: 201203 Shanghai City Newton Road, Pudong New Area Zhangjiang hi tech Park No. 501 Applicant after: Shanghai MicroPort Medical Equipment (Group) Co., Ltd. Address before: 201203 Shanghai City Newton Road, Pudong New Area Zhangjiang hi tech Park No. 501 Applicant before: Weichuang Medical Equipment (Shanghai) Co., Ltd. |
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Free format text: CORRECT: APPLICANT; FROM: WEICHUANG MEDICAL EQUIPMENT (SHANGHAI) CO., LTD. TO: SHANGHAI MICROPORT MEDICAL EQUIPMENT (GROUP) CO., LTD. |
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Application publication date: 20110803 |