CN102133352A - Asparagus oral liquid for preventing and curing tumor disease and preparation method thereof - Google Patents
Asparagus oral liquid for preventing and curing tumor disease and preparation method thereof Download PDFInfo
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- CN102133352A CN102133352A CN 201110059499 CN201110059499A CN102133352A CN 102133352 A CN102133352 A CN 102133352A CN 201110059499 CN201110059499 CN 201110059499 CN 201110059499 A CN201110059499 A CN 201110059499A CN 102133352 A CN102133352 A CN 102133352A
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- asparagus
- amino acids
- tumor disease
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Abstract
The invention discloses an asparagus oral liquid for preventing and curing tumor disease and a preparation method thereof. The asparagus oral liquid is prepared by following steps: taking fresh asparagus as raw material, cleaning, juicing or extracting the fresh asparagus, concentrating, intercepting and finely filtering the fresh asparagus by ceramic film molecules so as to obtain an asparagus extract with higher effective ingredient content, and adding proper auxiliary materials so as to prepare the oral liquid. The asparagus oral liquid is used for preventing and curing the tumor disease, has the functions of improving the immunity of a patient, inhibiting and contracting local tumor, klling tumour cells in the body of the patient, reducing the side effects of concurrent chemoradiotherapy, enhancing the sensitization of concurrent chemoradiotherapy, eliminating the toxic and side effects of nausea, vomiting, anorexia, poor sleeping quality, alopecia, pain and the like caused by concurrent chemoradiotherapy and increasing erythrocyte and leukocyte, has the obvious effect of helping producing saliva and slaking thirst, and has the advantages that the curative effect is stable, the using is convenient, and the like; and for the liquid, an industrial production device is simple and concise, the operation is convenient, the cost is low, the automatic degree is high, and the quality of products is easy to control.
Description
Technical field
The invention belongs to medical technical field, be specifically related to asparagus oral liquor medicine of a kind of prevention, treatment tumor disease and preparation method thereof.
Background technology
Along with modern society's high speed development, various paathogenic factors are more and more, as environmental pollution, unhygienic diet, pressure is excessive, and living not, rhythm and pace of moving things etc. all will cause tumor patient more and more diversified, and present a rapidly rising trend, at present the expert is consistent thinks, operation, radiation and chemotherapy are considered to treat " three magic weapons " of tumor, solved to a certain extent really cancer at the moment with partial some problem.But its side effect is very big, and wherein the overwhelming majority can cause leukopenia.Cancer is the disease of a general, so-called systemic disease, though partial in other words tumor excision, but remain in the cancerous cell of blood in human body in liquid, lymphsystem and each organ-tissue, under certain conditions, cancerous cell is activated, and undergos mutation at some position, forms tumor promptly so-called " recurrence, diffusion and transfer " again.Operation and radiotherapy can only solve local problem; Chemotherapy also can not be killed all cancerous cell because of being subjected to the each side condition restriction, and the injury of human heaviness is easy to form the secondary tumor.Traditional method of treatment mostly is " treating the poisonous disease with poisonous drugs ", though can kill and wound some cancerous cell, has also damaged a large amount of human normal tissue cells, and what is called loses more than gain.And traditional Chinese medicine cancer also mostly all is with some the medicine of severe toxicity such as Mylabris, arsenicum, Natrii Sulfas, Fructus Bruceae, Semen Strychni etc. to be arranged, if these Chinese medicines are long-term or large dose oral administration also can cause certain infringement to some internal organs of human body, and might produce accumulate poisoning.Therefore seeking new Therapeutic Method according to traditional Chinese medical science strengthening vital QI to eliminate pathogenic factors theory very presses for.
Germinatus Phragmitis (Asparagus officinals L.) formal name used at school asparagus is Liliaceae Asparagus herbaceos perennial.Have another name called Thallus Gracilariae, the spire Radix Stemonae.According to one's analysis, it contains medicinal ingredients such as steroidal soap, flavonoid and free amino acid agedoite, glutamic acid, lysine, vitamin A, B1, B2, B6, C, multiple nutritional components such as trace element-selenium, zinc, ferrum and protein, carbohydrate, sugar.Classify Germinatus Phragmitis as " on top grade " in the Shennong's Herbal, be only second to Radix Ginseng, obey fat reducing and long life for a long time and prolong life.Motherland's medical science thinks that Germinatus Phragmitis has effects such as " lung-clearing thirst-quenching are separated all meat poison, relieving stranguria by diuresis ", domesticly now is used for the outgrowth treatment of lobules of mammary gland.Extensive day by day to Germinatus Phragmitis clinical practice and food development both at home and abroad in recent years.Asparagus oral liquor is compared with tumour medicine, has six big characteristics such as globality is strong, tumour inhibiting rate is high, have no side effect, indication is wide, treatment is convenient, medical expense is low.Wherein Zui Da advantage is only to kill and wound cancerous cell selectively, does not only damage the normal cell of human body, also helps the recovery and the raising of patient's immunity of organisms.For symptom that alleviates cancer patient and misery, improve life quality, prolong life, reduce the mortality rate of cancer, its important meaning is all arranged.
Summary of the invention
Existing Germinatus Phragmitis tablet in market and capsule, but patient takes totally unfavorable, swallow to patient and to bring very big misery, take middle the problems referred to above that exist in order to solve preparation, purpose of the present invention has just provided a kind of steady quality, efficiently quick-acting, easy to use, with Germinatus Phragmitis total amino acids, total nitrogen medicine is main component, and the treatment tumor disease has the formulation preparation method of significant curative effect.
The present invention adopts following technical scheme to achieve these goals:
The asparagus oral liquor medicine of prevention, treatment tumor disease wherein mainly contains Germinatus Phragmitis extract, contains total amino acids 2-20%, total nitrogen 1-10% and other compositions 70-97% in the described Germinatus Phragmitis extract.
The asparagus oral liquor medicine of described prevention, treatment tumor disease, described total amino acids is that 18 seed amino acids, other compositions of needed by human body are organized enzyme, Germinatus Phragmitis saponin, fatty acid and trace element.
The preparation method of the asparagus oral liquor medicine of described prevention, treatment tumor disease may further comprise the steps:
1) new fresh asparagus is cleaned and is squeezed the juice or decoct with water or 10-80% ethanol heating extraction, merges squeezeding juice or decocting liquid or extracting solution, crosses 100 orders-500 mesh sieve, filtrate for later use;
2) with 1) filtrate decompression of step preparation concentrate concentrated solution, the concentrated solution relative density is 1.02-1.12 (60 ℃-90 ℃), adds antiseptic, sweeting agent boils and makes dissolving, and is standby;
3) with 2) step gained medicinal liquid carries out molecular retention through the ceramic membrane filter device and filters, and ceramic membrane filter aperture is 0.1 μ m-0.5 μ m, and gained filtrate is fine straining liquid;
4) with 3) step gained fine straining liquid extract carries out total amino acids, total nitrogen and Aspartic Acid is measured, the determination data qualified samples that is up to specification, standby;
5) with 4) step gained qualified samples adds water and dilutes in right amount, mixing, every 10ml-50ml of fill, 100 ℃ of-110 ℃ of flowing steam sterilizations 30 minutes-60 minutes are distributed into box after the sterilization, packing, check, warehouse-in, promptly.
Beneficial effect of the present invention:
Asparagus oral liquor medicine of the present invention has the raising patient immune function in order to prevention, treatment tumor disease, suppresses to dwindle local tumor; The contact element inner tumour cell, the side effect that alleviates chemicotherapy, significant promoting the production of body fluid to quench thirst effect strengthens the chemicotherapy sensitization, remove that chemicotherapy causes feel sick, toxicities such as vomiting anorexia, sleep are poor, alopecia, pain, the rising red white corpuscle; Stable curative effect, advantage such as easy to use.The equipment of industrial product is succinct, easy to operate, cost is low, automaticity is high, be easy to control product quality.
The specific embodiment
Embodiment 1. Germinatus Phragmitis extract preparation methoies of the present invention:
Get new fresh asparagus, clean, squeeze juice is crossed 300 mesh sieves, and filtrate decompression is concentrated into relative density 1.06 (75 ℃), and the adding potassium sorbate is an amount of, and stevioside is an amount of, boils to make dissolving, and ceramic membrane (aperture 0.3 μ m) filters, and is the fine straining liquid extract; And record the content of total amino acids in the extract, total nitrogen and Aspartic Acid respectively with development process, N2 method and high performance liquid chromatography, and wherein total amino acids content is 2～20%, and total nitrogen is 1～10%, and Aspartic Acid content is 0.15～3%.
Embodiment 2. Germinatus Phragmitis extract preparation methoies of the present invention:
Get new fresh asparagus and add 10 times of water gagings decoctions three times, each 2 hours, collecting decoction, concentrating under reduced pressure gets concentrated solution, relative density 1.08 (85 ℃), the adding potassium sorbate is an amount of, and stevioside is an amount of, boil and make dissolving, ceramic membrane (aperture 0.1 μ m) filters, and is the fine straining liquid extract; And record the content of total amino acids in the extract, total nitrogen and Aspartic Acid respectively with development process, N2 method and high performance liquid chromatography, and wherein total amino acids content is 3～40%, and total nitrogen is 2～20%, and Aspartic Acid content is 0.3～5%.
Embodiment 3. Germinatus Phragmitis extract preparation methoies of the present invention:
Get new fresh asparagus and add 8 times of amount 70% ethanol heating extraction three times, each 1.5 hours, merge extractive liquid,, concentrating under reduced pressure gets concentrated solution.Concentrated solution adds hot water dilution, filter filtrate, it is an amount of to add potassium sorbate, stevioside is an amount of, boils to make dissolving, ceramic membrane (aperture 0.2 μ m) filters, and is the fine straining liquid extract; And record the content of total amino acids in the extract, total nitrogen and Aspartic Acid respectively with development process, N2 method and high performance liquid chromatography, and wherein total amino acids content is 2～30%, and total nitrogen is 2～12%, and Aspartic Acid content is 0.2～4%.
Embodiment 4. Germinatus Phragmitis extract preparation methoies of the present invention:
Get new fresh asparagus, clean, squeeze juice is crossed 100 mesh sieves, and filtrate decompression is concentrated into relative density 1.05 (80 ℃), and the adding potassium sorbate is an amount of, and stevioside is an amount of, boils to make dissolving, and ceramic membrane (aperture 0.1 μ m) filters, and is the fine straining liquid extract; And record the content of total amino acids in the extract, total nitrogen and Aspartic Acid respectively with development process, N2 method and high performance liquid chromatography, and wherein total amino acids content is 2～20%, and total nitrogen is 1～10%, and Aspartic Acid content is 0.15～3%.
The preparation method of embodiment 5. asparagus oral liquors of the present invention:
Form:
Germinatus Phragmitis extract 500g
Right amount of auxiliary materials
Make 1000ml
Get Germinatus Phragmitis extract and make dissolving, add appropriate amount of auxiliary materials, filter behind the mix homogeneously, be distributed into bottle, sterilization, packing, check, warehouse-in with pure water.And record the content of total amino acids in the extract, total nitrogen and Aspartic Acid respectively with development process, N2 method and high performance liquid chromatography, and wherein total amino acids content is for being not less than 1.2%, and total nitrogen is not less than 0.75%, and Aspartic Acid content is not less than 0.40%.
The preparation method of embodiment 6. asparagus oral liquors of the present invention:
Form:
Germinatus Phragmitis extract 100g
Right amount of auxiliary materials
Make 1000ml
Get Germinatus Phragmitis extract and make dissolving, add appropriate amount of auxiliary materials, filter behind the mix homogeneously, be distributed into bottle, sterilization, packing, check, warehouse-in with pure water.And record the content of total amino acids in the extract, total nitrogen and Aspartic Acid respectively with development process, N2 method and high performance liquid chromatography, and wherein total amino acids content is for being not less than 0.24%, and total nitrogen is not less than 0.15%, and Aspartic Acid content is not less than 0.08%.
The preparation method of embodiment 7. asparagus oral liquors of the present invention:
Form:
Germinatus Phragmitis extract 200g
Right amount of auxiliary materials
Make 1000ml
Get Germinatus Phragmitis extract and make dissolving, add appropriate amount of auxiliary materials, filter behind the mix homogeneously, be distributed into bottle, sterilization, packing, check, warehouse-in with pure water.And record the content of total amino acids in the extract, total nitrogen and Aspartic Acid respectively with development process, N2 method and high performance liquid chromatography, and wherein total amino acids content is for being not less than 0.48%, and total nitrogen is not less than 0.30%, and Aspartic Acid content is not less than 0.16%.
The preparation method of embodiment 8. asparagus oral liquors of the present invention:
Form:
Germinatus Phragmitis extract 300g
Right amount of auxiliary materials
Make 1000ml
Get Germinatus Phragmitis extract and make dissolving, add appropriate amount of auxiliary materials, filter behind the mix homogeneously, be distributed into bottle, sterilization, packing, check, warehouse-in with pure water.And record the content of total amino acids in the extract, total nitrogen and Aspartic Acid respectively with development process, N2 method and high performance liquid chromatography, and wherein total amino acids content is for being not less than 0.72%, and total nitrogen is not less than 0.45%, and Aspartic Acid content is not less than 0.24%.
Claims (3)
1. the asparagus oral liquor medicine of a prevention, treatment tumor disease is characterized in that: wherein mainly contain Germinatus Phragmitis extract, contain total amino acids 2-20%, total nitrogen 1-10% and other compositions 70-97% in the described Germinatus Phragmitis extract.
2. the asparagus oral liquor medicine of prevention according to claim 1, treatment tumor disease is characterized in that described total amino acids is that 18 seed amino acids, other compositions of needed by human body are organized enzyme, Germinatus Phragmitis saponin, fatty acid and trace element.
3. the preparation method of the asparagus oral liquor medicine of prevention according to claim 1, treatment tumor disease is characterized in that may further comprise the steps:
1) new fresh asparagus is cleaned and is squeezed the juice or decoct with water or 10-80% ethanol heating extraction, merges squeezeding juice or decocting liquid or extracting solution, crosses 100 orders-500 mesh sieve, filtrate for later use;
2) with 1) filtrate decompression of step preparation concentrate concentrated solution, the concentrated solution relative density is 1.02-1.12 (60 ℃-90 ℃), adds antiseptic, sweeting agent boils and makes dissolving, and is standby;
3) with 2) step gained medicinal liquid carries out molecular retention through the ceramic membrane filter device and filters, and ceramic membrane filter aperture is 0.1 μ m-0.5 μ m, and gained filtrate is fine straining liquid;
4) with 3) step gained fine straining liquid extract carries out total amino acids, total nitrogen and Aspartic Acid is measured, the determination data qualified samples that is up to specification, standby;
5) with 4) step gained qualified samples adds water and dilutes in right amount, mixing, every 10ml-50ml of fill, 100 ℃ of-110 ℃ of flowing steam sterilizations 30 minutes-60 minutes are distributed into box after the sterilization, packing, check, warehouse-in, promptly.
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| CN201110059499A CN102133352B (en) | 2011-03-12 | 2011-03-12 | Asparagus oral liquid for preventing and curing tumor disease and preparation method thereof |
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| CN201110059499A CN102133352B (en) | 2011-03-12 | 2011-03-12 | Asparagus oral liquid for preventing and curing tumor disease and preparation method thereof |
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| CN102133352A true CN102133352A (en) | 2011-07-27 |
| CN102133352B CN102133352B (en) | 2012-09-05 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102334687A (en) * | 2011-09-19 | 2012-02-01 | 中国农业大学 | Asparagus saponin oral liquid and preparation method thereof |
| CN104983013A (en) * | 2015-06-09 | 2015-10-21 | 秦皇岛长胜营养健康科技有限公司 | Production technology and application of instant drinking concentrated asparagus juice or syrup with 5-hydroxytryptamine homeostasis regulating function |
| CN106387625A (en) * | 2016-08-31 | 2017-02-15 | 秦皇岛长胜营养健康科技有限公司 | Chitosan modified asparagus lipidosome and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1840067A (en) * | 2006-01-17 | 2006-10-04 | 山东轻工业学院 | Chewing tablet of asparagus and preparation process thereof |
-
2011
- 2011-03-12 CN CN201110059499A patent/CN102133352B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1840067A (en) * | 2006-01-17 | 2006-10-04 | 山东轻工业学院 | Chewing tablet of asparagus and preparation process thereof |
Non-Patent Citations (1)
| Title |
|---|
| 《中国中医药信息杂志》 20051231 董洁等 无机陶瓷膜分离技术在中药领域的应用 40-42 3 第12卷, 第12期 2 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102334687A (en) * | 2011-09-19 | 2012-02-01 | 中国农业大学 | Asparagus saponin oral liquid and preparation method thereof |
| CN104983013A (en) * | 2015-06-09 | 2015-10-21 | 秦皇岛长胜营养健康科技有限公司 | Production technology and application of instant drinking concentrated asparagus juice or syrup with 5-hydroxytryptamine homeostasis regulating function |
| CN106387625A (en) * | 2016-08-31 | 2017-02-15 | 秦皇岛长胜营养健康科技有限公司 | Chitosan modified asparagus lipidosome and preparation method thereof |
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| Publication number | Publication date |
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| CN102133352B (en) | 2012-09-05 |
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Application publication date: 20110727 Assignee: Anhui Dongsheng International Pharmaceutical Co. Ltd. Assignor: Hefei Qixing Medical Technology Co., Ltd. Contract record no.: 2013340000088 Denomination of invention: Asparagus oral liquid for preventing and curing tumor disease and preparation method thereof Granted publication date: 20120905 License type: Exclusive License Record date: 20130620 |
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