CN102133291A - Traditional Chinese medicine preparation for treating anemia caused by infant spleen deficiency and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating anemia caused by infant spleen deficiency and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating anemia caused by infant spleen deficiency, which is prepared from dangshen, milk vetch, angelica, dried orange peel, tuckahoe, bighead atractylodes rhizome and licorice according to the traditional Chinese medicine theory by strictly screening and respectively preparing the raw medicines and combining the modern advanced technical preparation method. The traditional Chinese medicine preparation has the functions of strengthening the spleen, tonifying qi and nourishing the blood. The traditional Chinese medicine preparation can be used for treating anorexia, loose stool, sallow complexion, fatigue, asthenia and the like caused by infant spleen deficiency, and can be used for treating mild iron-deficiency anemia with the syndrome. The traditional Chinese medicine preparation solves the problems that an oral iron preparation for sick infants has irritation to the gastrointestinal tract and causes adverse reactions such as nausea, bellyache and diarrhea. The preparation has the advantages of reasonable prescription, exact treatment effect and low price, is safe and reliable, can be obtained easily, and is worthy of clinical popularization and application.
Description
Technical field
The present invention relates to a kind of pure Chinese medicinal preparation medicine for the treatment of anemia due to the infantile spleen deficiency, the invention still further relates to the preparation method of this medicine.
Background technology
Taste are source of generating QI and blood.The fortune functional disorder of chronic dietary nutrition Deficiency of Intake or taste all can cause the biochemical not enough of blood and the pathological change of formation blood deficiency.Blood deficiency is that blood loses void, how by due to severe loss of blood or the hemopoietic deficiency.According to hospital of traditional Chinese hospital, Beijing etc. 3074 children are carried out that the survey showed that, the iron deficiency anemia sickness rate is 31.5%, and wherein the spleen-deficient anemia accounts for 81.6%.We adopt invigorating the spleen and benefiting QI is main, be aided with and enrich blood and battalion's method is treated the card of deficiency of spleen-QI and stomach-QI, nutrient QI and blood being insufficient, promote the absorption of hemopoietic nutrient substance, efficiently solve the oral chalybeate of infant to gastrointestinal tract zest arranged, cause nausea, stomachache, diarrheal untoward reaction, also reached the purpose of the nutritional anemia that the control child causes owing to weakness of the spleen and stomach.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of Chinese medicine preparation that anemia due to the infantile spleen deficiency is had a good therapeutic effect and preparation method thereof.
The object of the present invention is achieved like this: a kind of Chinese medicine preparation for the treatment of anemia due to the infantile spleen deficiency, and it is the medicament of being made in the raw material of weight portion by following,
Radix Codonopsis 195-205; Radix Astragali 195-205; Radix Angelicae Sinensis 95-105; Pericarpium Citri Reticulatae 95-105; Poria 95-105; Rhizoma Atractylodis Macrocephalae 95-105; Radix Glycyrrhizae 45-55.
The Chinese medicine preparation of anemia due to the treatment infantile spleen deficiency, it is the medicament of being made in the raw material of weight portion by following,
Radix Codonopsis 200; The Radix Astragali 200; Radix Angelicae Sinensis 100; Pericarpium Citri Reticulatae 100; Poria 100; The Rhizoma Atractylodis Macrocephalae (stir-fry) 100; Radix Glycyrrhizae 50.
The Rhizoma Atractylodis Macrocephalae is handled through processed with honey for the Rhizoma Atractylodis Macrocephalae through parch, Radix Glycyrrhizae.
The Chinese medicine preparation of anemia is oral solutions, capsule, tablet or pill due to the treatment infantile spleen deficiency.
A kind of preparation method for the treatment of the Chinese medicine preparation of anemia due to the infantile spleen deficiency,
With seven flavor medicine material decoction pieces with alcohol dipping after percolation, collect the liquid of filtering and concentrate, leave standstill, filter, make different preparations then respectively.
The preparation method of oral liquid in the Chinese medicine preparation of anemia due to the treatment infantile spleen deficiency: with seven flavor medicine material decoction pieces with alcohol dipping after percolation, collect the liquid of filtering and concentrate, leave standstill, filter, other adds syrup and sodium benzoate, adds with behind the distilled water diluting, stirs evenly, and is static, filter, embedding, sterilization obtains oral liquid.
Capsular preparation method in the Chinese medicine preparation of anemia due to the treatment infantile spleen deficiency: with seven flavor medicine material decoction pieces with alcohol dipping after percolation, collect the liquid of filtering and concentrate, leave standstill, filter, drying is pulverized, and adds appropriate amount of starch, magnesium stearate, incapsulates, and promptly gets capsule.
The method for preparing tablet thereof of Chinese medicine preparation of anemia due to the treatment infantile spleen deficiency: with seven flavor medicine material decoction pieces with alcohol dipping after percolation, collect the liquid of filtering and concentrate, leave standstill, filter, drying is pulverized, and adds an amount of Icing Sugar, microcrystalline Cellulose, makes granule, tabletting, coating promptly gets tablet.
The preparation method of pill in the Chinese medicine preparation of anemia due to the treatment infantile spleen deficiency: percolation after when seven flavor medicine material decoction pieces is used alcohol dipping, collect the liquid of filtering and concentrate, leave standstill, filter, add the Mel refining, mix with starch again to middle honey, pill, dry then polishing promptly gets pill.
Exsanguine Chinese medicine preparation due to the treatment infantile spleen deficiency provided by the invention is selected pure natural Chinese herbal medicine compatibility for use, by the theory of Chinese medical science prescription, through the strictness screening, concocts respectively, makes in conjunction with modern vanguard technology.Be applicable to the treatment infantile spleen deficiency due to anemia.
For substantive distinguishing features of the present invention, effectiveness and safety are described better,, be described in detail its function below in conjunction with pharmacological effect, toxicity and clinical trial:
One, Expermental research on main pharmacodynamics
(1) this preparation is to the influence with the losing blood property blood deficiency mice of insufficiency of the spleen factor
High, normal, basic dosage is 20,10,5g/kg/ day, quite 5,2.5,1.25 times of the clinical amount of expection respectively; GUIPI WAN was 14 g/kg/ days, was equivalent to 5 times of clinical amount; Ferrous sulfate is 0.27g/kg/ day, is equivalent to 2 times of clinical amounts (above dosage all converts by body surface area).As a result, blank group hemoglobin is tested the 8th day than preceding significantly reduce (the P ﹤ 0.01) of experiment, tests and recovers to some extent in the 10th day, but still significantly be lower than experiment preceding (P ﹤ 0.01); Tested the 8th day, this product high dose group hemoglobin is higher than blank group (P ﹤ 0.01) very significantly, and suitable with ferrous sulfate, compares there was no significant difference (P ﹥ 0.01) with the GUIPI WAN group; In, the low dose group hemoglobin also is significantly higher than blank (P ﹤ 0.05); Tested the 10th day, high, middle dosage group hemoglobin still is higher than blank (P ﹤ 0.01), and with ferrous sulfate, GUIPI WAN group there was no significant difference (P ﹥ 0.05).
(2) this preparation is to the influence of losing blood property blood deficiency rabbit
High, normal, basic dosage was 7,3.5,1.75 g/kg/ days, was equivalent to expect 5,2.5,1.25 times of clinical amount respectively, and ferrous sulfate is 0.1g/kg/ day, is equivalent to 2 times of clinical amounts (above dosage all converts by body surface area).The result, blank group hemoglobin value reduces after the erythrocyte blood-letting very significantly, and blood net RBC number raises very significantly, though, still with before the experiment significant differences (P ﹤ 0.01) is arranged to experiment is whole along with the prolongation of time recovers gradually to some extent; The 3rd day (testing the 8th day) a little higher than blank group of senior middle school's low dose group hemoglobin value blood-letting, no statistical significant difference, high dose group hemoglobin value blood-letting the 5th, 7 and 9 days all very significantly (P ﹤ 0.01) or significantly (P ﹤ 0.05) be higher than the blank group, its effect slightly is better than or is equivalent to ferrous sulfate (P ﹥ 0.05); Each is tested before the blood-letting of networking RBC number and compares there was no significant difference before the experiment, several times all obviously raise after the blood-letting, blood-letting did not all have significant difference with the blank group on the 7th day, blood-letting the 9th day, high, normal, basic group very significantly (P ﹤ 0.01) or significantly (P ﹤ 0.05) be lower than the blank group, the effect of high dose group slightly is better than ferrous sulfate.
(3) to the influence of hemolytic blood deficiency mice
High, normal, basic dosage is 20,10,5g/kg/ day, quite 5,2.5,1.25 times of the clinical amount of expection respectively; GUIPI WAN was 7 g/kg/ days, was equivalent to 2.5 times (pressing body surface area converts) of clinical amount.As a result, each treated animal hemoglobin value all descends gradually behind the S.C APH, for the second time behind the S.C APH hemoglobin highly significant be lower than level before the experiment; Prolongation along with administration time, each is organized the hemoglobin value and demonstrates difference gradually, tested the 7th day, senior middle school's dosage group hemoglobin (P ﹤ 0.01) very significantly is higher than the blank group, test the 9th, 10 day each administration group hemoglobin value and all significantly or very significantly be higher than the blank group, clinical dosage with identical multiple compares, and middle dosage group is better than GUIPI WAN slightly, but does not have statistical significant difference.
(4) to the influence of hemopoietic deficiency blood deficiency mice
High, normal, basic dosage is 20,10,5g/kg/ day, quite 5,2.5,1.25 times of the clinical amount of expection respectively; GUIPI WAN was 7 g/kg/ days, was equivalent to 2.5 times of clinical amount; FUFANG EJIAO JIANG is 22ml/kg/ day, also is equivalent to 2.5 times (pressing body surface area converts) of clinical amount.As a result, through CO
60The blank group mice of irradiation and intact animal are relatively, test the 7th and 10 day leukocyte count and reduce (P ﹤ 0.01) very significantly, tested the 10th day, medullary cell mitotic index and spleen weight all reduce (P ﹤ 0.01) very significantly, and the spleen tuberosity is high-visible; Tested the 7th day, high, middle dosage group leukocyte count very significantly (P ﹤ 0.01) or significantly (P ﹤ 0.05) be higher than the blank group, tested the 10th day, high, medium and low dosage group leukocyte all is higher than blank group (P ﹤ 0.01) very significantly, shows that the effect of this product strengthens along with the prolongation of administration time; High, middle dosage group bone marrow mitotic index is higher than blank group (P ﹤ 0.01) very significantly, and high dose group also is higher than intact animal (P ﹤ 0.01) very significantly, each dosage group increases and the effect enhancing with dosage, clinical dosage with identical multiple compares, middle dosage group is a little less than FUFANG EJIAO JIANG, a little more than the GUIPI WAN group, but there is not statistical significant difference (P ﹥ 0.05); High, medium and low dosage group spleen tuberosity number average very significantly (P ﹤ 0.01) or significantly (P ﹤ 0.05) be higher than the blank group, and increase with dosage, effect strengthens, show that this product can obviously promote pluripotential hemopoietic stem cell propagation, clinical dosage with identical multiple compares, in the dosage group a little less than FUFANG EJIAO JIANG, but do not have statistical significant difference (P ﹥ 0.05), and a GUIPI WAN group and blank group comparison there was no significant difference (P ﹥ 0.05).
(5) to the influence of the weary source property mice with spleen deficiency of biochemistry
Three dosage is 10,5,2.5g/kg/ day, quite 2.5,1.25,0.625 times of the clinical amount of expection respectively; GUIPI WAN was 7 g/kg/ days, was equivalent to 2.5 times (pressing body surface area converts) of clinical amount.As a result, in the cold water swimming test, high, middle dosage group mice endurance is higher than the blank group very significantly, and increases and the effect enhancing with dosage, and with the clinical dosage comparison of identical multiple, high dose group is suitable with the GUIPI WAN group; High, middle dosage group mouse thymus weight, high dose group spleen are higher than blank group (P ﹤ 0.01 and P ﹤ 0.05) significantly, high, medium and low dosage group all is better than GUIPI WAN to the effect of mouse thymus, spleen, but do not have statistical significant difference (P ﹥ 0.05), this product does not have obvious influence to mice body weight, liver weight.
(6) Radix Et Rhizoma Rhei is caused the effect of mice with spleen deficiency
Three dosage is 10,5,2.5g/kg/ day, quite 2.5,1.25,0.625 times of the clinical amount of expection respectively; GUIPI WAN was 7 g/kg/ days, was equivalent to 2.5 times (pressing body surface area converts) of clinical amount.The result, the blank treated animal of Radix Et Rhizoma Rhei moulding and intact animal are relatively, body weight gain obviously slows down, the experiment end-body heavily is starkly lower than intact animal (P ﹤ 0.01), the peritoneal macrophage phagocytic function significantly reduces (P ﹤ 0.01), show tangible insufficiency of the spleen symptom, this product and blank group are relatively, show the mice weight increase, prolongation effect enhancing along with administration time, test whole high dose group and blank group comparison P ﹤ 0.05, with the clinical dosage comparison of identical multiple, the effect of high dose group obviously is better than GUIPI WAN (P ﹤ 0.05); High, medium and low dosage group all makes mice with spleen deficiency peritoneal macrophage phagocytic function strengthen, high, middle dosage group phagocytic percentage and phagocytic index (P ﹤ 0.01) very significantly are higher than the blank group, clinical dosage with identical multiple compares, the effect of this product is better than GUIPI WAN, but does not have statistical significant difference.
Conclusion: on losing blood property blood deficiency mouse model, this product shows the effect that significantly increases hemoglobin, and the intensity of its height, middle dosage group (5 times and 2.5 times of clinical amounts) and ferrous sulfate (2 times of clinical amounts), GUIPI WAN (5 times of clinical amounts) are quite; On losing blood property blood deficiency Rabbit Model, this product shows the effect that increases hemoglobin, RBC number and recover the net RBC number, and its high dose group (5 times of clinical amounts of expection) slightly is better than or is equivalent to ferrous sulfate (2 times of clinical amounts) in intensity; On hemolytic blood deficiency mouse model, this product shows the effect that significantly increases hemoglobin, and its intensity and GUIPI WAN are suitable; On hemopoietic deficiency blood deficiency mouse model, this product shows tangible leukocyte increasing number and medullary cell mitotic index, promote the effect of pluripotential hemopoietic stem cell propagation, the effect of its leukocyte increasing number is lower than FUFANG EJIAO JIANG and GUIPI WAN, it increases the medullary cell mitotic index and promotes that the effect and the FUFANG EJIAO JIANG of pluripotential hemopoietic stem cell propagation are suitable, and is better than GUIPI WAN; On the weary source property mice with spleen deficiency model of biochemistry, this product shows the effect that increases cold water swimming endurance, spleen and thymic weight; Cause on the mice with spleen deficiency model at Radix Et Rhizoma Rhei, this product shows weight increase, strengthens the effect of peritoneal macrophage phagocytic function, and its intensity and GUIPI WAN are quite or be better than GUIPI WAN.
In a word, by the pharmacodynamics test of six kinds of models, show through the observation of ten indexs: the effect that this product has tangible spleen invigorating and enriches blood.
Two, toxicity test research
(1) acute toxicity test research
According to " provisions for new drugs approval " requirement with " supplementary provisions of relevant Chinese medicine problem and explanation ", carried out that mice is oral, the mtd test of subcutaneous injection administration, and the LD of mouse peritoneal drug administration by injection
50Measure.
Conclusion: in mice oral administration mtd test, dosage be 100g crude drug/kg mice/time, be equivalent to expect 200 times (pressing the kg body weight calculates) of clinical amount, observed continuously then 7 days, none example is dead, and all well-grown is movable normal, dissected substantially in the 8th day after the administration, each internal organs shows no obvious abnormalities; In the mouse subcutaneous injection mtd test, dosage is 60g crude drug/kg, observed continuously then 7 days, none example is dead, the movable minimizing after the individual animal administration recovers normal after 2 hours, dissected substantially in the 8th day after the administration, each internal organs shows no obvious abnormalities, and there is slight irritant reaction an animal injection site; LD at the mouse peritoneal drug administration by injection
50In the mensuration, mice is to the maximum tolerated dose of this product (the po ﹥ 200 of g crude drug/kg), SC ﹥ 80, ip LD
50=80.516, mice po maximum tolerated dose is 400 times of the clinical consumption of expection.The clinical consumption safety that shows this product.
(2) long term toxicity test research:
Give the continuous feed of SD rat 90 days to be equivalent to 5,15,50 times of this product of drafting clinical amount, observe or inspection through general signs, body weight, behavior, routine blood test, liver, renal function, the overt toxicity reaction is not seen in aspects integrated surveys such as the perusal of vitals and histopathological examination.It is quite safe pointing out it to draft clinical consumption.
Three, clinical research
Case 430 examples are accepted in this product clinical trial altogether for medical treatment, be distributed as Longhua Hospital affiliated Shanghai University Of Chinese Traditional Medicine 110 examples, SHUGUANG HOSPITAL department of pediatrics 110 examples, the Wuhan City children's hospital department of Chinese medicine 100 examples, Hospital Attached to Hubei Chinese Medicine College's department of pediatrics 110 examples, wherein inpatient's 120 examples, outpatient's 310 examples, through random packet, double blind control therapeutic outcome, 122 examples are organized in treatment, clinical recovery 73 examples, produce effects 32 examples, 11 examples that take a turn for the better, invalid 6 examples, effective percentage is 95.08%; Matched group 122 examples, clinical recovery 66 examples, produce effects 34 examples, 10 examples that take a turn for the better, invalid 12 examples, effective percentage is 90.16%; Open group 186 examples, clinical recovery 101 examples, produce effects 49 examples, 23 examples that take a turn for the better, invalid 13 examples, effective percentage is 93.01%.
The clinical research of II phase shows that this product is a kind of safer medicine.
2, have no side effect: through the clinical observation of taking medicine for a long time, this medicine is not all found toxic and side effects to the heart, liver, kidney and hemopoietic function of bone marrow.
3, this preparation recipe is reasonable, and determined curative effect is safe and reliable, and medicine is easy to get, and is cheap, is worth clinical application.
The specific embodiment
Embodiment: the Chinese medicine preparation composition of raw materials of anemia is as follows due to the treatment infantile spleen deficiency:
Composition of raw materials one: Radix Codonopsis 195; The Radix Astragali 195; Radix Angelicae Sinensis 95; Pericarpium Citri Reticulatae 95; Poria 95; The Rhizoma Atractylodis Macrocephalae (stir-fry) 95; Radix Glycyrrhizae (processed with honey) 45.
Composition of raw materials two: Radix Codonopsis 200; The Radix Astragali 200; Radix Angelicae Sinensis 100; Pericarpium Citri Reticulatae 100; Poria 100; The Rhizoma Atractylodis Macrocephalae (stir-fry) 100; Radix Glycyrrhizae (processed with honey) 50.
Composition of raw materials three: Radix Codonopsis 205; The Radix Astragali 205; Radix Angelicae Sinensis 105; Pericarpium Citri Reticulatae 105; Poria 105; The Rhizoma Atractylodis Macrocephalae (stir-fry) 105; Radix Glycyrrhizae (processed with honey) 55.
The Rhizoma Atractylodis Macrocephalae is handled through processed with honey for the Rhizoma Atractylodis Macrocephalae through parch, Radix Glycyrrhizae.
The Chinese medicine oral liquid preparation of anemia due to the treatment infantile spleen deficiency: by above-mentioned prescription, with 65% alcohol dipping percolation after 24 hours, it is concentrated to collect the liquid of filtering with seven flavor medicine material decoction pieces, leave standstill, filter, adding concentration is 50 ﹪ ml/ml syrup and sodium benzoate, adjusting total amount with distilled water is 1000 volumes, stir evenly, static, filter, embedding, sterilization promptly gets oral liquid, and the addition of sodium benzoate is 3/1000ths of a cumulative volume.
The Chinese medicinal capsule preparation of anemia due to the treatment infantile spleen deficiency: by above-mentioned prescription, with 65% alcohol dipping percolation after 24 hours, it is concentrated to collect the liquid of filtering, and leaves standstill with seven flavor medicine material decoction pieces, filter, drying is pulverized, add appropriate amount of starch, magnesium stearate, incapsulate, promptly get capsule.
The Chinese medicinal tablet preparation of anemia due to the treatment infantile spleen deficiency: by above-mentioned prescription, with 65% alcohol dipping percolation after 24 hours, it is concentrated to collect the liquid of filtering, and leaves standstill with seven flavor medicine material decoction pieces, filter, drying is pulverized, and adds an amount of Icing Sugar, microcrystalline Cellulose, make granule, tabletting, coating promptly gets tablet.
The medicine pill preparation of anemia due to the treatment infantile spleen deficiency: by above-mentioned prescription, with 65% alcohol dipping percolation after 24 hours, it is concentrated to collect the liquid of filtering, and leaves standstill with seven flavor medicine material decoction pieces, filter, add the Mel refining, mix with starch again to middle honey, pill, dry then polishing promptly gets pill.
Claims (9)
1. Chinese medicine preparation for the treatment of anemia due to the infantile spleen deficiency, it is characterized in that: it is the medicament of being made in the raw material of weight portion by following:
Radix Codonopsis 195-205; Radix Astragali 195-205; Radix Angelicae Sinensis 95-105; Pericarpium Citri Reticulatae 95-105; Poria 95-105; Rhizoma Atractylodis Macrocephalae 95-105; Radix Glycyrrhizae 45-55.
2. the Chinese medicine preparation of anemia due to the treatment infantile spleen deficiency according to claim 1 is characterized in that: it is the medicament of being made in the raw material of weight portion by following,
Radix Codonopsis 200; The Radix Astragali 200; Radix Angelicae Sinensis 100; Pericarpium Citri Reticulatae 100; Poria 100; The Rhizoma Atractylodis Macrocephalae 100; Radix Glycyrrhizae 50.
3. the Chinese medicine preparation of anemia due to the treatment infantile spleen deficiency according to claim 1 and 2 is characterized in that: described preparation is oral solutions, capsule, tablet or pill.
4. the preparation method of the Chinese medicine preparation of anemia due to the preparation claim 3 described treatment infantile spleen deficiency is characterized in that:
With seven flavor medicine material decoction pieces with alcohol dipping after percolation, collect the liquid of filtering and concentrate, leave standstill, filter, make different preparations then respectively.
5. the preparation method of the preparation of anemia due to the treatment infantile spleen deficiency according to claim 1 is characterized in that: the Rhizoma Atractylodis Macrocephalae is handled through processed with honey for the Rhizoma Atractylodis Macrocephalae through parch, Radix Glycyrrhizae.
6. the preparation method of the Chinese medicine preparation of anemia due to the treatment infantile spleen deficiency according to claim 3 is characterized in that: the method for making of oral liquid: with seven flavor medicine material decoction pieces with alcohol dipping after percolation, collect the liquid of filtering and concentrate, leave standstill, filter, other adds syrup and sodium benzoate, adds with behind the distilled water diluting, stir evenly, static, filter embedding, sterilization obtains oral liquid.
7. the preparation method of the Chinese medicine preparation of anemia due to the treatment infantile spleen deficiency according to claim 3, it is characterized in that: capsular method for making: with seven flavor medicine material decoction pieces with alcohol dipping after percolation, the collection liquid of filtering concentrates, leave standstill, filter drying, pulverize, add appropriate amount of starch, magnesium stearate, incapsulate, promptly get capsule.
8. the preparation method of the Chinese medicine preparation of anemia due to the treatment infantile spleen deficiency according to claim 3, it is characterized in that: the method for making of tablet: with seven flavor medicine material decoction pieces with alcohol dipping after percolation, collect the liquid of filtering and concentrate, leave standstill, filter, drying is pulverized, and adds an amount of Icing Sugar, microcrystalline Cellulose, make granule, tabletting, coating promptly gets tablet.
9. the preparation method of the Chinese medicine preparation of anemia due to the treatment infantile spleen deficiency according to claim 3, it is characterized in that: the method for making of pill: with seven flavor medicine material decoction pieces with alcohol dipping after percolation, the collection liquid of filtering concentrates, leave standstill, filter, add the Mel refining to middle honey, mix with starch again, pill, dry then polishing promptly gets pill.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230468A (en) * | 2013-04-28 | 2013-08-07 | 苏州谷力生物科技有限公司 | Traditional Chinese medicine composition with functions of tonifying spleens and nourishing stomachs and preparation method thereof |
| CN104547171A (en) * | 2014-12-25 | 2015-04-29 | 湖南炎帝生物工程有限公司 | Traditional Chinese medicine composition for relieving physical fatigue, and preparation method and application of traditional Chinese medicine composition |
| CN104800677A (en) * | 2015-04-20 | 2015-07-29 | 王雪雁 | Traditional Chinese medicine preparation for treating infantile spleen deficiency and preparation method of traditional Chinese medicine preparation |
| CN107006708A (en) * | 2017-04-18 | 2017-08-04 | 哈尔滨中科生物工程有限公司 | Piglet Compound Chinese Herbs for Fatigue-Resistance of Animal, its preparation method and application prepared by a kind of asynchronous fermentation method |
| CN108066458A (en) * | 2017-12-29 | 2018-05-25 | 罗梅宏 | Yigong San powder with marveous Effect is in splenomegaly caused by preparation treatment anemia of chronic disease, infection or diseases associated with inflammation and the application in injury of mitochondria drug |
| CN109965170A (en) * | 2019-05-07 | 2019-07-05 | 江苏华桑食品科技有限公司 | A method of it prepares with the beverage for promoting sleep function |
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| CN101623380A (en) * | 2008-07-08 | 2010-01-13 | 张成赟 | Chinese medicinal composition for treating iron deficiency anemia |
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| CN101623380A (en) * | 2008-07-08 | 2010-01-13 | 张成赟 | Chinese medicinal composition for treating iron deficiency anemia |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230468A (en) * | 2013-04-28 | 2013-08-07 | 苏州谷力生物科技有限公司 | Traditional Chinese medicine composition with functions of tonifying spleens and nourishing stomachs and preparation method thereof |
| CN104547171A (en) * | 2014-12-25 | 2015-04-29 | 湖南炎帝生物工程有限公司 | Traditional Chinese medicine composition for relieving physical fatigue, and preparation method and application of traditional Chinese medicine composition |
| CN104800677A (en) * | 2015-04-20 | 2015-07-29 | 王雪雁 | Traditional Chinese medicine preparation for treating infantile spleen deficiency and preparation method of traditional Chinese medicine preparation |
| CN107006708A (en) * | 2017-04-18 | 2017-08-04 | 哈尔滨中科生物工程有限公司 | Piglet Compound Chinese Herbs for Fatigue-Resistance of Animal, its preparation method and application prepared by a kind of asynchronous fermentation method |
| CN108066458A (en) * | 2017-12-29 | 2018-05-25 | 罗梅宏 | Yigong San powder with marveous Effect is in splenomegaly caused by preparation treatment anemia of chronic disease, infection or diseases associated with inflammation and the application in injury of mitochondria drug |
| CN109965170A (en) * | 2019-05-07 | 2019-07-05 | 江苏华桑食品科技有限公司 | A method of it prepares with the beverage for promoting sleep function |
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| CN102133291B (en) | 2012-09-05 |
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