CN102114038A - Cold-system preparation method of south calcite as a Tibetan medicine - Google Patents
Cold-system preparation method of south calcite as a Tibetan medicine Download PDFInfo
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- CN102114038A CN102114038A CN 201110033366 CN201110033366A CN102114038A CN 102114038 A CN102114038 A CN 102114038A CN 201110033366 CN201110033366 CN 201110033366 CN 201110033366 A CN201110033366 A CN 201110033366A CN 102114038 A CN102114038 A CN 102114038A
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Abstract
The invention relates to a cold-system preparation method of south calcite as a Tibetan medicine. The method comprises the following steps of: (1) collecting mineral south calcite, cleaning, removing impurities, scrapping into particles with the granularity of 10-30 mm, adding auxiliaries, i.e., Radix Aconiti and potassium nitrate, heating and continuously boiling for 2-16 h to obtain the boiled south calcite; (2) rinsing the boiled south calcite with clear water until the rinsing liquid is clear as crystal, and drying until the weight is consistent to obtain the dry south calcite; and (3) grinding the dry south calcite, sieving with a screen of 20-100 meshes to obtain south calcite powder, uniformly mixing and stirring the south calcite powder with fresh milk and drying in shade to obtain a finished product. The cold-system preparation method is simple and convenient to operate and easy to implement and can greatly increase the content of effective trace elements in the south calcite without remarkably influencing the main contents, thereby the method can be used as a reference for preparing high south calcite and a standard preparation method of the south calcite as the Tibetan medicine.
Description
Technical field
The present invention relates to relate to the processing method of mineral substance Tibetan medicine material, relate in particular to a kind of cold system concocting method of Tibetan medicine Calcitum rubrum.
Background technology
Calcitum rubrum belongs to the mineral substance medicine, record " Calcitum rubrum is a carbonate calcite family calcite, and main component is a calcium carbonate " in 2010 editions Pharmacopoeia of the People's Republic of China appendix III.The main composition-calcium carbonate of removing on the books in addition also contains trace element such as copper, aluminum, zinc, magnesium, ferrum, manganese, strontium.Calcitum rubrum is extensive use of (70% compound recipe) with different " system property (heat, cold, flat) " in the tibetan traditional medicine of treatment gastropathy, and wherein is to concoct through processing more than 90%.Do not decide method but Mirabilitum crystallina " system " has, can't " follow the prescribed rules ".Gastropathy is being risen in the pharmacological action, too much hydrochloric acid in the calcium carbonate energy and in the gastric juice, zinc element can reduce inflammation and promote the regeneration of coat of the stomach mucomembranous cell, has the effect of local antibiosis.Copper content is than normal person's height in chronic gastritis, gastric ulcer patient gastric mucus, and the increase of copper content can suppress the absorption of zinc element.Patients with gastric cancer serum copper/zinc ratio compares with the normal person that there were significant differences, and the high low degree of copper/zinc and disease weight are proportional.
Calcitum rubrum is as mineral drug, and the kind of clear and definite its contained element and content size to research medicine metabolic process in vivo and how to bring into play pharmacological action significant, also are simultaneously the important references indexs of safety, scientific and reasonable medication.So calcium carbonate and zinc, copper changes of contents should become the standard that Calcitum rubrum is concocted effect of weighing after Calcitum rubrum is concocted.
Summary of the invention
Technical problem to be solved by this invention provides a kind of cold system concocting method that can specifically quantize, also can effectively improve the Tibetan medicine Calcitum rubrum of active constituent content in the Calcitum rubrum.
For addressing the above problem, the cold system concocting method of a kind of Tibetan medicine Calcitum rubrum of the present invention may further comprise the steps:
(1) mining thing Calcitum rubrum is cleaned remove impurity, and breaking into granularity into pieces is 10～30mm granule, adds adjuvant Radix Aconiti Kusnezoffii and Sal Nitri, heating, continue to boil 2～16 hours after, obtain Calcitum rubrum after the boiling; The mass ratio of described Radix Aconiti Kusnezoffii and described Sal Nitri is 1: 10～10: 1, and the mass ratio of described Calcitum rubrum and described Sal Nitri is 40: 1～400: 1, and the mass ratio of described Calcitum rubrum and described Radix Aconiti Kusnezoffii is 40: 1～400: 1;
(2) after the described boiling Calcitum rubrum with the clear water rinsing to rinsing liquid as clear as crystal after, dry to constant weight, obtain exsiccant Calcitum rubrum;
(3) with after the described exsiccant Calcitum rubrum grinding, cross 20～100 mesh sieves, obtain the Calcitum rubrum powder, after this Calcitum rubrum powder and the fresh milk mixing and stirring, under room temperature, dry in the shade, get product; Described fresh milk is 1: 1～1: 10 with the volume mass ratio of described Calcitum rubrum powder.
Bake out temperature in the described step (2) is 60 ℃～105 ℃.
Fresh milk in the described step (3) is meant that protein content is the milk of 1g～7g in every 100g fresh milk.
The present invention compared with prior art has the following advantages:
1, the present invention adopts adjuvant Radix Aconiti Kusnezoffii and Sal Nitri and Calcitum rubrum granule to carry out boiling, Calcitum rubrum after the boiling carries out composition measurement, compare and the product of giving birth to Calcitum rubrum, wherein calcium carbonate content changes not obvious, zinc element content has bigger rising, copper content has more by a small margin and to rise, thereby zinc, copper ratio obtain bigger increase; Simultaneously, the present invention adds to make after the milk has increased protein ingredient in the Calcitum rubrum, make it more effectively bring into play pharmacological action in gastrotherapy.
Detection method and result are as follows:
(1) method:
Instrument: VARAIN 220-FS AAS (U.S. VARAIN company).
Testing conditions such as following table 1:
Table 1 flame atomic absorption spectrometry working condition
Standard substance: calcium, zinc, copper standard solution, specification 20mL, concentration 1000 μ gmL
-1, stepwise dilution during use, sample introduction, with peak area to sample size drawing standard curve.
The preparation of sample: the Calcitum rubrum sample of gained of the present invention is accurately taken by weighing 0.2000g, place 30ml politef crucible, with adding 5mL hydrochloric acid after the water-wet, under 60 ℃～70 ℃ temperature conditions, heat on the electric hot plate in fume hood, sample is tentatively decomposed, to be evaporated take off during to surplus approximately 3mL cold slightly, add 5mL nitric acid, 5mL Fluohydric acid., 5mL perchloric acid then, add a cover the back under 100 ℃～130 ℃ temperature conditions, heating 0.5～1.5h on the electric hot plate, uncap, continue the heating silica removal,, should often shake crucible in order to reach the good silicon effect that flies.When being heated to when emitting the white cigarette of dense perchloric acid, add a cover, the organic carbide of black is decomposed, after treating the black Organic substance disappearance on the sidewall of crucible, uncap, drive white cigarette and steam and be thick, look the situation of clearing up to content, can add 3mL nitric acid, 3mL Fluohydric acid., 1mL perchloric acid again, repeat above digestion process.When white cigarette emits to the greatest extent and content when being thick once more, take off cold slightly, deionized water rinsing inwall and crucible cover, and add 1mL salpeter solution (1+1), and warm dissolved residue, full dose is transferred in the 100mL volumetric flask then, be settled to graticule after the cooling, shake up, to be measured.Do three sample blank contrasts simultaneously.
(2) the results are shown in Table 2:
Table 2 is given birth to product Calcitum rubrum and the comparison of making calcium, zinc and copper content in the Calcitum rubrum
| Material name | Calcium (g/kg) | Zinc (mg/kg) | Copper (mg/kg) | Zinc/copper |
| Give birth to Calcitum rubrum | 398.261 | 5.270 | 1.180 | 4.466 |
| The system Calcitum rubrum | 389.348 | 16.269 | 2.081 | 7.818 |
Press table 2 indicating value, concocting back Calcitum rubrum main composition-calcium carbonate has trace to reduce, and mainly is because the adding of milk.Make a living approximately 3 times of product of zinc element content, copper content is increase to some extent on the basis of the product of giving birth to, and zinc, copper content ratio increase by a fairly big margin.
In concocting process, add adjuvant Aconitum carmichjaelii Debx. and Sal Nitri, carry out heating and cooking.Sal Nitri has litholytic effect in boiling process, contained main component aconitine issues in the situation of heating that unboiled water is separated and Oxidation in Aconitum carmichjaelii Debx., have acidic materials such as acetic acid etc. in the group of taking off, react with the chemical compound of contained other element in calcium carbonate and the mineral, thereby cause the content of each element to change.This shows that boiling process is comparatively obvious to the influence of micronutrient levels in the Calcitum rubrum among the present invention, Calcitum rubrum performance curative effect is played an important role.
2, because the present invention quantized raw material granularity, adjuvant, boiling time etc., therefore, can significantly improve effective trace elements content in the Calcitum rubrum, simultaneously main component not produced appreciable impact, there are laws to abide by thereby make the process of preparing Chinese medicine operation of high Mirabilitum crystallina.
3, the present invention is easy and simple to handle, easy to implement.
4, the present invention comes from traditional method but is higher than traditional method, has set up the evaluation index of processed product, can be used as the standardized production method of Tibetan medicine Calcitum rubrum.
The specific embodiment
The cold system concocting method of 1 one kinds of Tibetan medicine Calcitum rubrums of embodiment may further comprise the steps:
(1) mining thing Calcitum rubrum is cleaned remove impurity, and breaking into granularity into pieces is 10～20mm granule.Take by weighing 100Kg Calcitum rubrum granule, insert in the container with adjuvant 2Kg Radix Aconiti Kusnezoffii and 2Kg Sal Nitri, add the 50L clear water and do not have Calcitum rubrum, heating keeps liquid level; After continuing to boil 3 hours, the upper water solution that inclines obtains Calcitum rubrum after the bottom boiling.
(2) after the boiling Calcitum rubrum with the clear water rinsing to rinsing liquid as clear as crystal after, dry to constant weight under 105 ℃ of temperature with constant temperature oven, obtain exsiccant Calcitum rubrum.
(3) exsiccant Calcitum rubrum is ground after, cross 40 mesh sieves, obtain the Calcitum rubrum powder, this Calcitum rubrum powder places container to mix with fresh milk, stir in the pasty state after, under room temperature, dry in the shade, get product.
Fresh milk is 1: 5 with the volume mass of Calcitum rubrum powder than (L/Kg).
Wherein fresh milk is meant that protein content is the milk of 1g～3.1g in every 100g fresh milk.
The cold system concocting method of 2 one kinds of Tibetan medicine Calcitum rubrums of embodiment may further comprise the steps:
(1) mining thing Calcitum rubrum is cleaned remove impurity, and breaking into granularity into pieces is 20～30mm granule.Take by weighing 400Kg Calcitum rubrum granule, insert in the container with adjuvant 1Kg Radix Aconiti Kusnezoffii and 1Kg Sal Nitri, add the 50L clear water and do not have Calcitum rubrum, heating keeps liquid level; After continuing to boil 4 hours, the upper water solution that inclines obtains Calcitum rubrum after the bottom boiling.
(2) after the boiling Calcitum rubrum with the clear water rinsing to rinsing liquid as clear as crystal after, dry to constant weight under 90 ℃ of temperature with constant temperature oven, obtain exsiccant Calcitum rubrum.
(3) exsiccant Calcitum rubrum is ground after, cross 60 mesh sieves, obtain the Calcitum rubrum powder, this Calcitum rubrum powder places container to mix with fresh milk, stir in the pasty state after, under room temperature, dry in the shade, get product.
Fresh milk is 1: 6 with the volume mass of Calcitum rubrum powder than (L/Kg).
Wherein fresh milk is meant that protein content is the milk of 6.0g～7.0g in every 100g fresh milk.
The cold system concocting method of 3 one kinds of Tibetan medicine Calcitum rubrums of embodiment may further comprise the steps:
(1) mining thing Calcitum rubrum is cleaned remove impurity, and breaking into granularity into pieces is 10～30mm granule.Take by weighing 100Kg Calcitum rubrum granule, insert in the container with adjuvant 1Kg Radix Aconiti Kusnezoffii and 2Kg Sal Nitri, add the 50L clear water and do not have Calcitum rubrum, heating keeps liquid level; After continuing to boil 8 hours, the upper water solution that inclines obtains Calcitum rubrum after the bottom boiling.
(2) after the boiling Calcitum rubrum with the clear water rinsing to rinsing liquid as clear as crystal after, dry to constant weight under 95 ℃ of temperature with constant temperature oven, obtain exsiccant Calcitum rubrum.
(3) exsiccant Calcitum rubrum is ground after, cross 80 mesh sieves, obtain the Calcitum rubrum powder, this Calcitum rubrum powder places container to mix with fresh milk, stir in the pasty state after, under room temperature, dry in the shade, get product.
Fresh milk is 1: 10 with the volume mass of Calcitum rubrum powder than (L/Kg).
Wherein fresh milk is meant that protein content is the milk of 2.0g～5.0g in every 100g fresh milk.
The cold system concocting method of 4 one kinds of Tibetan medicine Calcitum rubrums of embodiment may further comprise the steps:
(1) mining thing Calcitum rubrum is cleaned remove impurity, and breaking into granularity into pieces is 10～20mm granule.Take by weighing 400Kg Calcitum rubrum granule, insert in the container with adjuvant 1Kg Radix Aconiti Kusnezoffii and 10Kg Sal Nitri, add the 50L clear water and do not have Calcitum rubrum, heating keeps liquid level; After continuing to boil 2 hours, the upper water solution that inclines obtains Calcitum rubrum after the bottom boiling.
(2) after the boiling Calcitum rubrum with the clear water rinsing to rinsing liquid as clear as crystal after, dry to constant weight under 75 ℃ of temperature with constant temperature oven, obtain exsiccant Calcitum rubrum.
(3) exsiccant Calcitum rubrum is ground after, cross 20 mesh sieves, obtain the Calcitum rubrum powder, this Calcitum rubrum powder places container to mix with fresh milk, stir in the pasty state after, under room temperature, dry in the shade, get product.
Fresh milk is 2: 5 with the volume mass of Calcitum rubrum powder than (L/Kg).
Wherein fresh milk is meant that protein content is the milk of 1.5g～6.0g in every 100g fresh milk.
The cold system concocting method of 5 one kinds of Tibetan medicine Calcitum rubrums of embodiment may further comprise the steps:
(1) mining thing Calcitum rubrum is cleaned remove impurity, and breaking into granularity into pieces is 10～20mm granule.Take by weighing 300Kg Calcitum rubrum granule, insert in the container with adjuvant 2Kg Radix Aconiti Kusnezoffii and 4Kg Sal Nitri, add the 50L clear water and do not have Calcitum rubrum, heating keeps liquid level; After continuing to boil 16 hours, the upper water solution that inclines obtains Calcitum rubrum after the bottom boiling.
(2) after the boiling Calcitum rubrum with the clear water rinsing to rinsing liquid as clear as crystal after, dry to constant weight under 60 ℃ of temperature with constant temperature oven, obtain exsiccant Calcitum rubrum.
(3) exsiccant Calcitum rubrum is ground after, cross 100 mesh sieves, obtain the Calcitum rubrum powder, this Calcitum rubrum powder places container to mix with fresh milk, stir in the pasty state after, under room temperature, dry in the shade, get product.
Fresh milk is 3: 4 with the volume mass of Calcitum rubrum powder than (L/Kg).
Wherein fresh milk is meant that protein content is the milk of 4.0g～7.0g in every 100g fresh milk.
The cold system concocting method of 6 one kinds of Tibetan medicine Calcitum rubrums of embodiment may further comprise the steps:
(1) mining thing Calcitum rubrum is cleaned remove impurity, and breaking into granularity into pieces is 10～20mm granule.Take by weighing 400Kg Calcitum rubrum granule, insert in the container with adjuvant 10Kg Radix Aconiti Kusnezoffii and 1Kg Sal Nitri, add the 50L clear water and do not have Calcitum rubrum, heating keeps liquid level; After continuing to boil 16 hours, the upper water solution that inclines obtains Calcitum rubrum after the bottom boiling.
(2) after the boiling Calcitum rubrum with the clear water rinsing to rinsing liquid as clear as crystal after, dry to constant weight under 80 ℃ of temperature with constant temperature oven, obtain exsiccant Calcitum rubrum.
(3) exsiccant Calcitum rubrum is ground after, cross 40 mesh sieves, obtain the Calcitum rubrum powder, this Calcitum rubrum powder places container to mix with fresh milk, stir in the pasty state after, under room temperature, dry in the shade, get product.
Fresh milk is 1: 1 with the volume mass of Calcitum rubrum powder than (L/Kg).
Wherein fresh milk is meant that protein content is the milk of 5.0g～7.0g in every 100g fresh milk.
Claims (3)
1. the cold system concocting method of a Tibetan medicine Calcitum rubrum may further comprise the steps:
(1) mining thing Calcitum rubrum is cleaned remove impurity, and breaking into granularity into pieces is 10～30mm granule, adds adjuvant Radix Aconiti Kusnezoffii and Sal Nitri, heating, continue to boil 2～16 hours after, obtain Calcitum rubrum after the boiling; The mass ratio of described Radix Aconiti Kusnezoffii and described Sal Nitri is 1: 10～10: 1, and the mass ratio of described Calcitum rubrum and described Sal Nitri is 40: 1～400: 1, and the mass ratio of described Calcitum rubrum and described Radix Aconiti Kusnezoffii is 40: 1～400: 1;
(2) after the described boiling Calcitum rubrum with the clear water rinsing to rinsing liquid as clear as crystal after, dry to constant weight, obtain exsiccant Calcitum rubrum;
(3) with after the described exsiccant Calcitum rubrum grinding, cross 20～100 mesh sieves, obtain the Calcitum rubrum powder, after this Calcitum rubrum powder and the fresh milk mixing and stirring, under room temperature, dry in the shade, get product; Described fresh milk is 1: 1～1: 10 with the volume mass ratio of described Calcitum rubrum powder.
2. the cold system concocting method of a kind of Tibetan medicine Calcitum rubrum as claimed in claim 1 is characterized in that: the bake out temperature in the described step (2) is 60 ℃～105 ℃.
3. the cold system concocting method of a kind of Tibetan medicine Calcitum rubrum as claimed in claim 1 is characterized in that: the fresh milk in the described step (3) is meant that protein content is the milk of 1g～7g in every 100g fresh milk.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104324048A (en) * | 2014-10-23 | 2015-02-04 | 西南民族大学 | Preparation method of gypsum rubrum |
| CN110787184A (en) * | 2019-12-03 | 2020-02-14 | 平措绕吉 | Method for processing alabaster |
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| CN1038406A (en) * | 1988-10-15 | 1990-01-03 | 西藏自治区藏医院 | The processing method of medicinal MERCURY POWDER (seat platform) |
| CN101199470A (en) * | 2007-11-24 | 2008-06-18 | 甘肃奇正藏药有限公司 | Calcite medical dental cream and process for preparing same |
| CN101401818A (en) * | 2008-11-21 | 2009-04-08 | 陈元涛 | Sada mechanized forging process |
| CN101543530A (en) * | 2009-04-30 | 2009-09-30 | 西藏金哈达药业有限公司 | Method for preparing Tibetan medicament seven-ingredient scrap-iron preparation for treating hepatic diseases |
-
2011
- 2011-01-27 CN CN2011100333665A patent/CN102114038B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1038406A (en) * | 1988-10-15 | 1990-01-03 | 西藏自治区藏医院 | The processing method of medicinal MERCURY POWDER (seat platform) |
| CN101199470A (en) * | 2007-11-24 | 2008-06-18 | 甘肃奇正藏药有限公司 | Calcite medical dental cream and process for preparing same |
| CN101401818A (en) * | 2008-11-21 | 2009-04-08 | 陈元涛 | Sada mechanized forging process |
| CN101543530A (en) * | 2009-04-30 | 2009-09-30 | 西藏金哈达药业有限公司 | Method for preparing Tibetan medicament seven-ingredient scrap-iron preparation for treating hepatic diseases |
Non-Patent Citations (2)
| Title |
|---|
| 《中央民族大学学报(自然科学版)》 20080831 杨玉等 传统矿物藏药及其炮制工艺研究 83-87 1-3 第17卷, 第3期 2 * |
| 《现代中西医结合杂志》 20000630 撒吉等 矿物药"君西"在藏药中的临床应用 1159-1160 1-3 第9卷, 第12期 2 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104324048A (en) * | 2014-10-23 | 2015-02-04 | 西南民族大学 | Preparation method of gypsum rubrum |
| CN110787184A (en) * | 2019-12-03 | 2020-02-14 | 平措绕吉 | Method for processing alabaster |
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| CN102114038B (en) | 2012-08-22 |
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