CN102103139A - Constant temperature vibration reaction device - Google Patents
Constant temperature vibration reaction device Download PDFInfo
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- CN102103139A CN102103139A CN2009102012939A CN200910201293A CN102103139A CN 102103139 A CN102103139 A CN 102103139A CN 2009102012939 A CN2009102012939 A CN 2009102012939A CN 200910201293 A CN200910201293 A CN 200910201293A CN 102103139 A CN102103139 A CN 102103139A
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- eccentric wheel
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Abstract
The invention discloses a constant temperature vibration reaction device. The device comprises a constant temperature device and a vibration device, wherein the constant temperature device comprises a constant temperature cabinet shell (02), a constant temperature cabinet upper cover (01), an object stage (03), an object stage bracket (11), an air circulation device (10), a temperature sensor (12), a radiating fin 1 (13) and a heating sheet (14); the vibration device comprises an eccentric wheel (05), a motor fixing plate (06), a motor (07), a vibration bracket (08) and a fixed base (09); the constant temperature device is fixed on the vibration device through a constant temperature cabinet bracket (04); and the motor (07) drives the eccentric wheel (05) to drive the whole constant temperature reaction device to vibrate. The reaction device has a uniform and stable temperature, is reliable in vibration and convenient to use, has a simple structure, low cost and long service life, and can be used for biochemical reaction in the detection process of a biological chip, enzyme linked immunosorbent assay and the like.
Description
Technical field
The present invention relates to the reaction unit in biology, clinical medical inspection and the chemical analysis, exactly, is a kind of miniature constant temperature reaction unit at biochip and enzyme linked immunosorbent detection process.
Background technology
Diagnosis is a kind of molecular biology inspection technology of forefront with biochip, is that the clinical examination field has one of major progress of characteristics of the times.This technological breakthrough the limitation of traditional method of inspection, have detect flux greatly, accurately and fast, the advantage of trace.Biochip and support equipment biochip supplies analysis, biochip reaction apparatus are formed detection system, have demonstrated fully robotization, systematization, the informationization of advanced medical diagnosis on disease technology.In biochip or ELISA experiment, reacting fully, washing up hill and dale is to guarantee its result necessary condition accurately and reliably.
At present, only be directed to the plate machine of washing of ELISA on the market, also be not directed to the plate machine of washing of chip film washing, more will not react and wash the reaction instrument that both combine.And the conventional Bioexperiment based on the ELISA reaction all is to add the pattern of washing the plate machine by the reaction of constant temperature shaking table to operate, and test period is long, complex operation, and the use of multiple devices has increased the error of experiment.Therefore, it is a kind of at biochip that this area presses for exploitation, collection chip film reaction and washing function and one, isothermal reaction, vibration and the cleaning device of also compatible elisa plate bar simultaneously.Biochip reaction apparatus that the present invention relates to and full-automatic biological chips detection system are such instruments, and temperature-controlling reaction apparatus is the important component part of biochip reaction apparatus and full-automatic biological chips detection system.
Bioexperiment based on the ELISA reaction all is to operate by the pattern of reacting on independent constant temperature shaking table instrument at present, biochip is to grow up on the basis of ELISA, still continued the operator scheme of reacting, so also do not have on the plate machine to occur to supply the thermostat of ELISA or chip isothermal reaction in washing before by on independent constant temperature shaking table instrument.And existing constant temperature shaking table often all is than relatively large equipment, and heating arrangement roughly has two kinds.A kind of fairly simple, directly heat by electrothermal tube; Another kind of slightly more complicated heats water by elder generation with electrothermal tube, and then carries out water-bath indirect heating form with hot water and heat.Insulation construction adopts monolayer material to surround the simple closed system that forms, and dodge gate then all is that the form with loam cake or side sliding door is fixed on the constant temperature oven casing by an axle.These structures interior temperature of holding device are to a certain extent stablized in certain amplitude, but also have following defective:
1. cause the temperature inside the box heterogeneity easily, higher relatively such as electrothermal tube annex or hot water accessory temperature, and particularly dead angle place temperature is lower in other places.
2. vibrating device is arranged on thermostat inside, and the vibrating device complex structure, and is bulky, strengthened the constant temperature oven volume inside, further aggravated the inhomogenous degree of the temperature inside the box.
In the case air circulation device be arranged on the side or above, air flow can make the liquid evaporation in the reaction system, influences test result.
4. volume is just huger, and power consumption is big, also is suitable in the automation equipment simultaneously.
5. complex structure, the manufacturing cost height.
Summary of the invention
The purpose of this invention is to provide biochemical temperature-controlling reaction apparatus such as a kind of simple small and exquisite biochip and enzyme linked immunological (ELISA).When biochip or ELISA vibrated isothermal reaction, the leakproofness of thermostat was good, and temperature stabilization is even in the casing, vibrate reliable and stablely, and the result accurately stablizes, and not only reduces experimental error greatly, is more conducive to the integrated of automation equipment.
The object of the present invention is achieved like this: the invention provides a kind of constant temperature vibration reaction unit, include thermostat (1) and vibrating device (2), described vibrating device comprises eccentric wheel (05), motor fixing plate (06), motor (07), vibration rack (08) and firm banking (09).
Described thermostat (1) comprises constant temperature oven shell (02), constant temperature oven loam cake (01), objective table (03), stage carrier (11), air circulation device (10), temperature sensor (12), heat radiator one (13) and heating plate (14).
Described thermostat (1) is fixed on the vibrating device (2) by constant temperature oven support (04), drives eccentric wheel (05) drive entire reaction device by motor (07) and vibrates.
Described eccentric wheel (05) is the derby of centre-of gravity shift or nonmetal, and eccentric wheel (05) is fixed on the axle of motor (07), and the rotating band movable eccentric wheel (05) by motor (07) axle rotates.
Described vibration rack (08) is the solid-state material that has elasticity and can keep its shape under normal conditions.
Described solid-state material is preferably shell fragment, spring or rubber-like rubber.
It is significant that the present invention compares effect with existing technology:
1. among the present invention vibrating device is arranged on outside the thermostat, has reduced the space size of thermostat, also avoided vibrating device, further improved temperature controlled precision of thermostat and reliability temperature controlled influence in the thermostat.
2. vibrating device adopts the simplest motor to add eccentric device among the present invention, has simplified vibrational structure, has reduced cost, has improved stability.
3. the present invention is simple in structure, and volume is small and exquisite, and is stable, is more convenient for being integrated in robotization or the semi-automatic equipment and uses.
Description of drawings
Fig. 1. be schematic three dimensional views of the present invention;
Fig. 2. be front-view schematic diagram of the present invention;
Fig. 3. for the A-A of Fig. 2 to cross section view;
Fig. 4. for looking synoptic diagram in a left side of the present invention.
Embodiment
Below in conjunction with accompanying drawing, the present invention is further described, but do not limit the scope of the invention.
As shown in the figure, (01) is the constant temperature oven loam cake, and (02) is the constant temperature oven shell, (03) be objective table, (04) is the constant temperature oven support, and (05) is eccentric wheel, (06) be motor fixing plate, (07) is motor, and (08) is vibration rack, (09) be firm banking, (10) are air circulation device, and (11) are stage carrier, (12) be temperature sensor, (13) be heat radiator one, (14) are heating plate, and (15) are heat radiator two.
In an embodiment of the present invention, temperature-controlling reaction apparatus is made up of constant temperature oven shell (02), constant temperature oven loam cake (01), objective table (03), stage carrier (11), air circulation device (10), temperature sensor (12), heat radiator one (13), heating plate (14) and temperature controller etc.Thermostat is formed the confined space of rectangular parallelepiped by constant temperature oven shell (02) and constant temperature oven loam cake (01), the heat transferred heat radiator one (13) that heating plate (14) energising heating produces, and pass through air circulation device (10) driven air circulating transfer and give whole constant temperature oven, the Current Temperatures that temperature controller feeds back according to temperature sensor (12) is controlled the electric current of heating plate (14) in real time.Constant temperature oven shell (02) and constant temperature oven loam cake (01) are made up of the heat-resisting heat-barrier material of single or multiple lift.Heating plate (14) in the thermostat is an electric heater unit, also is provided with 4 temperature sensors (12), controls by temperature controller, can detect the subtle change of temperature in the casing delicately, guarantees the constant temperature effect.Be provided with heat radiator one (13) and air circulation device (10) in the thermostat, heat radiator one (13) is by Heat Conduction Material or directly be close on the heating plate (14), and air circulation device (10) is made up of single or multiple fans.Because conventional constant temperature oven directly is arranged on circulating device constant temperature oven side or top, and its space is bigger, cause air directly on biochip or elisa plate bar, to flow, be easy to like this liquid in biochip or the elisa plate bar detection hole is dried up, cause reaction system to change, influence testing result.And the solution of success of the present invention this problem.In the embodiments of the invention, heat radiator one (13) and air circulation device (10) are arranged on objective table (03) below, air circulation device (10) makes the direction flow circuit of air to heat radiator one (13), hot-air passes to biochip or elisa plate bar top from the objective table periphery again, air flow does not directly have influence on the liquid in biochip or the elisa plate bar detection hole like this, has guaranteed the temperature uniformity in the whole thermostat simultaneously again.
In an embodiment of the present invention, provide a kind of vibrating device of temperature-controlling reaction apparatus, formed by eccentric wheel (05), motor fixing plate (06), motor (07), vibration rack (08) and firm banking (09) etc.Eccentric wheel (05) is the derby of centre-of gravity shift, mounting hole by the skew center of gravity is fixed on the axle of motor (07), energising is rotated motor (07) axle, rotates thereby drive eccentric wheel (05), takes place to change fast to produce vibration owing to eccentric rotation makes the center of gravity of whole vibration system.In an embodiment of the present invention, vibration rack (08) can keep its intrinsic form for having certain flexible shell fragment when motor stops operating, and keeps the fixed position of temperature-controlling reaction apparatus, makes things convenient for the mechanical positioning of thermostat.
In an embodiment of the present invention, thermostat is fixed on by constant temperature oven support (04) on the motor fixing plate (06) of vibrating device, drives eccentric wheel (05) drive entire reaction device by motor (07) and vibrates.
Should be understood that those skilled in the art can do various increases and decreases or modification to the present invention after reading foregoing of the present invention, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Claims (6)
1. a constant temperature vibration reaction unit includes thermostat (1) and vibrating device (2), it is characterized in that described vibrating device comprises eccentric wheel (05), motor fixing plate (06), motor (07), vibration rack (08) and firm banking (09).
2. constant temperature vibration reaction unit according to claim 1, it is characterized in that described thermostat (1) comprises constant temperature oven shell (02), constant temperature oven loam cake (01), objective table (03), stage carrier (11), air circulation device (10), temperature sensor (12), heat radiator one (13) and heating plate (14).
3. constant temperature vibration reaction unit according to claim 1 is characterized in that described thermostat (1) is fixed on the vibrating device (2) by constant temperature oven support (04), drives eccentric wheel (05) drive entire reaction device by motor (07) and vibrates.
4. constant temperature vibration reaction unit according to claim 1 and 2, it is characterized in that, described eccentric wheel (05) is the derby of centre-of gravity shift or nonmetal, and eccentric wheel (05) is fixed on the axle of motor (07), and the rotating band movable eccentric wheel (05) by motor (07) axle rotates.
5. constant temperature vibration reaction unit according to claim 1 and 2 is characterized in that described vibration rack (08) is the solid-state material that has elasticity and can keep its shape under normal conditions.
6. constant temperature vibration reaction unit according to claim 5 is characterized in that described solid-state material can be shell fragment, spring or rubber-like rubber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102012939A CN102103139A (en) | 2009-12-17 | 2009-12-17 | Constant temperature vibration reaction device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102012939A CN102103139A (en) | 2009-12-17 | 2009-12-17 | Constant temperature vibration reaction device |
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| CN102103139A true CN102103139A (en) | 2011-06-22 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012079507A1 (en) * | 2010-12-16 | 2012-06-21 | 福建省电力有限公司 | Device and method for measuring magnetic induction intensity based on colossal magnetoresistive effect |
| CN104048904A (en) * | 2014-06-23 | 2014-09-17 | 中国石油大学(华东) | Experimental device and method for testing surfactant adsorption property under resonance wave action |
| CN105572158A (en) * | 2014-11-05 | 2016-05-11 | 内蒙古伊利实业集团股份有限公司 | Detecting equipment and method for heat stability of liquid milk product |
| CN106345780A (en) * | 2016-11-07 | 2017-01-25 | 百奥森（江苏）食品安全科技有限公司 | Plate washing machine with oscillating and incubating functions |
| CN107478572A (en) * | 2017-07-11 | 2017-12-15 | 浙江大学 | A kind of system and its probe unit and assay method for being used to determine prepreg viscosity |
| CN110376118A (en) * | 2019-06-05 | 2019-10-25 | 天津英创汇智汽车技术有限公司 | A kind of DV test device for EHCU assembly |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2795858Y (en) * | 2005-02-24 | 2006-07-12 | 穆海东 | Objective table of biological chip reactor and constant temperature reactor |
| CN201253579Y (en) * | 2008-08-29 | 2009-06-10 | 山东省农业科学院中心实验室 | Multifunctional oscillator |
| CN201313042Y (en) * | 2009-04-16 | 2009-09-23 | 上海一恒科学仪器有限公司 | Heating cyclotron oscillator |
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2009
- 2009-12-17 CN CN2009102012939A patent/CN102103139A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2795858Y (en) * | 2005-02-24 | 2006-07-12 | 穆海东 | Objective table of biological chip reactor and constant temperature reactor |
| CN201253579Y (en) * | 2008-08-29 | 2009-06-10 | 山东省农业科学院中心实验室 | Multifunctional oscillator |
| CN201313042Y (en) * | 2009-04-16 | 2009-09-23 | 上海一恒科学仪器有限公司 | Heating cyclotron oscillator |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012079507A1 (en) * | 2010-12-16 | 2012-06-21 | 福建省电力有限公司 | Device and method for measuring magnetic induction intensity based on colossal magnetoresistive effect |
| CN104048904A (en) * | 2014-06-23 | 2014-09-17 | 中国石油大学(华东) | Experimental device and method for testing surfactant adsorption property under resonance wave action |
| CN105572158A (en) * | 2014-11-05 | 2016-05-11 | 内蒙古伊利实业集团股份有限公司 | Detecting equipment and method for heat stability of liquid milk product |
| CN106345780A (en) * | 2016-11-07 | 2017-01-25 | 百奥森（江苏）食品安全科技有限公司 | Plate washing machine with oscillating and incubating functions |
| CN107478572A (en) * | 2017-07-11 | 2017-12-15 | 浙江大学 | A kind of system and its probe unit and assay method for being used to determine prepreg viscosity |
| CN107478572B (en) * | 2017-07-11 | 2020-05-08 | 浙江大学 | System for measuring viscosity of prepreg, probe device and measuring method thereof |
| CN110376118A (en) * | 2019-06-05 | 2019-10-25 | 天津英创汇智汽车技术有限公司 | A kind of DV test device for EHCU assembly |
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Application publication date: 20110622 |