CN102089079B - 用于实施化学检定的设备和方法 - Google Patents

用于实施化学检定的设备和方法 Download PDF

Info

Publication number
CN102089079B
CN102089079B CN200980126819XA CN200980126819A CN102089079B CN 102089079 B CN102089079 B CN 102089079B CN 200980126819X A CN200980126819X A CN 200980126819XA CN 200980126819 A CN200980126819 A CN 200980126819A CN 102089079 B CN102089079 B CN 102089079B
Authority
CN
China
Prior art keywords
sample
unit
sensing
test
sample carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200980126819XA
Other languages
English (en)
Chinese (zh)
Other versions
CN102089079A (zh
Inventor
罗伯特·安德鲁·波特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agplus Diagnostics Ltd
Secco Holdings Ltd
UK Secretary of State for Business Innovation and Skills
Original Assignee
UK Secretary of State for Innovation Universities and Skills
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UK Secretary of State for Innovation Universities and Skills filed Critical UK Secretary of State for Innovation Universities and Skills
Publication of CN102089079A publication Critical patent/CN102089079A/zh
Application granted granted Critical
Publication of CN102089079B publication Critical patent/CN102089079B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/4166—Systems measuring a particular property of an electrolyte
    • G01N27/4168—Oxidation-reduction potential, e.g. for chlorination of water
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Electrochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN200980126819XA 2008-07-10 2009-05-26 用于实施化学检定的设备和方法 Expired - Fee Related CN102089079B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0812681.5A GB0812681D0 (en) 2008-07-10 2008-07-10 Apparatus and methods for effecting chemical assays
GB0812681.5 2008-07-10
PCT/GB2009/001310 WO2010004241A1 (en) 2008-07-10 2009-05-26 Apparatus and methods for effecting chemical assays

Publications (2)

Publication Number Publication Date
CN102089079A CN102089079A (zh) 2011-06-08
CN102089079B true CN102089079B (zh) 2013-10-16

Family

ID=39722100

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980126819XA Expired - Fee Related CN102089079B (zh) 2008-07-10 2009-05-26 用于实施化学检定的设备和方法

Country Status (9)

Country Link
US (2) US20110171735A1 (enExample)
EP (1) EP2323764B1 (enExample)
JP (1) JP5774479B2 (enExample)
CN (1) CN102089079B (enExample)
AT (1) ATE550098T1 (enExample)
AU (1) AU2009269860C1 (enExample)
GB (1) GB0812681D0 (enExample)
NZ (1) NZ590220A (enExample)
WO (1) WO2010004241A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9862984B2 (en) 2006-04-21 2018-01-09 Nanobiosym, Inc. Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents
US11275084B2 (en) * 2010-01-15 2022-03-15 Stanford University Successive sampling device and associated method
GB201105828D0 (en) 2011-04-06 2011-05-18 Vivacta Ltd A device for detecting an analyte
JP2013142663A (ja) * 2012-01-12 2013-07-22 Mitsubishi Chemical Medience Corp 電気的分析方法
GB201217390D0 (en) 2012-09-28 2012-11-14 Agplus Diagnostics Ltd Test device and sample carrier
US10309954B2 (en) 2012-12-12 2019-06-04 Green Domain Design Llc Assay apparatus
US11320418B2 (en) 2012-12-12 2022-05-03 Iassay, Inc. Modular hand-held point of care testing system
CN105142789A (zh) * 2013-03-15 2015-12-09 纳诺拜希姆公司 用于移动设备分析核酸和蛋白质的系统和方法
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
KR101583017B1 (ko) * 2015-07-17 2016-01-06 주식회사 지노바이오 MIP(Magnetic Iron Particles)분리 시스템
CN112517091B (zh) * 2020-10-28 2022-07-29 清华大学 生物样品中微小物质的分离方法
CN114192202B (zh) * 2021-12-09 2022-09-06 中国农业大学 一种应用于微流控芯片的便携式磁珠自动化混合模块
CN114813697B (zh) * 2022-03-16 2022-12-27 江苏暖阳半导体科技有限公司 micro LED芯片的高通量多通道快速拉曼检测系统
WO2024252153A1 (en) 2023-06-08 2024-12-12 Aureum Diagnostics Limited Methods and Devices For Detecting Analytes
GB202308560D0 (en) 2023-06-08 2023-07-26 Aureum Diagnostics Ltd Methods and devices for detecting analytes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005046437A2 (en) * 2003-11-05 2005-05-26 Separation Technology, Inc. Disposable fluid sample collection device
CN1909828A (zh) * 2004-01-15 2007-02-07 皇家飞利浦电子股份有限公司 自适应生理监视系统及其使用方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096669A (en) * 1988-09-15 1992-03-17 I-Stat Corporation Disposable sensing device for real time fluid analysis
US6071394A (en) * 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
US5835329A (en) * 1995-06-05 1998-11-10 Solid Phase Sciences Corporation Apparatus for agitation separation of magnetic particles
US20010055812A1 (en) * 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US6709869B2 (en) * 1995-12-18 2004-03-23 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US6159739A (en) * 1997-03-26 2000-12-12 University Of Washington Device and method for 3-dimensional alignment of particles in microfabricated flow channels
US6300138B1 (en) * 1997-08-01 2001-10-09 Qualigen, Inc. Methods for conducting tests
FI107080B (fi) * 1997-10-27 2001-05-31 Nokia Mobile Phones Ltd Mittauslaite
CA2320296A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6326612B1 (en) * 1998-10-13 2001-12-04 Texas Instruments Incorporated System and method for optical sensing utilizing a portable, detachable sensor cartridge
AU5646800A (en) * 1999-03-02 2000-09-21 Helix Biopharma Corporation Card-based biosensor device
ATE356355T1 (de) * 1999-06-18 2007-03-15 Cardiogenics Inc Verfahren zur prozessführung chemilumineszenter bindungstests
EP1259786A4 (en) * 2000-02-07 2006-05-03 Applied Color Systems Inc PORTABLE COLORIMETRIC MEASURING DEVICE
IL151477A0 (en) * 2000-03-09 2003-04-10 Clinical Analysis Corp Medical diagnostic system
US8518328B2 (en) * 2005-12-27 2013-08-27 Honeywell International Inc. Fluid sensing and control in a fluidic analyzer
FR2810739B1 (fr) * 2000-06-26 2007-01-26 Centre Nat Rech Scient Immunodosage electrochimiques a l'aide de marqueurs metalliques colloidaux
US20040248093A1 (en) * 2000-11-27 2004-12-09 Coombs James Howard Magneto-optical bio-discs and systems including related methods
US20020197733A1 (en) * 2001-06-20 2002-12-26 Coventor, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US6975395B1 (en) * 2002-03-18 2005-12-13 Finisar Corporation Handheld optical channel performance monitor and optical spectrum analyzer
KR100480338B1 (ko) * 2002-08-08 2005-03-30 한국전자통신연구원 극소량의 유체제어를 위한 미세 유체제어소자
US7838296B2 (en) * 2002-08-28 2010-11-23 Separation Technology, Inc. Methods and apparatus for ultrasonic determination of red blood cell indices
US20040058457A1 (en) * 2002-08-29 2004-03-25 Xueying Huang Functionalized nanoparticles
JP2004279179A (ja) * 2003-03-14 2004-10-07 Shimadzu Corp 分析システム
JP4644192B2 (ja) * 2003-07-01 2011-03-02 エフ．ホフマン−ラ ロシュ アーゲー 電気化学的アフィニティーバイオセンサーシステム及び方法
US7208784B2 (en) * 2003-10-07 2007-04-24 Quantum Logic Devices, Inc. Single-electron transistor for detecting biomolecules
GB0327094D0 (en) * 2003-11-21 2003-12-24 Inverness Medical Switzerland Laminated device
US8343074B2 (en) * 2004-06-30 2013-01-01 Lifescan Scotland Limited Fluid handling devices
US20060263818A1 (en) * 2005-05-23 2006-11-23 Axel Scherer High throughput multi-antigen microfluidic fluorescence immunoassays
US20060270049A1 (en) * 2005-05-25 2006-11-30 Board Of Supervisors Of Louisiana State University & A & M College Enhanced detection of analytes on surfaces using gold nanoparticles
US20070202561A1 (en) * 2006-02-10 2007-08-30 Becton Dickinson And Company Electronic Detection Immunoassays that Utilize a Binder Support Medium
GB2436616A (en) * 2006-03-29 2007-10-03 Inverness Medical Switzerland Assay device and method
PL2047253T3 (pl) * 2006-07-17 2016-06-30 Universal Biosensors Pty Ltd Detekcja elektrochemiczna ruchliwości cząstek magnetycznych
KR101153748B1 (ko) * 2008-05-07 2012-06-14 재단법인서울대학교산학협력재단 바이오센서로 유용한 새로운 형태의 금／은 코어쉘 복합체
US8372435B2 (en) * 2008-06-23 2013-02-12 Princeton University Modular monolayer coatings for selective attachment of nanoparticles to biomolecules

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005046437A2 (en) * 2003-11-05 2005-05-26 Separation Technology, Inc. Disposable fluid sample collection device
CN1909828A (zh) * 2004-01-15 2007-02-07 皇家飞利浦电子股份有限公司 自适应生理监视系统及其使用方法

Also Published As

Publication number Publication date
EP2323764A1 (en) 2011-05-25
CN102089079A (zh) 2011-06-08
NZ590220A (en) 2014-02-28
US20110171735A1 (en) 2011-07-14
AU2009269860A1 (en) 2010-01-14
EP2323764B1 (en) 2012-03-21
GB0812681D0 (en) 2008-08-20
AU2009269860B2 (en) 2015-01-22
JP2011527430A (ja) 2011-10-27
US20170059519A1 (en) 2017-03-02
AU2009269860C1 (en) 2015-07-09
JP5774479B2 (ja) 2015-09-09
ATE550098T1 (de) 2012-04-15
WO2010004241A1 (en) 2010-01-14

Similar Documents

Publication Publication Date Title
CN102089079B (zh) 用于实施化学检定的设备和方法
JP2011527430A5 (enExample)
CN102089661B (zh) 用于实施化学检定的样品载体
CN112782393B (zh) 用于检测和量化分析物的系统和方法
CN104471384A (zh) 临床诊断系统
US11358140B2 (en) Apparatus for automatic sampling of biological species employing an amplification with a magnetic nanoparticle and propulsion method
US20160363550A1 (en) Mobile sample analysis system, mobile measurement device, and method for providing analysis results
CN101915736B (zh) 测定仪器、测定装置和测定方法
KR20160057481A (ko) 진단 시험을 위한 방법 및 시스템
US20220250060A1 (en) Integrated, point of sale, blood testing systems and methods
US20140235480A1 (en) Ultra-sensitive Detection of Analytes
US9625465B2 (en) Clinical diagnostic systems
EP4220165A1 (en) Method and device for the detection of traumatic brain injuries
US20230182133A1 (en) Systems and methods for processing and testing biological samples
US12023674B2 (en) Apparatus for automatic sampling of biological species employing disk microfluidics system
US20230225644A1 (en) Reusable and electrochemically active device for measurement of concentration of bioanalytes
JP2011196820A (ja) 採血管
US20170102378A1 (en) Industrial design of stand-alone assay system
WO2013015781A1 (en) Microchips and methods for testing a fluid sample
EP4473312A1 (en) Systems and methods for processing and testing biological samples

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20151117

Address after: England Hampshire

Patentee after: AGPLUS DIAGNOSTICS LTD.

Address before: England Hampshire

Patentee before: SECCO Holdings Ltd.

Effective date of registration: 20151117

Address after: England Hampshire

Patentee after: SECCO Holdings Ltd.

Address before: London, England

Patentee before: THE SECRETARY OF STATE FOR BUSINESS,INNOVATION & SKILLS OF HER MAJESTY'S BRITANNIC GOVERNMENT

Effective date of registration: 20151117

Address after: London, England

Patentee after: THE SECRETARY OF STATE FOR BUSINESS,INNOVATION & SKILLS OF HER MAJESTY'S BRITANNIC GOVERNMENT

Address before: London, England

Patentee before: The Secretary of State for Innovation Universities & Skills of Her Majesty's Britannic Government

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20131016

CF01 Termination of patent right due to non-payment of annual fee