CN102079745B - Production method of silymarin - Google Patents
Production method of silymarin Download PDFInfo
- Publication number
- CN102079745B CN102079745B CN 200910238368 CN200910238368A CN102079745B CN 102079745 B CN102079745 B CN 102079745B CN 200910238368 CN200910238368 CN 200910238368 CN 200910238368 A CN200910238368 A CN 200910238368A CN 102079745 B CN102079745 B CN 102079745B
- Authority
- CN
- China
- Prior art keywords
- silymarin
- softening
- production method
- silybum marianum
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 title claims abstract description 51
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 title claims abstract description 51
- 235000017700 silymarin Nutrition 0.000 title claims abstract description 48
- 229960004245 silymarin Drugs 0.000 title claims abstract description 43
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 29
- 238000000605 extraction Methods 0.000 claims abstract description 21
- 244000272459 Silybum marianum Species 0.000 claims abstract description 12
- 235000010841 Silybum marianum Nutrition 0.000 claims abstract description 12
- 239000002904 solvent Substances 0.000 claims abstract description 11
- 238000001035 drying Methods 0.000 claims abstract description 10
- 238000003756 stirring Methods 0.000 claims abstract description 10
- 239000003513 alkali Substances 0.000 claims abstract description 9
- 238000012216 screening Methods 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- 239000007864 aqueous solution Substances 0.000 claims description 11
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 8
- 238000004062 sedimentation Methods 0.000 claims description 7
- 239000007921 spray Substances 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 11
- FDQAOULAVFHKBX-UHFFFAOYSA-N Isosilybin A Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC(=CC=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 FDQAOULAVFHKBX-UHFFFAOYSA-N 0.000 abstract description 9
- FDQAOULAVFHKBX-KMRPREKFSA-N (+)-Isosilybin A Natural products C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC(=CC=C3O2)[C@@H]2[C@@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 FDQAOULAVFHKBX-KMRPREKFSA-N 0.000 abstract description 8
- FDQAOULAVFHKBX-HKTJVKLFSA-N (2r,3r)-3,5,7-trihydroxy-2-[(2r,3r)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC(=CC=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 FDQAOULAVFHKBX-HKTJVKLFSA-N 0.000 abstract description 8
- KDMGQPNVTKUNHV-UHFFFAOYSA-N Isosilybin Natural products C1=C(O)C(OC)=CC=C1C1C(CO)OC2=CC=C(C3C(C(=O)C4=C(O)C=C(O)C=C4O3)O)C=C2O1 KDMGQPNVTKUNHV-UHFFFAOYSA-N 0.000 abstract description 8
- 235000014899 silybin Nutrition 0.000 abstract description 8
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 abstract description 7
- 229930003944 flavone Natural products 0.000 abstract description 7
- 150000002212 flavone derivatives Chemical class 0.000 abstract description 7
- 235000011949 flavones Nutrition 0.000 abstract description 7
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 abstract description 7
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 2
- 238000010298 pulverizing process Methods 0.000 abstract description 2
- 238000000825 ultraviolet detection Methods 0.000 abstract description 2
- 239000000047 product Substances 0.000 abstract 3
- 238000011049 filling Methods 0.000 abstract 2
- VLGROHBNWZUINI-UHFFFAOYSA-N Silybin Natural products COc1cc(ccc1O)C2OC3C=C(C=CC3OC2CO)C4Oc5cc(O)cc(O)c5C(=O)C4O VLGROHBNWZUINI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 229940043175 silybin Drugs 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 9
- 229950000628 silibinin Drugs 0.000 description 8
- 238000007599 discharging Methods 0.000 description 5
- 231100001261 hazardous Toxicity 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- CYGIJEJDYJOUAN-UHFFFAOYSA-N Isosilychristin Natural products C1=C(O)C(OC)=CC(C2C3C=C(C4C(C3=O)(O)OCC42)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 CYGIJEJDYJOUAN-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 1
- 241000320380 Silybum Species 0.000 description 1
- RIAZZJBPJQWPIS-UHFFFAOYSA-N Silychristin Natural products COc1cc(ccc1O)C2OC3C(C=C(C=C3O)C4Oc5cc(O)cc(O)c5C(=O)C4O)C2CO RIAZZJBPJQWPIS-UHFFFAOYSA-N 0.000 description 1
- MZBGBHVFCYCYLX-UHFFFAOYSA-N Silydianin Natural products COc1cc(ccc1O)C2C3COC4(O)C3C=C(C5Oc6cc(O)cc(O)c6C(=O)C5O)C2C4=O MZBGBHVFCYCYLX-UHFFFAOYSA-N 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 208000031320 Teratogenesis Diseases 0.000 description 1
- 238000003811 acetone extraction Methods 0.000 description 1
- 230000003035 anti-peroxidant effect Effects 0.000 description 1
- 230000000702 anti-platelet effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 230000002279 cholagogic effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- -1 dehydro-silibinin Chemical compound 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000002481 ethanol extraction Methods 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 238000003810 ethyl acetate extraction Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000004223 radioprotective effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- BMLIIPOXVWESJG-LMBCONBSSA-N silychristin Chemical compound C1=C(O)C(OC)=CC([C@H]2[C@@H](C3=C(C(=CC(=C3)[C@@H]3[C@H](C(=O)C4=C(O)C=C(O)C=C4O3)O)O)O2)CO)=C1 BMLIIPOXVWESJG-LMBCONBSSA-N 0.000 description 1
- BMLIIPOXVWESJG-UHFFFAOYSA-N silychristin A Natural products C1=C(O)C(OC)=CC(C2C(C3=C(C(=CC(=C3)C3C(C(=O)C4=C(O)C=C(O)C=C4O3)O)O)O2)CO)=C1 BMLIIPOXVWESJG-UHFFFAOYSA-N 0.000 description 1
- CYGIJEJDYJOUAN-JSGXPVSSSA-N silydianin Chemical compound C1=C(O)C(OC)=CC([C@H]2[C@H]3C=C([C@@H]4[C@@](C3=O)(O)OC[C@@H]42)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 CYGIJEJDYJOUAN-JSGXPVSSSA-N 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200910238368 CN102079745B (en) | 2009-12-01 | 2009-12-01 | Production method of silymarin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200910238368 CN102079745B (en) | 2009-12-01 | 2009-12-01 | Production method of silymarin |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102079745A CN102079745A (en) | 2011-06-01 |
CN102079745B true CN102079745B (en) | 2013-09-11 |
Family
ID=44085964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200910238368 Active CN102079745B (en) | 2009-12-01 | 2009-12-01 | Production method of silymarin |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102079745B (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102225085B (en) * | 2011-06-20 | 2012-09-05 | 黑龙江大学 | Method for extracting holy thistle total flavonoids from holy thistle stalks |
CN103408538B (en) * | 2013-08-27 | 2015-06-24 | 白心亮 | Method for extracting silymarin |
CN103408539B (en) * | 2013-08-28 | 2016-04-06 | 天津泰阳制药有限公司 | The production method of high-purity silymarin |
CN103446212B (en) * | 2013-09-11 | 2015-11-11 | 白心亮 | A kind of liver protection product |
EP2959910A1 (en) * | 2014-06-26 | 2015-12-30 | Bionorica Se | Milk thistle extract of fruit shells of Silybum marianum, process of manufacture and use |
CN105503843B (en) * | 2016-01-23 | 2018-07-10 | 内蒙古昶辉生物科技股份有限公司 | A kind of preparation method of silymarin |
CN107663201A (en) * | 2016-07-29 | 2018-02-06 | 内蒙古昶辉生物科技股份有限公司 | A kind of method that silymarin is extracted using ethanol |
CN107698572A (en) * | 2016-07-29 | 2018-02-16 | 内蒙古昶辉生物科技股份有限公司 | A kind of extracting method of silymarin |
CN107663200A (en) * | 2016-07-29 | 2018-02-06 | 内蒙古昶辉生物科技股份有限公司 | A kind of silymarin gradient extracting method using ethyl acetate |
CN106188020A (en) * | 2016-07-29 | 2016-12-07 | 内蒙古昶辉生物科技股份有限公司 | A kind of silymarin gradient extracting method using ethanol |
CN106008484B (en) * | 2016-07-29 | 2019-03-12 | 内蒙古昶辉生物科技股份有限公司 | A kind of extracting method of silymarin |
CN106243095A (en) * | 2016-07-29 | 2016-12-21 | 内蒙古昶辉生物科技股份有限公司 | A kind of method using ethyl acetate to extract silymarin |
CN107260787B (en) * | 2017-08-09 | 2020-07-21 | 江苏中兴药业有限公司 | Method for improving dissolution of effective components of silybum marianum shells |
CN110028499B (en) * | 2019-05-10 | 2021-08-03 | 晨光生物科技集团股份有限公司 | Industrial method for producing high-quality silymarin |
CN117402151B (en) * | 2023-12-15 | 2024-03-08 | 天津玉健生物工程有限公司 | Method for producing high content silybum marianum extract |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1395573A (en) * | 2000-01-11 | 2003-02-05 | 比奥雷克斯健康有限公司 | Extraction of flavonoids |
CN1560046A (en) * | 2004-03-03 | 2005-01-05 | 西安理工大学 | Process for extracting water grind thisvine using alcohole as single organic dissolvent |
-
2009
- 2009-12-01 CN CN 200910238368 patent/CN102079745B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1395573A (en) * | 2000-01-11 | 2003-02-05 | 比奥雷克斯健康有限公司 | Extraction of flavonoids |
CN1560046A (en) * | 2004-03-03 | 2005-01-05 | 西安理工大学 | Process for extracting water grind thisvine using alcohole as single organic dissolvent |
Non-Patent Citations (3)
Title |
---|
史劲松等.水飞蓟素提取工艺的改进和探讨.《中国野生植物资源》.2006,第25卷(第6期),第52-54页. |
水飞蓟素提取工艺的改进和探讨;史劲松等;《中国野生植物资源》;20061231;第25卷(第6期);第52-54页 * |
贾丽娜.水飞蓟有效成分的提取研究.《中国优秀博硕士学位论文全文数据库 (硕士)工程科技Ⅰ辑》.2006,(第3期),第B016-74页. * |
Also Published As
Publication number | Publication date |
---|---|
CN102079745A (en) | 2011-06-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102079745B (en) | Production method of silymarin | |
CN101531690B (en) | New technology for extracting tea saponin and tea seed oil from tea seeds by using water as solvent | |
CN103463123B (en) | Method for extracting effective constituents from maca | |
CN102115611B (en) | Method for performing steam explosion on chestnut hulls and coproducing pigment, tanning extract and active carbon | |
CN103030710A (en) | Resource utilization method of camellia oleifera shells | |
CN107382672A (en) | Utilize the method and its cannabidiol product of supercritical carbon dioxide extracting cannabidiol | |
CN102676290A (en) | Ultrasonic assisted supercritical CO2 hemp seed oil extraction method | |
CN101338248A (en) | Supercritical process for extracting and recovering oil in solid oil crops | |
CN102453601B (en) | Extraction method of Cinnamomum camphora seed oil by ultrasound-assisted compound enzyme | |
CN104673497A (en) | Extraction technology of plant essential oil, polysaccharide and flavone | |
CN102060728A (en) | Method for extracting capsorubin and capsaicin from chillies | |
CN105062686A (en) | Method for extracting lavender essential oil | |
CN102388987B (en) | Ultrasound-assisted tea oil extraction method | |
CN104059163A (en) | Novel method for preparing Qinghai Qaidam lycium barbarum polysaccharide in extraction and separation manner | |
CN106702802A (en) | Method for extracting high-purity cellulose from stalks in ionic liquid-sulfamic acid binary system | |
CN103664988A (en) | Extraction and separation method for artemisinin | |
CN102493246A (en) | Method for extracting and separating cellulose from biomass solid waste | |
CN107468822A (en) | A kind of resin extraction process of high-purity tea polypenols | |
CN106436411A (en) | Method for cleanly producing paper pulp through steam explosion | |
CN104313928A (en) | Method for efficiently separating hemicellulose from straws | |
CN102174606A (en) | Combined extraction method of blackberry seed oil and anthocyanin in blackberry juice production byproducts | |
CN101092436A (en) | Process engineering for producing oligo xylose through physical exploding smash method | |
CN105440166A (en) | Method used for extracting hemicellulose with low pigment content | |
CN112980569A (en) | Production process for supercritical extraction of zanthoxylum schinifolium by using CO2 | |
CN102524706B (en) | Method for grinding to form powder by using steam-exposition assisted konjac wet method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: KAILU EVER BRILLIANCE BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: BAI XINLIANG Effective date: 20150302 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20150302 Address after: 028400 the Inner Mongolia Autonomous Region Tongliao Kailu County Kailu Town Eastern Industrial District Patentee after: Kailu Zhaohui Biotechnology Co.,Ltd. Address before: 028400 Tongliao city the Inner Mongolia Autonomous Region Kailu County Gongnong Street No. 1 Patentee before: Bai Xinliang |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20160523 Address after: 011517 Hohhot city Helingeer County Inner Mongolia Shengle economic Park Patentee after: INNER MONGOLIA CHANGHUI BIOLOGICAL TECHNOLOGY Co.,Ltd. Address before: The eastern outskirts of the industrial district of Tongliao city Inner Mongolia town 028400 Kailu Kailu County Patentee before: Kailu Zhaohui Biotechnology Co.,Ltd. |
|
C56 | Change in the name or address of the patentee | ||
CP01 | Change in the name or title of a patent holder |
Address after: 011517 Hohhot city Helingeer County Inner Mongolia Shengle economic Park Patentee after: INNER MONGOLIA CHANGHUI BIOTECHNOLOGY CO.,LTD. Address before: 011517 Hohhot city Helingeer County Inner Mongolia Shengle economic Park Patentee before: INNER MONGOLIA CHANGHUI BIOLOGICAL TECHNOLOGY Co.,Ltd. |
|
CP02 | Change in the address of a patent holder | ||
CP02 | Change in the address of a patent holder |
Address after: 028400 no.0427, Dongjiao Industrial Park, Kailu Town, Kailu County, Tongliao City, Inner Mongolia Autonomous Region Patentee after: INNER MONGOLIA CHANGHUI BIOTECHNOLOGY CO.,LTD. Address before: 011517 Hohhot city Helingeer County Inner Mongolia Shengle economic Park Patentee before: INNER MONGOLIA CHANGHUI BIOTECHNOLOGY CO.,LTD. |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A production method of Silymarin Effective date of registration: 20210222 Granted publication date: 20130911 Pledgee: Agricultural Bank of China Limited Helingeer County sub branch Pledgor: INNER MONGOLIA CHANGHUI BIOTECHNOLOGY Co.,Ltd. Registration number: Y2021150000016 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220321 Granted publication date: 20130911 Pledgee: Agricultural Bank of China Limited Helingeer County sub branch Pledgor: INNER MONGOLIA CHANGHUI BIOTECHNOLOGY CO.,LTD. Registration number: Y2021150000016 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A production method of Silymarin Effective date of registration: 20220330 Granted publication date: 20130911 Pledgee: Agricultural Bank of China Limited Helingeer County sub branch Pledgor: INNER MONGOLIA CHANGHUI BIOTECHNOLOGY CO.,LTD. Registration number: Y2022150000027 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230301 Granted publication date: 20130911 Pledgee: Agricultural Bank of China Limited Helingeer County sub branch Pledgor: INNER MONGOLIA CHANGHUI BIOTECHNOLOGY CO.,LTD. Registration number: Y2022150000027 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A production method of silymarin Effective date of registration: 20230307 Granted publication date: 20130911 Pledgee: China Minsheng Banking Corp Hohhot branch Pledgor: INNER MONGOLIA CHANGHUI BIOTECHNOLOGY CO.,LTD. Registration number: Y2023150000031 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20231031 Granted publication date: 20130911 Pledgee: China Minsheng Banking Corp Hohhot branch Pledgor: INNER MONGOLIA CHANGHUI BIOTECHNOLOGY CO.,LTD. Registration number: Y2023150000031 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A Production Method of Silymarin Effective date of registration: 20231101 Granted publication date: 20130911 Pledgee: China Minsheng Banking Corp Hohhot branch Pledgor: INNER MONGOLIA CHANGHUI BIOTECHNOLOGY CO.,LTD. Registration number: Y2023150000154 |