CN102078336A - Traditional Chinese medicine composition with function of improving microcirculation and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition with function of improving microcirculation and preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition which has a function of improving microcirculation. In order to achieve the purpose, the invention adopts the following technical scheme: the active components contained in the traditional Chinese medicine composition are prepared from the following raw materials in parts by weight by adopting a corresponding preparation method: 10-30 parts of ground beetle, 10-30 parts of leech, 10-30 parts of earthworm, 10-30 parts of scorpion, 10-30 parts of centipede, 10-30 parts of stiff silkworm and 10-30 parts of oplopanax elatus. The traditional Chinese medicine composition has the function of improving microcirculation.
Description
Technical field
The present invention relates to the Chinese medicine preparation technical field, be specifically related to a kind of Chinese medicine composition and method for making and application with microcirculation improvement.
Background technology
The blood vessel of human body is the pipeline of pumping blood, and it is as same great river, and branch is the same with soil around irrigating gradually.Also circumvascular histiocyte in nutrition.When blood arrived tiny arteriole through trunk, its widely distributed capillary network of flowing through converged and flows into tiny venule.Because this part external caliber is very little, is invisible to the naked eye, only just can see at microscopically, therefore be called microcirculation.The someone proposes microcirculatory notion except blood microcirculation in recent years, also comprises the microcirculation of lymph fluid and tissue fluid, and they are meant the lymph fluid microcirculation in the lymphatic capillary and small organize ducted tissue fluid circulation.But usually said microcirculation is meant the blood microcirculation that research is more deep.In the blood vessel of blood microcirculation, the arteriole that guide blood flows into because tube wall has smooth muscle, can shrink and diastole, is determining microcirculatory influx; The effusive venule of guide blood, tube wall also has smooth muscle, and its activity is determining the discharge of capillary blood flow; And blood capillary does not have smooth muscle, have only the basement membrane of one deck vascular endothelial cell and outside, so wall is the thinnest, and by tube wall turnover blood vessel, its main function is to carry out mass exchange to material easily.
Since the twenties, just begun microcirculatory research, but this noun of microcirculation is just formal definite and use in first U.S.'s microcirculation meeting in 1954.Countries in the world are set up microcirculation association one after another since over half a century, have held six worldwide microcirculation conferences, three Asia microcirculation conferences.Microcirculatory research from microscopically direct observation blood flow, is deep into cell and molecular level.
Microcirculation providing organization cell oxygen and nutriment are taken away metabolic waste, have guaranteed the carrying out of normal activities.Microcirculation disorders has participated in the generation of numerous disease, as acute inflammation, wound, burn, shock, and chronic Peptic Ulcers, hepatitis, liver cirrhosis, senile hypertension, diabetes, cardiovascular and cerebrovascular disease etc.Therefore microcirculation improvement helps the rehabilitation of the strong and disease of health, and the method for the microcirculation improvement of seeking is paid attention to by medical circle always.
The method of microcirculation improvement and blood flow increasing comprises medicine and non-drug therapy two big classes.With Anisodamine, atropine, Anisodine etc. are representative in pharmacotherapy, and their common features are the expansion blood capillaries, accelerate blood flow rate, thus blood flow increasing.The Anisodamine effect that China extracts from the medical herbs Radix Anisodi Tangutici in the Danggula Mountains, Qinghai is the most outstanding, it has tangible expansion blood capillary and blood flow increasing effect, also reduce platelet and leukocytic gathering simultaneously and reduce microthrombusis, nowadays it has become the medicine that China clinician treats an extensive use of microcirculation disorders and some critically ill patient of rescue.Blood-activating and stasis-removing Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Polygoni Cuspidati etc. also are significantly increased the blood flow effect in addition.
In non-drug therapy, multiple physiotherapy commonly used comprises that ultrashort wave, frequency spectrum, He-Ne Lasers, thermotherapy, mineral bath etc. all have the effect of expansion blood capillary and blood flow increasing.
Along with factors such as the variation of the improvement of the raising of people's living standard, dietary structure, life style and gene, the sickness rate of microcirculation disturbance is obvious ascendant trend.Prevalence height, relapse rate height are the main features of microcirculation disturbance disease, reflect that simultaneously the demand in microcirculation disturbance disease therapeuticing medicine market is huge.Chinese patent medicine occupies critical role in microcirculation disturbance disease medication market, because the Chinese patent medicine side effect is little, determined curative effect is applicable to long-term prescription, has adapted to the microcirculation disturbance disease characteristics of recurrence easily, and clinical practice is very extensive.
Summary of the invention
Goal of the invention:, the object of the present invention is to provide a kind of Chinese medicine composition with microcirculation improvement in order to address the above problem.In order to reach this order ground, adopt following technical scheme:
Technical scheme: a kind of Chinese medicine composition with microcirculation improvement, its contained active component is prepared from by the following raw materials in part by weight proportioning: Eupolyphaga Seu Steleophaga 10-30 part, Hirudo 10-30 part, Pheretima 10-30 part, Scorpio 10-30 part, Scolopendra 10-30 part, Bombyx Batryticatus 10-30 part and Radix Morinae Bulleyanae 10-30 part.
A kind of Chinese medicine composition with microcirculation improvement, its contained active component is prepared from by the following raw materials in part by weight proportioning: 20 parts of 20 parts of Eupolyphaga Seu Steleophagas, 20 parts of Hirudos, 20 parts of Pheretimas, 20 parts of Scorpios, 20 parts of Scolopendras, 20 parts of Bombyx Batryticatus and Radix Morinae Bulleyanaes.
It is characterized in that dosage form is a lyophilized powder.
Prepare above-mentioned method, it is characterized in that preparation process is: get the medicine of recipe quantity, put into mortar with Chinese medicine composition of microcirculation improvement, add liquid nitrogen (15g/g), freezing rapidly, smooth out with the fingers and freeze the piece crushing, be transferred to mortar and grind, add liquid nitrogen while grinding, until becoming smalls (150 order); Smooth out with the fingers ground medicine and be transferred in the lyophilizing bottle, use the freezer dryer lyophilization, lyophilization is divided into pre-freeze, distillation and secondary distillation three phases, pre-freeze stage: smooth out with the fingers the temperature inside the box and reduce to-39 ℃ to-41 ℃, kept 6-8 hour; Sublimation stage: when the temperature of condenser reached-39 ℃ to-41 ℃, to the whole system evacuation, pressure was arranged between the 15-20 handkerchief, and temperature rose to 1-3 ℃ at 20-30 minute, kept 16-18 hour; Secondary sublimation stage: smooth out with the fingers temperature and rise to 22-28 ℃, kept 8-12 hour, make lyophilized powder.
Method for optimizing is: above-mentioned preparation method with Chinese medicine composition of microcirculation improvement, and the pre-freeze stage smoothes out with the fingers lyophilization the temperature inside the box earlier and falls-40 ℃, keeps 7 hours; When sublimation stage reached-40 ℃ when the temperature of condenser, to the whole system evacuation, pressure was arranged on 18 handkerchiefs, and temperature rose to 2 ℃ in the time of 25 minutes, kept 17 hours; Secondary sublimation stage: smooth out with the fingers temperature and rise to 25 ℃, kept 10 hours, make lyophilized powder.
Beneficial effect: from theory of Chinese medical science, Eupolyphaga Seu Steleophaga removing blood stasis with potent drugs blood among the we, reuniting the fractured tendons and bones.Be used for the muscles and bones folding and hinder blood stasis amenorrhea, lump in the abdomen mass in the abdomen.Extracting solution and water extract-alcohol precipitation liquid have antithrombotic to form and thrombolytic effect respectively; But extract anticoagulant and adhesion rate reduce aggregation number; Total alkaloids can improve cardiac muscle and brain to the tolerance of ischemia, and the oxygen consumption of the reduction heart, cerebral tissue; Decocting liquid has the effect of the fat of accent, can delay atherosclerotic formation; Extract can suppress the hepatic injury due to the D-galactose and hepatoprotective effect is arranged.Treat multiple disease, call its " main by stagnant blood, blood stasis, month close, the removing blood stasis removing food stagnancy is poly-".Cure its eliminating pathogenic factor for supporting vital QI of holy Zhang Zhongjing, the disease of Hirudo-Chinese crude drug treatment " blood stasis ", " water knot " has shown the curative effect that it is unique.Hirudo injection 2g/k g intravenous injection can promote the absorption of hematoma of experimental rabbit acute cerebral hemorrhage, alleviates inflammatory reaction and edema around the cerebral tissue, alleviates intracranial pressure and raises, and improves local circulation, helps the recovery of function of nervous system; The partial experimental hematoma of the rabbit ear also there is the promotion Absorption. Pheretima heat clearing away, spasmolytic, diuresis, detoxifcation.Cure mainly calentura mania and irritation, infantile convulsion, cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain, urinary obstruction, Fengshi Guanjie pain, diseases such as hemiplegia.External is coated with diseases such as erysipelas, dermatitis rhus.It has thrombolytic and anticoagulation modern study.Scorpio endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Be used for infantile convulsion, the tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.Scolopendra endogenous wind stopping spasmolytic, merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain.Be used for infantile convulsion, the tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom.That Bombyx Batryticatus can relieve internal heat is anticancer, expelling wind to relieve convulsion, mass dissipating and swelling eliminating.The all medicines in full side are harmonious, and play function of promoting blood circulation to disperse blood clots altogether, are used for the microcirculation disturbance disease.This subject study; can actively prevent and treat the generation and the development of microcirculation disturbance effectively; this is for the health of the existence that improves vast middle-aged and elderly people with quality of life, the vast middle-aged and elderly people of protection, and then the raising productivity, significant and higher utility.Because primary disease sickness rate height is estimated to use once marketing, must smooth out with the fingers and produce good social benefit and economic benefit.
The specific embodiment
1, in conjunction with the specific embodiment, the present invention is further described as follows: listed weight proportion takes by weighing institute of the present invention in the according to the form below
Need raw material, unit: g
| Eupolyphaga Seu Steleophaga | Hirudo | Pheretima | Scorpio | Scolopendra | Bombyx Batryticatus | Radix Morinae Bulleyanae | |
| Embodiment 1 | 10 | 30 | 10 | 30 | 10 | 30 | 10 |
| Embodiment 2 | 20 | 20 | 20 | 20 | 20 | 20 | 20 |
| Embodiment 3 | 30 | 10 | 30 | 10 | 30 | 10 | 30 |
Among the present invention, Eupolyphaga Seu Steleophaga is the female worm dry body of Corydiidae insecticide eupolyphoge sinensis EupolyphagasinensisWalker or Ji eupolyphoge sinensis Steleophagphancyi (Boleny), has another name called eupolyphoge sinensis.Hirudo is the dry all of Hirudinidae animal Hirudo Whitmania pigraWhitman, Hirudo Hirudo nipponica Whitman or whitmania acranulata Whitman Whitmania acranulata Whitman.Pheretima (Geosaurus) is the dry body of the Annelida hard iron earthworm animal Pheretima aspergillum Pheretimaas pergilum of section (E Perrier), popular Pheretimatschiliensis P vulgarisChen, William Pheretimatschiliensis P guillelmi (Michaelsen) or comb the region between the heart and the diaphragm hair earthworm PpectiniferaMichaelsen.Scorpio is the dry body of Buthidae animal Scorpio Buthus martensii Karsch.Scolopendra is the Scorpio body of the Scolopendpa Subspinipes Mutilans L. KOCH Scolopendra subspini-pes mutilans L.Koch of animal Scolopendra section.Bombyx Batryticatus be Bombycidae insecticide silkworm Bombyx mori L.4～5 the larva in age infect (or artificial vaccination) muscardine Beauveriabassiana (Bals.) Vuill. and lethal dry body.Radix Morinae Bulleyanae be Stichopodidae animal Radix Morinae Bulleyanae Stichopus japonicus Sekenka remove the internal organs dry body.
2. preparation embodiment
Embodiment 1
Get Eupolyphaga Seu Steleophaga 10g, Hirudo 30g, Pheretima 10g, Scorpio 30g, Scolopendra 10g, Bombyx Batryticatus 30g and Radix Morinae Bulleyanae 10g, clean, put into mortar, add liquid nitrogen 2250g, freezing rapidly, smooth out with the fingers and freeze the piece crushing, be transferred to mortar and grind, add liquid nitrogen while grinding, until becoming 150 order smalls; Smooth out with the fingers ground medicine and be transferred in the lyophilizing bottle, use the freezer dryer lyophilization, lyophilization is divided into pre-freeze, distillation and secondary distillation three phases, pre-freeze stage: the temperature inside the box is reduced to-39 ℃, kept 6 hours; Sublimation stage: when the temperature of condenser reached-39 ℃, to the whole system evacuation, pressure was arranged between 18 handkerchiefs, and temperature rose to 3 ℃ at 25 minutes, kept 17 hours; Secondary sublimation stage: smooth out with the fingers temperature and rise to 25 ℃, kept 10 hours, make lyophilized powder.
Embodiment 2
Get Eupolyphaga Seu Steleophaga 20g, Hirudo 20g, Pheretima 20g, Scorpio 20g, Scolopendra 20g, Bombyx Batryticatus 20g and Radix Morinae Bulleyanae 20g, clean, put into mortar, add liquid nitrogen 2100g, freezing rapidly, smooth out with the fingers and freeze the piece crushing, be transferred to mortar and grind, add liquid nitrogen while grinding, until becoming 150 order smalls; Smooth out with the fingers ground medicine and be transferred in the lyophilizing bottle, use the freezer dryer lyophilization, lyophilization is divided into pre-freeze, distillation and secondary distillation three phases, pre-freeze stage: smooth out with the fingers the temperature inside the box and reduce to-41 ℃, kept 6 hours; Sublimation stage: when the temperature of condenser reached-41 ℃, to the whole system evacuation, pressure was arranged between 18 handkerchiefs, and temperature rose to 3 ℃ at 25 minutes, kept 17 hours; Secondary sublimation stage: smooth out with the fingers temperature and rise to 25 ℃, kept 10 hours, make lyophilized powder.
Embodiment 3
Get Eupolyphaga Seu Steleophaga 30g, Hirudo 10g, Pheretima 30g, Scorpio 10g, Scolopendra 30g, Bombyx Batryticatus 10g and Radix Morinae Bulleyanae 30g, clean, put into mortar, add liquid nitrogen 2250g, freezing rapidly, will freeze the piece crushing, be transferred to mortar and grind, add liquid nitrogen while grinding, until becoming 150 order smalls; Smooth out with the fingers ground medicine and be transferred in the lyophilizing bottle, use the freezer dryer lyophilization, lyophilization is divided into pre-freeze, distillation and secondary distillation three phases, pre-freeze stage: smooth out with the fingers the temperature inside the box and reduce to-40 ℃, kept 6 hours; Sublimation stage: when the temperature of condenser reached-40 ℃, to the whole system evacuation, pressure was arranged between 18 handkerchiefs, and temperature rose to 3 ℃ at 25 minutes, kept 17 hours; Secondary sublimation stage: smooth out with the fingers temperature and rise to 25 ℃, kept 10 hours, make lyophilized powder.
3. to microcirculatory influence experiment
3.1 experiment material
3.1.1 the animal health Kunming mouse is male, body weight 18-22g is provided production licence by Nanjing University of Traditional Chinese Medicine's Experimental Animal Center: SCXK (Soviet Union) 2002-0053.
3.1.2 medicine and reagent prop up (being equivalent to contain crude drug 2g) TONGSAIMAI PIAN by the microcirculation improvement lyophilized powder specification 1g/ of embodiment 2 preparations, Rhizoma Arisaematis pharmaceutcal corporation, Ltd in Nanjing provides lot number: 20081028
3.1.3 instrument WT-6 type microcirculation instrument, Xuzhou optical instrument head factory is produced
3.2 statistical analysis utilizes SPSS 11.0 softwares that data are carried out one factor analysis of variance, there is the significance meaning P＜0.05 for difference.
Utilization multiple comparisons LSD method.
3.3 experimental technique and result
3.3.1 method
A, get 50 of Kunming mouses, be divided into five groups, be respectively this lyophilized powder high dose group (4g crude drug amount/kg), middle dosage group (2g crude drug amount/kg), low dose group (1g/ crude drug amount kg), positive drug TONGSAIMAI PIAN group (4.5g/kg), five groups of normal control groups.Wherein 3 dosage groups, TONGSAIMAI PIAN groups are pressed above-mentioned dosage gastric infusion, and the normal control group awards the 2ml distilled water, every morning 1 time.B, after administration one week, the back was by every mice 1% sodium pentobarbital 0.01mL/g intraperitoneal injection of anesthesia, with medical rubber patch unhairing on auricle, smooth out with the fingers mice and ventrad be fixed on down on the mice observation platform, a little liquid paraffin of auricle surface dropping.Observe administration group and the blank influence of organizing Mice Auricle venous capillary input tap footpath, same position, output tap footpath and velocity of blood flow.
3.3.2 result
This lyophilized powder is to microcirculation of mouse auricle influence (n=10; X ± SD, %)
Annotate: compare with the blank group:
*P＜0.05,
*P＜0.01
The result shows: this lyophilized powder can make Mice Auricle venous capillary input tap footpath, the obviously expansion of output tap footpath (with the blank group than P＜0.05), velocity of blood flow accelerate (with matched group than P＜0.01), show that this lyophilized powder has the effect of microcirculation improvement preferably.
Claims (6)
1. Chinese medicine composition with microcirculation improvement, its contained active component is prepared from by the following raw materials in part by weight proportioning: Eupolyphaga Seu Steleophaga 10-30 part, Hirudo 10-30 part, Pheretima 10-30 part, Scorpio 10-30 part, Scolopendra 10-30 part, Bombyx Batryticatus 10-30 part and Radix Morinae Bulleyanae 10-30 part.
2. Chinese medicine composition with microcirculation improvement, its contained active component is prepared from by the following raw materials in part by weight proportioning: 20 parts of 20 parts of Eupolyphaga Seu Steleophagas, 20 parts of Hirudos, 20 parts of Pheretimas, 20 parts of Scorpios, 20 parts of Scolopendras, 20 parts of Bombyx Batryticatus and Radix Morinae Bulleyanaes.
3. the Chinese medicine composition that has microcirculation improvement as claimed in claim 1 or 2 is characterized in that dosage form is a lyophilized powder.
4. method for preparing the Chinese medicine composition that has microcirculation improvement as claimed in claim 1 or 2, it is characterized in that preparation process is: the medicine and the mixing of getting recipe quantity, clean the back and become block with liquid nitrogen freezing, smooth out with the fingers to freeze and be transferred to the mortar grinding after piece is crushed, add liquid nitrogen while grinding, the gross weight that adds liquid nitrogen is 15 times of drug weight, until wearing into smalls; Ground medicine is transferred in the lyophilizing bottle, uses the freezer dryer lyophilization:
A. pre-freeze stage: earlier lyophilization the temperature inside the box is reduced to-39 ℃ to-41 ℃, kept 6～8 hours;
B. sublimation stage: when the temperature of condenser reached-39 ℃ to-41 ℃, to the whole system evacuation, pressure was arranged between 15～20 handkerchiefs, and temperature rose to 1～3 ℃ at 20-30 minute, kept 16～18 hours;
C. secondary sublimation stage: smooth out with the fingers temperature and rise to 22～28 ℃, kept 8～12 hours, make lyophilized powder.
5. according to claims 1 described preparation method with Chinese medicine composition of microcirculation improvement, the pre-freeze stage smoothes out with the fingers lyophilization the temperature inside the box earlier and reduces to-40 ℃, keeps 7 hours; When sublimation stage reached-40 ℃ when the temperature of condenser, to the whole system evacuation, pressure was arranged on 18 handkerchiefs, and temperature rose to 2 ℃ in the time of 25 minutes, kept 17 hours; Secondary sublimation stage: smooth out with the fingers temperature and rise to 25 ℃, kept 10 hours, make lyophilized powder.
6. Chinese medicine composition as claimed in claim 1 or 2 has application in the microcirculation improvement medicine in preparation.
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| CN105285989A (en) * | 2015-11-12 | 2016-02-03 | 张柏荣 | Life span-prolonging health-preserving formula and health-preserving method |
| CN106491943A (en) * | 2016-10-25 | 2017-03-15 | 周林江 | A kind of medicine for improving microcirculation in human body |
| CN107693728A (en) * | 2017-08-31 | 2018-02-16 | 河南中医药大学 | A kind of beneficial marrow Chinese medicinal capsule for treating apoplexy |
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| CN107693728A (en) * | 2017-08-31 | 2018-02-16 | 河南中医药大学 | A kind of beneficial marrow Chinese medicinal capsule for treating apoplexy |
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