CN102062517B - Device and method for cooling plate layer after carrying out steam sterilization by utilizing vacuum freeze dryer - Google Patents
Device and method for cooling plate layer after carrying out steam sterilization by utilizing vacuum freeze dryer Download PDFInfo
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- CN102062517B CN102062517B CN 201010607658 CN201010607658A CN102062517B CN 102062517 B CN102062517 B CN 102062517B CN 201010607658 CN201010607658 CN 201010607658 CN 201010607658 A CN201010607658 A CN 201010607658A CN 102062517 B CN102062517 B CN 102062517B
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Abstract
The invention relates to a device for cooling a plate layer after carrying out steam sterilization by utilizing a vacuum freeze dryer. The device is characterized by comprising a circulation pump and a plate type heat exchanger mutually connected, wherein one end of a plate layer assembly arranged in a front box is connected with the circulation pump, and the other end of the plate layer assembly is connected with the plate type heat exchanger; the plate type heat exchanger is connected with a refrigerating system; the high-temperature liquid of the plate layer assembly is transmitted into the plate type heat exchanger through the circulation pump and exchanges energy with low-temperature substances generated by the refrigerating system in the plate type heat exchanger, thereby realizing the temperature reduction; and the high-temperature liquid after the temperature reduction is returned to the front box through the circulation pump, thereby realizing the gradual temperature reduction of the plate layer assembly. The invention also provides a cooling method adopting the device. According to the invention, the temperature is reduced to about 25 DEG C from the temperature after the sterilization, only 2 hours are needed, and 10 hours can be saved in one production cycle, thereby enhancing the production efficiency.
Description
Technical field
The present invention relates to cooling device and the cooling means of a kind of vacuum freeze drier at the steam sterilizing metaplax layer.
Background technology
Vacuum freeze drying (abbreviation freeze dryer) but be exactly to freeze the hydrous matter of freeze-drying or solution at low temperatures in advance, under vacuum environment, make the material dehydration obtain dry article then.Freeze dryer has preceding case and condenser (cold-trap), and the effect of condenser is exactly to trap condenser inside to the water of preceding case material, after the production of this batch is accomplished, eliminate the ice of condenser with steam, to carry out the production of next batch product.After carrying out moise-heat sterilization, need the flaggy cooling just can be carried out the production of next batch.Do not have a kind of cooling device at present, the flaggy temperature behind the steam sterilizing is basically all more than 100 ℃, and the time that cool off naturally the sterilization back is very long, usually more than 12 hours, has brought great influence so often for client's production cycle and output.
Summary of the invention
The purpose of this invention is to provide a kind of freeze dryer steam sterilizing metaplax layer cooling device of cool time that reduces.
In order to achieve the above object; A technical scheme of the present invention has provided a kind of vacuum freeze drier steam sterilizing metaplax layer cooling device; It is characterized in that: comprise interconnective circulating pump and plate type heat exchanger, flaggy assembly one end of case links to each other with circulating pump before being positioned at, and the other end links to each other with plate type heat exchanger; Plate type heat exchanger connects refrigeration system; The high-temp liquid of flaggy assembly is sent in the plate type heat exchanger through circulating pump, and the cryogenic substance positive energy exchange that in plate type heat exchanger, produces with refrigeration system is realized cooling, realizes the progressively cooling of flaggy assembly before the high-temp liquid after the cooling returns through circulating pump again in the case.
Further, on said flaggy assembly and pipeline that said circulating pump links to each other and on said flaggy assembly and pipeline that said plate type heat exchanger links to each other, be respectively equipped with first temp probe and second temp probe.
Said refrigeration system comprises water condenser, oil eliminator, screw compressor and the vapour liquid separator of series connection; Vapour liquid separator directly connects said plate type heat exchanger; Said plate type heat exchanger is connected successively and is linked to each other with vapour liquid separator behind mechanical type expansion valve and the plate cooling magnetic valve; The mechanical type expansion valve also is connected to the pipeline between vapour liquid separator and the plate type heat exchanger; One end of motor hydrojet magnetic valve links to each other with vapour liquid separator, and the other end and plate cooling magnetic valve links to each other with pipeline between the water condenser.
Another technical scheme of the present invention has provided a kind of cooling means of utilizing above-mentioned vacuum freeze drier steam sterilizing metaplax layer cooling device, and it is characterized in that: step is:
Step 1, open refrigeration screw compressor and plate cooling magnetic valve, close after 1 minute between continuing to after a little while, the ON cycle pump operation closes after 2 minutes at least;
If the temperature of second temp probe greater than 80 ℃, then gets into step 1 again in step 2, the judgement circulation line, otherwise, get into step 3;
Step 3, that plate is cooled off magnetic valve is separated, and the frequency of opening does---and opened for 5 seconds, closed for 5 seconds, circulating pump is opening always then;
The temperature of the temperature of second temp probe in step 4, the judgement circulation line if temperature greater than 40 ℃, then gets into step 3 again, otherwise gets into step 5;
Step 5, plate is cooled off magnetic valve continue out, after the temperature of second temp probe reaches 25 ℃ in circulation line, finish the flaggy cooling procedure, closing plate cooling magnetic valve, cold screw compressor and circulating pump.
The invention provides a kind of method that reduces the cooling device of freeze dryer steam sterilizing metaplax layer cool time and adopt this device; Temperature after sterilization is reduced to about 25 ℃; Only need 2 hours time, a production cycle can be saved 10 hours time, has improved production efficiency.
Description of drawings
Fig. 1 is a kind of vacuum freeze drier steam sterilizing metaplax layer cooling device sketch map provided by the invention.
The specific embodiment
Specify the present invention below in conjunction with embodiment.
Embodiment 1
As shown in Figure 1; Be a kind of vacuum freeze drier steam sterilizing metaplax layer cooling device provided by the invention; Comprise interconnective circulating pump 14 and plate type heat exchanger 13, flaggy assembly 9 one ends of case 8 link to each other with circulating pump 14 before being positioned at, and the other end links to each other with plate type heat exchanger 13; Plate type heat exchanger 13 connects refrigeration system; The high-temp liquid of flaggy assembly 9 is sent in the plate type heat exchanger 13 through circulating pump 14, and the cryogenic substance positive energy exchange that in plate type heat exchanger 13, produces with refrigeration system is realized cooling, realizes the progressively cooling of flaggy assembly 9 before the high-temp liquid after the cooling returns through circulating pump 14 again in the case 8.
On flaggy assembly 9 and pipeline that circulating pump 14 links to each other and on flaggy assembly 9 and pipeline that plate type heat exchanger 13 links to each other, be respectively equipped with first temp probe 10 and second temp probe 7.
Said refrigeration system comprises water condenser 1, oil eliminator 2, screw compressor 3 and the vapour liquid separator 5 of series connection; Vapour liquid separator 5 directly connects said plate type heat exchanger 13; Said plate type heat exchanger 13 mechanical type expansion valve 12 and plate cooling magnetic valve 11 backs of connecting successively link to each other with vapour liquid separator 5; Mechanical type expansion valve 12 also is connected to the pipeline between vapour liquid separator 5 and the plate type heat exchanger 13; One end of motor hydrojet magnetic valve 6 links to each other with vapour liquid separator 5, and the other end and plate cooling magnetic valve 11 links to each other with pipeline between the water condenser 1.
In the steam sterilizing process; After the dry completion of vaporization, will carry out the flaggy cooling, because the flaggy cooling is in the process of steam sterilizing; After both having had only the flaggy cooling procedure to finish; Steam sterilizing could finish, and therefore, need not judge other technological requirement condition of freeze-drying casing at this flaggy process for cooling.
The flaggy cooling procedure is: at first open refrigeration screw compressor 3, open plate cooling magnetic valve 11, close after 1 minute duration; 14 operations of ON cycle pump were closed after 2 minutes, judged the temperature of second temp probe 7 in the circulation line, if greater than 80 ℃; Open the circularly cooling of plate cooling magnetic valve 11 above repeating, be not more than 80 ℃ up to the temperature of second temp probe 7, plate cooling magnetic valve 11 is separated; Opened for 5 seconds, closed for 5 seconds, circulating pump 14 is opened always; Judge the temperature of temp probe 7 in the circulation line, if temperature greater than 40 ℃, the circularly cooling above the 11 separated repetitions of plate cooling magnetic valve is not more than 40 ℃ up to temperature; Plate cooling magnetic valve 11 continues out; After the temperature of second temp probe 7 reaches 25 ℃ in circulation line, finish the flaggy cooling procedure, close plate cooling magnetic valve 11, close screw compressor 3, close circulating pump 14.
Claims (3)
1. vacuum freeze drier steam sterilizing metaplax layer cooling device; It is characterized in that: comprise interconnective circulating pump (14) and plate type heat exchanger (13); Flaggy assembly (9) one ends that are positioned at preceding case (8) link to each other with circulating pump (14); The other end links to each other with plate type heat exchanger (13); Plate type heat exchanger (13) connects refrigeration system; The high-temp liquid of flaggy assembly (9) is admitted in the plate type heat exchanger (13); The cryogenic substance positive energy exchange that in plate type heat exchanger (13), produces with refrigeration system is realized cooling; High-temp liquid after the cooling returns the progressively cooling that realizes flaggy assembly (9) in the preceding case (8) through circulating pump (14) again, and said refrigeration system comprises water condenser (1), oil eliminator (2), screw compressor (3) and the vapour liquid separator (5) of series connection, and an end of said plate type heat exchanger (13) directly connects vapour liquid separator (5); The other end of said plate type heat exchanger (13) mechanical type expansion valve (12) and plate cooling magnetic valve (11) back of connecting successively links to each other with vapour liquid separator (5); Mechanical type expansion valve (12) also is connected between vapour liquid separator (5) and the pipeline that plate type heat exchanger (13) directly links to each other, and an end of motor hydrojet magnetic valve (6) links to each other with vapour liquid separator (5), and the other end and plate cooling magnetic valve (11) link to each other with pipeline between the water condenser (1).
2. a kind of vacuum freeze drier steam sterilizing metaplax layer cooling device as claimed in claim 1 is characterized in that: on said flaggy assembly (9) and pipeline that said circulating pump (14) links to each other and on said flaggy assembly (9) and pipeline that said plate type heat exchanger (13) links to each other, be respectively equipped with first temp probe (10) and second temp probe (7).
3. one kind is utilized the cooling means of vacuum freeze drier steam sterilizing metaplax layer cooling device according to claim 1, and it is characterized in that: step is:
Step 1, open screw compressor (3) and plate cooling magnetic valve (11), close after 1 minute between continuing to after a little while, ON cycle pump (14) operation is closed after 2 minutes at least;
The temperature of second temp probe (7) if greater than 80 ℃, then gets into step 1 again in step 2, the judgement circulation line, otherwise, get into step 3;
Step 3, that plate is cooled off magnetic valve (11) is separated, and the frequency of opening does---and opened for 5 seconds, closed for 5 seconds, circulating pump (14) then is opening always;
The temperature of second temp probe (7) in step 4, the judgement circulation line if temperature greater than 40 ℃, then gets into step 3 again, otherwise gets into step 5;
Step 5, plate is cooled off magnetic valve (11) continue out, after the temperature of second temp probe (7) reaches 25 ℃ in circulation line, finish the flaggy cooling procedure, closing plate cooling magnetic valve (11), screw compressor (3) and circulating pump (14).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010607658 CN102062517B (en) | 2010-12-28 | 2010-12-28 | Device and method for cooling plate layer after carrying out steam sterilization by utilizing vacuum freeze dryer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010607658 CN102062517B (en) | 2010-12-28 | 2010-12-28 | Device and method for cooling plate layer after carrying out steam sterilization by utilizing vacuum freeze dryer |
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| Publication Number | Publication Date |
|---|---|
| CN102062517A CN102062517A (en) | 2011-05-18 |
| CN102062517B true CN102062517B (en) | 2012-10-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201010607658 Active CN102062517B (en) | 2010-12-28 | 2010-12-28 | Device and method for cooling plate layer after carrying out steam sterilization by utilizing vacuum freeze dryer |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105466158A (en) * | 2015-12-28 | 2016-04-06 | 康美正道（天津）生物科技有限公司 | Freeze dryer special for freeze drying piece of active factors |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4407140A (en) * | 1979-07-04 | 1983-10-04 | Kyowa Vacuum Engineering, Ltd. | Vacuum apparatus |
| CN2416463Y (en) * | 2000-04-11 | 2001-01-24 | 北京天利医药设备有限公司 | Vacuum freezing dryer |
| CN201355176Y (en) * | 2009-01-20 | 2009-12-02 | 上海舒博拉尼制药设备有限公司 | Protector capable of rapidly cooling plate layers after steam sterilizing of freeze dryer |
| CN101858689A (en) * | 2010-06-11 | 2010-10-13 | 上海东富龙科技股份有限公司 | Energy-saving freeze dryer and control method thereof |
| CN201945143U (en) * | 2010-12-28 | 2011-08-24 | 上海东富龙科技股份有限公司 | Lamination cooling device of vacuum freezer dryer after steam sterilization |
-
2010
- 2010-12-28 CN CN 201010607658 patent/CN102062517B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4407140A (en) * | 1979-07-04 | 1983-10-04 | Kyowa Vacuum Engineering, Ltd. | Vacuum apparatus |
| CN2416463Y (en) * | 2000-04-11 | 2001-01-24 | 北京天利医药设备有限公司 | Vacuum freezing dryer |
| CN201355176Y (en) * | 2009-01-20 | 2009-12-02 | 上海舒博拉尼制药设备有限公司 | Protector capable of rapidly cooling plate layers after steam sterilizing of freeze dryer |
| CN101858689A (en) * | 2010-06-11 | 2010-10-13 | 上海东富龙科技股份有限公司 | Energy-saving freeze dryer and control method thereof |
| CN201945143U (en) * | 2010-12-28 | 2011-08-24 | 上海东富龙科技股份有限公司 | Lamination cooling device of vacuum freezer dryer after steam sterilization |
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| CN102062517A (en) | 2011-05-18 |
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Address after: 201109 Shanghai city Minhang District Fanghe Road No. 2199 Patentee after: Dongfulong Technology Group Co.,Ltd. Address before: 201109 Shanghai city Minhang District Fanghe Road No. 2199 Patentee before: SHANGHAI TOFFLON SCIENCE AND TECHNOLOGY Co.,Ltd. |
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