CN204006776U - A kind of freeze drying box refrigeration system - Google Patents
A kind of freeze drying box refrigeration system Download PDFInfo
- Publication number
- CN204006776U CN204006776U CN201420314404.3U CN201420314404U CN204006776U CN 204006776 U CN204006776 U CN 204006776U CN 201420314404 U CN201420314404 U CN 201420314404U CN 204006776 U CN204006776 U CN 204006776U
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- Prior art keywords
- cooling assembly
- freeze dryer
- main
- auxiliary cooling
- flaggy
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- 238000005057 refrigeration Methods 0.000 title claims abstract description 59
- 238000004108 freeze drying Methods 0.000 title claims description 36
- 238000001816 cooling Methods 0.000 claims abstract description 107
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims abstract description 64
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 22
- 239000007788 liquid Substances 0.000 claims description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims description 11
- 238000009835 boiling Methods 0.000 claims description 8
- 238000007710 freezing Methods 0.000 claims description 7
- 230000008014 freezing Effects 0.000 claims description 7
- 239000003507 refrigerant Substances 0.000 claims description 6
- 230000008901 benefit Effects 0.000 abstract description 2
- 230000006872 improvement Effects 0.000 description 7
- 229920006395 saturated elastomer Polymers 0.000 description 6
- 238000001704 evaporation Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000004821 distillation Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002061 vacuum sublimation Methods 0.000 description 2
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000005496 eutectics Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
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- Drying Of Solid Materials (AREA)
Abstract
The utility model discloses a kind of refrigerating system of freeze dryer, this system comprises more than one group main cooling assembly and more than one group auxiliary cooling assembly, and described main cooling assembly is shape in parallel to form the independent cooling closed circuit to cold hydrazine on freeze dryer and flaggy with auxiliary cooling assembly; Described main cooling assembly from auxiliary cooling assembly, adopt different refrigeration media.The utlity model has simple and compact for structure, easy and simple to handle, can improve refrigeration, improve the advantages such as functional reliability.
Description
Technical field
The utility model is mainly concerned with freeze-drier field, refers in particular to the refrigeration system that is applicable to freeze drying box.
Background technology
Vacuum freeze drier (hereinafter to be referred as freeze dryer) is the best equipment that pharmaceutical industry and food service industry are carried out medicine and freeze-drying of food, so-called freeze drying, be exactly first to need cryodesiccated article (goods) pre-freeze at low temperatures, then by the method for vacuum sublimation and Dissociative adsorption, make the moisture of goods reduce to the level that cannot maintain biologically and chemical reaction in long-time, vacuum sublimation drying stage, free water frozen in material is under the corresponding saturated vapor pressure condition lower than its eutectic point, mode with distillation is all overflowed, entering into condensing surface build-ups ice, after distillation finishes, generally can remove more than 85% moisture, and the parsing-desiccation stage, after lyophilization completes, the a small amount of adsorbed water of remaining part (is adsorbed on material cell membrane and polar molecule, the water not freezing, generally account for 10% left and right of total moisture content) in the mode of evaporating, remove.
At present, refrigeration system of freeze dryer operated by rotary motion, conventional is freon refrigeration system, liquid nitrogen refrigerating system.Freon refrigeration system is compared with liquid nitrogen refrigerating system low price, but the limit low temperature producing is higher, makes freeze dryer when resolution phase, produce the saturated vapor pressure reduction of ice less, makes in freeze-drying prods still surplus some adsorbed water, affects freeze-drying prods quality.And the employing cold-producing medium lower compared with freon evaporating temperature, such as liquid nitrogen, its price comparatively expensive (expense comprises that liquid nitrogen is bought, liquid nitrogen transports, liquid nitrogen under atmospheric pressure gasifies loss etc.), is approximately three times of left and right of compression-type refrigeration, and user generally cannot bear.
Utility model content
The technical problems to be solved in the utility model is just: the technical problem existing for prior art, the utility model provides a kind of simple and compact for structure, easy and simple to handle, freeze drying box refrigeration system that can improve refrigeration, freeze-drying operating efficiency.
For solving the problems of the technologies described above, the utility model by the following technical solutions:
A refrigerating system of freeze dryer, comprises more than one group main cooling assembly and more than one group auxiliary cooling assembly, and described main cooling assembly is shape in parallel to form the independent cooling closed circuit to cold hydrazine on freeze dryer and flaggy with auxiliary cooling assembly; Described main cooling assembly from auxiliary cooling assembly, adopt different refrigeration media.
Further improvement as the utility model system: the cooling assembly that described main cooling assembly freezes to freeze dryer for pre-freeze-drying stage under nominal situation and lyophilization; Described auxiliary cooling assembly is the parsing-desiccation stage under nominal situation and the cooling assembly under fault condition, freeze dryer being freezed.
Further improvement as the utility model system: under identical atmospheric pressure, the boiling temperature of the medium that freezes in described auxiliary cooling assembly is lower than the boiling temperature of the medium that freezes in main cooling assembly.
Further improvement as the utility model system: described main cooling assembly adopts freon as refrigeration medium, auxiliary cooling assembly adopts liquid nitrogen as refrigeration medium.
Further improvement as the utility model system: described in every group, Zhu's cooling assembly comprises the main refrigeration cycle of cold hydrazine and the main refrigeration cycle of flaggy, the main refrigeration cycle of cold hydrazine is for the condenser coil of cold hydrazine on freeze dryer is freezed, and the main refrigeration cycle of flaggy is for freezing to the flaggy of freeze dryer; Described in every group, auxiliary cooling assembly comprises cold hydrazine auxiliary cooling closed circuit and flaggy auxiliary cooling closed circuit, cold hydrazine auxiliary cooling closed circuit is for the condenser coil of cold hydrazine on freeze dryer is freezed, and flaggy auxiliary cooling closed circuit is for freezing to the flaggy of freeze dryer.
Further improvement as the utility model system: each refrigeration cycle includes by the connected control valve of pipeline, plate type heat exchanger and refrigerating medium circulating pump.
Further improvement as the utility model system: pass linkage control valve is set on the refrigeration cycle of described auxiliary cooling assembly, for avoid the plate type heat exchanger of auxiliary cooling assembly at the refrigeration medium of main cooling assembly main cooling assembly when opening duty.
Each refrigeration cycle includes by the connected control valve of pipeline and plate type heat exchanger; The main refrigeration cycle of described cold hydrazine and cold hydrazine auxiliary cooling closed circuit share and carry one group of refrigerant cycle pump, and the main refrigeration cycle of described flaggy and flaggy auxiliary cooling closed circuit share and carry one group of refrigerant cycle pump.
Described every group of refrigerant cycle pump includes two refrigerant cycle pumps, and one is main pump, and another one is stand-by pump.
Compared with prior art, the utility model has the advantage of:
1, the utility model has comprised two kinds of main cooling assembly and auxiliary cooling assemblies with different refrigeration media, utilize two kinds of different boiling temperatures of refrigeration medium, can increase the pressure differential of freeze drying box and cold hydrazine, produce the saturated vapor pressure reduction of larger ice, freeze-drying prods is build-up ice on condenser coil surface under pressure reduction motive force at the steam of resolution phase evaporation, until freeze dryer arrives its corresponding saturated vapor pressure, reach the parsing limit, freeze-drying completes, the interior moisture of this freeze-drying prods will be reduced again, improve freeze-drying prods quality.
2, the freeze dryer in the utility model also can select to open or cut out auxiliary cooling assembly according to manufacturing technique requirent in pre-freeze dry model, lyophilization pattern, participation by auxiliary cooling assembly can be shortened whole lyophilization cycle greatly, improves freeze-drying production efficiency.
3, the utlity model has independent, the in parallel cooling assembly of two covers, when a certain cover breaks down, a set ofly in addition can play the standby effect of fault, greatly improved equipment reliability of operation.
Accompanying drawing explanation
Fig. 1 is the structural principle schematic diagram of the utility model in concrete application example.
Marginal data:
1, condenser coil; 2, flaggy; 3, flaggy heater.
The specific embodiment
Below with reference to Figure of description and specific embodiment, the utility model is described in further details.
A kind of refrigerating system of freeze dryer of the present utility model, comprise more than one group main cooling assembly and more than one group auxiliary cooling assembly, described main cooling assembly is shape in parallel to form the independent cooling closed circuit to cold hydrazine on freeze dryer and flaggy 2 with auxiliary cooling assembly.Main cooling assembly from auxiliary cooling assembly, adopt different refrigeration media, and the boiling temperature of the medium that freezes in auxiliary cooling assembly is lower than the boiling temperature of the medium that freezes in main cooling assembly.For example, main cooling assembly can adopt freon as refrigeration medium, and auxiliary cooling assembly can adopt liquid nitrogen as refrigeration medium.Be appreciated that in other embodiment, also can adopt according to actual needs other refrigeration media mix, this also should be in protection domain of the present utility model.
In preferred embodiment, can be according to actual needs, the refrigeration medium adopting in auxiliary cooling assembly is preferably under atmospheric pressure evaporating temperature lower than-46.5 ℃.
In instantiation, described in every group, main cooling assembly comprises the main refrigeration cycle of cold hydrazine and the main refrigeration cycle of flaggy, the main refrigeration cycle of cold hydrazine is for the condenser coil 1 of cold hydrazine on freeze dryer is freezed, and the main refrigeration cycle of flaggy is for freezing to the flaggy 2 of freeze dryer; Described in every group, auxiliary cooling assembly comprises cold hydrazine auxiliary cooling closed circuit and flaggy auxiliary cooling closed circuit, cold hydrazine auxiliary cooling closed circuit is for the condenser coil 1 of cold hydrazine on freeze dryer is freezed, and flaggy auxiliary cooling closed circuit is for freezing to the flaggy 2 of freeze dryer.
As shown in Figure 1, be the structural principle schematic diagram of the utility model in a concrete application example.Each refrigeration cycle includes by the connected control valve of pipeline, plate type heat exchanger and refrigerating medium circulating pump.Wherein:
The main refrigeration cycle of cold hydrazine comprises the first control valve T1, the first plate type heat exchanger S1 and the first refrigerating medium circulating pump M1 being connected by pipeline, to form the circularly cooling to condenser coil 1 on the freeze dryer in closed circuit.
The main refrigeration cycle of flaggy comprises the second control valve T2, the second plate type heat exchanger S2 and the second refrigerating medium circulating pump M2 being connected by pipeline, to form the circularly cooling to flaggy 2 on the freeze dryer in closed circuit.
Cold hydrazine auxiliary cooling closed circuit comprises the 3rd control valve T3, three-plate type heat exchanger S3 and the 3rd refrigerating medium circulating pump M3 being connected by pipeline, to form the circularly cooling to condenser coil 1 on the freeze dryer in closed circuit.
Flaggy auxiliary cooling closed circuit comprises the 4th control valve T4, the 4th plate type heat exchanger S4 and the 4th refrigerating medium circulating pump M4 being connected by pipeline, to form the circularly cooling to flaggy 2 on the freeze dryer in closed circuit.
Further, pass linkage control valve is set on the refrigeration cycle of auxiliary cooling assembly, to guarantee at main cooling assembly when opening duty, its refrigeration medium is by the plate type heat exchanger of avoiding in auxiliary cooling assembly, because now this board-like hot device is in off position; This pass linkage control valve is that first in figure closes linkage control valve T5 and the second pass linkage control valve T6.
Further, whole main cooling assembly and auxiliary cooling assembly are controlled by PLC controller, i.e. the keying of all control valves requires automatically to control according to actual process by PLC controller.
In other embodiments, above-mentioned the first refrigerating medium circulating pump M1 and the second refrigerating medium circulating pump M2 can also be merged into a circulating pump, for circularly cooling loop, come, this also should be in protection domain of the present utility model.
Operation principle, system of the present utility model in the specific implementation, the steps include: according to technological requirement
(1) pre-freeze dry model; When freeze dryer is the pre-freeze-drying stage, PLC controller will cut out the 3rd control valve T3, the 4th control valve T4, first and close linkage control valve T5 and the second pass linkage control valve T6, and now auxiliary cooling assembly is in out-of-work state.Open the first control valve T1 and the second control valve T2, main cooling assembly unlatching work, it lowers the temperature to the flaggy 2 in freeze drying box and the condenser coil 1 in cold hydrazine simultaneously, and its refrigeration principle is consistent.The refrigeration of condenser coil 1 of take is example explanation, main cooling assembly work, pass through plate type heat exchanger, its refrigeration medium (freon) and refrigerating medium (silicone oil) carry out heat exchange, the temperature of refrigerating medium is reduced, refrigerating medium, through corresponding refrigerating medium circulating pump forced circulation in pipeline, condenser coil 1, constantly circulates refrigerating medium and reaches refrigeration transmission thereby realized in whole system.
(2) lyophilization pattern; When freeze dryer is in the lyophilization stage, PLC controller will cut out the 3rd control valve T3, the 4th control valve T4, first and close linkage control valve T5 and the second pass linkage control valve T6, and auxiliary cooling assembly is in out-of-work state.Open the first control valve T1 and the second control valve T2, main cooling assembly will freeze to condenser coil 1, the freeze drying box in freeze dryer by under the effect at flaggy heater 3 to flaggy 2 distillation of heating.
(3) parsing-desiccation pattern, when freeze dryer enters the parsing-desiccation stage, PLC controller will cut out the first control valve T1 and the second control valve T2, main cooling assembly quits work, open the 3rd control valve T3, first closes linkage control valve T5 and second closes linkage control valve T6, the work of auxiliary cooling assembly, pass through plate type heat exchanger, its refrigeration medium (liquid nitrogen) and refrigerating medium heat exchange, the temperature of refrigerating medium is sharply reduced (under the atmospheric pressure of liquid nitrogen refrigerating, boiling temperature is about-196 ℃), increased the pressure differential of freeze drying box and cold hydrazine, reduced cold hydrazine saturated vapor pressure, make freeze-drying prods under pressure reduction motive force, make it on condenser coil 1 surface, build-up ice at the steam of resolution phase evaporation, until freeze dryer arrives its saturated vapor pressure, reach the parsing limit, freeze-drying completes, the interior moisture of this freeze-drying prods will be reduced again, improved freeze-drying prods quality.
Further, the utility model also comprises fault redundance pattern, when in freeze dryer, main cooling assembly breaks down, PLC controller will be opened the 3rd control valve T3, first and close linkage control valve T5, auxiliary cooling assembly will be as backup refrigeration system, freeze to flaggy 2, condenser coil 1 simultaneously, ensured the normal operation of freeze dryer.So under malfunction and in pre-freeze-drying during the stage, the 4th control valve T4 and second closes linkage control valve T6 and also opens.
Be appreciated that; in another embodiment; also can be chosen in pre-freeze dry model, lyophilization pattern and open auxiliary cooling assembly according to manufacturing technique requirent; participation by auxiliary cooling assembly can be shortened whole lyophilization cycle greatly; improve freeze-drying production efficiency, this also belongs to protection domain of the present utility model.
Below be only preferred embodiment of the present utility model, protection domain of the present utility model is also not only confined to above-described embodiment, and all technical schemes belonging under the utility model thinking all belong to protection domain of the present utility model.It should be pointed out that for those skilled in the art, the some improvements and modifications not departing under the utility model principle prerequisite, should be considered as protection domain of the present utility model.
Claims (9)
1. a refrigerating system of freeze dryer, it is characterized in that, comprise more than one group main cooling assembly and more than one group auxiliary cooling assembly, described main cooling assembly is shape in parallel to form the independent cooling closed circuit to cold hydrazine on freeze dryer and flaggy with auxiliary cooling assembly; Described main cooling assembly from auxiliary cooling assembly, adopt different refrigeration media.
2. refrigerating system of freeze dryer according to claim 1, is characterized in that, the cooling assembly that described main cooling assembly freezes to freeze dryer for pre-freeze-drying stage under nominal situation and lyophilization; Described auxiliary cooling assembly is the parsing-desiccation stage under nominal situation and the cooling assembly under fault condition, freeze dryer being freezed.
3. refrigerating system of freeze dryer according to claim 2, is characterized in that, under identical atmospheric pressure, the boiling temperature of the medium that freezes in described auxiliary cooling assembly is lower than the boiling temperature of the medium that freezes in main cooling assembly.
4. refrigerating system of freeze dryer according to claim 3, is characterized in that, described main cooling assembly adopts freon as refrigeration medium, and auxiliary cooling assembly adopts liquid nitrogen as refrigeration medium.
5. according to the refrigerating system of freeze dryer described in any one in claim 1～4, it is characterized in that, described in every group, main cooling assembly comprises the main refrigeration cycle of cold hydrazine and the main refrigeration cycle of flaggy, the main refrigeration cycle of cold hydrazine is for the condenser coil of cold hydrazine on freeze dryer is freezed, and the main refrigeration cycle of flaggy is for freezing to the flaggy of freeze dryer; Described in every group, auxiliary cooling assembly comprises cold hydrazine auxiliary cooling closed circuit and flaggy auxiliary cooling closed circuit, cold hydrazine auxiliary cooling closed circuit is for the condenser coil of cold hydrazine on freeze dryer is freezed, and flaggy auxiliary cooling closed circuit is for freezing to the flaggy of freeze dryer.
6. refrigerating system of freeze dryer according to claim 5, is characterized in that, each refrigeration cycle includes by the connected control valve of pipeline, plate type heat exchanger and refrigerating medium circulating pump.
7. refrigerating system of freeze dryer according to claim 5, it is characterized in that, pass linkage control valve is set on the refrigeration cycle of described auxiliary cooling assembly, for avoid the plate type heat exchanger of auxiliary cooling assembly at the refrigeration medium of main cooling assembly main cooling assembly when opening duty.
8. refrigerating system of freeze dryer according to claim 5, is characterized in that, each refrigeration cycle includes by the connected control valve of pipeline and plate type heat exchanger; The main refrigeration cycle of described cold hydrazine and cold hydrazine auxiliary cooling closed circuit share one group of refrigerating medium circulating pump, and the main refrigeration cycle of described flaggy and flaggy auxiliary cooling closed circuit share one group of refrigerating medium circulating pump.
9. refrigerating system of freeze dryer according to claim 8, is characterized in that, described every group of refrigerant cycle pump includes two refrigerant cycle pumps, and one is main pump, and another one is stand-by pump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420314404.3U CN204006776U (en) | 2014-06-13 | 2014-06-13 | A kind of freeze drying box refrigeration system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420314404.3U CN204006776U (en) | 2014-06-13 | 2014-06-13 | A kind of freeze drying box refrigeration system |
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| CN204006776U true CN204006776U (en) | 2014-12-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420314404.3U Expired - Lifetime CN204006776U (en) | 2014-06-13 | 2014-06-13 | A kind of freeze drying box refrigeration system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104534729B (en) * | 2014-06-13 | 2016-08-31 | 楚天科技股份有限公司 | A kind of refrigerating system of freeze dryer and the control method of this refrigeration system |
| CN106766542A (en) * | 2016-12-28 | 2017-05-31 | 上海原能细胞医学技术有限公司 | Biological specimen freezer |
-
2014
- 2014-06-13 CN CN201420314404.3U patent/CN204006776U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104534729B (en) * | 2014-06-13 | 2016-08-31 | 楚天科技股份有限公司 | A kind of refrigerating system of freeze dryer and the control method of this refrigeration system |
| CN106766542A (en) * | 2016-12-28 | 2017-05-31 | 上海原能细胞医学技术有限公司 | Biological specimen freezer |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20141210 |