CN102036980A - 作为IKK-β丝氨酸苏氨酸蛋白激酶抑制剂的取代噻吩羧酰胺 - Google Patents

作为IKK-β丝氨酸苏氨酸蛋白激酶抑制剂的取代噻吩羧酰胺 Download PDF

Info

Publication number
CN102036980A
CN102036980A CN2009801189111A CN200980118911A CN102036980A CN 102036980 A CN102036980 A CN 102036980A CN 2009801189111 A CN2009801189111 A CN 2009801189111A CN 200980118911 A CN200980118911 A CN 200980118911A CN 102036980 A CN102036980 A CN 102036980A
Authority
CN
China
Prior art keywords
alkyl
group
hydrogen
optional
described compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801189111A
Other languages
English (en)
Chinese (zh)
Inventor
D·F·C·莫法特
S·J·戴维斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chroma Therapeutics Ltd
Original Assignee
Chroma Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0807642A external-priority patent/GB0807642D0/en
Priority claimed from GB0815550A external-priority patent/GB0815550D0/en
Application filed by Chroma Therapeutics Ltd filed Critical Chroma Therapeutics Ltd
Publication of CN102036980A publication Critical patent/CN102036980A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CN2009801189111A 2008-04-26 2009-04-23 作为IKK-β丝氨酸苏氨酸蛋白激酶抑制剂的取代噻吩羧酰胺 Pending CN102036980A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0807642.4 2008-04-26
GB0807642A GB0807642D0 (en) 2008-04-26 2008-04-26 IKK- serine-threonine protein kinase inhibitors
GB0815550A GB0815550D0 (en) 2008-08-27 2008-08-27 IKK-beta serine-threonine protein kinase inhibitors
GB0815550.9 2008-08-27
PCT/GB2009/001051 WO2009130475A1 (en) 2008-04-26 2009-04-23 Substituted thiophenecarboxamides as ikk-beta serine-, threonine-protein kinase inhibitors

Publications (1)

Publication Number Publication Date
CN102036980A true CN102036980A (zh) 2011-04-27

Family

ID=40786701

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801189111A Pending CN102036980A (zh) 2008-04-26 2009-04-23 作为IKK-β丝氨酸苏氨酸蛋白激酶抑制剂的取代噻吩羧酰胺

Country Status (13)

Country Link
US (1) US20110046210A1 (https=)
EP (1) EP2285797A1 (https=)
JP (1) JP2011518817A (https=)
KR (1) KR20110020784A (https=)
CN (1) CN102036980A (https=)
AU (1) AU2009239772A1 (https=)
BR (1) BRPI0911480A2 (https=)
CA (1) CA2722660A1 (https=)
EA (1) EA201001708A1 (https=)
IL (1) IL208654A0 (https=)
MX (1) MX2010011643A (https=)
WO (1) WO2009130475A1 (https=)
ZA (1) ZA201008027B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012176930A (ja) * 2010-10-07 2012-09-13 Santen Pharmaceut Co Ltd ウレイド基とアミノカルボニル基を置換基として有するチオフェン誘導体を有効成分として含有する新規ｊａｋ３阻害剤
GB201211310D0 (en) 2012-06-26 2012-08-08 Chroma Therapeutics Ltd CSF-1R kinase inhibitors
HUE046132T2 (hu) 2012-10-17 2020-02-28 Macrophage Pharma Ltd N-[2-{4-[6-amino-5-(2,4-difluor-benzoil)-2-oxopiridin-1(2H)-il]-3,5-difluor-fenil}etil]-l-alanin és annak tercbutil-észtere
ES2656012T3 (es) 2013-02-06 2018-02-22 Bayer Cropscience Aktiengesellschaft Derivados de pirazol sustituidos con halógeno como pesticidas
GB201713975D0 (en) 2017-08-31 2017-10-18 Macrophage Pharma Ltd Medical use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003010158A1 (en) * 2001-07-25 2003-02-06 Astrazeneca Ab Novel compounds
WO2004063186A1 (en) * 2003-01-15 2004-07-29 Astrazeneca Ab Thiophene-carboxamide derivatives and their use as inhibitors of the enzime ikk-2
WO2008002246A1 (en) * 2006-06-28 2008-01-03 Astrazeneca Ab A pharmaceutical composition comprising an ikk2 inhibitor and a second active ingrdient.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200900616A1 (ru) * 2006-11-01 2010-04-30 Хрома Терапьютикс Лтд. Ингибиторы ikk-бета серин-треонин протеинкиназы
ATE524454T1 (de) * 2006-11-01 2011-09-15 Chroma Therapeutics Ltd Inhibitoren von ikk-beta serinthreoninproteinkinase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003010158A1 (en) * 2001-07-25 2003-02-06 Astrazeneca Ab Novel compounds
WO2004063186A1 (en) * 2003-01-15 2004-07-29 Astrazeneca Ab Thiophene-carboxamide derivatives and their use as inhibitors of the enzime ikk-2
WO2008002246A1 (en) * 2006-06-28 2008-01-03 Astrazeneca Ab A pharmaceutical composition comprising an ikk2 inhibitor and a second active ingrdient.

Also Published As

Publication number Publication date
CA2722660A1 (en) 2009-10-29
EA201001708A1 (ru) 2011-06-30
BRPI0911480A2 (pt) 2018-04-03
EP2285797A1 (en) 2011-02-23
ZA201008027B (en) 2011-07-27
IL208654A0 (en) 2010-12-30
US20110046210A1 (en) 2011-02-24
JP2011518817A (ja) 2011-06-30
MX2010011643A (es) 2010-11-30
KR20110020784A (ko) 2011-03-03
WO2009130475A1 (en) 2009-10-29
AU2009239772A1 (en) 2009-10-29

Similar Documents

Publication Publication Date Title
EP2078007B1 (en) Ikk-beta serine-threonine protein kinase inhibitors
EP2086956B1 (en) Inhibitors of ikk- beta serine-threonine protein kinase
JP5043120B2 (ja) ヒストンデアセチラーゼの阻害剤としてのヒドロキサメート
WO2021088885A1 (zh) 一种靶向i型prmt的化合物及其制备方法和应用
CN102036980A (zh) 作为IKK-β丝氨酸苏氨酸蛋白激酶抑制剂的取代噻吩羧酰胺
JP2011518814A (ja) Ｉｋｋ−ベータセリン−スレオニンプロテインキナーゼの阻害剤
EP2421844A1 (en) Thiophene inhibitors of ikk-b serine-threonine protein kinase
CN101541779A (zh) IKK-β丝氨酸-苏氨酸蛋白激酶抑制剂
CN101437799B (zh) p38MAP激酶抑制剂
AU2006350475B2 (en) Hydroxamates as inhibitors of histone deacetylase

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20110427