CN102033042B - Optical waveguide biochemical sensor testing device - Google Patents

Optical waveguide biochemical sensor testing device Download PDF

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Publication number
CN102033042B
CN102033042B CN2009100937668A CN200910093766A CN102033042B CN 102033042 B CN102033042 B CN 102033042B CN 2009100937668 A CN2009100937668 A CN 2009100937668A CN 200910093766 A CN200910093766 A CN 200910093766A CN 102033042 B CN102033042 B CN 102033042B
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China
Prior art keywords
optical waveguide
prism
coupling prism
sample cell
input
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Expired - Fee Related
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CN2009100937668A
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CN102033042A (en
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祁志美
刘瑞鹏
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Dongguan Qian'an Detecting Technology Co ltd
Institute of Electronics of CAS
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Dongguan Qian'an Detecting Technology Co ltd
Institute of Electronics of CAS
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Abstract

The invention discloses an optical waveguide biochemical sensor testing device, which comprises a base, a flowing sample cell holder, a prism and a prism compaction assembly, wherein the prism compaction assembly comprises an unloosening screw, an elastic element and an inverted L-shaped compaction block; two sides of the flowing sample cell holder are respectively provided with a supporting seat; the supporting seat is movably connected with the prism compaction assembly; the flowing sample cell holder is concavely arranged in the middle of a lower end face of the flowing sample cell holder and is communicated with the outside through a sample input/output pipeline; a sealing ring is arranged at the periphery of the flowing sample cell holder; the base is hinged and clamped with the flowing sample cell holder; an optical waveguide is arranged on the base; the coupling prism is positioned below the inverted L-shaped compaction block of the prism compaction assembly; and the bottom surface of the coupling prism is tightly contacted with the optical waveguide under the action of pre-compacting the elastic element. The base of the testing device is hinged with the flowing sample cell holder so as to conveniently assemble, disassemble and replace the optical waveguide; a flowing sample cell, the flowing sample cell holder and the prism compaction assembly are arranged into a whole, the contact pressing force of the prism and the optical waveguide is constant; and the testing device has a novel structure, high testing accuracy and high repeatability and is convenient to operate.

Description

Optical waveguide biochemical sensor proving installation
Technical field
The present invention relates to optical waveguide coupled and field of sensing technologies, is a kind of optical waveguide biochemical sensor proving installation, is the vitals that is used for the optical waveguide sensing testing.
Background technology
Optical waveguide is a kind of important integrated optical device, in gas, chemistry and field of biosensors purposes is widely arranged.This is that anti-electromagnetic interference (EMI) need not to use many advantages such as fluorescence labeling agent in biochemistry is surveyed because optical waveguide sensor has highly sensitively.Optical waveguide sensor often adopts the prism-coupled method to excite and the output optical waveguide guided mode, adopts the input mode that flows that testing sample is carried out real-time detection simultaneously.For example; People such as Ross in 2003 have utilized separated component fabrication spectroelectrochemistry sensor [S.E.Ross, Y.Shi, C.J.Seliskar such as planar optical waveguide, sample cell, input and output coupling prism; W.R.Heineman, Electrochimica Acta 48 (2003) 3313-3323.]; People such as Umemura also utilized a pair of coupling prism and a sample cell to prepare planar optical waveguide chemical sensor [T.Umemura, H.Hotta, T.Abe in 2006; Y.Takahashi; H.Takiguchi, M.Uehara, T.Odake; K.Tsunoda, Anal.Chem.78 (2006) 7511-7516.].These by prism coupler and sample cell etc. separate optical waveguide sensor assembling and debugging very complicated that device constitutes, use inconvenience, stability is not high, repeatability is relatively poor.In order to improve the optical waveguide sensor performance, be necessary the prism coupler and the sample cell that flows are carried out architecture advances, through appropriate design and combination, make it to be integrated in one.
Summary of the invention
The purpose of this invention is to provide a kind of optical waveguide biochemical sensor proving installation, it is simple and practical, and is easy to operate, and complex structure, operating difficulties, the precision that has solved existing correlation technique is not high, the problem of poor repeatability.
For realizing above-mentioned purpose, technical solution of the present invention is:
A kind of optical waveguide biochemical sensor proving installation comprises base, the sample stall that flows, input and output coupling prism, prism holds down assembly and support; Its mobile sample stall both sides have a bearing respectively, respectively be connected with on two bearings one the cover input or output the coupling prism hold down assembly;
Base and mobile sample stall vertically use axial screw hinged in a side, and the mobile sample stall of hinged relative opposite side is provided with clamping screw, and base is provided with the clamping screw that matches;
Between base and mobile sample stall apparent surface, be provided with optical waveguide, mobile sample cell, O-ring seal; Optical waveguide is overlying on base upper surface, and light guide surface is long-pending less than base upper surface; At least one mobile sample cell is arranged with the middle part, lower surface in the sample stall that flows, and mobile sample cell interlinks through sample input, output channel and the external world of the mobile sample stall of up/down perforation; The sample cell cylindrical that flows is provided with O-ring seal, and O-ring seal is between optical waveguide upper surface and mobile sample stall lower surface;
Input, output coupling prism lay respectively at optical waveguide upper surface two ends, are positioned at the bearing below, during use, hold down assembly the coupling prism is pressed on the waveguide top surface by inputing or outputing the coupling prism;
Base articulated section lateral surface is fixed on support one end, the support other end be fixed on the optical table or the sensor casing in; The central axis of support overlaps with the rectangular edge of coupling prism;
During use, with articulated section and clamping screw, screw with each parts clamped and located.
Described optical waveguide biochemical sensor proving installation, the cover that respectively has been dynamically connected on its said two bearings inputs or outputs the coupling prism and holds down assembly; Wherein, the coupling prism holds down assembly, and comprises that at least two are not deviate from screw, flexible member, an inverted L shape briquetting; Bearing is provided with the screw of at least two perforations, and it is suitable with screw respectively not deviate from screw, and each is not deviate from screw and passes the bearing screw, and it passes the part cylindrical and is arranged with flexible member, and the top is fixed in the inverted L shape briquetting.
Described optical waveguide biochemical sensor proving installation; Its said input, output coupling prism lay respectively at optical waveguide upper surface two ends; Be positioned at bearing below, during use, hold down assembly the coupling prism is pressed on the optical waveguide upper surface by inputing or outputing the coupling prism;
This input, output coupling prism lay respectively in the inverted L shape briquetting lower concave part that prism holds down assembly, and the inclined-plane of two coupling prisms is outside, the parallel optical waveguide upper surface that is affixed in bottom surface, and the right angle face is perpendicular to the optical waveguide upper surface.
Described optical waveguide biochemical sensor proving installation; On its said base articulated section lateral surface; Vertically each level of two ends is provided with a support mounting hole, and support mounting hole axis overlaps with the corresponding rectangular edge extended line that inputs or outputs coupling prism bottom surface respectively.
Described optical waveguide biochemical sensor proving installation; Its said input, output coupling prism lay respectively in the inverted L shape briquetting lower concave part that prism holds down assembly; The top end face that is input, output coupling prism contacts with the recess upper end medial surface of inverted L shape briquetting, and the vertical side of input, output coupling prism contacts with the interior vertical plane of the recess side of inverted L shape briquetting.
The invention has the advantages that: the present invention acts on the prism with the constant snap-in force of the good flexible member of preset, guarantees to reach the efficient and good coupling effect of repeatability of prism and waveguide; Integrated mobile sample cell of the present invention and prism hold down assembly bearing in one, have avoided the difficulty of split device when install adjustment is changed waveguide, have improved the repeatability and the precision of test; The present invention also couples together base and mobile sample stall in hinged way, makes things convenient for Fast Installation to change waveguide and the mobile sample cell of cleaning.Apparatus structure is novel simultaneously, and is easy to operate, simple and practical, and measuring accuracy is high, good reproducibility.
Description of drawings
Fig. 1: the front view of a kind of optical waveguide biochemical sensor proving installation of the present invention;
Fig. 2: the front view of a kind of optical waveguide biochemical sensor proving installation of the present invention;
Fig. 3: the side view of a kind of optical waveguide biochemical sensor proving installation of the present invention;
Fig. 4: the optical waveguide polarization result of interference synoptic diagram that utilizes proving installation of the present invention to obtain.
Embodiment
A kind of optical waveguide biochemical sensor proving installation of the present invention is patent of invention (the invention application number: further improve on the basis 200910080063.1) in application before.
Like Fig. 1, Fig. 2, shown in Figure 3; It is a kind of optical waveguide biochemical sensor proving installation of the present invention; Among the figure, flow sample stall 1, flexible member 2, inverted L shape briquetting 3, prism 4, waveguide 5, base 6, O-ring seal 7, clamping screw 8, lower surface 9, do not deviate from screw 10, axial screw 11, support 12, sample cell 13, sample input and output pipeline 14 flow.
Base 6 upper surfaces are covered with optical waveguide 5, and the surface area of optical waveguide 5 is less than the surface area of base 6 upper surfaces; Input and output couplings prism 4a, 4b are positioned at optical waveguide 5 upper surface two ends, and inverted L shape briquetting 3 aligned in position that hold down assembly with prism; Base 6 one sides are fixed on support 12 1 ends, and are fixed on the optical table or in the casing through support 12 other ends; The central axis of support 12 overlaps with the rectangular edge of input coupling prism 4a.
Sample stall 1 both sides of flowing have a bearing respectively, are used to carry a cover and input or output the coupling prism and hold down assembly.Every cover input or output prism hold down assembly by two do not deviate from screw 10, two springs 2, an inverted L shape briquetting 3 is formed.Bearing is provided with the screw of two perforations, and it is suitable with screw respectively neither to deviate from screw 10, and each is not deviate from screw 10 and passes the bearing screw, and it passes the part cylindrical and is arranged with spring 2, two tops and is fixed in inverted L shape briquetting 3.
Input and output couplings prism 4a, 4b lay respectively in inverted L shape briquetting 3 lower concave parts that prism holds down assembly; The inclined-plane of coupling prism 4a, 4b is outside; Coupling prism 4a, parallel optical waveguide 5 upper surfaces that are affixed in 4b bottom surface; Coupling prism 4a, 4b right angle face are perpendicular to optical waveguide 5 upper surfaces, and coupling prism 4a, 4b are held down assembly by prism and be pressed on optical waveguide 5 upper surfaces; The sample cell 13 that flows is positioned at 9 middle parts, lower surface of mobile sample stall 1, and sample cell 13 peripheries that flow are with O-ring seal 7 sealings, and mobile sample cell 13 is connected with extraneous through sample input and output pipeline 14a, the 14b of the mobile sample stall 1 of up/down perforation.When being used for the test of biochemical sensors such as gas, liquid when these apparatus of the present invention, testing sample can input or output the sample cell 13 that flows through sample input and output pipeline 14a, 14b.
Two cover prisms in holding down assembly do not deviate from screw 10 with inverted L shape briquetting 3 can along the screw that connects up and down spiral shell move; Spring 2 is between bearing and the inverted L shape briquetting 3; 2 pairs of inverted L shape briquettings of the spring that is pre-compacted 3 produce constant compression force; And pressure is passed to input and output couplings prism 4a, 4b through inverted L shape briquetting 3, make the contact pressure of input and output coupling prism 4a, 4b and waveguide 5 constant; Wherein, the top end face of input and output coupling prism 4a, 4b contacts with the recess upper end medial surface of inverted L shape briquetting 3, and the vertical side of input and output coupling prism 4a, 4b contacts with the interior vertical plane of the recess side of inverted L shape briquetting 3.
Base 6 is hinged with mobile sample stall 1 usefulness axial screw 11, makes the sample stall 1 base 6 rotation closure or openness relatively that flow, and makes things convenient for installing and replacing waveguide 5 and cleans the sample cell 13 that flows; Base 6 is tightened up with clamping screw (not illustrating among the figure) by clamping screw 8 with mobile sample stall 1 closed back, and compresses the O-ring seal 7 of sample cell 13 peripheries that flow, and has prevented that sample leaks in the mobile sample cell 13.When closure or openness flow sample stall 1 during with base 6, can be simultaneously be coupled prism 4a, 4b, the sample cell 13 that flows of input and output be removed waveguide 5 or be pressed in the waveguide 5, and make things convenient for installing and replacing waveguide 5, O-ring seal 7, and clean the sample cell 13 that flows.
Base 6 inwardly has a support mounting hole with each level of the vertical two ends of lateral surface of axial screw 11 articulated sections; Support mounting hole axis overlaps with the corresponding rectangular edge extended line that inputs or outputs coupling prism 4a, 4b bottom surface respectively, and a support 12 can be installed on arbitrarily in the support mounting hole.
A kind of optical waveguide biochemical sensor proving installation of the present invention with the good flexible member 2 constant snap-in forces of preset act on prism 4a, 4b is last, guarantees to reach the coupling effect of the efficient and good reproducibility of prism 4a, 4b and waveguide 5; And integrated bearing and mobile sample cell 13 avoided the difficulty of split device when install adjustment is changed waveguide 5 in one, improved the repeatability and the precision of test; Also in hinged way base 6 and mobile sample stall 1 are coupled together, make things convenient for Fast Installation to change waveguide 5 and the mobile sample cell 13 of cleaning.
Embodiment:
Flow sample cell 13 and the sample stall 1 of flowing processed by organic glass, and base 6 is processed by duralumin, and whole plant bulk is 76mm * 43mm * 30mm.Device is fixed in the sensor casing by support 12; A branch of He-Ne linearly polarized laser directive input coupling prism 4a; Change incident angle through swinging mounting 12; Under a certain specific incident angle, He-Ne laser is coupled into optical waveguide 5 becomes guided mode, and guided mode transfers to prism 4b and is coupled output optical waveguide.Output light is surveyed by analyzing.The testing liquid sample inputs or outputs the sample cell 13 that flows through sample input and output pipeline 14a, 14b under the driving of peristaltic pump (not illustrating among the figure), the liquid refractivity in the sample cell 13 that flows is changed.The variation of liquid refractivity is by the evanescent field perception of optical waveguide 5, thereby causes the variation of guided wave phase place.Accurately measure the variation of guided wave phase place through the polarization interference measuring method, finally obtain the refractive index parameter of fluid sample.As shown in Figure 4, be the optical waveguide polarization interference experiment result who utilizes proving installation of the present invention to obtain, its interference fringe is to be that 3% the NaCl WS causes through changing to weight ratio to the liquid in the mobile sample cell 13 from water.

Claims (5)

1. optical waveguide biochemical sensor proving installation comprises base, the sample stall that flows, input and output coupling prism, prism holds down assembly and support; It is characterized in that the sample stall both sides of flowing have a bearing respectively, respectively be connected with a cover on two bearings and input or output the coupling prism and hold down assembly;
Base and mobile sample stall vertically use axial screw hinged in a side, and the mobile sample stall of hinged relative opposite side is provided with clamping screw, and base is provided with the clamping screw that matches;
Between base and mobile sample stall apparent surface, be provided with optical waveguide, mobile sample cell, O-ring seal; Optical waveguide is overlying on base upper surface, and light guide surface is long-pending less than base upper surface; At least one mobile sample cell is arranged with the middle part, lower surface in the sample stall that flows, and mobile sample cell interlinks through sample input, output channel and the external world of the mobile sample stall of up/down perforation; The sample cell cylindrical that flows is provided with O-ring seal, and O-ring seal is between optical waveguide upper surface and mobile sample stall lower surface;
Input, output coupling prism lay respectively at optical waveguide upper surface two ends, are positioned at the bearing below, during use, hold down assembly the coupling prism is pressed on the optical waveguide upper surface by inputing or outputing the coupling prism;
Base articulated section lateral surface is fixed on support one end, the support other end be fixed on the optical table or the sensor casing in; The central axis of support overlaps with the rectangular edge of input coupling prism;
During use, with base articulated section and clamping screw, clamp screw with each parts clamped and located.
2. optical waveguide biochemical sensor proving installation as claimed in claim 1 is characterized in that, the cover that respectively has been dynamically connected on said two bearings inputs or outputs the coupling prism and holds down assembly; Wherein, the coupling prism holds down assembly, and comprises that at least two are not deviate from screw, flexible member, an inverted L shape briquetting; Bearing is provided with the screw of at least two perforations, and it is suitable with screw respectively not deviate from screw, and each is not deviate from screw and passes the bearing screw, and it passes the part cylindrical and is arranged with flexible member, and the top is fixed in the inverted L shape briquetting.
3. according to claim 1 or claim 2 optical waveguide biochemical sensor proving installation; It is characterized in that; Said input, output coupling prism lay respectively at optical waveguide upper surface two ends; Be positioned at bearing below, during use, hold down assembly the coupling prism is pressed on the optical waveguide upper surface by inputing or outputing the coupling prism;
This input, output coupling prism lay respectively in the inverted L shape briquetting lower concave part that prism holds down assembly, and the inclined-plane of two coupling prisms is outside, the parallel optical waveguide upper surface that is affixed in bottom surface, and the right angle face is perpendicular to the optical waveguide upper surface.
4. optical waveguide biochemical sensor proving installation as claimed in claim 1; It is characterized in that; On the lateral surface of said base articulated section; Vertically each level of two ends is provided with a support mounting hole, and support mounting hole axis overlaps with the corresponding rectangular edge extended line that inputs or outputs coupling prism bottom surface respectively.
5. like claim 1 or 3 described optical waveguide biochemical sensor proving installations; It is characterized in that; Said input, output coupling prism lay respectively in the inverted L shape briquetting lower concave part that prism holds down assembly; The top end face that is input, output coupling prism contacts with the recess upper end medial surface of inverted L shape briquetting, and the vertical side of input, output coupling prism contacts with the interior vertical plane of the recess side of inverted L shape briquetting.
CN2009100937668A 2009-09-28 2009-09-28 Optical waveguide biochemical sensor testing device Expired - Fee Related CN102033042B (en)

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CN102928344B (en) * 2012-10-26 2014-12-31 湖北三江航天红峰控制有限公司 Locking mechanism for photoelectric sensor
CN114700975B (en) * 2022-04-11 2023-10-10 清华大学 Flexible optical waveguide-based attitude sensor and robot

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EP0737308B1 (en) * 1993-06-02 1998-03-11 Hoechst Aktiengesellschaft Optical sensor for detection of chemical species
CN1315656A (en) * 2000-03-29 2001-10-03 中国科学院长春光学精密机械与物理研究所 Spectrometer with integrated light channel structure and process for preparing its integrated light channel package
CN101813622A (en) * 2009-02-19 2010-08-25 中国科学院电子学研究所 Optical-waveguide two-channel interferometer array
CN101839799A (en) * 2009-03-18 2010-09-22 中国科学院电子学研究所 Light-guide testing device

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5133597A (en) * 1990-12-26 1992-07-28 Industrial Technology Research Institute Method and device for measuring the transmission loss and optical waveguide
EP0737308B1 (en) * 1993-06-02 1998-03-11 Hoechst Aktiengesellschaft Optical sensor for detection of chemical species
CN1315656A (en) * 2000-03-29 2001-10-03 中国科学院长春光学精密机械与物理研究所 Spectrometer with integrated light channel structure and process for preparing its integrated light channel package
CN101813622A (en) * 2009-02-19 2010-08-25 中国科学院电子学研究所 Optical-waveguide two-channel interferometer array
CN101839799A (en) * 2009-03-18 2010-09-22 中国科学院电子学研究所 Light-guide testing device

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Title
Susan E. Ross, et al..Spectroelectrochemical sensing: planar waveguides.《Electrochimica Acta》.2003,第48卷3313-3323. *
Tomonari Umemura, et al..Slab Optical Waveguide High-Acidity Sensor Based on an Absorbance Change of Protoporphyrin IX.《Analytical Chemistry》.2006,第78卷(第21期),7511-7516. *
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