CN102028229B - Amino acids compound for enhancing immunity and preparation method thereof - Google Patents
Amino acids compound for enhancing immunity and preparation method thereof Download PDFInfo
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Abstract
The invention provides an amino acids compound for enhancing immunity, which is prepared from following raw materials by weight parts: 40 to 120 parts of isoleucine, 45 to 135 parts of leucine, 76.5 to 229.5 parts of lysine hydrochloride, 21.5 to 64.5 parts of methionine, 35 to 105 parts of phenylalanine, 40 to 120 parts of valine, 30 to 90 parts of threonine, 39 to 117 parts of arginine, 23 to 69 parts of histidine, 37.5 to 112.5 parts of glycine, 50 to 150 parts of aspartate, 900 to 2700 parts of dry mushroom, 750 to 2250 parts of medlar and 250 to 750 parts of liquorice. The amino acids compound for enhancing immunity of the invention is prepared by using 11 amino acids as the main ingredients and using the extracting solution of mushroom, medlar and liquorice rich in plant polysaccharide as auxiliary ingredients, so as to achieve the effects of anti-fatigue, enhancing immunity and enhancing the body physique.
Description
Technical field
The present invention relates to a kind of functional food for strengthening immunity, specifically, relate to a kind of amino acid composition for strengthening immunity.
Background technology
The human immune system is divided into two kinds of specific immunity and nospecific immunities.The former refers to special defence capability for certain bacterium, and such as the antibody for anti-tubercle bacillus, it is effective to tulase; And nospecific immunity refers to bacterium and the viral defence capability that can both resist and eliminate them to any kind, can resist a series of viruses such as common cold virus such as interferon.
Standing main force in the immune system is white blood cell and lymphocyte, and the main matter that consists of these weapons is exactly protein.Antibody is a kind of immunoglobulin (Ig), and ill but sometimes can recover for illness without medical help is exactly that antibody has been brought into play defense function.But when the human body internal protein was inadequate, health just can't be made antibody, will weaken the immunity of bacterium.Therefore, only have the enough protein of the health of supply, just can keep powerful immune system.Ancient Times in China medical science has had immunologic concept, argument such as " in healthy tendency deposits; heresy can not be done " mentioned in " interior warp ", " healthy tendency " wherein is namely relevant with the immunologic function of human body, " perverse trend " then with modern medicine in pathogenic microorganism, self denatured antigen and mutant cell etc. similar.
Summary of the invention
The object of the present invention is to provide a kind of amino acid composition for strengthening immunity, enhancing human body constitution.
Another object of the present invention is to provide the preparation method of described amino acid composition.
The present invention also aims to provide the purposes of described amino acid composition.
In order to realize purpose of the present invention, the amino acid composition for strengthening immunity of the present invention, it adopts the raw material of following weight portion to make:
40～120 parts of isoleucines, 45～135 parts of leucines, 76.5～229.5 parts of FE-5s, 21.5～64.5 parts of methionine, 5～105 parts of phenylalanine-3,4-quinones, 40～120 parts of valines, 30～90 parts of threonines, 39～117 parts of arginine, 23～69 parts of histidines, 37.5～112.5 parts of glycine, 50～150 parts of asparatates, 900～2700 parts of dried thin mushrooms, 750～2250 parts of matrimony vines, 250～750 parts in Radix Glycyrrhizae.
Wherein, preferably: 80 parts of isoleucines, 90 parts of leucines, 153 parts of FE-5s, 43 parts of methionine, 70 parts of phenylalanines, 80 parts of valines, 60 parts of threonines, 78 parts of arginine, 46 parts of histidines, 75 parts of glycine, 100 parts of asparatates, 1800 parts of dried thin mushrooms, 1500 parts of matrimony vines, 500 parts in Radix Glycyrrhizae.
Amino acid composition of the present invention, it also contains one or more auxiliary materials that are selected from honey, sucrose, glucose, maltose, xylitol, the potassium sorbate.
Amino acid composition for strengthening immunity of the present invention, it is by the following method preparation: will mix with matrimony vine, Radix Glycyrrhizae after the dried thin mushroom stripping and slicing, decoct 2～3h behind the water soaking 20～30min with 8～12 times of weight, 200 mesh sieves filter; Filter residue boils 1～2h with the decocting of 6～10 times of weight again, and 200 mesh sieves filter; Merge filtrate twice, being concentrated into relative density is 1.15～1.20, filters, and the filtrate cooling is left standstill; Get supernatant, add successively 11 seed amino acids, then add auxiliary material, the rear boiling sterilization that stirs, cooling.
Amino acid composition of the present invention, its amino acid whose composition and proportioning are to amino acid requirement pattern (FAO (Food and Agriculture Organization of the United Nation) and the World Health Organization (FAO/WHO) standard according to human body, what 1985), the amino acid compositional model of protein, egg protein and human milk was formulated in the human plasma, except containing 7 kinds of essential amino acids (isoleucine, leucine, lysine, methionine, phenylalanine, valine, threonine), also contain the arginine that has the positive nitrogen equilibrium safeguarded, promotes wound healing, immunological regulation and enhancing development effect; Has the histidine that helps tissue growth and reparation, reinforcement sexual function, promotes the gastric secretion effect; Have the function of the central nervous system kept and the glycine of prostate health, raising immunity, reduction high cholesterol and high fat of blood; With the asparatate with enhancing endurance, relieving fatigue, enhancement metabolism, protection liver, booster immunization effect, above-mentioned 11 seed amino acids synergy can have the good effect that strengthens immunity.
In addition, by inquiring about a large amount of pharmacology and clinical research data, amino acid composition of the present invention also is equipped with the extract of mushroom, matrimony vine and the Radix Glycyrrhizae of being rich in thick polysaccharide on the basis of above-mentioned amino acid ligand ratio.Thick polysaccharide compound is a kind of immunomodulator, and it has tumor growth, the immune cell activated of inhibition, improve the effect such as body's immunity, and normal cell is had no side effect.Therefore, add the extract of mushroom, matrimony vine and the Radix Glycyrrhizae of being rich in plant polyose, can reach auxiliary antifatigue, strengthen the effect of immunity, thereby can also add the effect that an amount of honey and acesulfame potassium play flavor adjustment in addition.
The formulation of the present composition is oral formulations, is preferably oral liquid.Described oral liquid has the taste sweetness, be easy to take and carry all advantages such as comparatively convenient of storage, and composition oral liquid of the present invention contains lysine 204～612mg among every 100mL,, arginase 12 89～867mg., asparatate 176.5～529.5mg,, thick polysaccharide 7～10mg.
Above-mentioned oral liquid is taken 2 times every day, each serving can reach the effect that strengthens immunity with 10ml.
The present invention also provides the method for preparing above-mentioned composition, and it comprises the steps:
1) will mix with matrimony vine, Radix Glycyrrhizae after the dried thin mushroom stripping and slicing, decoct 2～3h behind the water soaking 20～30min with 8～12 times of weight, 200 mesh sieves filter; Filter residue boils 1～2h with the decocting of 6～10 times of weight again, and 200 mesh sieves filter; Merge filtrate twice, being concentrated into relative density is 1.15～1.20, filters, and filtrate is put under freezer 4 degree celsius temperature leave standstill 8～12h;
2) then get supernatant and be heated to 80～100 ℃, add successively 11 seed amino acids, be stirred to dissolving behind every adding one seed amino acid, and then add next seed amino acid; Then add auxiliary material, the rear boiling sterilization 30min that stirs makes oral formulations after the cooling.
The present invention also provides described composition for the preparation of the application in the functional food that strengthens immunity.
The invention has the advantages that, amino acid composition for strengthening immunity of the present invention, its amino acid whose proportioning meets human body to the ratio of amino acid requirement pattern, on the basis of selecting 7 kinds of essential amino acids, be equipped with arginine, histidine, glycine and asparatate, totally 11 seed amino acids form amino acid master side, and be equipped with the extract of mushroom, matrimony vine and the Radix Glycyrrhizae of being rich in plant polyose, thereby reach the effect of antifatigue, enhancing immunity, enhancing human body constitution, this product research achievement is better than existing similar functional food.
The specific embodiment
By the following specific examples further illustrate the invention, but be not used for limiting the scope of the invention.
Embodiment 1
Raw material: isoleucine 40g, leucine 45g, FE-5 76.5g, methionine 21.5g, phenylalanine-3,4-quinone 5g, valine 40g, threonine 30g, arginine 39g, histidine 23g, glycine 37.5g, asparatate 50g, dried thin mushroom (SB/T10039-92) 900g, matrimony vine 750g, Radix Glycyrrhizae 250g, honey 1000g, acesulfame potassium 1.25g.
The preparation method:
1, with mixing with matrimony vine, Radix Glycyrrhizae (one one of the Pharmacopoeia of the People's Republic of China (version in 2005)) after the dried thin mushroom stripping and slicing, decoct 3h behind the water soaking 30min with 10 times of weight, 200 mesh sieves filter; Filter residue boils 2h with the decocting of 8 times of weight again, and 200 mesh sieves filter; Merge filtrate twice, being concentrated into relative density is 1.20, filters, and filtrate is put into freezer leave standstill 8h;
2, then get supernatant and be heated to 80 ℃, add successively 11 seed amino acids, be stirred to dissolving behind every adding one seed amino acid, and then add next seed amino acid; Then add honey and acesulfame potassium, the rear boiling sterilization 30min that stirs, cooling adds purified water again;
3, then through refrigeration spend the night, flame filter press filters, collect filtrate to the clean stainless steel receiver through cleaning and sterilizing, with plastic bottle filling mechanical irrigation easy to break envelope, then with the water-bath sterilizer 30min that under 115 ℃ of temperature, sterilizes, pack at last and make the oral liquid finished product.
Embodiment 2
Raw material: isoleucine 80g, leucine 90g, FE-5 153g, methionine 43g, phenylalanine 70g, valine 80g, threonine 60g, arginine 78g, histidine 46g, glycine 75g, asparatate 100g, dried thin mushroom (SB/T10039-92) 1800g, matrimony vine 1500g, Radix Glycyrrhizae 500g, honey 2000g, acesulfame potassium 2.5g.
The preparation method:
1, with mixing with matrimony vine, Radix Glycyrrhizae (one one of the Pharmacopoeia of the People's Republic of China (version in 2005)) after the dried thin mushroom stripping and slicing, decoct 2h behind the water soaking 20min with 8 weight, 200 mesh sieves filter; Filter residue boils 2h with the decocting of 10 times of weight again, and 200 mesh sieves filter; Merge filtrate twice, being concentrated into relative density is 1.15, filters, and filtrate is put into freezer leave standstill 12h
2, then get supernatant and be heated to 100 ℃, add successively 11 seed amino acids, be stirred to dissolving behind every adding one seed amino acid, and then add next seed amino acid; Then add honey and acesulfame potassium, the rear boiling sterilization 30min that stirs, cooling adds purified water again;
3, then through refrigeration spend the night, flame filter press filters, collect filtrate to the clean stainless steel receiver through cleaning and sterilizing, with plastic bottle filling mechanical irrigation easy to break envelope, then with the water-bath sterilizer 30min that under 115 ℃ of temperature, sterilizes, pack at last and make the oral liquid finished product.
Embodiment 3
Raw material: isoleucine 120g, leucine 135g, FE-5 229.5g, methionine 64.5g, phenylalanine 105g, valine 120g, threonine 90g, arginine 117g, histidine 69g, glycine 112.5g, asparatate 150g, mushroom 2700g, matrimony vine 2250g, Radix Glycyrrhizae 750g, honey 3000g, acesulfame potassium 3.75g.
The preparation method: identical with embodiment 1, make for the oral liquid finished product that strengthens immunity.
Below further specify the present invention by toxicity and function test, toxicity and function test are all used the oral liquid that is used for strengthening immunity that embodiment 2 makes (hereinafter referred to as the fragrant Qi oral liquid of amino acid).
Test example 1 toxicological test
One, test objective: whether the check product has toxicity.
Two, test material:
The fragrant Qi oral liquid of the amino acid that sample: embodiment 2 makes according to human body oral liquid recommended amounts 20ml every day, becomes body weight for humans to press 60kg and calculates, and gets 4 times of concentrates and tests.
Experimental animal: cleaning level Kunming mouse.
Three, test method:
1, acute toxicity test in mice: 20 of cleaning level Kunming mouses, male and female half and half, body weight 18-22g. dosage design is female to be 40ml/kgbw, and male is 40ml/kgbw, the oral liquid that embodiment 2 is made by the disposable per os gavage of the dosage of 0.2ml/10gbw to tested material.Animal overnight fasting before the gavage is freely drunk water, and gives normal diet after the gavage, observes 14d, record poisoning sign and death condition.
The result shows: female, male mice acute oral MTD belongs to nontoxic level all greater than 40ml/kgBW.
2, Salmonella reversion test: adopt to mix and send out and some examination method, in two kinds of methods, add respectively or do not add the Activated in Vitro system tested material is tested.Five dosage are established in test, are respectively 0.016 μ g/ ware, 0.08 μ g/ ware, 0.4 μ g/ ware, 2.0 μ g/ wares, 10.0 μ g/ wares, establish simultaneously from beaming back change, solvent control and positive solvent control group.Each dosage is made three plates, and test repeats once.The result is negative.
3, PCEMNR micronucleus test: 50 of cleaning level Kunming mouses, male and female half and half, body weight 26-30g.With the positive contrast of the endoxan of 0.04g/kgbw dosage, the negative contrast of distilled water, 3 dosage of test group are respectively 10.0ml/kgbw, 20ml/kgbw, 40ml/kgbw, press the 24 hours gavages in 0.20ml/10gbw volume interval 2 times to mouse.The result is negative.
4, mouse sperm deformity test: 25 of cleaning level Kunming mouses, male, body weight 28-31g; With the positive contrast of the endoxan of 0.04g/kgbw dosage, the negative contrast of distilled water, 3 dosage of test group are 10.0ml/kgbw, 20ml/kgbw, 40ml/kgbw respectively, gives mouse stomach, and the result is negative.
5,30 days feeding trials: get 80 of cleaning level Wistar kind rats, male and female half and half, body weight 66-87g, rat is divided into basic, normal, high three dosage groups, give respectively oral liquid 1.67ml/kg, 16.7ml/kg, 33.3ml/kg that embodiment 2 makes, press the 1ml/100gbw preparating liquid, continuously gastric infusion 30d.
Evaluation criterion according to 30 days feeding trials in Ministry of Public Health's " health food check and assessment technique standard " (version in 2003) is judged, the result shows: in tested measures range, the oral liquid that the embodiment of the invention 2 makes all has no significant effect body weight gain, food-intake, total foodstuff utilization rate, main organs weight in wet base and dirty/body ratio, the hematological indices of rat; Dosage and control group ratio in buck the 1st all food utilizations, difference has utmost point conspicuousness (p＜0.01), jenny urea nitrogen individual groups measured value and control group ratio in the biochemical indicator, difference has statistical significance, but the abiology meaning; Main organs also has no the specificity pathological change.
Four, conclusion (of pressure testing):
Composition for strengthening immunity of the present invention has no side effect, and mouse polychromatic erythrocyte micronucleus test, mouse sperm deformity test, Salmonella reversion test all are negative; Feed to detect afterwards in 30 days and show that product of the present invention is showed no obvious impact to body weight gain, food-intake, total foodstuff utilization rate, main organs weight in wet base and dirty/body ratio, the hematological indices etc. of rat.
Test example 2 function tests
One, test objective: whether the check product has the health care that strengthens immunity
Two, test material:
The fragrant Qi oral liquid of the amino acid that sample: embodiment 2 makes, stoste is pitchy liquid, 10ml/ props up;
Experimental animal: 192 of cleaning level Kunming mouses, body weight is 20～24g;
Dosage is selected and sample treatment: establish the basic, normal, high dosage group of oral liquid, give the amino acid that embodiment 2 makes fragrant Qi oral liquid, its dosage is respectively 0.33ml/kgbw, 3.3ml//kgbw, 10.00ml//kgbw (be equivalent to respectively human body RD 1,10,30 times); Establish simultaneously negative control group (giving isopyknic distilled water).
To each group mouse continuous gastric infusion 30 days, every day gavage once, the gavage volume is 0.1ml/10gbw.
Key instrument and reagent: electronic scale, semi-automatic biochemical analyzer, clean bench, blood counting instrument, full-automatic ELIASA, microscope etc.
Three, test method:
The determination experiment of cleaning up experiment, SPL conversion test, NK cytoactive by delayed allergy (DTH), immune organ, HD50 value and PFC mensuration, Peritoneal Macrophage Phagocytosis, mouse carbon carries out assessment of function.The result is shown in table 1～6.
The impact of the fragrant Qi Oral Liquid On Mice of table 1 amino acid DTH
*: compare P＜0.05 with negative control group;
*: compare P＜0.01 with negative control group
By as seen from Table 1, middle and high dosage group mouse foot sole of the foot thickened degree obviously increases, with negative control group relatively, difference has conspicuousness (P＜0.05 or P＜0.01).
The impact of the fragrant Qi Oral Liquid On Mice of table 2 amino acid spleen IgM PFC
*: compare P＜0.05 with negative control group;
*: compare P＜0.01 with negative control group
By as seen from Table 2, middle and high dosage group mouse spleen antibody forming cell number is apparently higher than recessive control group, Epidemiological Analysis by statistics, and its difference has conspicuousness (P＜0.05 or P＜0.01).
The fragrant Qi Oral Liquid On Mice of table 3 amino acid half hemolytic dose (HC
50) impact
By as seen from Table 3, each dosage group mice serum HD50 value (HC
50) compare no significant difference (P＞0.05) with control group.
The fragrant Qi oral liquid of table 4 amino acid is on the impact of macrophage phagocytic function
By as seen from Table 4, each dosage group Turnover of Mouse Peritoneal Macrophages phagocytic rate and phagocytic index, Analysis of variance, its group difference is without conspicuousness (P＞0.05).
The impact that the fragrant Qi Oral Liquid On Mice of table 5 amino acid carbon is cleaned up ability
By as seen from Table 5, each dosage group mouse carbon is cleaned up ability and negative control group relatively, no significant difference (P＞0.05).
The impact of the fragrant Qi Oral Liquid On Mice of table 6 amino acid NK cytoactive
By as seen from Table 6, the active Analysis of variance of each dosage group NK cells in mice, no significant difference (P＞0.05).
Four, conclusion (of pressure testing):
According to above-mentioned result of the test, judge with the related standards in Ministry of Public Health's " health food check and assessment technique standard " (version in 2003), illustrate that the present composition has the effect that strengthens immunity to mouse.
Although, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (7)
1. amino acid composition that be used for to strengthen immunity is characterized in that it adopts the raw material of following weight portion to make:
40～120 parts of isoleucines, 45～135 parts of leucines, 76.5～229.5 parts of FE-5s, 21.5～64.5 parts of methionine, 5～105 parts of phenylalanine-3,4-quinones, 40～120 parts of valines, 30～90 parts of threonines, 39～117 parts of arginine, 23～69 parts of histidines, 37.5～112.5 parts of glycine, 50～150 parts of asparatates, 900～2700 parts of dried thin mushrooms, 750～2250 parts of matrimony vines, 250～750 parts in Radix Glycyrrhizae;
Described amino acid composition prepares by the following method: will mix with matrimony vine, Radix Glycyrrhizae after the dried thin mushroom stripping and slicing, decoct 2～3h behind the water soaking 20～30min with 8～12 times of weight, 200 mesh sieves filter; Filter residue boils 1～2h with the decocting of 6～10 times of weight again, and 200 mesh sieves filter; Merge filtrate twice, being concentrated into relative density is 1.15～1.20, filters, and the filtrate cooling is left standstill; Get supernatant, add successively 11 seed amino acids, then add auxiliary material, the rear boiling sterilization that stirs, cooling.
2. amino acid composition according to claim 1 is characterized in that, it adopts the raw material of following weight portion to make:
80 parts of isoleucines, 90 parts of leucines, 153 parts of FE-5s, 43 parts of methionine, 70 parts of phenylalanines, 80 parts of valines, 60 parts of threonines, 78 parts of arginine, 46 parts of histidines, 75 parts of glycine, 100 parts of asparatates, 1800 parts of dried thin mushrooms, 1500 parts of matrimony vines, 500 parts in Radix Glycyrrhizae.
3. amino acid composition according to claim 1 is characterized in that, it also contains one or more auxiliary materials that are selected from honey, sucrose, glucose, maltose, xylitol or the potassium sorbate.
4. the described composition of any one is characterized in that according to claim 1-3, and the formulation of described composition is oral formulations.
5. composition according to claim 4 is characterized in that, described oral formulations is oral liquid.
6. prepare the method for the described amino acid composition of claim 4, it is characterized in that, it comprises the steps:
1) will mix with matrimony vine, Radix Glycyrrhizae after the dried thin mushroom stripping and slicing, decoct 2～3h behind the water soaking 20～30min with 8～12 times of weight, 200 mesh sieves filter; Filter residue boils 1～2h with the decocting of 6～10 times of weight again, and 200 mesh sieves filter; Merge filtrate twice, being concentrated into relative density is 1.15～1.20, filters, and filtrate is put under 4 ℃ of temperature of freezer leave standstill;
2) then get supernatant and be heated to 80～100 ℃, add successively 11 seed amino acids, be stirred to dissolving behind every adding one seed amino acid, and then add next seed amino acid; Then add auxiliary material, the rear boiling sterilization 30min that stirs makes oral formulations after the cooling.
7. the described amino acid composition of claim 1-5 any one is for the preparation of the application in the functional food that strengthens immunity.
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| CN1543857A (en) * | 2003-11-13 | 2004-11-10 | 上海奥医高科技实业有限公司 | Health food having functions of postponing senescence and increasing bone mineral density |
| CN1762236A (en) * | 2005-11-02 | 2006-04-26 | 江中药业股份有限公司 | Health-caring product capable of increasing human immunity and its preparation method |
| CN101756090A (en) * | 2009-12-18 | 2010-06-30 | 中国人民武装警察部队医学院 | Physical power recovery agent and applications thereof |
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| CN1543857A (en) * | 2003-11-13 | 2004-11-10 | 上海奥医高科技实业有限公司 | Health food having functions of postponing senescence and increasing bone mineral density |
| CN1762236A (en) * | 2005-11-02 | 2006-04-26 | 江中药业股份有限公司 | Health-caring product capable of increasing human immunity and its preparation method |
| CN101756090A (en) * | 2009-12-18 | 2010-06-30 | 中国人民武装警察部队医学院 | Physical power recovery agent and applications thereof |
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