CN102018756A - Application of gentian serving as antiviral drug - Google Patents
Application of gentian serving as antiviral drug Download PDFInfo
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- CN102018756A CN102018756A CN 201010584627 CN201010584627A CN102018756A CN 102018756 A CN102018756 A CN 102018756A CN 201010584627 CN201010584627 CN 201010584627 CN 201010584627 A CN201010584627 A CN 201010584627A CN 102018756 A CN102018756 A CN 102018756A
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Abstract
The invention relates to an application of gentian serving as an antiviral drug, belonging to the field of application of drugs. The gentian accounts for 100wt% of antiviral drugs. In the invention, the gentian is the antiviral drug which has the characteristics of broad spectrum, high efficiency and no toxic and side effects.
Description
Technical field
The present invention relates to of the application of a kind of Radix Gentianae, belong to the purposes field of medicine as the treatment antiviral drugs.
Background technology
Hospital or pharmacy are used for the treatment of viral inflammation at present, 'Shuang Hualian ' injection (oral) liquid or import Western medicine that Chinese medicine is generally commonly used, and 'Shuang Hualian ' injection (oral) medicine can only be treated not too serious infection.Mostly the Western medicine of usefulness is the class nucleosides material now, and clinical use has certain limitation, and toxic and side effects is big.
Summary of the invention
The object of the present invention is to provide of the application of a kind of Radix Gentianae as the treatment antiviral drugs.
Technical solution: Radix Gentianae is as the application of treatment antiviral drugs, and in the treatment antiviral drugs, Radix Gentianae accounts for very weight fraction.
Radix Gentianae is as treatment antiviral drugs preparation method, and the extraction of Radix Gentianae: Radix Gentianae extract is very easily water-soluble, available digestion method, and the extraction dry is 27%-28%; Or to extract dry with percolation be 25%; Or with no aerial parts quality preferably Radix Gentianae through the sterilization after, be ground into fine powder and directly incapsulate;
The preparation oral liquid, with Radix Gentianae digestion 3 times, get and precedingly be condensed into 1: 1 or 2: 1 for 2 times altogether promptly: 2ml includes the 1g crude drug, and the 3rd time digestion liquid is used for digestion next time;
The preparation injection, must select the under ground portion of high-quality Radix Gentianae, screening is clean, be ground into fine powder, with the percolation method sepage be condensed into 1: 1 or 1: 1.5, that is: the 1ml concentrated solution includes the 1.5g crude drug, pack in the glass container, after leaving standstill 24 hours, aspirate its supernatant ampere of packing into, can use for intramuscular injection or intravenous injection.
Radix Gentianae also claims Radix Gentianae, and Chinese materia medica record Radix Gentianae bitter cold is used as bitter tonic, and record can not be obeyed for a long time in addition, obeys impairment of YIN for a long time.But well-known doctor Zhang Xichun explains Radix Gentianae and says: it is strong that Radix Gentianae is obeyed light body of step for a long time.It seems that forefathers are individual's experience to the saying of Radix Gentianae.
Introduce research process below to Radix Gentianae:
Research to Radix Gentianae is that the late father began the sixties in last century, the late father works in the Weifang City, Shandong Province, because of the area, Shandong summer and autumn the viral encephalitis sickness rate very high, the patient because of encephalitis death in hospital often sees, in that age, the basic hospital antiviral Western medicine of China does not have, viral encephalitis is just used Supporting Therapy, open several secondary Chinese medicines again, but most of poor effect, can patient life, entirely by patient's self immune state decision.
The late father screens from various Chinese medicinal formulaes, finds all prescriptions that adds Radix Gentianae, and patient can get out of danger smoothly.The late father just treats viral encephalitis in the hospital of his work with Radix Gentianae compatibility prescription, has obtained extraordinary effect, and case fatality rate reduces, and patient's hospital stays shortens.Radix Gentianae be used for viral hepatitis and various disease of viral infection, all obtained better curative effect thereafter.
The inventor began to treat various viral diseases with Radix Gentianae before 25 years, found that curative effect is fabulous, and general antiviral agents can not be compared, and as domestic 'Shuang Hualian ' injection commonly used (oral) liquid, can only treat not too serious infection.One routine female patient is arranged, the teacher, defeated SHUANGHUANLIAN first quarter moon is invalid because of catching a cold, and finds the inventor, gives with Radix Gentianae extracting solution 15g (containing crude drug) to add the quiet notes of normal saline i.e. recovery from illness in 3 days.More can not compare for the import Western medicine with Radix Gentianae, mostly the Western medicine of usefulness is the class nucleosides material now, clinical use has certain limitation, and toxic and side effects is big, not only controls bad disease, bad ruling by men on the contrary, have an example to be inventor's working unit personnel, certain large hospital contagious department is lived in hepatitis B acute attack before 20 years, treat with the import antiviral agents, after treatment a period of time, hydrosarca and tangible poisoning manifestations have occurred, haveed no alternative but leave hospital, use the Radix Gentianae treatment instead, took medicine 1 year, surface antigen is turned out cloudy, and physical recovery is good, the retirement of working, health are healthy always.
The inventor is example surplus Radix Gentianae treatment hepatitis B 50, and the anti-hepatitis B surface antigen rate reaches 60%, and also all liver function is normal for the case of not turning out cloudy, the HBV load also obviously reduces, to hepatitis A, as long as take medicine 3 months, just health and check all normal, one routine hepatitis E case was once arranged, want to join the army, only problem was arranged because of liver function, can not achieve one's goal in 2 years, got through coroner's relation on the 3rd year, and achieved one's goal and join the army, after joining the army, army rechecks, it is undesired to detect liver function again, because of some ability of his father, is not is not cleared up and discharged, his father is sent to army with inventor's medicine, it is taken, and all are normal after 5 months, and certain medical officer feels strange.More than the explanation Radix Gentianae is had a liking for hepatovirus excellent curative is all arranged various.
Radix Gentianae also has scavenging action to cryptovirus in the human body, and two routine patients are arranged, and lip portion is repeatedly generation herpes often, through taking Radix Gentianae powder (10g every day) 1 month, herpes takes place no longer later on.
Two examples are arranged: the men and women is a case each, acute multiple peripheral neuritis, and this is the disease that a kind of cause of disease is unable to explain clearly, it is extremely many to press on the internal medicine cause of disease, the viral infection of saying so confirms but there is excellent drug, so final conclusion never, hospital is a symptomatic treatment, the inventor gives oral Radix Gentianae, and every day, 15g recovered normal gradually after 1 month, so my conclusion: the cause of disease of multiple peripheral neuritis mainly is a viral infection, and which kind of virus it be unclear that.
Cough property asthma is a kind of persistent ailment in internal medicine, and at child's pilosity, many nothings of internist way mostly is Chinese traditional treatment, with the Radix Gentianae treatment tangible curative effect is arranged, and child's medication is convenient.
Radix Gentianae has high efficiency to some viruses, two examples are arranged because of upper respiratory tract infection, concurrent meningitic pupil, have a fever, vomit, can not take food and water, in local transfusion every day and adding SHUANGHUANLIAN, treated 7-8 days, invalid and vomiting day by day increases the weight of, and finds the inventor to require treatment, because of the patient is the child, water inlet all will be vomitted, oral drugs are difficulty especially, gives intramuscular injection Radix Gentianae every day 2 times, and (medicinal liquid is 1: 1.5 to each 4ml, be that every ml contains crude drug 1.5g) medication i.e. no longer vomiting in the 2nd day, can normally take food in the 3rd day.As seen Radix Gentianae is fabulous to the effect of killing Respirovirus.
Respiratory virus infection is often seen in the north, great majority with SHUANGHUANLIAN or obey several doses of Chinese medicines will be good, but it is just powerless to infect serious people's SHUANGHUANLIAN, it is extremely many to add the Respirovirus kind again, basic unit can't understand fully it is which kind of virus, can only unify viral therapy, the inventor once controlled two routine special respiratory tract infection patients: 30 years old certain section hospital of the first routine male admits to hospital by phthisis miliaris, be in hospital and do not feel any better in 2 years, health wastes away, find the inventor, see that the X-ray sheet sees that two lungs are dispersed in the big scleroma of most small rice grains, distribution person is in the majority along bronchus, supposition may be a respiratory syncytial virus infection, tuberculosis is given with the Radix Gentianae treatment recovery from illness in 3 months absolutely not.
Second example betides 2003, when atypical pneumonia was very popular, 40 years old fever of patient male gone to see a doctor by the income isolation ward, not SARS through looking into, consider pulmonary tuberculosis, change tuberculosis ward over to, tuberculosis except continuing to check, general pulmonary tuberculosis is not had a high fever, then leave hospital, each clinic sees that the hyperpyrexia patient keeps outside of the door, and the inventor has accepted this patient, see the lung sheet, the high density lesser tubercle shade that has majority to be dispersed in has many places high density strip shade simultaneously, but does not have large stretch of shade that merges, consider to have the inflammation of bronchia, the inflammation that pulmonary parenchyma is also arranged is given with the Radix Gentianae treatment recovery from illness in 3 months.Above example illustrates pulmonary's viral infection, and with the Radix Gentianae treatment, curative effect is fabulous.
Radix Gentianae treatment herpetic keratitis, really be that As the medicine took effect, the symptoms lessened, routine herpetic keratitis surplus invention ruled 10 by men, all be red, the i.e. disappearance of itching of 1 day eye behind the eye dripping, 2 days herpess of eye dripping disappear, and do not have sense of discomfort, have two routine children's to suffer from herpes keratitis, opened the idoxuridine collyrium in hospital, eye dripping 3 days is ineffective, and point at the moment cries and screams because of the sense of discomfort child, uses the Radix Gentianae eye dripping instead, promptly healed in two days, in addition, Radix Gentianae also has fabulous effect to trachoma, pink eye disease, the treatment ophthalmic, medication seldom, by weight with 1: 0.2 (1ml contains the 0.2g crude drug) the medicinal liquid drop get final product.
The treatment skin diseases, routine condyloma acuminatum surplus the inventor treats 10 has the heavy especially patient of two examples, and the about diameter 8-10cm of crissum skin is taken by the wart-like lump of projection entirely, the long 1cm that reaches, short 2-3mm, intensive more near anus more, it is oral to give Radix Gentianae, every day 15g, use the leachate partial smearing in addition, after one month, all wart-like lumps all disappear.
One woman was once arranged, because of accompanying its grandmother to see a doctor, see that unintentionally this woman's whole face all is a molluscum contagiosum, the general every 1cm2 of density just has one, two forearms and the back of the hand also all overgrow with molluscum, its grandmother says: be the department of dermatologry of hospital of a few family, also obeyed Chinese medicine, all can not cure, existing household is often anxious for this reason, give clothes Radix Gentianae powder 15g every day, 20 days begin to disappear, and it is neat and tidy that 1 month rear face and upper limb disappear.Radix Gentianae treatment human papillomavirus not only acts on by force, and rapid-action.More than illustrate Radix Gentianae multiple section is belonged to the viral fabulous curative effect that all has, it relates to has a liking for hepatovirus, neurotropic virus, influenza virus, negative myxovirus, togavirus, herpesvirus, human papillomavirus.Because what the inventor did is clinical experiment, is at random, thus have in a lot of viruses are not included in, but found out that the Radix Gentianae antiviral does not have selectivity, but widely.
Radix Gentianae also has good action to animal virus in addition, for two examples:
Last position friend peasant talked about and raises pigs in 15 years, the local swine fever that often takes place that they live, and hyperpyrexia after the swine diseases is not taken food, very fast death, the veterinary has no idea, and I tell him to take back by two bottles of injection Radix Gentianae (every bottle of 250ml) for him, am placed on sombre local back up.Swine fever takes place again in his village after 1 year, he has remembered this two bottles of medicines, use big syringe, a shot 50ml, (not at a position), neighbours require also to inject this medicine to the pig of his family, (just having lucky psychology in arms), the result has spent the popular phase except the pig degree of safety of their two families, and other other pigs are all dead.The tame pig farm of inventor to, see that a big boar whole body covers with variola, ask why not its owner disposes it, owner says that its performance is fine, and the piglets of breeding is fine, and I give him a bag Radix Gentianae powder, every day 50g, add feedstuff and feed, whole body variola delustering after month has become a fine big boar that sees.
The clinical research of Radix Gentianae is late father's sixties in last century, and the inventor continued clinical observation before 25 years, and year was a sophisticated research kind surplus front and back had experienced 50.The antiviral kind of Chinese medicine is a lot, can only treat common cold through these medicines such as Rhizoma Coptidis commonly used, Cortex Phellodendri, Radix Scutellariae, Radix Et Rhizoma Rhei, Folium Isatidis, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae, Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentiss, or not too serious respiratory tract infection, be used for the treatment have a liking for hepatovirus, the neurotropic virus effect is just not ideal, these Chinese medicines are effective to certain virus mostly on the one hand again, and it is invalid to other virus, but virus is of a great variety, for viral infection, be which kind of viral infection is difficult to accomplish very fast can the making a definite diagnosis of basic hospital.The Radix Gentianae antiviral effect does not have selectivity, and all viruses are all had extremely strong virus killing effect, and Radix Gentianae is the good medicine that the Nature is granted human treatment's viral infection.
Effective ingredient about Radix Gentianae, it is glycyrrhizin that Ministry of Public Health in 2003 is measured its antiviral ingredients, and the Chinese Central Television (CCTV) broadcasted at that time: our country finds that a kind of medicine has antiviral effect widely, and its composition is a glycyrrhizin, do not say the title of this medicine, this medicine is a Radix Gentianae.Glycyrrhizin is as the antiviral ingredients of Radix Gentianae, its viricidal machine-processed supposition may be to tag, because the no peplos structure of virus, be to be close to exposed DNA or RNA, as long as the nucleotide chain of virus touches glycyrrhizin, promptly lose activity, and removed by body, so shown the efficient and potent effect that Radix Gentianae is killed virus, it can not enter nucleus, so do not damage cell, may Here it is the reason of pair cell nuclear inner virus weak curative effect, hepatitis A virus (HAV) does not enter nucleus, so only took medicine 3 months, promptly thoroughly cures, and hepatitis B virus enters in the nucleus, so weak curative effect must be taken medicine and can be turned out cloudy more than half a year, some case is taken medicine and still can not be turned out cloudy in 1 year.
Toxic and side effects about Radix Gentianae, the inventor we can say that according to for many years the experience and the observation of numerous cases Radix Gentianae has no side effect, and puts down in writing as for Chinese medicine: obey impairment of YIN for a long time, just extremely bitter according to its flavor,, hardship is promptly cold, and cold is impairment of YIN, it is a kind of reasoning of flavour of a drug, have no basis, the inventor sees the patient that a part was taken medicine 2 years, does not see toxic and side effects.For the antiviral agents of pretending usefulness is arranged, to remember its teratogenesis unavoidably, because used Western medicine antiviral agents all is the nucleosides material of synthetic, replace the part nucleoside in the viral gene chain and make virally inactivated with it, and the Radix Gentianae active substance is not a nucleoside, so pair cell is not had a damaging action, the inventor also does overtesting with rabbit, female rabbit of copulation is added Radix Gentianae powder 4g in feedstuff (this amount is very big, be equivalent to more than 5 times of people's consumption) fed 15 days continuously, observation post produces rabbit, and female rabbit of all feeding Radix Gentianae does not all produce monster.As seen the Radix Gentianae effect of only killing the virus, and the effect of not damaged body.
The physicochemical property of Radix Gentianae leachate: high temperature resistant, to boil repeatedly, its character and character are constant, and be not low temperature resistant, and leachate freezes, and after the dissolving, solution becomes gets muddy, at ambient temperature, places after 2 years again, and its character is constant, still has extremely strong antiviral efficacy.
The inventor with the medicine of Radix Gentianae preparation name into: virus is clear, and meaning is promptly removed all infective virus, be a kind of wide spectrum, efficient, have no side effect antiviral drugs.
The specific embodiment
Radix Gentianae is as the application of treatment antiviral drugs, and in the treatment antiviral drugs, Radix Gentianae accounts for very weight fraction.
Radix Gentianae is as treatment antiviral drugs preparation method, and the extraction of Radix Gentianae: Radix Gentianae extract is very easily water-soluble, available digestion method, and the extraction dry is 27%-28%; Or to extract dry with percolation be 25%; Or with no aerial parts quality preferably Radix Gentianae through the sterilization after, be ground into fine powder and directly incapsulate;
The preparation oral liquid, with Radix Gentianae digestion 3 times, get and precedingly be condensed into 1: 1 or 2: 1 for 2 times altogether promptly: 2ml includes the 1g crude drug, and the 3rd time digestion liquid is used for digestion next time;
The preparation injection, must select the under ground portion of high-quality Radix Gentianae, screening is clean, be ground into fine powder, with the percolation method sepage be condensed into 1: 1 or 1: 1.5, that is: the 1ml concentrated solution includes the 1.5g crude drug, pack in the glass container, after leaving standstill 24 hours, aspirate its supernatant ampere of packing into, can use for intramuscular injection or intravenous injection.
Usage and consumption: if not too serious viral infection, as flu, herpes labialis, oral dry powder, every day, 10g got final product, or 10 milliliters of oral liquids (containing crude drug 10g).Treat more serious viral infection, oral immersion 15g (crude drug) or intramuscular injection, quiet notes 15g, (annotate: intramuscular injection, part have slight distending pain, do not sting Severe Pain and have as penicillin, intravenous drip does not have any bad sensation, and intramuscular injection and quiet notes system are in propria persona experienced).
Claims (2)
1. Radix Gentianae is characterized in that as the application of treatment antiviral drugs, and in the treatment antiviral drugs, Radix Gentianae accounts for very weight fraction.
2. Radix Gentianae is as the preparation method of treatment antiviral drugs, it is characterized in that, the extraction of Radix Gentianae: Radix Gentianae extract is very easily water-soluble, available digestion method, the extraction dry is 27%-28%, or to extract dry with percolation be 25%, or with no aerial parts quality preferably Radix Gentianae after sterilizing, be ground into fine powder and directly incapsulate;
The preparation oral liquid, with Radix Gentianae digestion 3 times, get and precedingly be condensed into 1: 1 or 2: 1 for 2 times altogether promptly: 2ml includes the 1g crude drug, and the 3rd time digestion liquid is used for digestion next time;
The preparation injection, must select the under ground portion of high-quality Radix Gentianae, screening is clean, be ground into fine powder, with the percolation method sepage be condensed into 1: 1 or 1: 1.5, that is: the 1ml concentrated solution includes the 1.5g crude drug, pack in the glass container, after leaving standstill 24 hours, aspirate its supernatant ampere of packing into, can use for intramuscular injection or intravenous injection.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1965853A (en) * | 2006-11-06 | 2007-05-23 | 中国人民解放军第四军医大学 | Application of gentiopicroside in preparation of antiviral medicament |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1965853A (en) * | 2006-11-06 | 2007-05-23 | 中国人民解放军第四军医大学 | Application of gentiopicroside in preparation of antiviral medicament |
Non-Patent Citations (3)
| Title |
|---|
| 《卫生研究》 20080930 李鑫等 龙胆抗病毒有效部位(RG2-1)体外抗呼吸道合胞病毒作用机制的初步研究 591-593 1 第37卷, 第05期 2 * |
| 《哈尔滨医科大学学报》 20070825 陈振华等 龙胆抗病毒有效部位RG3-1体外抑制呼吸道合胞病毒作用的研究 344-348 1 第41卷, 第04期 2 * |
| 《疾病控制杂志》 20070410 李鑫等 龙胆抗病毒有效部位RG2-1体外抗RSV作用的实验研究 154 1 第11卷, 第02期 2 * |
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Application publication date: 20110420 |