CN102018595A - Targeting inner ear droplet drug dispenser and use method thereof - Google Patents
Targeting inner ear droplet drug dispenser and use method thereof Download PDFInfo
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- CN102018595A CN102018595A CN 201010602665 CN201010602665A CN102018595A CN 102018595 A CN102018595 A CN 102018595A CN 201010602665 CN201010602665 CN 201010602665 CN 201010602665 A CN201010602665 A CN 201010602665A CN 102018595 A CN102018595 A CN 102018595A
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- microdroplet
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Abstract
The invention belongs to the technical field of medical appliances, in particular to a targeting inner ear droplet drug dispenser and a use method thereof. On the basis of the utilization of new material and imageology study, an ultrathin polyimide tube is connected with a micro upgrading injector to realize dispensing drug to the inner ear via the middle ear in the mode of super minimally invasive target. Single dispensing volume in rats is only 2 microlitres and is 10-20 microlitres in the human body. The live animal magnetic resonance imaging research proves that the drug can be dispensed to the inner ear by the product of the invention within half an hour and is evenly distributed on the cochlea after 3 hours, and a minimum quantity of drug is distributed in the non-curative areas, such as the middle ear and the like. Therefore, the targeting inner ear droplet drug dispenser can furthest reduce side effect caused by non-specific distribution of drug at the same time of achieving a treatment effect. The invention is superior to the market product and is an inner ear drug dispenser with the brand-new concept.
Description
Technical field
The invention belongs to technical field of medical instruments, be specifically related to a kind of internal ear microdroplet medicine dispenser and using method thereof.
Background technology
Carry out medicine through injection of tympanum to internal ear and throw in, the internal ear medicine that is considered to so far microtrauma is thrown in mode, reduces side effects of pharmaceutical drugs by the distribution of limit drug at other positions of body.Yet the drug dose that absorbs, swallows through the pharyngotympanic tube drain through middle ear mucosa enters the amount of internal ear far above it.The pharmacokinetics of internal ear requires routinely to carry out medicine and throws in, and in fact infeasible through the tympanum direct injection.Therefore, a kind of process oeil de boeuf of particular design carries out the device that medicine is thrown in to internal ear: the Silverstein MicroWick device of the U.S. has appeared on the market.But this assembly dia is very thick, needs to install and use through the middle ear ventilation duct, and wound is big, cause easily infecting, and volume injected is very big, the side effect that can't avoid the absorption at above-mentioned non-target position to cause.
Summary of the invention
The object of the present invention is to provide a kind of easy to operate, wound is little, and can avoid non-target position to absorb causing the targeting internal ear microdroplet medicine dispenser of side effect.
The inventor find that the transport of drug from middle ear to the internal ear exists oval window and two approach of oeil de boeuf, and the oval window approach is more effective than oeil de boeuf approach through secular internal ear MRI investigation.Histological research shows, the stapedial ligament that connects stapes floor and oval window is by porous fibrillin (36-kDa microfibril-associated glycoprotein, MAGP-36) and hyaluronic acid form, the oeil de boeuf than three-decker is more prone to by various medicines in theory.On this basis, the present invention has designed a kind of internal ear microdroplet medicine dispenser.This medicine dispenser is connected and forms with microsyringe (as the micro updating injection device) by ultra-fine polyimide tube, realizes that super Wicresoft targeting ground carries out medicine through middle ear to internal ear and throws in.Its structure as shown in Figure 1.
Among the present invention, the internal diameter of described ultra-fine polyimide tube is 100 μ m-140 μ m, and external diameter is 160 μ m--200 μ m.
The using method of targeting internal ear microdroplet medicine dispenser of the present invention is, carries out the micropore puncture with syringe needle on tympanum, and the aperture is less than 1 millimeter; Ultra-fine polyimide tube with targeting internal ear microdroplet medicine dispenser is implanted in the tympanum medial wall through this micropore then; When needs continue the medicine input, with the bio-compatibility binding agent ultra-fine polyimide tube is fixed in external auditory meatus, with micro updating injection device timing injectable drug.
Use this internal ear microdroplet medicine dispenser, the single volume dosed only is 2 microlitres rat, is the 10--20 microlitre the mankind.
The living animal MRI investigation confirms, product of the present invention just can be thrown in medicine to internal ear within half an hour, medicine is at the cochlea uniform distribution after 3 hours, the drug distribution of non-area for treatment such as middle ear is few, when realizing therapeutic effect, reduce the side effect that causes because of the non-special distribution of medicine to greatest extent, reduce and infect complication rate.
Description of drawings
Fig. 1 is a targeting internal ear microdroplet medicine dispenser structure chart.
Fig. 2 is that the nuclear magnetic resonance of living rats internal ear shows through the DYNAMIC DISTRIBUTION of product release gadolinium of the present invention at internal ear.
Number in the figure: 1 is microsyringe, and 2 is connection tube, and 3 is ultra-fine polyimide tube.
The specific embodiment
As shown in Figure 1, targeting internal ear microdroplet medicine dispenser of the present invention is connected to form through intermediate connection tube 2 by microsyringe 1 and ultra-fine polyimide tube 3.Wherein, microsyringe 1 adopts the micro updating injection device, and the internal diameter of ultra-fine polyimide tube 3 is 122 μ m, and external diameter is 180 μ m, and the bore at intermediate connection tube 2 two ends mates with the injection bore of microsyringe 1 and the caliber of ultra-fine polyimide tube 3 respectively.
During use, carry out small puncture with syringe needle on tympanum, the aperture is less than 1 millimeter.Ultra-fine polyimide tube 3 with targeting internal ear microdroplet medicine dispenser is implanted in the tympanum medial wall through this hole then.When needs continue the medicine input, with the bio-compatibility binding agent ultra-fine polyimide tube 3 is fixed in external auditory meatus, regularly inject (rat is 2 microlitres at every turn, and human be the 10--20 microlitre at every turn) with the micro updating injection device.Began to occur the internal ear drug distribution in 30 minutes, be evenly distributed at internal ear in 3 hours, see shown in Figure 2.
Claims (4)
1. targeting internal ear microdroplet medicine dispenser is characterized in that being connected with the micro updating injection device by ultra-fine polyimide tube and forms.
2. targeting internal ear microdroplet medicine dispenser according to claim 1, the internal diameter that it is characterized in that described ultra-fine polyimide tube are 100 μ m-140 μ m, and external diameter is 160 μ m--200 μ m.
3. the using method of a targeting internal ear microdroplet medicine dispenser as claimed in claim 1 is characterized in that carrying out the micropore puncture with syringe needle on tympanum, and the aperture is less than 1 millimeter; Ultra-fine polyimide tube with targeting internal ear microdroplet medicine dispenser is implanted in the tympanum medial wall through this micropore then; When needs continue the medicine input, with the bio-compatibility binding agent ultra-fine polyimide tube is fixed in external auditory meatus, with micro updating injection device timing injectable drug.
4. using method according to claim 3 is characterized in that the amount of injectable drug, and rat is 2 microlitres at every turn, and human be the 10--20 microlitre at every turn.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010602665 CN102018595A (en) | 2010-12-23 | 2010-12-23 | Targeting inner ear droplet drug dispenser and use method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010602665 CN102018595A (en) | 2010-12-23 | 2010-12-23 | Targeting inner ear droplet drug dispenser and use method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102018595A true CN102018595A (en) | 2011-04-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010602665 Pending CN102018595A (en) | 2010-12-23 | 2010-12-23 | Targeting inner ear droplet drug dispenser and use method thereof |
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| Country | Link |
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| CN (1) | CN102018595A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004077476A (en) * | 2002-08-01 | 2004-03-11 | Commissariat A L'energie Atomique | Apparatus for injecting/mixing liquid droplets |
| CN101528283A (en) * | 2005-01-24 | 2009-09-09 | 纽罗赛斯特克公司 | Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues |
| US20100016450A1 (en) * | 2008-07-21 | 2010-01-21 | Otonomy, Inc. | Controlled release delivery devices for the treatment of otic disorders |
-
2010
- 2010-12-23 CN CN 201010602665 patent/CN102018595A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004077476A (en) * | 2002-08-01 | 2004-03-11 | Commissariat A L'energie Atomique | Apparatus for injecting/mixing liquid droplets |
| CN101528283A (en) * | 2005-01-24 | 2009-09-09 | 纽罗赛斯特克公司 | Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues |
| US20100016450A1 (en) * | 2008-07-21 | 2010-01-21 | Otonomy, Inc. | Controlled release delivery devices for the treatment of otic disorders |
Non-Patent Citations (1)
| Title |
|---|
| 《Journal of Biomedical Materials Research Part B:Applied Biomaterials》 20081031 Jing Zou,et al Distribution of Lipid Nanocapsules in Different Cochlear Cell Populations After Round Window Membrane Permeation 第10-18页 1-4 第87B卷, 第1期 * |
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Application publication date: 20110420 |