CN102008640A - Oral preparation capable of tonifying qi and building body and preparation method thereof - Google Patents
Oral preparation capable of tonifying qi and building body and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an oral preparation capable of tonifying qi and building body, which is prepared from the following main drug-effect raw materials in parts by weight: 1000-1500 parts of ginseng, 1250-1750 parts of Chinese magnoliavine fruit, 2250-2750 parts of radix ophiopogonis, 2750-3250 parts of astragalus mongholicus, 1250-1750 parts of radix polygoni multiflori preparata, 1500-1750 parts of angelica sinensis, 1000-1500 parts of radix puerariae, 500-1000 parts of ligusticum wallichii, 500-1000 parts of safflower and 500-1000 parts of red paeony root through a conventional traditional Chinese medicine decocting method. The oral preparation is capable of tonifying qi and nourishing blood as well as building body and calming mind, and is used for improving the competitive readiness, enhancing the capabilities of physical work and brainwork such as sports tournament, training, working, travelling and the like, and reinforcing the physique of aged and elderly people and valetudinarian.
Description
Technical field
The present invention relates to a kind of drug regimen for the treatment of overstrain class deficiency syndrome, particularly a kind of is the pharmaceutical preparation that is used for benefiting qi and nourishing blood, promoting blood circulation to remove obstruction in the collateral that raw material is made with the vegetable Chinese herbal medicine, is particularly useful for sports medical science; The invention still further relates to the preparation method of this pharmaceutical preparation.
Background technology
Competitive ability reduces the category that belongs to Chinese medicine " overstrain ", " labor " is meant in all cases overworked of body, the athlete is exactly the immalleable excessive movements amount of body or has increased new excessive loads again or on the basis that last time, fatigue was not eliminated as yet under sick and wounded still unrecovered situation, the training that too early participation and body, function are incompatible etc.Record " overexertion leading to consumption of QI " in " element is asked and lifted sick opinion ", over-drastic training strain, cause the human body motive, lung qi, temper, kidney qi, gastric qi deficient, the deficiency of vital energy can not biochemical essence of water and grain, the supplement nutrition vital organs of the human body, extremity bones of the body collectively, thereby the cloudy and empty deficient symptom of a series of gas occurs, on sports medical science, claim overtraining syndrome.At present, Shang Weiyou is specially at the Chinese medicine preparation of this disease development.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of QI invigorating and keeps fit oral formulations, can benefiting qi and nourishing blood, strong body benefit is refreshing, be used to improve competitive state, improve the ability of physical work such as sports tournament, training, work, tourism and mental work, strengthen middle-aged and elderly people and valetudinarian, invalid's body constitution; For this reason, the present invention provides the preparation method that this QI invigorating is kept fit oral formulations simultaneously.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
A kind of QI invigorating is kept fit oral formulations, and the main pharmacodynamics raw material of making this Chinese medicine preparation by ratio of weight and the number of copies is: Radix Ginseng 1000-1500; Fructus Schisandrae Chinensis 1250-1750; Radix Ophiopogonis 2250-2750; Radix Astragali 2750-3250; Radix Polygoni Multiflori Preparata 1250-1750; Radix Angelicae Sinensis 1500-1750; Radix Puerariae 1000-1500; Rhizoma Chuanxiong 500-1000; Flos Carthami 500-1000; Radix Paeoniae Rubra 500-1000.
As a kind of improvement technical scheme of the present invention, the main pharmacodynamics raw material of making this Chinese medicine preparation by ratio of weight and the number of copies is: Radix Ginseng 1250; Fructus Schisandrae Chinensis 1500; Radix Ophiopogonis 2500; The Radix Astragali 3000; Radix Polygoni Multiflori Preparata 1500; Radix Angelicae Sinensis 1750; Radix Puerariae 1250; Rhizoma Chuanxiong 750; Flos Carthami 750; Radix Paeoniae Rubra 750.
Above-mentioned QI invigorating is kept fit the preparation method of oral formulations, the steps include: described ten flavor pharmacodynamic raw materials mixing by ratio of weight and the number of copies, decoct with water 1-4 time, and each 1-4 hour, filtration, merging filtrate is condensed into thick paste; Add 3～9 times of amount ethanol, shake up, leave standstill, get supernatant, residue adds 1-4 and doubly measures 65-95% ethanol, shakes up, and leaves standstill, and gets supernatant, merges supernatant twice, reclaims ethanol, is condensed into thick paste; Figuration and preparation, promptly.
As a kind of improvement technical scheme of preparation method of the present invention, its preparation process is: described ten flavor pharmacodynamic raw materials are mixing by ratio of weight and the number of copies, decoct with water 2 times, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate is condensed into thick paste; Add 5.5-6 and doubly measure ethanol, shake up, leave standstill, get supernatant, residue adds 2 times of amount 85% ethanol, shakes up, and leaves standstill, and gets supernatant, merges supernatant twice, reclaims ethanol, is condensed into thick paste; Add cane sugar powder, mixing is made granule, drying, promptly.
A kind of improvement technical scheme as preparation method of the present invention; the concrete operations of described figuration and preparation step are; the gained thick paste adds or dry back adding cane sugar powder or other pharmaceutically acceptable excipient for the second time; make granule or other acceptable clinically pills, drop pill, tablet, capsule, suspensoid, oral liquid, promptly.
Adopt the beneficial effect that technique scheme produced to be:
Function of the present invention cures mainly: benefiting qi and nourishing blood, strong body benefit are refreshing, are used to improve competitive state, improve the ability of physical work such as sports tournament, training, work, tourism and mental work, strengthen middle-aged and elderly people and valetudinarian, invalid's body constitution.
Pharmacological action of the present invention: we are that to close the Radix Astragali be principal agent to SHENGMAI SAN with Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis.The Radix Astragali and ginseng compatibility, Radix Ginseng is not relatively from strong, and invigorating primordial QI, blood promotes the production of body fluid.Going back compatibility in addition has Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Flos Carthami, the function of tool inrigorating qi and promoting blood circulation, and Radix Astragali power obligate is walked, all row whole bodies, the power with the moving all medicines of boosting makes the prosperous blood of gas capable, tonify without causing stagnation.Chinese angelica blood supplementing and blood, Radix Polygoni Multiflori the liver and the kidney tonifying, nourishing blood to expel wind, Radix Puerariae yang invigorating expelling pathogenic factors from muscles, relieving restlessness are quenched the thirst, and three medicines are combined into accessory drugs.Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra are arranged among the we, quite like SIWU TANG, but Radix Rehmanniae Preparata of no use, and used baked polygonum capitatum simply, Radix Polygoni Multiflori effect is similar to Radix Rehmanniae Preparata, does not have cold and heat, the greasy fraud that stagnates but character is gentle.Change the Radix Paeoniae Alba into Radix Paeoniae Rubra in addition, get the property of its heat clearing away.Radix Puerariae is in this side, and the ginseng of both can having help others is carried gas, can help Radix Ophiopogonis, Fructus Schisandrae Chinensis to promote the production of body fluid again.Adjuvant Flos Carthami, Radix Paeoniae Rubra, Rhizoma Chuanxiong three medicines can both promoting blood circulation to disperse blood clots and relieves pain, and the Radix Paeoniae Rubra bitter cold is let out stagnant heat in the blood, the stagnation of QI in the hot warm promoting the circulation of blood of Rhizoma Chuanxiong, and Flos Carthami can stimulate the menstrual flow by blood stasis dispelling, the then cold Wen Xiangji that matches, the blood circulation and removing stasis pain relieving, effect is stronger.All medicine compatibilities close the Radix Astragali based on the SHENGMAI SAN of benefiting QI and nourishing blood, assist a ruler in governing a country with things such as promoting flow of QI and blood the liver and the kidney tonifying and blood, finish benefiting qi and nourishing blood, strong body benefit god's effect jointly.
Benefiting qi and nourishing blood of the present invention, promoting blood circulation to remove obstruction in the collateral are evident in efficacy.Test shows, after serveing on 3-5 days present compositions between athlete's match period, can be by QI invigorating, tonifying YIN, invigorate blood circulation, improve corticocerebral ability to work, make the metabolic capacity of each system vigorous, the supply of oxygen and energy when promoting violent match the, the maximum potential of performance body, reach and improve competitive state, improve the purpose of competitive ability.Simultaneously, verify that through clinical practice this preparation has no adverse reaction, toxicity is less, and is safe and reliable.
Below the test example further illustrates beneficial effect of the present invention.Wherein employed outturn sample of the present invention is the granule product of following embodiment 1 preparation.Usage and dosage of the present invention is during human trial: boiled water is taken after mixing it with water, a 15g.
Test example 1 is observed swimming continuance time and the hypoxia endurance time variation after white mice is taken the present invention
Test (1) white mice swimming with a load attached to the body breakdown test.
Purpose: observe white mice and take behind the particulate decocting liquid of the present invention's preparation influence to its swimming ability.
Method: select 70 of healthy male white mouses, body weight 17-20 gram, equal fasting is 12 hours before the test, and is divided into 2 groups at random, 35 every group, carries out following processing respectively: matched group, irritate stomach with normal saline 0.3ml; Test group, for fear of the influence of sugar to test, the particulate decocting liquid 0.3ml that uses the present invention's preparation instead irritates stomach (being equivalent to crude drug 0.61 gram).
Test: above two treated animals are irritated stomach and are carried out the swimming with a load attached to the body breakdown test after 2 hours, every mice institute loading weight is 5% of its body weight, tie up behind forelimb, be equivalent to 2-3 thoracic vertebra place, elasticity is suitable to be as the criterion with not slippage, put into 37 ℃ ± 1 ℃ sea water bath at one time after tying up, write down its swimming lethal time.
The result: result of the test sees Table 1.
Table 1. white mice swimming with a load attached to the body breakdown test result relatively
Analyze: by table 1 as seen, test group obviously prolongs than matched group swimming with a load attached to the body ability, and learning processing P value by statistics has very significant difference less than 0.01, illustrates that the particulate decocting liquid of the present invention's preparation has remarkable result to the motor capacity that improves white mice.
Test (2) white mice hypoxia endurance test.
Purpose: observe white mice and take behind the particulate decocting liquid of the present invention's preparation influence to its hypoxia-bearing capability.
Method and test: this test is selected 80 of white mice according to test (1) condition, handles with two kinds of dosage regimens then:
A kind of is that 40 white mice are divided into test group, matched group at random, every group each 20, test group is irritated stomach 1 time with decocting liquid 0.3ml of the present invention, matched group with the equivalent normal saline, puts into the airtight wide-mouth mill of 150ml bottle after 2 hours respectively, observes its caused by anoxia dead time.
Another kind is that 20 white mice are divided into 2 groups, and test group with the equivalent normal saline, was regularly irritated stomach morning and afternoon every day each 1 day with decocting liquid 0.4ml of the present invention, matched group, and for three days on end, the same method is observed its caused by anoxia dead time.
The result: result of the test sees Table 2,3.
Analyze: as seen by table 2,3, two kinds of scheme result of the tests of anoxia enduring are roughly the same, test group is respectively P value＜0.05 and P value＜0.01, significant difference is all arranged, but more remarkable with latter's scheme, illustrate that decocting liquid of the present invention has remarkable result (but accumulated dose should not be too little) to the ability that improves the white mice anoxia enduring.
The outdoor fixed quantitative load of test example 2 athletes is taken the effect observation of sample of the present invention.
Object: 6 of amateur sports school, Hebei province swimmers (being freestyle swimming), wherein the male is 4,2 of women; 4 of the track and field team members of Hebei province Sports Group are the women, amount to 10.
Method: adopt double blinding dual analog Self-control method.Divide and carry out for 2 times, negative sample was taken in test for the first time in preceding 2-2.5 hour, be placebo (coach and athlete all do not know the details), for the second time every 1-2 days, took equivalent sample of the present invention (identical) in 2-2.5 hour before the test, observe influence sports achievement and vital capacity with the placebo profile of taking last time.
Allow the swimmer repeat to swim 4 * 100 meters, 4 * 100 meters of athlete's repetition runnings, the 1st time and the 2nd interval 1 minute; The 2nd time and the 3rd interval 2 minutes; The 3rd time and the 4th interval 3 minutes.The athlete will swim or run at every turn to full capacity, writes down vital capacity after the achievement of each race or trip and experiment work finish to have a rest 2 minutes (all test 2 times, select wherein data are once bigger) by the couch.
The external environmental condition of each test keeps being equal to, and test period, personnel and instrument immobilize, and allows the athlete to do the warm up that is fit to oneself.
The result: take the swimmer of placebo, along with the prolongation of movement time, fatigue phenomenon has appearred in body, and sports achievement descends, and the average speed of the 2nd 100 meters trips has on average descended 2.27 seconds than 100 meters trips for the first time; Take the athlete of placebo, the 2nd time 100 meters average speed than for the first time 100 meters descended 0.3 second.
Take the test result of sample of the present invention, significant change has taken place in swimmer's achievement and vital capacity, among 6 swimmers, when the 1st time 100 meters ratios are taken placebo, has 3 to improve achievement.From the contrast of average achievement as can be seen, the 1st time 100 meters improved 0.15 second; Improved 1.74 seconds for the 2nd time; Improved 1.64 seconds for the 3rd time; The 4th improved 1.35 seconds, and all the test than " placebo " is significantly increased.Wherein the 3rd time and the 4th have surpassed the achievement of the 2nd trip, wherein there is the achievement of 100 meters of 3 the 4th but to surpass 100 meters achievement for the first time, illustrate that speed endurance does not only have to descend to increase on the contrary, the meansigma methods of vital capacity is also than 400 milliliters of the improves of obeying " placebo " simultaneously.
Significant change has equally also taken place in athlete's achievement and vital capacity, in 4 team members, the 1st time 100 meters have 3 to improve achievement.From the contrast of average achievement as can be seen, the 1st time 100 meters improved 0.03 second; Improved 0.23 second for the 2nd time; Improved 0.25 second for the 3rd time; The 4th improved 0.2 second, and all the test than " placebo " is significantly increased.The meansigma methods of vital capacity improves 200 milliliters.
The indoor fixed quantitative load of test example 3 athletes is taken the effect observation of sample of the present invention.
Each 8 of national team's swimming, athletes, 2 of the cyclists of provinces and cities, be divided into test group and matched group, physical examination and laboratory fixed quantitative load (treadmill function experiment and PWC170 constitution test) before and after having carried out taking medicine require the couch respectively to carry out once technical test before and after the athlete takes the present invention.
Result of the test shows that pulse, blood pressure, pneusomete flicker value etc. had no significant change when the athlete was quiet before and after taking the present invention.But treadmill index ratio was taken the preceding balanced growth 10.28 of the present invention, PWC balanced growth 117.92 before and after the mensuration of test of treadmill fixed quantitative load and PWC170, test group were taken the present invention.Test group comparison ability to work before and after taking the present invention all is significantly improved, and with matched group significant difference (P＜0.01 is arranged relatively; P＜0.05).Show that the present invention has the effect that improves the athletes ' body ability to work.
Take Evaluation on effect of the present invention between 4 pairs of 86 athlete's match periods of test example.
The athlete observes athlete's whole body and local fatigue after taking the present invention between match period there is a change for the better, and mental status, appetite, sleep are made moderate progress; Athlete's sensory recovery of 40.5% is better than past; What 47.3% athlete was total feels that improvement is arranged; 43.1% athlete has improved sports achievement in play.All take athlete of the present invention except that seminal emission, abdominal distention are arranged individually, and other all do not have uncomfortable reaction.
The specific embodiment
Following examples describe the present invention in detail.Prepare various raw material used in the present invention and items of equipment and be conventional commercially available prod, all can buy directly acquisition by market.
Embodiment 1
A kind of QI invigorating is kept fit oral formulations, and the main pharmacodynamics raw material of making this Chinese medicine preparation by ratio of weight and the number of copies is: Radix Ginseng 1250; Fructus Schisandrae Chinensis 1500; Radix Ophiopogonis 2500; The Radix Astragali 3000; Radix Polygoni Multiflori Preparata 1500; Radix Angelicae Sinensis 1750; Radix Puerariae 1250; Rhizoma Chuanxiong 750; Flos Carthami 750; Radix Paeoniae Rubra 750.
The preparation method of present embodiment product is: above ten flavors, decoct with water 2 times, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate is condensed into thick paste, adds 5.5-6 and doubly measures ethanol, shake up, leave standstill, get supernatant, residue adds 2 times of amount 85% ethanol, shake up, leave standstill, get supernatant, merge supernatant twice, reclaim ethanol, be condensed into thick paste, add cane sugar powder an amount of (consumption of cane sugar powder is: make every 15g raw medicinal herbs make the 10g product particle), mixing, make granule, drying, promptly.
Embodiment 2
A kind of QI invigorating is kept fit oral formulations, and its main pharmacodynamics material composition is with embodiment 1.
The preparation method of present embodiment product is: above-mentioned ten flavor pharmacodynamic raw materials, decoct with water 2 times, 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate is condensed into thick paste, adds cane sugar powder an amount of (consumption of cane sugar powder is: make every 15g raw medicinal herbs make the 10g product particle), mixing, make granule, drying, promptly.
Embodiment 3
A kind of QI invigorating is kept fit oral formulations, and the main pharmacodynamics raw material of making this Chinese medicine preparation by ratio of weight and the number of copies is: Radix Ginseng 1500; Fructus Schisandrae Chinensis 1750; Radix Ophiopogonis 2750; The Radix Astragali 3250; Radix Polygoni Multiflori Preparata 1750; Radix Angelicae Sinensis 1500; Radix Puerariae 1000; Rhizoma Chuanxiong 500; Flos Carthami 500; Radix Paeoniae Rubra 500.
The preparation method of present embodiment product is with embodiment 1.
Embodiment 4
A kind of QI invigorating is kept fit oral formulations, and the main pharmacodynamics raw material of making this Chinese medicine preparation by ratio of weight and the number of copies is: Radix Ginseng 1000; Fructus Schisandrae Chinensis 1250; Radix Ophiopogonis 2250; The Radix Astragali 2750; Radix Polygoni Multiflori Preparata 1250; Radix Angelicae Sinensis 1500; Radix Puerariae 1000; Rhizoma Chuanxiong 500; Flos Carthami 500; Radix Paeoniae Rubra 500.
The preparation method of present embodiment product is with embodiment 2.
In addition, the dried cream mixture of the above embodiment of the present invention preparation can be used for preparing clinically the raw material of oral formulations such as tablet, granule, powder, oral liquid, pill, drop pill.
Foregoing description only proposes as the enforceable technical scheme of the present invention, not as the single restrictive condition to its technical scheme itself.
Claims (5)
1. a QI invigorating is kept fit oral formulations, it is characterized in that the main pharmacodynamics raw material of making this Chinese medicine preparation by ratio of weight and the number of copies is: Radix Ginseng 1000-1500; Fructus Schisandrae Chinensis 1250-1750; Radix Ophiopogonis 2250-2750; Radix Astragali 2750-3250; Radix Polygoni Multiflori Preparata 1250-1750; Radix Angelicae Sinensis 1500-1750; Radix Puerariae 1000-1500; Rhizoma Chuanxiong 500-1000; Flos Carthami 500-1000; Radix Paeoniae Rubra 500-1000.
2. QI invigorating according to claim 1 is kept fit oral formulations, and it is characterized in that: the main pharmacodynamics raw material of making this Chinese medicine preparation by ratio of weight and the number of copies is: Radix Ginseng 1250; Fructus Schisandrae Chinensis 1500; Radix Ophiopogonis 2500; The Radix Astragali 3000; Radix Polygoni Multiflori Preparata 1500; Radix Angelicae Sinensis 1750; Radix Puerariae 1250; Rhizoma Chuanxiong 750; Flos Carthami 750; Radix Paeoniae Rubra 750.
3. each described QI invigorating of claim 1-2 is kept fit the preparation method of oral formulations, and its characterization step is: described ten flavor pharmacodynamic raw materials are mixing by ratio of weight and the number of copies, decoct with water 1-4 time, and each 1-4 hour, filtration, merging filtrate is condensed into thick paste; Add 3～9 times of amount ethanol, shake up, leave standstill, get supernatant, residue adds 1-4 and doubly measures 65-95% ethanol, shakes up, and leaves standstill, and gets supernatant, merges supernatant twice, reclaims ethanol, is condensed into thick paste; Figuration and preparation, promptly.
4. QI invigorating according to claim 3 is kept fit the preparation method of oral formulations, and its characterization step is: described ten flavor pharmacodynamic raw materials are mixing by ratio of weight and the number of copies, decocts with water 2 times, 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate is condensed into thick paste; Add 5.5-6 and doubly measure ethanol, shake up, leave standstill, get supernatant, residue adds 2 times of amount 85% ethanol, shakes up, and leaves standstill, and gets supernatant, merges supernatant twice, reclaims ethanol, is condensed into thick paste; Add cane sugar powder, mixing is made granule, drying, promptly.
5. QI invigorating according to claim 3 is kept fit the preparation method of oral formulations; it is characterized in that: the concrete operations of described figuration and preparation step are; the gained thick paste adds or dry back adding cane sugar powder or other pharmaceutically acceptable excipient for the second time; make granule or other acceptable clinically pills, drop pill, tablet, capsule, suspensoid, oral liquid, promptly.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104645229A (en) * | 2015-02-04 | 2015-05-27 | 北京全净通一科技有限公司 | Five-element medicated bath decoction and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732562A (en) * | 2009-12-29 | 2010-06-16 | 四川省中医药科学院中医研究所 | Traditional Chinese medicine for tonifying kidneys, strengthening heart, dissipating blood stasis and activating collaterals |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101732562A (en) * | 2009-12-29 | 2010-06-16 | 四川省中医药科学院中医研究所 | Traditional Chinese medicine for tonifying kidneys, strengthening heart, dissipating blood stasis and activating collaterals |
Non-Patent Citations (1)
| Title |
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| 《卫生部颁药品标准中药成分制剂第二十册》 19981231 药典委员会 益气强身颗粒 287 1-5 , 2 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104645229A (en) * | 2015-02-04 | 2015-05-27 | 北京全净通一科技有限公司 | Five-element medicated bath decoction and preparation method thereof |
| CN104645229B (en) * | 2015-02-04 | 2018-02-13 | 北京全净通一科技有限公司 | A kind of five-element's dipping dissipates and preparation method |
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Inventor after: Tao Jun Inventor after: Zhang Hua Inventor after: Ban Shuxian Inventor after: Zhang Linyu Inventor after: Hua Qianli Inventor after: Wang Naihao Inventor after: Xu Jin Inventor before: Tao Jun Inventor before: Xu Jin Inventor before: Hua Qianli Inventor before: Wang Naihao Inventor before: Ban Shuxian |
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Free format text: CORRECT: INVENTOR; FROM: TAO JUN XU JIN HUA QIANLI WANG NAIHAO BAN SHUXIAN TO: TAO JUN ZHANG HUA BAN SHUXIAN ZHANG LINYU HUA QIANLI WANG NAIHAO XU JIN |
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