CN102008315B - 一种ct、mri同步检测定位针 - Google Patents
一种ct、mri同步检测定位针 Download PDFInfo
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- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
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Abstract
本发明公开了一种CT、MRI同步检测定位针，包括硅胶管，硅胶管内设有引导针，引导针两侧设有空腔，空腔内设有隔膜，将空腔分为若干小室，小室内置有液体，其中，位于引导针一侧的若干小室内置有CT对比剂，位于引导针另一侧的若干小室内置有MRI对比剂。本发明采用活体内植入特别设计的硅胶定位针，并通过多平面重建技术，达到不同的影像资料和病理资料的同步比较，可广泛用于肿瘤实验研究。
Description
技术领域
本发明涉及一种CT、MRI同步检测定位针。
背景技术
目前，功能影像学的发展使CT和MRI能够测量越来越多的功能性指标，如血流灌注参数，反映氧供情况的参数。实际应用时，为与组织病理学切片或免疫组化切片图像做到一一对应，准确的评价其效果，需要一种可靠的同步定位装置和方法。
发明内容
针对上述现有技术，本发明提供了一种CT、MRI同步检测定位针。
本发明是通过以下技术方案实现的：
一种CT、MRI同步检测定位针，包括硅胶管，硅胶管内设有引导针，引导针两侧设有空腔，空腔内设有隔膜，将空腔分为若干小室，小室内置有液体，其中，位于引导针一侧的若干小室内置有CT对比剂，位于引导针另一侧的若干小室内置有MRI对比剂，包绕每个小室的硅胶管制成不同颜色。
所述置有CT对比剂的小室有5-20个，置有MRI对比剂的小室与CT对比剂的小室数量相同。小室内对比剂的浓度可以根据情况和需求来确定。
优选的，置有CT对比剂的小室有10个，其中，每个小室内CT对比剂的浓度(碘浓度)依次为：300mg/ml，150mg/ml，75mg/ml，40mg/ml，20mg/ml，10mg/ml，5mg/ml，2.5mg/ml，1.25mg/ml，0.625mg/ml；相对应地，置有MRI对比剂的小室也有10个，其中，每个小室内MRI对比剂的浓度依次为：0.5mol/L，0.25mol/L，0.125mol/L，0.0625mol/L，0.03125mol/L，0.02mol/L，0.01mol/L，0.005mol/L，0.0025mol/L，0.00125mol/L。
所述硅胶管外缘设有至少一个缺口，方便识别所用。当需要多个定位针时，可选用不同缺口数的针，以便区别。
所述置有CT对比剂的小室与置有MRI对比剂的小室的硅胶壁的颜色不相同，以便区别。
制备时，预先将CT对比剂和MRI对比剂置于小室内，然后密封。
使用时，将荷瘤动物麻醉，根据精度需要将2-3根将定位针插入瘤体内，拔除引导针，即可根据需要进行CT或MRI扫描显像，定位针在断层图像上显示为信号强度梯度变化的标记，根据对应的信号强度，可知道CT和MRI显像的相对位置，并可据此进行图像的重叠(或融合)；在处死动物以后，将瘤组织取出，经常规病理组织切片后，与CT或MRI对比剂小室相对应的硅胶壁呈现不同的颜色，故可知道病理切片与CT或MRI扫描结果的相对位置。
本发明采用活体内植入特别设计的硅胶定位针，并通过多平面重建技术，达到不同的影像资料和病理资料的同步比较，可广泛用于肿瘤实验研究。
附图说明
图1为本发明的结构示意图；
图2为本发明的横截面结构示意图；
图3为本发明的纵截面结构示意图。
其中，1、硅胶管；2、引导针；3、空腔；4、缺口；5、隔膜；6、小室。
具体实施方式
下面结合附图和实施例对本发明作进一步的说明。
一种CT、MRI同步检测定位针，包括硅胶管1，硅胶管1内设有引导针2，如图1、图2、图3所示，引导针2两侧设有空腔3，空腔3内设有隔膜5，将空腔3分为若干小室6，小室6内置有液体，其中，位于引导针2一侧的若干小室6内置有CT对比剂，位于引导针2另一侧的若干小室6内置有MRI对比剂。
置有CT对比剂的小室有10个，如图3所示，其中，每个小室内CT对比剂的浓度(碘浓度)依次为：300mg/ml，150mg/ml，75mg/ml，40mg/ml，20mg/ml，10mg/ml，5mg/ml，2.5mg/ml，1.25mg/ml，0.625mg/ml；相对应地，置有MRI对比剂的小室也有10个，其中，每个小室内MRI对比剂的浓度依次为：0.5mol/L，0.25mol/L，0.125mol/L，0.0625mol/L，0.03125mol/L，0.02mol/L，0.01mol/L，0.005mol/L，0.0025mol/L，0.00125mol/L。
所述硅胶管外缘设有缺口，方便识别所用。
制备时，预先将CT对比剂和MRI对比剂置于小室内，然后密封。
使用时，将荷瘤动物麻醉，根据精度需要将2-3根将定位针插入瘤体内，拔除引导针，即可根据需要进行CT或MRI扫描显像，定位针在断层图像上显示为信号强度梯度变化的标记，根据对应的信号强度，可知道CT和MRI显像的相对位置，并可据此进行图像的重叠(或融合)；在处死动物以后，将瘤组织取出，经常规病理组织切片后，与CT或MRI对比剂小室相对应的硅胶壁呈现不同的颜色，故可知道病理切片与CT或MRI扫描结果的相对位置。
本发明采用活体内植入特别设计的硅胶定位针，并通过多平面重建技术，达到不同的影像资料和病理资料的同步比较，可广泛用于肿瘤实验研究。
Claims (5)
1.一种CT、MRI同步检测定位针，其特征在于：包括硅胶管，硅胶管内设有引导针，引导针两侧设有空腔，空腔内设有隔膜，将空腔分为若干小室，小室内置有液体，其中，位于引导针一侧的若干小室内置有CT对比剂，位于引导针另一侧的若干小室内置有MRI对比剂。
2.根据权利要求1所述的一种CT、MRI同步检测定位针，其特征在于：所述置有CT对比剂的小室有5-20个，置有MRI对比剂的小室与CT对比剂的小室数量相同。
3.根据权利要求2所述的一种CT、MRI同步检测定位针，其特征在于：所述置有CT对比剂的小室有10个，其中，每个小室内CT对比剂的浓度依次为：300mg/ml，150mg/ml，75mg/ml，40mg/ml，20mg/ml，10mg/ml，5mg/ml，2.5mg/ml，1.25mg/ml，0.625mg/ml；相对应地，置有MRI对比剂的小室也有10个，其中，每个小室内MRI对比剂的浓度依次为：0.5mol/L，0.25mol/L，0.125mol/L，0.0625mol/L，0.03125mol/L，0.02mol/L，0.01mol/L，0.005mol/L，0.0025mol/L，0.00125mol/L。
4.根据权利要求1所述的一种CT、MRI同步检测定位针，其特征在于：所述硅胶管外缘设有至少一个缺口。
5.根据权利要求1所述的一种CT、MRI同步检测定位针，其特征在于：所述置有CT对比剂的小室与置有MRI对比剂的小室的硅胶壁的颜色不相同。
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| CN 201110001927 CN102008315B (zh) | 2011-01-06 | 2011-01-06 | 一种ct、mri同步检测定位针 |
| US13/377,044 US8588888B2 (en) | 2011-01-06 | 2011-04-25 | CT and MRI synchronous detection positioning needle |
| PCT/CN2011/000716 WO2012092692A1 (zh) | 2011-01-06 | 2011-04-25 | 一种ct、mri同步检测定位针 |
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| CN102008315B (zh) * | 2011-01-06 | 2012-04-04 | 山东大学 | 一种ct、mri同步检测定位针 |
| US8588888B2 (en) | 2011-01-06 | 2013-11-19 | Shandong University | CT and MRI synchronous detection positioning needle |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1644162A (zh) * | 2005-01-17 | 2005-07-27 | 天津医科大学总医院 | 立体定向头颅pet－ct和mri影像融合检查方法及装置 |
| CN201244277Y (zh) * | 2008-08-08 | 2009-05-27 | 宋开友 | 一种新型血管造影用导管 |
| CN201929968U (zh) * | 2011-01-06 | 2011-08-17 | 山东大学 | 一种ct、mri同步检测定位针 |
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| JPS63294838A (ja) * | 1987-05-27 | 1988-12-01 | Nec Corp | 放射線治療計画装置 |
| US6419680B1 (en) * | 1993-06-10 | 2002-07-16 | Sherwood Services Ag | CT and MRI visible index markers for stereotactic localization |
| US5713828A (en) * | 1995-11-27 | 1998-02-03 | International Brachytherapy S.A | Hollow-tube brachytherapy device |
| US7691087B2 (en) * | 2002-11-25 | 2010-04-06 | Scimed Life Systems, Inc. | Injection device |
| EP1741469A1 (en) * | 2005-07-08 | 2007-01-10 | Engineers & Doctors Wallstén Medical A/S | Method of guiding an irradiation equipment |
| US20090217932A1 (en) * | 2008-03-03 | 2009-09-03 | Ethicon Endo-Surgery, Inc. | Intraluminal tissue markers |
| CN101513357B (zh) * | 2009-03-23 | 2011-06-01 | 祝慧鹏 | 股动脉顺行穿刺针 |
| CN201591856U (zh) * | 2010-01-21 | 2010-09-29 | 张庆玲 | 医用档案消毒柜 |
| CN102008315B (zh) * | 2011-01-06 | 2012-04-04 | 山东大学 | 一种ct、mri同步检测定位针 |
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| CN1644162A (zh) * | 2005-01-17 | 2005-07-27 | 天津医科大学总医院 | 立体定向头颅pet－ct和mri影像融合检查方法及装置 |
| CN201244277Y (zh) * | 2008-08-08 | 2009-05-27 | 宋开友 | 一种新型血管造影用导管 |
| CN201929968U (zh) * | 2011-01-06 | 2011-08-17 | 山东大学 | 一种ct、mri同步检测定位针 |
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Inventor after: Ma Dedong Inventor after: Xiao Wei Inventor after: Lu Hongxiu Inventor after: Zeng Qingshi Inventor before: Ma Dedong Inventor before: Xiao Wei Inventor before: Xu Lisheng Inventor before: Zheng Chunyan Inventor before: Lu Hongxiu Inventor before: Xue Yuwen |
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