CN102002434A - Gallnut times flower oil combination and preparation method thereof - Google Patents
Gallnut times flower oil combination and preparation method thereof Download PDFInfo
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- CN102002434A CN102002434A CN 201010578998 CN201010578998A CN102002434A CN 102002434 A CN102002434 A CN 102002434A CN 201010578998 CN201010578998 CN 201010578998 CN 201010578998 A CN201010578998 A CN 201010578998A CN 102002434 A CN102002434 A CN 102002434A
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Abstract
The invention provides a gallnut times flower oil combination and a preparation method thereof. The gallnut times flower oil combination is prepared according to the following steps of: continuously lixiviating times flower and an organic solvent for 1 to 5 times with 0.5 to 1 hour at a time through a hot reflux method or a percolation method between the room temperature and 95 DEG C, filtering, evaporating a filter liquor and recovering the solvent to obtain the gallnut times flower oil combination. Alternatively, the gallnut times flower oil combination is prepared according to the following steps of: extracting raw materials for separation by utilizing supercritical CO2 between the room temperature and 90 DEG C at the pressure of 5 Mpa to 50 Mpa, and decompressing for separation to obtain the gallnut oil. The gallnut times flower oil combination mainly comprises unsaturated fatty acid, saturated fatty acid and a free fatty acid compound, wherein the unsaturated fatty acid accounts for 18 to 25%; and the saturated fatty acid accounts for 65 to 74%. The products of the invention can be used for producing medicaments for treating diabetes.
Description
Technical field
The present invention relates to doubly spend fat or oil composition that extracts into raw material and preparation method thereof with Turkey-galls.
Background technology
Turkey-galls is China's characteristic Forest products, and output accounts for world's gross output 95%, is the large outlet Chinese medicinal materials of China.Have the title of " Chinese Turkey-galls " in the world.Turkey-galls national standard (GB5848-86) is divided into angle times class, tripe times class, times flower class three classes with commodity, the angle doubly, tripe times hydrolyzable tannin (tannin) content is up to 60.0 ~ 67.0%, quality better, record into Pharmacopoeia of the People's Republic of China conventional Chinese medicine material, doubly the flower class is because of tannin content low (〉=30%), and resource does not make full use of.
Domesticly in recent years hypoglycemic pharmacology of Turkey-galls and active principle are furtherd investigate, it is Chinese gall oil that clear and definite Turkey-galls is controlled " quenching one's thirst " hypoglycemic main ingredient, main chemical compositions is 8 kinds of lipid acid such as capric acid, lauric acid, tetradecanoic acid, palmitinic acid, stearic acid, grease, linolic acid, linolenic acid, and develops Chinese medicine two kind new medicines that are used for the treatment of the diabetes B Chinese gall oil.But existing bibliographical information with the angle doubly, the Chinese gall oil yield extracted of tripe times Chinese medicinal materials is extremely low, generally only 0.8 ~ 2.4%, in addition the angle doubly, tripe times resource-constrained, the price of medicinal material height, the clinical preparation medication is limited to.
Summary of the invention
The object of the present invention is to provide a kind of people is times the caul-fat composition and the method thereof of raw material extraction with flower doubly, and it has obtained component and Chinese gall oil is close, and oil yield is up to 7.5% times caul-fat composition.
For achieving the above object, embodiment of the present invention are: a kind of Turkey-galls times caul-fat oil/fat composition, made by following method: will doubly spend and reject a stalk, coarse crushing is the ratio adding organic solvent of 1:3 ~ 30g/mL in doubly spending with the weightmeasurement ratio of organic solvent, in room temperature to 95 ℃, heat reflow method or percolation continuous extraction 1 ~ 5 time each 0.5 ~ 1 hour, filter, solvent is reclaimed in the filtrate evaporation, gets shallow pale brown oily liquids.
Doubly to spend aphid or Zhou Shi doubly to spend aphid to cause 4 classes that goitre forms doubly colored for a flower aphid doubly, red times of colored aphid, iron for described times of flower.
Described organic solvent is sherwood oil, 6# solvent, normal hexane or ethyl acetate.
Turkey-galls of the present invention times caul-fat oil/fat composition also can be made by following method: with the raw material supercritical CO
2Extracting and separating, extraction temperature are room temperature to 90 ℃, pressure 5Mpa ~ 50Mpa, and decompression separation is produced times caul-fat.
Turkey-galls of the present invention times caul-fat oil/fat composition mainly is made up of unsaturated fatty acids, saturated fatty acid and free fatty acids compounds, contains unsaturated fatty acids 18 ~ 25%, saturated fatty acid 65 ~ 74%; Unsaturated fatty acids mainly comprises oleic acid, linoleic acid plus linolenic acid compounds, and saturated fatty acid mainly comprises capric acid, lauric acid, tetradecanoic acid, palmitinic acid and stearic acid compound.
Embodiment
Embodiment 1: gets and doubly spends 100g, the adding sherwood oil (60 ~ 90 ℃, boiling range, down together) 500 mL, and be heated to 60 ℃ of backflow 2h, filter; Filter residue adds sherwood oil (60 ~ 90 ℃) 500 mL secondary thermal backflow lixiviate 2h, filters; Merging filtrate reclaims sherwood oil, makes Turkey-galls times caul-fat fat 6.1g.
Embodiment 2: get and doubly spend 100g, add sherwood oil (30 ~ 60 ℃) 500 mL, be heated to 60 ℃ of backflow 2h, filter; Filter residue adds sherwood oil (30 ~ 60 ℃) 500 mL secondary thermal backflow lixiviate 2h, filters; Merging filtrate reclaims sherwood oil, makes Turkey-galls times caul-fat fat 5.8g.
Embodiment 3: get and doubly spend 100g, add sherwood oil (30 ~ 60 ℃) 500 mL, be heated to 40 ℃ of backflow 6h, filter; Filter residue adds sherwood oil (30 ~ 60 ℃) 500 mL secondary thermal backflow lixiviate 6h, filters; Merging filtrate reclaims sherwood oil, makes Turkey-galls times caul-fat fat 5.4g.
Embodiment 4: get and doubly spend 100g, add 6# solvent 500 mL, be heated to 40 ℃ of backflow 2h, filter; Filter residue adds 6# solvent 500 mL secondary thermal backflow lixiviate 2h, filters; Merging filtrate reclaims the 6# solvent, makes Turkey-galls times caul-fat fat 5.2g.
Embodiment 5: get and doubly spend 100g, add 6# solvent 500 mL, be heated to 40 ℃ of backflow 2h, filter; Filter residue adds 6# solvent 500 mL secondary thermal backflow lixiviate 2h, filters; Filter residue adds three thermal backflow lixiviates of 6# solvent 500 mL 2h, filters; Merging filtrate reclaims the 6# solvent, makes Turkey-galls times caul-fat fat 5.9g.
Embodiment 6: get and doubly spend 100g, add 6# solvent 2000 mL, be heated to 70 ℃ of backflow 4h, filter, reclaim the 6# solvent, make Turkey-galls times caul-fat fat 6.5g.
Embodiment 7: get and doubly spend 100g, add normal hexane 500 mL, be heated to 40 ℃ of backflow 6h, filter; Filter residue adds normal hexane 500 mL secondary thermal backflow lixiviate 6h, filters; Merging filtrate reclaims normal hexane, makes Turkey-galls times caul-fat fat 5.5g.
Embodiment 8: get and doubly spend 100g, add normal hexane 500 mL, be heated to 60 ℃ of backflow 6h, filter; Filter residue adds normal hexane 500 mL secondary thermal backflow lixiviate 6h, filters; Merging filtrate reclaims normal hexane, makes Turkey-galls times caul-fat fat 5.9g.
Embodiment 9: get and doubly spend 100g, add ethyl acetate 500 mL, be heated to 60 ℃ of backflow 6h, filter; Filter residue adds ethyl acetate 500 mL secondary thermal backflow lixiviate 6h, filters; Merging filtrate reclaims ethyl acetate, makes Turkey-galls times caul-fat fat 7.2g.
Embodiment 10: get and doubly spend 1000g, put supercritical CO
2Extracting and separating is a room temperature in extraction temperature, CO
2Pressure 20Mpa, extracting and separating 6 hours, decompression separation get a times caul-fat 66.5g.
After measured and detect, above-mentioned each routine prepared Turkey-galls times caul-fat yield 5.0 ~ 7.5%, its fat or oil composition mainly is made up of unsaturated fatty acids, saturated fatty acid and free fatty acids compounds, and wherein unsaturated fatty acids 18 ~ 25%, saturated fatty acid 65 ~ 74%; Unsaturated fatty acids mainly comprises oleic acid, linolic acid, linolenic acid compounds, and saturated fatty acid mainly comprises capric acid, lauric acid, tetradecanoic acid, palmitinic acid, stearic acid compound.
Claims (7)
1. Turkey-galls times caul-fat oil/fat composition, it is characterized in that, by comprising that following method makes: will doubly spend and reject a stalk, coarse crushing is the ratio adding organic solvent of 1:3 ~ 30g/mL in doubly spending with the weightmeasurement ratio of organic solvent, in room temperature to 95 ℃, heat reflow method or percolation continuous extraction 1 ~ 5 time each 0.5 ~ 1 hour, filter, solvent is reclaimed in the filtrate evaporation, gets shallow pale brown oily liquids.
2. a Turkey-galls times caul-fat oil/fat composition is characterized in that, by comprising that following method makes: with the raw material supercritical CO
2Extracting and separating, extraction temperature are room temperature to 90 ℃, pressure 5Mpa ~ 50Mpa, and decompression separation is produced times caul-fat.
3. Turkey-galls according to claim 1 and 2 times caul-fat oil/fat composition, it is characterized in that, contain unsaturated fatty acids 18 ~ 25%, saturated fatty acid 65 ~ 74%, unsaturated fatty acids comprises oleic acid, linoleic acid plus linolenic acid compounds, and saturated fatty acid comprises capric acid, lauric acid, tetradecanoic acid, palmitinic acid and stearic acid compound.
4. the preparation method of a Turkey-galls as claimed in claim 1 times caul-fat oil/fat composition, it is characterized in that, method comprises: will doubly spend and reject a stalk, coarse crushing is the ratio adding organic solvent of 1:3 ~ 30g/mL in doubly spending with the weightmeasurement ratio of organic solvent, in room temperature to 95 ℃, heat reflow method or percolation continuous extraction 1 ~ 5 time each 0.5 ~ 1 hour, filter, solvent is reclaimed in the filtrate evaporation, gets shallow pale brown oily liquids.
5. the preparation method of a Turkey-galls as claimed in claim 2 times caul-fat oil/fat composition is characterized in that method comprises: will doubly spend and use supercritical CO
2Extracting and separating, extraction temperature are room temperature to 90 ℃, pressure 5Mpa ~ 50Mpa, and decompression separation is produced times caul-fat.
6. according to the preparation method of claim 4 or 5 described Turkey-galls times caul-fat oil/fat composition, it is characterized in that doubly to spend aphid or Zhou Shi doubly to spend aphid to cause 4 classes that goitre forms doubly colored for a flower aphid doubly, red times of colored aphid, iron for described times of flower.
7. the preparation method of Turkey-galls according to claim 4 times caul-fat oil/fat composition is characterized in that described organic solvent is sherwood oil, 6# solvent, normal hexane or ethyl acetate.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010578998 CN102002434A (en) | 2010-12-08 | 2010-12-08 | Gallnut times flower oil combination and preparation method thereof |
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| CN 201010578998 CN102002434A (en) | 2010-12-08 | 2010-12-08 | Gallnut times flower oil combination and preparation method thereof |
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| CN102002434A true CN102002434A (en) | 2011-04-06 |
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| CN 201010578998 Pending CN102002434A (en) | 2010-12-08 | 2010-12-08 | Gallnut times flower oil combination and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1232866A (en) * | 1998-04-21 | 1999-10-27 | 李素琼 | Gallnut oil and its extraction process and application in pharmacy |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1232866A (en) * | 1998-04-21 | 1999-10-27 | 李素琼 | Gallnut oil and its extraction process and application in pharmacy |
Non-Patent Citations (1)
| Title |
|---|
| 《中国药学杂志》 20051030 蒲旭峰等 五倍子降血糖有效组分的药理筛选 第1470-1473页 2-3、5 第40卷, 第19期 * |
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Application publication date: 20110406 |