CN102000223A - Traditional Chinese medicine compound preparation for treating vascular dementia as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine compound preparation for treating vascular dementia as well as preparation method and application thereof Download PDFInfo
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- CN102000223A CN102000223A CN 201010547193 CN201010547193A CN102000223A CN 102000223 A CN102000223 A CN 102000223A CN 201010547193 CN201010547193 CN 201010547193 CN 201010547193 A CN201010547193 A CN 201010547193A CN 102000223 A CN102000223 A CN 102000223A
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Abstract
The invention discloses a traditional Chinese medicine compound preparation for treating vascular dementia as well as a preparation method and application thereof. The compound preparation is prepared from the following traditional Chinese medicine raw materials in percentage by weight: 25-35 percent of radix astragali, 25-35 percent of Radix Puerariae, 15-20 percent of pollen typhae, 5-15 percent of safflower, 5-10 percent of Ligusticum wallichii and 5-15 percent of Radix Glycyrrhizae Preparata. In the invention, an oral traditional Chinese medicine preparation for treating the vascular dementia, with good curative effect and small toxic and side effects, is prepared by applying a scientific method and a modern technique and taking the theory of traditional Chinese medicine as the basis. Proved by clinical experiment research, the traditional Chinese medicine preparation takes the better improvement action on the cognitive competence, the neural defect repair, the hemarheology index and the like of paralytics and has better clinical application prospect.
Description
Technical field
The present invention relates to compound Chinese medicinal preparation, be specifically related to a kind of compound Chinese medicinal preparation and preparation method thereof and application of the treatment vascular dementia that contains Chinese medicines such as the Radix Astragali, Radix Puerariae.
Background technology
Along with the aging day by day of population, the sickness rate of apoplexy is ascendant trend year by year.The patient is behind acute cerebral ischemia, often being accompanied by the neuronal degeneration that extensively is dispersed in is the feature secondary brain injury, cause its cognitive dysfunction, neurological functional deficit to increase the weight of gradually, generally be referred to as vascular dementia, directly threaten old people's Health and Living quality.Present most clinical research is positioned cerebral ischemia early treatment and the time window innerlich anwenden of acute stage.For the research of senile dementia, the traditional Chinese medical science is commonly considered as because pathogenic factor such as gas, blood, expectorant, strongly fragrant, fire cause the vital essence loss, and the brains inanition is due to the insufficiency of primordial QI, imbalance of YIN and YANG.More rare about suffering from acute stroke later vascular dementia clinical research and experimentation, still the medicine of patient's cognitive function is generally promoted and can be improved really to incapability so far.
In clinical practice, Shao Nianfang etc. (Journal of Traditional Chinese Medicine, 1997 the 38th the 8th phases of volume) people adopts invigorating kidney, promoting blood circulation collateral dredging inducing resuscitation method, and with Chinese prescriptions such as Radix Ginseng, Radix Polygoni Multiflori, Rhizoma Chuanxiongs, hemorheology index has clear improvement behind the patient treatment.China has just used dihuang drink side's plus-minus (the Sichuan traditional Chinese medical science, 2004 the 22nd the 12nd phases of volume), is principal agent with Radix Rehmanniae Preparata, Herba Cistanches, Fructus Corni etc., and the effect the kidney invigorating is given birth to marrow and filled brain, treatment senile dementia, total effective rate 96.15%.Happy congruence of week (traditional Chinese medical science research, the 14th the 2nd phase of volume of calendar year 2001) with prescriptions such as Fructus Lycii, Radix Polygoni Multiflori, Radix Ginsengs, is observed the influence to Model of Dementia learning and memory in rats ability, and the result shows that treatment rat senile dementia is relevant with dosage.
The present invention nourishes heart cube with benefiting QI for activating blood circulation, brain-strengthening, and reusing Radix Astragali is monarch drug, and strongly invigorating primordial QI is a ministerial drug with heavy dose of Radix Puerariae, and spasmolytic is promoted blood circulation, and assistant is messenger drug with Pollen Typhae, Flos Carthami, Rhizoma Chuanxiong activating blood circulation to dissipate blood stasis with the Radix Glycyrrhizae Preparata, the multiple arteries and veins that nourishes blood, coordinating the actions of various ingredients in a prescription.
Summary of the invention
Technical problem to be solved by this invention is that research design can improve patient's cognitive function, improves the repair ability of patient's neurologic impairment, improves the compound Chinese medicinal preparation of patient's hemorheology index.
The invention provides a kind of compound Chinese medicinal preparation (" side at the age of one hundred years old ") for the treatment of vascular dementia.
Compound preparation is pressed column weight amount per distribution ratio by each raw material of Chinese medicine and is made among the present invention:
Radix Astragali 25-35%, Radix Puerariae 25-35%, Pollen Typhae 15-20%, Flos Carthami 5-15%, Rhizoma Chuanxiong 5-10% and Radix Glycyrrhizae Preparata 5-15%.
Compound preparation is preferably pressed column weight amount per distribution ratio by each raw material of Chinese medicine and is made among the present invention: Radix Astragali 30%, Radix Puerariae 28%, Pollen Typhae 18%, Flos Carthami 9%, Rhizoma Chuanxiong 7% and Radix Glycyrrhizae Preparata 8%.
The present invention nourishes heart cube with benefiting QI for activating blood circulation, brain-strengthening.The Radix Astragali is the QI invigorating key medicine, the function strongly invigorating primordial QI, and again because of the mutual root of QI and blood, qi as the commander of blood, so aged debility, first deficiency of vital energy is lost, it is monarch drug that the cardiovascular and cerebrovascular disease due to the blood stasis BI-syndrome involved the blood vessels is reused Radix Astragali.Pueraria root functional YIN nourishing and the production of body fluid promoting, expelling pathogenic factors from muscles give birth to be loose, so be ministerial drug with heavy dose of Radix Puerariae, give birth to the QI and blood of loosing, and spasmolytic is promoted blood circulation.Pollen Typhae, Flos Carthami, Rhizoma Chuanxiong are the key medicine of blood circulation promoting and blood stasis dispelling, and the blood of the feasible the whole body of Flos Carthami wherein, Rhizoma Chuanxiong more are good at logical brain and are risen and loose, and it is turbid that Pollen Typhae then is longer than promoting blood circulation, and three medicines share and complement each other, and play the merit of blood circulation promoting and blood stasis dispelling, tonneau brain network altogether.Radix Glycyrrhizae Preparata is we's a messenger drug, the multiple arteries and veins that nourishes blood, coordinating the actions of various ingredients in a prescription.
Another object of the present invention provides the preparation method of the compound Chinese medicinal preparation (" side at the age of one hundred years old ") of above-mentioned treatment vascular dementia, and this method comprises the following steps:
Take by weighing above-mentioned Radix Astragali, Radix Puerariae, Pollen Typhae, Rhizoma Chuanxiong, Flos Carthami and Radix Glycyrrhizae Preparata Six-element medical material according to the prescription proportioning, decoct with water 2-3 time, the 5-15 that each amount of water is a medical material weight doubly decocted 1-3 hour.The leaching medicine juice is evaporated to relative density 1.05-1.15, and crushed after being dried becomes 40 orders-200 order fine powder, adds conventional pharmaceutic adjuvant, makes the oral formulations that includes but not limited to granule, capsule, tablet.
Described drying means comprises vacuum drying, spray drying etc.
Another purpose of the present invention provides the application of compound Chinese medicinal preparation in pharmacy of above-mentioned treatment vascular dementia.
Compound preparation of the present invention is through clinical use, and the result shows that its cognitive function improvement to vascular dementia has tangible effect, and neurologic impairment is had certain repair, improves the effect of cutting of whole blood viscosity height and is better than nimodipine.Therefore, can be used for preparing the medicine for the treatment of vascular dementia.
The present invention is based on theory of Chinese medical science, utilization scientific method and modern technologies have been developed the Chinese medicine preparation of a kind of good effect, treatment vascular dementia that toxic and side effects is little, prove through clinical and experimental study, this Chinese medicine preparation has a better role to paralytic's cognitive competence, neurologic defect reparation, hemorheology index etc., and good clinical application prospect is arranged.
The specific embodiment
Embodiment 1
Take by weighing medical material: Radix Astragali 8000g, Radix Puerariae 7500g, Pollen Typhae 4500g, Flos Carthami 2500g, Rhizoma Chuanxiong 2500g, Radix Glycyrrhizae Preparata 2500g decocts with water 2 times, and each amount of water is 280 liters, decocts 2 hours.Leaching merges 2 medicine juice, is evaporated to relative density 1.10, and vacuum drying is ground into 80 order fine powders, adds 40g stevioside and 300g dextrin, makes 1000 bags of granules.
Embodiment 2
Take by weighing medical material: Radix Astragali 10000g, Radix Puerariae 7000g, Pollen Typhae 3000g, Flos Carthami 3000g, Rhizoma Chuanxiong 3000g, Radix Glycyrrhizae Preparata 2000g, add the water water yield and decoct 2 times, the amount of water water yield is 470 liters for the first time, decocts 2 hours, the amount of water water yield is 200 liters for the second time, decocts 1 hour, and leaching merges 2 medicine juice, be evaporated to relative density 1.05, spray drying adds lactose 200g and Pulvis Talci 3g as diluent and lubricant, is pressed into 4000.
Embodiment 3
In hospitals such as Rui Jin, Shanghai hospital, the 9th the People's Hospitals, Shanghai City, the product granule that the embodiment of the invention 1 makes (" side at the age of one hundred years old "), using method: boiled water is taken after mixing it with water, every day secondary, each 1 bag.Being applied to treat cerebral infarction, is contrast with the nimodipine, using method: oral, every day secondary, each 1.Go into group 160 routine patients altogether, 80 examples are organized in treatment, matched group 80 examples, and the result is as follows:
1) the relatively employing MMSE scale of cognitive function all carries out the scoring of MMSE scale to the patient before and after treatment, integration 〉=21 are slight, and integration 10b20 is a moderate, and integration≤9 are severe.Treatment group treatment back MMSE integration is that (24.40 ± 5.66) are divided, matched group is that (25.44 ± 4.20) are divided, two groups than all be significantly increased before the treatment (P＜0.01), and comparing difference does not have significance (P＞0.05) between two groups, show that two medicines all can improve the MMSE integration, improve patient's cognitive function, " side at the age of one hundred years old " effect is similar to nimodipine.
The MMSE integration relatively before and after table 1 treatment
* p＜0.01, relatively preceding with treatment
2) the CSS scale is relatively adopted in the neurologic impairment reparation, and the patient is all carried out CSS scoring before and after treatment, and 0～15 is divided into light-dutyly, and 16～30 are divided into medium-sizedly, and 31～45 are divided into heavy type.Treatment group treatment back CSS integration is that (7.04 ± 5.41) are divided, and matched group is that (7.31 ± 6.44) are divided, and two groups of treatment back CSS integrations all reduce, and before the treatment significant difference (P＜0.01) are arranged; Relatively, the treatment group is better than matched group between two groups, and difference has significance (P＜0.01).Illustrate that two medicines all have certain repair to neurologic impairment, and " side at the age of one hundred years old " is better than nimodipine.(seeing Table 2)
The CSS integration relatively before and after table 2 treatment
* p＜0.01, relatively preceding with treatment;
△ △Compare with the nimodipine group p＜0.01
3) hemorheological indexes is checked zero difference through t before two groups of patient treatments of hemorheology.Relatively, the whole blood viscosity height is cut, blood plasma viscosity, packed cell volume all have clear improvement (P＜0.01) before and after the treatment group treatment, and whole blood viscosity is low cuts, Fibrinogen does not have obvious improvement; The matched group packed cell volume reduces (P＜0.01) before the treatment, and the whole blood viscosity height cuts, lowly cut, blood plasma viscosity, Fibrinogen do not have obvious improvement.Two groups of comparisons are cut difference at height significance (P＜0.01), illustrates that " side at the age of one hundred years old " improves the effect of cutting of whole blood viscosity height and be better than nimodipine.(seeing Table 3)
Hemorheology index relatively before and after table 3 treatment
* p＜0.01, relatively preceding with treatment;
△ △Compare with the nimodipine group p＜0.01
Claims (7)
1. a compound Chinese medicinal preparation for the treatment of vascular dementia is characterized in that, described middle compound preparation is pressed column weight amount per distribution ratio by each raw material of Chinese medicine and made:
Radix Astragali 25-35%, Radix Puerariae 25-35%, Pollen Typhae 15-20%, Flos Carthami 5-15%, Rhizoma Chuanxiong 5-10% and Radix Glycyrrhizae Preparata 5-15%.
2. a compound Chinese medicinal preparation for the treatment of vascular dementia according to claim 1 is characterized in that, described middle compound preparation is pressed column weight amount per distribution ratio by each raw material of Chinese medicine and made:
Radix Astragali 30%, Radix Puerariae 28%, Pollen Typhae 18%, Flos Carthami 9%, Rhizoma Chuanxiong 7% and Radix Glycyrrhizae Preparata 8%.
3. the preparation method as the compound Chinese medicinal preparation of each treatment vascular dementia in claim 1 or 2 is characterized in that this method comprises the following steps:
Take by weighing Radix Astragali, Radix Puerariae, Pollen Typhae, Rhizoma Chuanxiong, Flos Carthami and Radix Glycyrrhizae Preparata Six-element medical material, decoct with water 2-3 time, the 5-15 that each amount of water is a medical material weight doubly decocted 1-3 hour; The leaching medicine juice is concentrated into relative density 1.05-1.15, and crushed after being dried becomes fine powder, adds conventional pharmaceutic adjuvant, makes oral formulations.
4. according to the application of claim 3, it is characterized in that described drying means comprises vacuum drying or spray drying; Crushed after being dried becomes 40 orders-200 order fine powder.
5. one kind as the application of each compound Chinese medicinal preparation in claim 1 or 2 in the medicine of preparation treatment vascular dementia.
6. according to the application of claim 5, it is characterized in that described medicine is made oral formulations by each raw material of Chinese medicine as active component and pharmaceutic adjuvant.
7. according to the application of claim 6, it is characterized in that described oral formulations is granule, tablet or capsule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102240380A (en) * | 2011-06-13 | 2011-11-16 | 许建成 | Traditional Chinese medicine preparation for treating senile vascular dementia |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1476849A (en) * | 2002-08-21 | 2004-02-25 | 韩海龙 | Medicine composition for promoting blood circulation and removing stasis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1476849A (en) * | 2002-08-21 | 2004-02-25 | 韩海龙 | Medicine composition for promoting blood circulation and removing stasis |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102240380A (en) * | 2011-06-13 | 2011-11-16 | 许建成 | Traditional Chinese medicine preparation for treating senile vascular dementia |
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