CN101999897A - Microelectrode propelling device and method - Google Patents
Microelectrode propelling device and method Download PDFInfo
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- CN101999897A CN101999897A CN 201010536398 CN201010536398A CN101999897A CN 101999897 A CN101999897 A CN 101999897A CN 201010536398 CN201010536398 CN 201010536398 CN 201010536398 A CN201010536398 A CN 201010536398A CN 101999897 A CN101999897 A CN 101999897A
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Abstract
The invention discloses a microelectrode propelling device and a microelectrode propelling method. The device comprises a gasket, a box body, a nut, screws, a slide block and a bottom plate. The propelling method comprises the following steps that: the periphery of the bottom plate is arranged into a step shape, the bottom plate is positioned on a skull by positioning screws through two semicircular holes serving as positioning reference on the bottom plate and positioning holes at corresponding positions on the skull, and the bottom plate and the skull are bonded and fixed through dental cement; the bottom plate is connected with the box body through concavely and convexly matched grooves; the slide block is arranged inside a slideway of the box body, an array plate is arranged on a stepped groove of the slide block so as to fix a microelectrode, the position of a hole on the array plate is the position of intersecting axles of a sagittal plane and a coronal plane at a brain region-specified space encoding position, a horizontal position of the array plate is a propelling surface of a propeller, and the propeller performs electrical brain stimulation and encephalographic record on the whole brain region. The propelling device has the characteristics that: the operation is simple and the structure is light, and the device is suitable for labs for researching animal brain regions.
Description
Technical field
The present invention is a kind of manual microelectrode propeller, is used for microelectrode feeding in the free active gecko brain under the waking state.
Background technology
How the information of extraneous things is encoded in brain and transmits, and is an important subject in the brain science always.The encoded question of nerve information is neural basic problem.The information of things adopts bulk encoding to help stability and accuracy that nerve information is expressed by neuron colony coding, and can produce the difference of Duoing than the neuron number by combination and represent, thereby has improved neural ability to express.Research is expressed the high-order characteristic of a plurality of neuron mutual relation in the cluster and then developed other more efficiently coding modes is the problems with development prospect.
Space-time code pattern between the neuron, determine the EEG signals and the dependency of motor behavior in the brain district that motion is relevant, and a series of researchs of the variation of animal movement behavior under the extraneous input stimulus signal conditioning or the like all need insert predetermined position to microelectrode exactly.The basic driver that is applied to little driving of animal information collection at present has three kinds: hydraulic-driven, gear drive, screw mechanism.Ranck(Ranck J.R. Brain Unit Activity During Behavior. 1973:76-79.) be one of people who uses the earliest screw mechanism.His little driving comprises two screws, in the chamber of a hollow that is contained in another.The screw of outside sticks to little driving on the brain of animal, and the screw of the inside is used for fixing microelectrode.Also rotation thereupon of microelectrode when the screw of the inside rotates.This microelectrode propeller structure is more coarse, and can only carry out unipolar propelling.
Tang of The Fourth Military Medical University is the Wang Julei of the hospital (patent No.: CN 201157420Y) designed a kind of manual microelectrode propeller that is used for larger animals such as monkey, cat all.This micro-thruster is provided with pushing ram on pedestal, the pushing ram center is a screw rod, and the screw rod rotation can drive slide block and move up and down, and electrode plug is fixed on the slide block, can realize that electrode advances.This manual microelectrode propeller advantage is: scale is arranged on the rotating ring, can realize accurately controlling, and the displacement of electrode can reach 4mm.Its shortcoming is: (1) overall structure is big, and weight is big, mainly is suitable for larger animal; (2) fairly simple with being connected of skull, come off easily; (3) can only be used for unipolar record and stimulation test.
The MS. Fee(MS Fee of AT﹠T Labs, A Leonardo. NEUROSCI METH 2001: (112) 83-94) but designed a kind of electrode micro-thruster of auto-feed, be used for the brain signal collection of speckle passeris montani saturati.Microelectrode is fixed on the threaded slide block, and slide block can slide up and down along a threaded cylinder.When the motor band the cylinder rotation, slide block will be with microelectrode to move up and down.This microelectrode propeller advantage is: (1) diameter is 6mm, and height is 17mm, shortage in weight 1.5g, and structure is small and exquisite, goes for meiofauna; (2) each passage is a DC MOTOR CONTROL, can realize the independent feeding of triple channel, each other not influence; (3) adopt direct current generator to drive, the degree of accuracy of feeding is very high.MS. the angle of rake shortcoming of Fee is: the limited amount in the site that (1) is used to gather, and the utilization rate of animal is lower; (2) and directly fixed between the skull, be applicable to most of animals, but for the special animal of some skull structures (as gecko) and be not suitable for; (3) adopted three diameter 1.9mm, weight is about the direct current generator of 100mg, so the cost of complete equipment is very high.
Plexon company provides MD-04 and two kinds of microelectrode propellers of MD-08, has the interface slide block of 4 and 8 self-movements respectively.The interface slide block is placed in the slideway of casing correspondence.Each interface slide block can load 1-4 microelectrode.Screwed hole is arranged on the slide block, and when clockwise rotating screw, slide block will drive microelectrode and slide up and down.Below slide block, be provided with guide hole, can guide microelectrode to slide in orbit.Between casing and skull, there are four screws to be connected.This angle of rake advantage is: the independent feeding of (1) multichannel; (2) in light weight; (3) volume is little; (4) assembling easily; (5) cost performance height; (6) independent microelectrode switching interface; (7) can realize 1/8 and 3,/16 two kind of feeding.Its shortcoming is: the disposable use of (1) interface slide block, not reproducible use; (2) implantation site is more fixing, is difficult for change; (3) with skull fixing not firm, particularly be not suitable for the special animals of skull structure such as gecko.
The Keith A. Stengel(patent No.: US 7769421) designed middle microelectrode propeller.Ultimate principle also is to utilize the manual promotion of screw thread.But be designed to oblique 30 ° slideway in casing, screw promotes slide block and moves along slideway.Fixing capillary tube on slide block, the record microelectrode is fixed on the capillary tube, moves up and down with slide block.Bottom at casing is provided with guide pipe, and lower end capillaceous penetrates in the guide pipe, is specifying the site to move up and down to guarantee microelectrode.The bottom is direct and skull is fixed.This angle of rake advantage is: the independent feeding of (1) 14 passage; (2) use capillary tube and the bonded method of guide pipe, enlarged the design space; (3) bottom is little with the bonded area of skull, and convenient and skull is fixed; Its shortcoming is: the employing between (1) and the skull is conventional fixing, particularly is not suitable for the special animals of skull structure such as gecko; (2) assembling is loaded down with trivial details, takes time and effort; (3) processing cost is than higher; (4) implantation site is more fixing, is difficult for change; (5) the disposable use of slide block, not reproducible use.
The Manuputy Ronald Jozef Domingus(patent No. of Holland:
EP2135548 (A1)) designed middle microelectrode propeller.Ultimate principle also is to utilize the manual promotion of screw thread.He becomes 60 ° triangle to the configuration design of six slide blocks, can be spacing mutually between such six slide blocks, and when double-screw bolt rotated, slide block can only move up and down.The record microelectrode is fixed on the slide block, can realizes the bottom and top feed of microelectrode.This angle of rake advantage is: (1) realizes the independent feeding of 6 passages; (2) front-end amplifier directly is connected with the microelectrode propeller; (3) utilize the slide block profile directly spacing, reduced the difficulty of processing of casing; (4) simplified overall structure, be simple and easy to use.Its shortcoming is: the contact area between (1) and the skull is bigger, is not suitable for the special animals of skull structure such as gecko; (2) implantation site of microelectrode is fixed, implantable microelectrode regional fewer; (3) the disposable use of slide block, not reproducible use; (4) in animals such as geckos, structure is bigger, is unfavorable for that animal is free movable.
Because above microelectrode propeller is primarily aimed at animals such as rat, cat, apply to the stimulation and record experiment of gecko, a lot of problems are arranged, as can't being connected with the skull of gecko, implantable microelectrode regional smaller, or the like.Therefore we need design a microelectrode propeller, and it is simple in structure, and is in light weight, can perfectly be fixed on the skull of gecko, and can realize the electrical brain stimulation and the record of multidigit point.
Summary of the invention
The present invention seeks to provides microelectrode propulsion plant and the method for a kind of gecko in body record and stimulation at the defective that prior art exists, and is used for record and the stimulation test at body of gecko.
The present invention adopts following technical scheme for achieving the above object:
Microelectrode propulsion plant of the present invention, comprise pad, casing, nut, screw, slide block and base plate, wherein base plate is connected by the mutual corresponding concavo-convex groove that matches that is provided with casing, base plate is fixed on the skull, be provided with the slideway corresponding in the casing with slide block, step trough and installing hole are set on the slide block, array board is installed with fixing microelectrode on the step trough, nut embeds the installing hole on the slide block, and link to each other with slide block is fastening, ramp design becomes half slot to be used to limit slide block to rotate, it can only be moved up and down along screw, pad has limited moving up and down of screw, and screw can only rotate in the original place.Preferably, the described concavo-convex groove that matches is dovetail groove or circular groove.
Preferably, described array board is the thin plate of thickness 300～500 μ m, has equally distributed through hole on the array board, pitch of holes according to scope at 300～600 μ m.
Preferably, described ram travel is not less than 5mm.
The propulsion method of microelectrode propulsion plant may further comprise the steps:
(1), base plate around be arranged to steppedly, dog screw is positioned base plate on the skull by the locating hole of two semicircle orifices on the base plate as relevant position on location benchmark and the skull, it is cement-bonded and fixing that base plate and skull pass through dentistry;
(2), base plate adopts the concavo-convex groove that matches to be connected with casing;
(3), casing slideway built-in sliding block, array board is installed with fixing microelectrode on the slide block step trough, the position in the hole on the array board is the sagittal plane of specific space encoding position, brain interval and the concurrent aces position of coronal plane, the horizontal level of array board is angle of rake pressure surface, and propeller carries out electrical brain stimulation and eeg recording to whole brain zone.
The present invention has following beneficial effect:
(1), determines base plate shape and fixed form according to animal brain parietal bone form and size.The fixed position of base plate has determined the position of a whole set of microelectrode propulsion system with respect to the brain district, therefore at first needs to determine the base plate position.The present invention has opened the location benchmark of two semicircle orifices as base plate on base plate, and two locating holes are made in the relevant position on parietal bone, implants dog screw, can determine the base plate position.In the experiment, the dentistry cement that is used for fixing, and fixing not firm between the parietal bone are implanted dog screw and can significantly be strengthened bond strength between base plate and the parietal bone.The base plate size has determined integrally-built size to a certain extent, for reducing the design and the manufacture difficulty of microelectrode propulsion system, the overall structure of system will be tried one's best greatly, and the region area that can be used for fixed base plate in testing on the other hand is very little, and this has limited the size of base plate to a certain extent.The present invention has realized optimal design according to the shape that the form and the structural topology of parietal bone goes out base plate.Stepped being designed to around the base plate, help the coating of dentistry cement and fixing.
(2), consider convenient processing and experiment assembling, base plate and cabinet design composition body structure, base plate is connected with casing employing dovetail groove.Such design had both helped the processing and manufacturing of each part, had guaranteed connection and location between the part again.
(3), propeller slideway built-in sliding block, array board is installed with fixing microelectrode, with the hole fixed electrode on the array board.Be processed with aperture uniformly at intervals on the array board.Microelectrode passes and just can use glue that microelectrode is fixed on little bore edges after aperture arrives assigned address.Adopted hole array board fixed electrode among the present invention, increased the position of implantable electrode greatly, can carry out electricity irritation and eeg recording whole experiment brain district.The position in hole determines that according to sagittal plane and the planar coordinate of volume shape the position in the coronal plane is determined by propeller according to the interval specific space encoding position of brain on the slide block.Propeller can carry out electrical brain stimulation and eeg recording to whole midbrain zone.
(4), the present invention adopts the screw mandrel slide block mechanism as power propulsion system.Microelectrode propeller claimed structure is small and exquisite, advances flexibly, so the power propulsion system in the propeller has been selected the simplest mechanism---the screw mandrel slide block mechanism.Simultaneously, two pads restriction screws move up and down about adopting, and nut is embedded in the slide block.In addition, adopt the screw-nut of standard among the present invention, reduced the difficulty of cost of processing and processing.
(5), overall structure adopts closed design.When the particularity of gecko brain structure requires microelectrode to implant, carry out operation of opening cranium, remove part cerebral dura mater and arachnoidea, to expose experiment brain district.And the gecko brain of postoperative with must be isolated from the outside, so the present invention adopted closed design, feed arrangement is all surrounded by casing.When the present invention applies to eeg signal acquisition on the other hand, require the microelectrode of drawing that signal is arranged is shielded, closed design can guarantee good shield effectiveness.
(6), the present invention adopts titanium or aluminium alloy as making material.The microelectrode propeller need be fixed on above the skull of gecko, if weight is too big, gecko can't be born, and will influence the normal activity of gecko.The density of titanium alloy is 4.5
, only being equivalent to 60% of steel, specific strength is very high, can either guarantee that overall structure is in light weight, can guarantee the intensity of thin-walled parts again, guarantees that overall structure is indeformable in actual mechanical process, improves the positional precision that microelectrode is implanted.
Description of drawings
Fig. 1 is the angle of rake sketch map of microelectrode.Wherein (a) is the top view sketch map; (b) for overlooking the observation sketch map.
Fig. 2 is the sketch map of slide block.
Fig. 3 is the sketch map of the location and the Experimental Area of Gekko Swinhonis head position.Wherein (c) is the top view sketch map; (d) for overlooking the observation sketch map.
Label title among Fig. 1: 1-pad; The 2-casing; The 3-nut; The 4-screw; The 5-slide block; The 6-base plate.
Label title among Fig. 2: 7-step trough.
Label title among Fig. 3: 8-coronal suture; The 9-bregma; The 10-parietal bone; The 11-posterior.
The specific embodiment
Fig. 1 is the angle of rake sketch map of microelectrode.As schemed to adopt moving up and down of two pads, 1 restriction screws 4, so screw 4 can only rotate in the original place and nut 3 and 5 fastening linking to each other of slide block.When rotating screw 4, slide block 5 has been limited rotation by casing 2, so slide block 5 can only move up and down along screw 4 with nut 3.When microelectrode be fixed on slide block 5 agglutinating hole array boards after, microelectrode also can be along with slide block 5 moves up and down.
Fig. 2 is the sketch map of slide block.Using the zone of indicating among the figure is step trough, and the hole array board is used to bond.
Fig. 3 is the sketch map of the location and the Experimental Area of Gekko Swinhonis head position.Test available zone and be the parietal bone between bregma and the lambda, i.e. the zone that marks with thick line, its gross area is approximately 90mm
2
With a concrete example of implementing using method of the present invention is described below in conjunction with Fig. 1, Fig. 2, Fig. 3.
The portable weight of gecko head is limited, considers the free-moving influence to gecko, and angle of rake weight can not surpass 5g, so the microelectrode propeller must be simple in structure, in light weight.The present invention has adopted screw drive, and it is simple in structure light and handy, is convenient to operation.And there is sutura (coronal suture) in experiment brain district between gecko parietal bone and the frontal bone under parietal bone, in conjunction with not tight, parietal bone and frontal bone can produce bigger relatively rotating, so the microelectrode propeller must be fixed on the parietal bone, and can not surpass coronal suture.
1, according to the installation diagram of Fig. 1, fixing in place nut 3 and hole array board.Be used for nut 3 and be fixed in the fluting of slide block 5 by 502 glue, control nut will be with the hole be coaxial up and down, otherwise the influence silk
The transmission of bar slide block mechanism.The step trough 7 position fixing hole array boards of in slide block 5, reserving.At first contrast the size polishing hole array board of step trough 7, guarantee that the edge is smooth.Then, be the location benchmark with the ladder, the hole array board is covered on step trough 7 with 502 glue.After treating that 502 gellings are solid, polishing gluing position guarantees that slide block 5 can unobstructed slip in casing 2.At last slide block is assemblied in the casing.
2, with being fixed on the position finder after the Gekko Swinhonis anesthesia, make its brain be in the standard setting state.With the fontanel point is the location benchmark, adopts location high speed cranium to be drilled in parietal bone appropriate location symmetry and bores two locating holes, and be screwed into dog screw.Next step parietal bone 10 hackings that will apply dentistry cement, help strengthening the bond strength of dentistry cement and parietal bone 10.Gecko is carried out operation of opening cranium, cut off cerebral dura mater and arachnoidea, expose experiment brain district.
3, because parietal bone 10 is uneven, at first apply a small amount of dentistry cement, guarantee base plate 6 horizontal positioned at parietal bone 10 and base plate 6 calmodulin binding domain CaMs.Apply a small amount of dentistry cement in the front and back of base plate 6, base plate 6 is fixed on the parietal bone 10.After treating that dentistry thes cement solidifies, the casing 2 that has assembled is cooperated with base plate 6.Around casing 2 and base plate 6, apply dentistry cement, notice that dentistry cement does not surpass coronal suture 8.
4,, implant microelectrode at needed point, and they are fixed on the array board of hole according to bregma 9 positions.At last all holes of not using with 502 glue sealing.
5, the skin of head of gecko is sewed up in skin and the muscular tissue sterilization to exposing, and microelectrode is connected with the stimulation interface, treats that post-operative recovery carries out chronic experiment.
6, after gecko recovers three to four days, gecko is carried out postoperative electricity irritation or eeg recording experiment, if the some effect at place is undesirable, can turn screw 4, realize the propelling of microelectrode under the body experiment.
Claims (5)
1. microelectrode propulsion plant, it is characterized in that comprising pad (1), casing (2), nut (3), screw (4) slide block (5) and base plate (6), wherein base plate (6) is connected by the mutual corresponding concavo-convex groove that matches that is provided with casing (2), base plate (6) is fixed on the skull, be provided with in the casing (2) and the corresponding slideway of slide block (5), step trough (7) and installing hole are set on the slide block (5), step trough (7) go up to be installed array board with fixing microelectrode, nut (3) embeds the installing hole on the slide block (5), and with fastening linking to each other of slide block (5), ramp design becomes semi-circular groove to be used to limit slide block (5) rotation, it can only be moved up and down along screw (4), pad (1) has limited moving up and down of screw (4), and screw (4) can only rotate in the original place.
2. microelectrode propulsion plant according to claim 1 is characterized in that the described concavo-convex groove that matches is dovetail groove or circular groove.
3. microelectrode propulsion plant according to claim 1 is characterized in that described array board is the thin plate of thickness 300～500 μ m, has equally distributed through hole on the array board, and the pitch of holes scope is at 300～600 μ m.
4. microelectrode propulsion plant according to claim 1 is characterized in that described slide block (5) stroke is not less than 5mm.
5. propulsion method based on the described microelectrode propulsion plant of claim 1 is characterized in that may further comprise the steps:
(1), base plate (6) around be arranged to stepped, dog screw is positioned base plate (6) on the skull jointly by the locating hole of two semicircle orifices on the base plate (6) as relevant position on location benchmark and the skull, and base plate (6) and skull are cement-bonded and fixing by dentistry;
(2), base plate (6) adopts the concavo-convex groove that matches to be connected with casing (2);
(3), casing (2) slideway built-in sliding block (5), array board is installed with fixing microelectrode on slide block (5) step trough, the position in the hole on the array board is the sagittal plane of specific space encoding position, brain interval and the concurrent aces position of coronal plane, the horizontal level of array board is angle of rake pressure surface, and propeller carries out electrical brain stimulation and eeg recording to whole brain zone.
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| CN201010536398A CN101999897B (en) | 2010-11-09 | 2010-11-09 | Microelectrode propelling device and method |
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| CN201010536398A CN101999897B (en) | 2010-11-09 | 2010-11-09 | Microelectrode propelling device and method |
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| CN101999897B CN101999897B (en) | 2012-09-26 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102334988A (en) * | 2011-07-28 | 2012-02-01 | 河海大学常州校区 | Manual combined type microelectrode propeller and production method thereof |
| CN103690262A (en) * | 2013-11-29 | 2014-04-02 | 南京航空航天大学 | Electrode adapter for avian chronic brain function researches and fixing method |
| CN106618563A (en) * | 2016-11-09 | 2017-05-10 | 中国人民解放军第三军医大学 | Light reusable microelectrode propeller and embedding method thereof |
| CN109480836A (en) * | 2019-01-11 | 2019-03-19 | 苏州大学附属儿童医院 | A kind of eeg monitoring wearable device |
| CN114305435A (en) * | 2021-12-21 | 2022-04-12 | 中国科学院空天信息创新研究院 | Head-mounted brain cognitive space navigation cell detection microelectrode driver |
| CN116269411A (en) * | 2023-03-26 | 2023-06-23 | 中国科学院昆明动物研究所 | Tree shrew cranial nerve electrophysiology recording electrode device |
| WO2024113424A1 (en) * | 2022-12-02 | 2024-06-06 | 中国科学院深圳先进技术研究院 | Device for advancing and protecting implantable electrode |
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| US7769421B1 (en) * | 2005-07-13 | 2010-08-03 | Neuralynx, Inc. | Multi-electrode microdrive array |
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| 《中国优秀硕士学位论文全文数据库基础科学辑》 20080815 蔡雷 《刺激大壁虎基底神经核对运动行为的影响》 A006-16-A006-17 , 第8期 2 * |
| 《中国博士学位论文全文数据库工程科技II辑》 20090515 王文波 《大壁虎运动人工诱导的基础研究》 C028-10-C028-11 , 第5期 2 * |
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