CN101995477B - 用于液体样品分析的系统 - Google Patents

用于液体样品分析的系统 Download PDF

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Publication number
CN101995477B
CN101995477B CN201010249308.1A CN201010249308A CN101995477B CN 101995477 B CN101995477 B CN 101995477B CN 201010249308 A CN201010249308 A CN 201010249308A CN 101995477 B CN101995477 B CN 101995477B
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CN
China
Prior art keywords
sample
reagent
processing unit
channel
unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201010249308.1A
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English (en)
Chinese (zh)
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CN101995477A (zh
Inventor
M·格劳泽尔
O·古特曼
H-M·海因
M·海因利希
R·D·耶吉
E·乌斯特布罗克
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN101995477A publication Critical patent/CN101995477A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G01N35/085—Flow Injection Analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN201010249308.1A 2009-08-07 2010-08-06 用于液体样品分析的系统 Expired - Fee Related CN101995477B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09167520.7A EP2952906A1 (en) 2009-08-07 2009-08-07 System for the analysis of liquid samples
EP09167520.7 2009-08-07

Publications (2)

Publication Number Publication Date
CN101995477A CN101995477A (zh) 2011-03-30
CN101995477B true CN101995477B (zh) 2015-02-25

Family

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Family Applications (1)

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CN201010249308.1A Expired - Fee Related CN101995477B (zh) 2009-08-07 2010-08-06 用于液体样品分析的系统

Country Status (4)

Country Link
US (1) US8940249B2 (https=)
EP (1) EP2952906A1 (https=)
JP (1) JP5395011B2 (https=)
CN (1) CN101995477B (https=)

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CN108027203B (zh) * 2015-07-22 2020-11-03 北卡罗来纳-查佩尔山大学 具有利用冰成核剂的冻结-解冻阀的流体装置和相关的操作和分析方法
CN105651767B (zh) * 2015-12-29 2018-06-05 厦门大学 一种使用3d打印模具制备的即吸即测液体检测装置
CN105699448B (zh) * 2016-01-14 2018-02-06 京东方科技集团股份有限公司 一种尿液检测方法及尿液检测装置
GB201704758D0 (en) * 2017-01-05 2017-05-10 Illumina Inc Reagent channel mixing systema and method
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CN107782673A (zh) * 2017-11-21 2018-03-09 苏州市苏测检测技术有限公司 食品质量检测用样品量化快检设备
KR20190071381A (ko) 2017-12-14 2019-06-24 (주)이노진 엘이디를 이용한 혈액기반 체외진단장치 및 방법
KR102037177B1 (ko) 2017-12-14 2019-10-28 (주)이노진 혈액기반 체외진단장비의 공조장치
KR20190071390A (ko) 2017-12-14 2019-06-24 (주)이노진 혈액기반 체외진단장비의 시약공급장치
EP3594681B1 (en) 2018-07-10 2024-08-28 Alpha M.O.S. Device for characterising a fluid sample
CA3121127C (en) * 2018-11-30 2023-06-13 Illumina, Inc. Systems and methods for active warming of a cartridge
KR102095747B1 (ko) 2018-12-10 2020-04-20 주식회사 이앤에스헬스케어 Led단일광원과 제어부의 교체형 모듈을 갖는 체외진단장치
KR102152629B1 (ko) 2018-12-10 2020-09-07 주식회사 이앤에스헬스케어 광진단부 교체 모듈을 구비한 체외진단장치
KR102185272B1 (ko) 2018-12-10 2020-12-01 주식회사 이앤에스헬스케어 체외진단장치
KR102157567B1 (ko) 2018-12-10 2020-09-18 주식회사 이앤에스헬스케어 피펫장비 고정용 디바이스를 갖는 체외진단장치
IL275785B2 (en) * 2020-07-01 2024-08-01 Strauss Water Ltd Liquid dispensing arrangements and methods
CN114324906A (zh) * 2020-09-27 2022-04-12 青岛海尔电冰箱有限公司 微流控检测系统及其控制方法、冰箱
US20240299935A1 (en) * 2023-03-06 2024-09-12 Fluidion US Inc. Reagent Delivery System for Microfluidic Chemical Analyzer

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Also Published As

Publication number Publication date
JP2011039050A (ja) 2011-02-24
US8940249B2 (en) 2015-01-27
US20110189052A1 (en) 2011-08-04
EP2952906A1 (en) 2015-12-09
JP5395011B2 (ja) 2014-01-22
CN101995477A (zh) 2011-03-30

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