CN101983613A - Computer-aided device for screening mild cognitive impairment (MCI) of old people - Google Patents
Computer-aided device for screening mild cognitive impairment (MCI) of old people Download PDFInfo
- Publication number
- CN101983613A CN101983613A CN2010105084062A CN201010508406A CN101983613A CN 101983613 A CN101983613 A CN 101983613A CN 2010105084062 A CN2010105084062 A CN 2010105084062A CN 201010508406 A CN201010508406 A CN 201010508406A CN 101983613 A CN101983613 A CN 101983613A
- Authority
- CN
- China
- Prior art keywords
- mci
- test
- scale
- unit
- result
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
Abstract
The invention relates to a computer-aided device for screening mild cognitive impairment (MCI) of old people. The device comprises an MCI test server and an inspection client, wherein the MCI test server comprises a personal information memorizing unit, a scale memorizing unit for supplying a test scale for objectively judging the MCI to the MCI test inspection client, a scale sending unit, a response receiving unit, an MCI degree counting and memorizing unit, an MCI identifying and comparing unit and a result sending unit; and the inspection client comprises a basic information entering unit, a basic information sending unit, a scale receiving unit, a scale expressing unit, a response acquiring unit, a response sending unit, a result receiving unit and a result displaying unit. The test paper of the test scale comprises orientation force, memory, notice, watchfulness, calculation power, language denomination, delayed recall, verbal fluency, pattern recognition, verbal understanding, abstract ability and visual structure skill. The invention has the advantages of definite reliability and validity and good reliability, and is simple in operation and convenient in general survey.
Description
Technical field
The invention belongs to computer technology, network technology and communication technology at old mild cognitive impairment (Mild cognitive impairment, MCI) application of diagnosis aspect, be applicable in rehabilitation center, hospital, nursing house, community and family, be used for the super early screening and the auxiliary diagnosis of senile dementia.
Background technology
(Alzheimer's Disease AD) is one group of disease that the cause of disease is not bright to alzheimer disease, and cardinal symptom is comprehensive decline of intelligence, causes the forfeiture of viability, is one of important diseases that causes old people's deformity.According to investigations, the prevalence northern area over-65s of China's alzheimer disease is 6.9%, southern area 3.9%; Annual New Development patient is about 1,800,000, and is dead 105.6 ten thousand, estimates that China has 2,000 ten thousand patients approximately.Dementia makes family and society take care of burden to be increased, and Sweden is used in dull-witted patient's about 5,000,000 dollars of medical expense every year, and the U.S. spends in dull-witted various expenses every year and reaches 80,000,000,000 dollars, comprises that treatment is taken care of.China does not have the statistics of this respect, and conservative estimation does not comprise the home care treatment, and by 1.5 ten thousand yuan of calculating of the average medical treatment and nursing expense of outpatient service for each person every year, the whole nation spends 30,000,000,000 yuan every year approximately.The medicine of clinical dementia treatment at present only is a symptomatic treatment, can't stop its development.Early discovery and early intervention are the only way outs.
Think that at present (Mild cognitive impairment is dull-witted early stage performance MCI) to mild cognitive impairment, and (amnestic MCI, aMCI), 1/2 people developed into dementia in 3～5 years especially to forget type MCI.Studies show that much MCI can regard the performance in early stage of dull-witted particularly AD morbidity as, along with the progress of cognitive function decline, a part of patient will finally develop and be AD, be 10-15%/year substantially, be 10 times of normal old people.Yu Baocheng etc. discover that the sickness rate of 60 years old old people MCI of China is 4.8%.The investigation in Shanghai in 1998 finds that the prevalence of MCI is 14.4%, and Beijing epidemiology statistics in 2000 shows that having 11.8% scratched by this sick being stranded.Discoveries such as Huang Juebin, MCI is respectively 8.0% to the average year conversion ratio of AD, and its relative risk is respectively 6 times of cognitive normal person.Therefore, how filtering out those in elderly population shows as the MCI patient of hypomnesis and intervenes timely and effectively and then seem particularly important.
Studies show that, the biochemical performance of cerebrospinal fluid (as amyloid A β 42, Protein tau level etc.), that functional image is learned feature (as functional MRI, nuclear medicine inspection), the detection of ApoE e4 allele etc. is remarkable to diagnosis and the predictive value of MCI, but these inspections limited because of operating, cost an arm and a leg or not by problem performance difficulties such as old people's acceptance.How to find a kind of survey tool, make it filter out that part of MCI patient quickly and easily in having the Chinese old people of huge population base, neural psychometry instrument has possessed characteristics such as easy, quick, effective.
Neuropsychological test is having important value aspect the quantification of MCI diagnosis, and still there is very big-difference in the appraisal tool of defined cognitive impairment scope and the order of severity and employing in the different diagnostic criterias.It is a lot of to check and examine at present cognitive scale both at home and abroad, checking and examining MCI the most widely used is simple and clear mental status examination (Mini-mental State Examination, MMSE), the cognitive assessment in Montreal (Montreal Cognitive Assessment, MoCA) scale.
MMSE is strong, easy to operate, consuming time few because of its sensitivity, it is universal, the most the most frequently used domestic and international senile dementia examination scale always, it comprise time and place orientation, language (repeat, name, understand instruction), mental arithmetic, at once with projects such as audition word memory in short-term, structure simulates, full marks 30 minutes, time-consuming 5～10min, test retest reliability 0.80～0.99, reliability 0.95～1.00 between the testing person, the sensitivity of diagnosis of dementias is mostly 80%～90%, and specificity is mostly 70%～80%.Domestic scholars Zhang Mingyuan etc. revised this scale in 1988, Chinese edition MMSE according to the description branch of the normal and AD that the different educational degree is made is: the illiteracy organizes 17 fens, primary school's group 20 minutes, middle school or above group 24 minutes, and being lower than description, to be divided into cognitive function impaired.Comprise multiple cognitive domain though MMSE checks and examine, bias toward top temporal lobe function; Good to checking and examining of orientation force, but language and memory are checked and examined fairly simple, the shared ratio of visual space is lower.Clinical practice finds that the MMSE score value exists overlapping, also has with mild AD and intersects in normal person and MCI.The Meta that Mitchell did analyzes and shows, MMSE is used to distinguish MCI and normal old people's sensitivity and poor specificity, is respectively 63.4% and 65.4%; Be used to distinguish the sensitivity of normal old people and dementia patients and specificity about 80% and 90%; The sensitivity that is used to distinguish dull-witted and MCI is 89.2%, and specificity only is 45.1%.Propositions such as Tang-Wai, MMSE is suitable for middle severe dementia patient, and the MCI examination is lacked sensitivity and specificity, can not be used to diagnose MCI separately.
For this reason, Nasreddine equals to formulate in 2005 the MoCA scale, to 94 routine MCI, 93 routine mild AD, the normal old people of 90 examples carries out MMSE and MoCA checks and examine, with 26 minutes as marginal value, the result shows that MoCA finds the sensitivity of MCI and mild AD up to 90% and 100%, and MMSE has only 18% and 78%; 2 specificity is all fine, and MoCA and MMSE are respectively 87% and 100%; The letter validity detects and shows that the MoCA internal consistency is up to 0.83.Using the research of MoCA also to show in Korea S, is that the sensitivity of Korea Spro's version MoCA examination MCI is 89% under 22/23 minute the situation with marginal value, and specificity is 84%, and internal consistency and test retest reliability are good; And MMSE can't be with MCI and normal old people's difference, with 25/26 minute as marginal value, the sensitivity 59% of examination MCI, specificity 70%.Same Arabic version MoCA is to the sensitivity 92.3% of MCI, and specificity 85.7% has good retest reliability and internal consistency.
Other scales that are used for examination MCI also have, cognitive abilities screening test (Cognitive Capacity Screening Examination), DemTect, picture clock test (Clock Drawing Test, CDT) and Addenbrooke's recognition tests scale (the Addenbrooke's Cognitive Examination, ACE) etc.The sensitivity that cognitive abilities screening detects MCI is 74.3%, when share with MMSE, brings up to 83%, and still the total points of 2 deal tables merging use is 47 minutes, and tediously long inconvenience is used.DemTect is used to distinguish MCI, AD and normal old people, but compares with MoCA, and the cognitive domain that the former measures is less, and lower to the sensitivity of MCI, DemTect is 80%, and MoCA has 90%.It is pretty good that CDT is used for AD and normal person's differentiation effect, but there is limitation in the examination of mild AD; Recently MMSE and CDT are united and use examination MCI pretty good, sensitivity 0.5 can be increased to 0.75 by what check and examine separately, and specificity is 0.69.Report ACE scales such as Galton CJ are whether prediction aMCI makes progress and be the good index of dementia, the patient of score value≤80 minute is〉to develop into dull-witted probability in the time in following 2 years bigger for 80 minutes patient, but this scale testing time is long, influences practical application.
Comparatively speaking, use MoCA examination MCI and demonstrate unique advantages, but MoCA is at the ground zero of promoting the use of of China, the letter validity is also indeterminate, use external MoCA also to have limitation and indiscriminately imitate, because wherein some is checked and examined project and is not suitable for the Chinese countryside old people, as naming, postpone the noun of memory etc.; Draw cube, alternately trail making test and schooling are closely related.
Summary of the invention
Some defectives that exist for the examination scale that overcomes present old mild cognitive impairment:, poor reliability, complicated operation on the low side as the letter validity, schooling is required high, the invention provides a kind ofly believe that validity is clear and definite, reliability is good, the device of simple to operate, the old mild cognitive impairment of computer-aided screening of being convenient to generally investigate, be applicable to China's culture background.
The technical solution adopted for the present invention to solve the technical problems is:
The device of the old mild cognitive impairment of a kind of computer-aided screening, described device comprise the MCI testing server and check client computer that described MCI testing server comprises:
Personal information mnemon is used to preserve tester's individual's essential information and test result;
Scale mnemon, be used to MCI test-based examination client computer to provide the test scale of objective judgement MCI, described test scale to comprise orientation force test question, memory test question, attention and Vigilance test question, computing power test question, language name test question, postpone to recall test question, word fluency test question, figure re-recognize test question, speech comprehension test question, abstracting power test question and TV structure skills tests topic;
The scale transmitting element is used for the MCI test scale is checked that to MCI client computer sends;
Answer receiving element, be used to receive the answer that comes from the relevant MCI test scale of MCI inspection client computer, and obtain tester's score value;
MCI degree statistics mnemon, be used for formerly old people tested with the clinical dementia scale and evaluate, default judge that primary school and the old people of following educational level are first threshold for the score value of MCI and judge the junior middle school and the old people of above educational level is second threshold value for the score value of MCI, described first threshold is less than second threshold value, and table 1 is judged for the combination of MCI degree statistics mnemon
The result:
Table 1
MCI differentiates comparing unit, is used for according to tester's score and schooling the table 1 of MCI degree statistics mnemon being tabled look-up, and obtains the corresponding judgment result;
Transmitting element is used for sending to the inspection client computer from the more unitary result of determination of MCI discrimination ratio as a result, simultaneously the result is sent to personal information mnemon and preserves;
Described MCI checks that client computer comprises:
Essential information typing unit is used to obtain tester's basic personal information;
The essential information transmitting element, the personal information that will obtain from the typing unit is sent to testing server and preserves;
The scale receiving element is used to receive the MCI test scale that sends over from the MCI testing server;
Scale is represented the unit, is used to the MCI test scale that shows that reception obtains;
Answer obtains the unit, is used to obtain that the tester operates response and the answer that obtains the MCI test scale;
Answer transmitting element, be used for obtaining the unit and obtain answering the back to MCI testing server transmission answer result in answer;
Receiving element is used to receive the test result information that sends over from the transmitting element as a result of testing server as a result;
Display unit is used for the test result information that the display result receiving element receives as a result.
Further, described inspection client computer also comprises: be used to read the OCR reading device of the test result of written test scale, described OCR reading device is obtained the unit with described answer and is connected.
Further again, draw the described first threshold and second threshold value according to sensitivity and specificity analyses.
Technical conceive of the present invention is: AD patient generally just is identified to the disease middle and advanced stage at present, has missed best intervention period.How by computer technology, network technology and communication technology to old people's general implementation early screening, find AD as early as possible, to the treatment of AD with delay advancing of disease positive effect is arranged.Revising, set up a cover and be fit to the low educational level elderly population of China, easy quick, standardized MCI examination scale, is a kind of good method.Consider that MMSE is used for the popularity of AD diagnosis, we revise on the basic clauses and subclauses of MMSE, according to the definition of cognition, early stage dull-witted main cognitive impairment characteristics, increase projects such as difficulty, attention and Vigilance that time-delay is remembered, word fluency, execution function, abstract summary, the test of picture clock, be intended to set up the scale of a cover rapid screening MCI.
Beneficial effect of the present invention mainly shows: have easy and simple to handle, generaI investigation easily, quick identification MCI, be early stage dull-witted identification service; The more similar neural Psychological Examination instrument of test scale " Chinese mild cognitive impairment examination scale " that adopts, the cognitive domain of containing is more comprehensive, also is fit to the old people of the low educational level of China.Because implement easily, the old people takes like a shot, and need not the doctor accompany.The old people and their family of thumping majority are benefited, and they have also alleviated burden on society in quality of life in raising.
Description of drawings
Fig. 1 is the responsive specificity analyses of primary school and following educational level.
Fig. 2 is junior middle school and the responsive specificity analyses of above educational level.
Fig. 3 is the function basic comprising block diagram of Chinese mild cognitive impairment screening apparatus (server-client mode).
Fig. 4 is the sketch map of language name.
The sketch map that Fig. 5 re-recognizes for figure.
Fig. 6 is the function basic comprising block diagram of Chinese mild cognitive impairment screening apparatus (unit mode).
Fig. 7 is the function basic comprising block diagram of Chinese mild cognitive impairment screening apparatus (OCR mode).
The specific embodiment
Below in conjunction with accompanying drawing the present invention is further described.
With reference to Fig. 1～Fig. 5, the device of the old mild cognitive impairment of a kind of computer-aided screening (MCI), described device comprises MCI testing server 1 and checks client computer 2, described MCI testing server 1 comprises: personal information mnemon 3 is used to preserve tester's individual's essential information and test result; Scale mnemon 4, be used to MCI test-based examination client computer to provide the test scale of objective judgement MCI, described test scale to comprise orientation force test question, memory test question, attention and Vigilance test question, computing power test question, language name test question, postpone to recall test question, word fluency test question, figure re-recognize test question, speech comprehension test question, abstracting power test question and TV structure skills tests topic; Scale transmitting element 5 is used for the MCI test scale is checked that to MCI client computer sends; Answer receiving element 6, be used to receive the answer that comes from the relevant MCI test scale of MCI inspection client computer; MCI degree statistics mnemon 7, be used for formerly old people tested with the clinical dementia scale and evaluate, the default score value of judging that primary school and the old people of following educational level are MCI is a first threshold, the old people of judgement junior middle school and above educational level is second threshold value for the score value of MCI, described first threshold is less than second threshold value
The source method of the score value of the first threshold and second threshold value is as follows: 3000 routine community senile people are carried out test of the present invention and clinical dementia scale (Clinical Dementia Rating, CDR) evaluation, according to sensitivity and specificity analyses (Fig. 1 and 2) draw judge primary school and the old people of following educational level for the score value of MCI be 25 minutes and below, the old people of judgement junior middle school and above educational level for the score value of MCI be 26 minutes and below;
ROC (Receive Operating Characteristic, experimenter's operating characteristic curve) tracing analysis teacher estimates a kind of method of diagnostic test quality and definite marginal value, become one of method commonly used in external body constitution and the health promotion research field in recent years, be widely used in fields such as clinical medicine and epidemiology at present.
At medical science diagnosis and treatment scene, the major issue that the doctor faced is patient's detection index to be made the judgement of " normally " or " unusually ", and one of foundation that the doctor judges is " feminine gender " or " positive " of testing result.When for same disease two or more diagnostic method being arranged, the tester need make evaluation to the quality of different diagnostic methods, and its evaluation criterion generally uses sensitivity (sensitivity) and specificity (specificity) to describe.For the diagnostic method that produces continuous diagnostic result, the ROC curve can combine analysis with the sensitivity and the specificity of this method.
Following 4 kinds of situations all may appear when using any diagnostic method to judge having or not of disease: and (1) true positives (true positive, TP): ill and testing result is positive; (2) false positive (false positive, FP): anosis but testing result is positive; (3) true negative (true negative, TN): anosis and testing result is negative; (4) false negative (false positive, FN): ill but testing result is negative.The relation of testing result and disease condition sees the following form 2.
Table 2
Insert every group number using a certain detection method to obtain in each grid of last table 2, and then can calculate sensitivity and the specificity that uses this diagnostic method.
Sensitivity (True Positive Rate)=
* 100%
Specificity (true negative rate)=
* 100%
The making principle of ROC curve is that continuous variable is set out a plurality of different marginal values, calculates corresponding sensitivity and specificity at each marginal value place, is abscissa with 1 – specificity again, is that vertical coordinate is depicted as curve with sensitivity.When multiple diagnostic method is compared, draw the ROC curve of various diagnostic methods respectively, compare the pairing area under a curve of the whole bag of tricks, area the greater diagnostic accuracy is higher.
The sensitivity specificity analyses:
Table 3 is the data of " primary school and following ":
| Positive (if＜=) | | Specificity | 1 – specificity | |
| 3.500 | 0.000 | 1.000 | 0.000 | |
| 5.500 | 0.004 | 1.000 | 0.000 | |
| 7.750 | 0.009 | 1.000 | 0.000 | |
| 9.250 | 0.017 | 1.000 | 0.000 | |
| 10.000 | 0.022 | 1.000 | 0.000 | |
| 10.750 | 0.026 | 1.000 | 0.000 | |
| 11.500 | 0.030 | 1.000 | 0.000 | |
| 12.250 | 0.035 | 1.000 | 0.000 | |
| 12.750 | 0.039 | 1.000 | 0.000 | |
| 13.250 | 0.052 | 1.000 | 0.000 | |
| 13.750 | 0.057 | 1.000 | 0.000 | |
| 14.250 | 0.065 | 1.000 | 0.000 | |
| 14.750 | 0.070 | 1.000 | 0.000 | |
| 15.250 | 0.091 | 1.000 | 0.000 | |
| 15.750 | 0.096 | 1.000 | 0.000 | |
| 16.250 | 0.113 | 1.000 | 0.000 | |
| 16.750 | 0.122 | 1.000 | 0.000 | |
| 17.250 | 0.143 | 1.000 | 0.000 | |
| 17.750 | 0.152 | 1.000 | 0.000 | |
| 18.250 | 0.196 | 1.000 | 0.000 | |
| 18.750 | 0.213 | 1.000 | 0.000 | |
| 19.250 | 0.257 | 1.000 | 0.000 | |
| 19.750 | 0.283 | 1.000 | 0.000 | |
| 20.250 | 0.335 | 1.000 | 0.000 | |
| 20.750 | 0.361 | 1.000 | 0.000 | |
| 21.250 | 0.417 | 1.000 | 0.000 | |
| 21.750 | 0.435 | 1.000 | 0.000 | |
| 22.250 | 0.474 | 1.000 | 0.000 | |
| 22.750 | 0.513 | 1.000 | 0.000 | |
| 23.250 | 0.587 | 0.993 | 0.007 | |
| 23.750 | 0.604 | 0.986 | 0.014 | |
| 24.250 | 0.670 | 0.979 | 0.021 | |
| 24.750 | 0.713 | 0.973 | 0.027 |
| 25.250 | 0.832 | 0.959 | 0.041 |
| 25.750 | 0.890 | 0.945 | 0.055 |
| 26.250 | 0.896 | 0.829 | 0.171 |
| 26.750 | 0.900 | 0.815 | 0.185 |
| 27.250 | 0.948 | 0.699 | 0.301 |
| 27.750 | 0.948 | 0.678 | 0.322 |
| 28.250 | 0.983 | 0.452 | 0.548 |
| 28.750 | 0.983 | 0.438 | 0.562 |
| 29.250 | 0.991 | 0.199 | 0.801 |
| 29.750 | 0.996 | 0.192 | 0.808 |
| 31.000 | 1.000 | 0.000 | 1.000 |
Table 3
Table 4 is the data in " middle school and more than ":
| Positive (if＜=) | | Specificity | 1 – specificity | |
| 14.500? | 0.000? | 1.000? | 0.000? | |
| 15.750? | 0.008? | 1.000? | 0.000? | |
| 16.500? | 0.017? | 1.000? | 0.000? | |
| 17.500? | 0.033? | 1.000? | 0.000? | |
| 18.500? | 0.050? | 1.000? | 0.000? | |
| 19.250? | 0.067? | 1.000? | 0.000? | |
| 19.750? | 0.075? | 1.000? | 0.000? | |
| 20.250? | 0.117? | 1.000? | 0.000? | |
| 20.750? | 0.133? | 1.000? | 0.000? | |
| 21.250? | 0.158? | 1.000? | 0.000? | |
| 21.750? | 0.167? | 1.000? | 0.000? | |
| 22.250? | 0.192? | 1.000? | 0.000? | |
| 22.750? | 0.242? | 1.000? | 0.000? | |
| 23.500? | 0.300? | 1.000? | 0.000? | |
| 24.250? | 0.425? | 0.991? | 0.009? | |
| 24.750? | 0.458? | 0.985? | 0.015? | |
| 25.250? | 0.542? | 0.963? | 0.037? | |
| 25.750? | 0.608? | 0.960? | 0.040? | |
| 26.250? | 0.725? | 0.932? | 0.068? | |
| 26.750? | 0.881? | 0.923? | 0.077? | |
| 27.250? | 0.883? | 0.820? | 0.180? | |
| 27.750? | 0.883? | 0.805? | 0.195? | |
| 28.250? | 0.942? | 0.563? | 0.437? | |
| 28.750? | 0.950? | 0.536? | 0.464? | |
| 29.250? | 0.992? | 0.279? | 0.721? | |
| 29.750? | 0.992? | 0.276? | 0.724? | |
| 31.000? | 1.000? | 0.000? | 1.000? |
Table 4
The foundation that the score value of above-mentioned threshold value is determined is to guarantee that sensitivity and two indexs of specificity all keep higher level, and therefore, according to the sensitivity and the specific data of " primary school and following ", selected numerical value is " 25.750 ", and promptly first threshold is chosen as 25 fens; According to " junior middle school and more than " sensitivity and specific data, selected numerical value is " 26.750 ", promptly first threshold is chosen as 26 fens.
Therefore the data, judging standard A) are score value, promptly 1) 26 minutes; 2) 25 minutes; Judging standard B) data in are schooling, promptly 1) and primary school and following; 2) junior middle school and more than;
Pass through A) and B) two kinds of judging standard classification, being divided into 3,2 levels respectively, thereby obtaining 6 kinds of different combinations, each combination all can be given different suggestion and the processing methods of tester, summarizes 6 kinds of different combinations with following this table:
The combination judged result of table 1 MCI degree statistics mnemon:
MCI differentiates comparing unit 8, is used for according to tester's score and schooling 6 kinds of combined situation of MCI degree statistics mnemon being tabled look-up, and obtains the corresponding judgment result; Transmitting element 9 as a result, are used for sending to the inspection client computer from the more unitary result of determination of MCI discrimination ratio, simultaneously the result are sent to personal information mnemon and preserve;
Described MCI checks that client computer 2 comprises: essential information typing unit 10 is used to obtain tester's basic personal information; Essential information transmitting element 11, the personal information that will obtain from the typing unit is sent to testing server and preserves; Scale receiving element 12 is used to receive the MCI test scale that sends over from the MCI testing server; Scale is represented unit 13, is used to the MCI test scale that shows that reception obtains; Answer obtains unit 14, is used to obtain that the tester operates response and the answer that obtains the MCI test scale; Answer transmitting element 15, be used for obtaining the unit and obtain answering the back to MCI testing server transmission answer result in answer; Receiving element 16 as a result, are used to receive the test result information that sends over from the transmitting element as a result of testing server; Display unit 17 as a result, are used for the test result information that the display result receiving element receives.
Described test scale is " Chinese mild cognitive impairment examination scale " (Chen Wei waits revision).
The tester can pass through equipment for surfing the net, on page displayed, the MCI test chart is answered one by one, the result of this answer is sent to the MCI testing server by computer network, server uses this device energy early discovery MCI according to this tested answer and tester's personal information calculating measured's MCI degree.In application to the MCI test scale, use for reference international scaling one cover meet the MCI examination scale of China's actual conditions, this scale is stored in the scale mnemon 4 in advance.
The present invention is divided into 3 levels, diagnostic criteria A with the cognitive score of computer statistics test): 1) A＞26; 2) 26 〉=A＞25; 3) 25 〉=A.Culture is divided into 2 levels, diagnostic criteria B): 1) primary school and following; 2) junior middle school and more than.According to above-mentioned two diagnostic criterias referring to table 1.
Work process of the present invention is: when the tester checks that by the MCI that networks client computer 2 enters the service page that MCI testing server 1 is provided.
At first, require the tester in typing unit 10, to import individual essential information, as name, sex, date of birth, marriage, schooling, telephone number; Hypomnesis situation, past medical histroy, the situation of snoring.The personal information of typing is saved in the individual essential information mnemon 3 through essential information transmitting element 11.
Below shown in be the Chinese mild cognitive impairment examination scale that the present invention adopts:
------orientation force:
" be which year today? month? the date? what day? ", " do you live at which? be positioned at which city? ", whenever answered questions 1 note 0.5 minute, 3 minutes altogether.
------memory:
" I will say several speech now; would you please listen to carefully; after I have said, please repeat to give an account of, and remember this several speech; because I can inquire again you after a few minutes ", " Flos Chrysanthemi, national flag, family, trees, ball " (noted: in 1 second of each noun, carefully say clearly, after answering the tested first time, require main examination to repeat the tested memory again in back), this is not scored.
------noted and Vigilance:
Along the back of the body " I say some numerals, and you carefully listen, and you just and then carry on the back after I finish, 6-1-9-4-7 " in the same old way.Correct meter 1 minute, mistake 0 minute.
Fall to carry on the back " I say some numerals, and you just fall to carry on the back 7-4-2 according to former number after I finish ".Correct meter 1 minute, mistake 0 minute.
" following I will read a series of numerals to Vigilance, please note to listen.When I read 1, you just clapped an assistant, did not clap hands when I read other numerals." demonstration: 5-4-1-3-2-1.Allow begin test after the tested understanding, read " 5-2-1-3-1-9-4-1-7-5-1-8-0-6-2-1-5-1-9-4-1-5-1-1-4-1-9-0-5-1-2 " with the speed of 1 numeral of per second.Entirely true or once wrong meter 1 minute.
3 minutes altogether.
------computing power:
" please calculate 100 and subtract 7 what equal, the number that draws subtracts 7 again, goes down always; know I say stop till ", subtract altogether 5 times, correct option is 93-86-79-72-65, if it is wrong, but next answer is right, then right still score, and for example answering is 93-85-78-71-64, the 85th, wrong, but other are correct, count 4 correctly, 1 mistake.Scoring: 5 entirely true meters 3 minutes, 3-4 correct meter 2 minutes, 1-2 correct meter 1 minute, 0 correct meter 0 minute.
--name of----language:
Show picture such as Fig. 5;
" what this is? ", correctly be radio, aircraft.Counted totally 2 minutes 1 fen for 1 every pair.
------word fluency:
" would you please to say as far as possible soon, as much as possible the title of the animal known to you, the time is 1 minute, begins now ".Write down tested answer, the number of animals of saying 〉=11 1 minute notice that mythical animals such as dragon, phoenix, kylin also calculate correctly.
------postpones to recall:
" ask you to say just now those several speech that I allow you remember, you also remember? " counted totally 5 minutes 1 fen for 1 every pair.
--figure is re-recognized----:
With reference to Fig. 5, " 4 figures are arranged here, would you please carefully see and will remember, see that I can take it away after 20 seconds, want you on an other card, 4 figures that you have seen to be found out then ".
Scoring: whenever look for and counted 4 minutes altogether 1 fen to 1.
------speech comprehension:
" would you please do, listen to carefully: clap your shoulder twice with your hands, will close eyes simultaneously always according to the instruction that I say." note and can not explain and repeat.Scoring: hands, shoulder, twice, closing eyes, each step is to counting totally 2 minutes 0.5 fen.
------abstracting power:
(tested) to what have a high degree of literacy: " a pair of speech is arranged here, ask you to summarize similarity between them, as train-automobile?." after the tested answer vehicles are correct, test: " Fructus Persicae-Fructus Citri tangerinae? " " Canis familiaris L.-lion? " " axe-saw? "
(to low tested of schooling): " what is there there two things here; asking you to have a talk about has similar between them? what has similar as train and automobile? " if testedly answer both and can both open or other accessory answers, main examination prompting " yes; but you will say that they all are the vehicles ", test then: " Fructus Persicae-Fructus Citri tangerinae? " " Canis familiaris L.-lion? " " axe-saw? "
Scoring: Fructus Persicae-Fructus Citri tangerinae is (correct: fruit; Fruit; Fruit.Correct meter 1 minute, mistake 0 minute)
Canis familiaris L.-lion is (correct: animal; Mammal; Vertebrates; Rudimentary animal; The animal of four feet.Correct meter 1 minute, mistake 0 minute.Notice that domestic animal, beasts are wrong)
Axe-saw is (correct: instrument; Wood working tool; Sawing timber instrument; Do woodwork.Correct meter 1 minute, mistake 0 minute)
------TV structure technical ability:
Point to pentagon, " please you according to the appearance of this figure aside blank space draw one living." scoring: pentagon need draw 5 clearly angle and 5 limits.Simultaneously, two pentagon infalls form rhombus.The shake of lines and the rotation of figure can be ignored.Correct meter 1 minute, mistake 0 minute.
" would you please clock and watch of 11: 10 of picture." scoring: met every standard meter 1 minute, totally 3 minutes:
ⅰ. profile 1 minute: shape can be circular or square, allows light defects
ⅱ. numeral 1 minute: unnecessary numeral must be finished and not have to all numerals; Numerical order must be correct and in affiliated quadrant; It can be Roman number; Numeral can be placed on outside the circle.
Iii. pointer is 1 minute: must point to correct position together by two pointers, hour hands must be significantly shorter than minute hand, and the center intersection point of pointer must be at Biao Nei and the center of approaching clock and watch.
Embodiment 2
With reference to Fig. 1, Fig. 2, Fig. 6, can not constitute server and client computer to some place communicates and also can adopt the unit mode to carry out the MCI diagnosis under the mutual situation, download MCI degree criterion and test scale from server, whole process is the same with embodiment 1, as shown in Figure 4, relevant MCI examination presentation of results is set forth owing to top, just omits these explanations here.
With reference to Fig. 1, Fig. 2, Fig. 7, do not have the place of computer to test to some and use OCR read test result then with paper, whole flow process is as shown in Figure 5.The tester writes on the problem of answering on the Answer List that pre-establishes earlier, read in computer by OCR reading device 18 then and carry out the judgement of MCI degree, whole decision process is the same with embodiment 1, the result is as shown in table 1, relevant MCI examination presentation of results is set forth owing to top, just omit these explanations here, MCI degree result of determination prints the test result report by print unit 19 as a result.
Claims (3)
1. the device of the old mild cognitive impairment of a computer-aided screening, it is characterized in that: described device comprises the MCI testing server and checks client computer that described MCI testing server comprises:
Personal information mnemon is used to preserve tester's individual's essential information and test result;
Scale mnemon, be used to MCI test-based examination client computer to provide the test scale of objective judgement MCI, described test scale to comprise orientation force test question, memory test question, attention and Vigilance test question, computing power test question, language name test question, postpone to recall test question, word fluency test question, figure re-recognize test question, speech comprehension test question, abstracting power test question and TV structure skills tests topic;
The scale transmitting element is used for the MCI test scale is checked that to MCI client computer sends;
Answer receiving element, be used to receive the answer that comes from the relevant MCI test scale of MCI inspection client computer, and obtain tester's score value;
MCI degree statistics mnemon, be used for formerly old people tested with the clinical dementia scale and evaluate, default judge that primary school and the old people of following educational level are first threshold for the score value of MCI and judge the junior middle school and the old people of above educational level is second threshold value for the score value of MCI, described first threshold is less than second threshold value, and table 1 is the combination judged result of MCI degree statistics mnemon:
MCI differentiates comparing unit, is used for according to tester's score and schooling the table 1 of MCI degree statistics mnemon being tabled look-up, and obtains the corresponding judgment result;
Transmitting element is used for sending to the inspection client computer from the more unitary result of determination of MCI discrimination ratio as a result, simultaneously the result is sent to personal information mnemon and preserves;
Described inspection client computer comprises:
Essential information typing unit is used to obtain tester's basic personal information;
The essential information transmitting element, the personal information that will obtain from the typing unit is sent to testing server and preserves;
The scale receiving element is used to receive the MCI test scale that sends over from the MCI testing server;
Scale is represented the unit, is used to the MCI test scale that shows that reception obtains;
Answer obtains the unit, is used to obtain that the tester operates response and the answer that obtains the MCI test scale;
Answer transmitting element, be used for obtaining the unit and obtain answering the back to MCI testing server transmission answer result in answer;
Receiving element is used to receive the test result information that sends over from the transmitting element as a result of testing server as a result;
Display unit is used for the test result information that the display result receiving element receives as a result.
2. the device of the old mild cognitive impairment of computer-aided screening as claimed in claim 1, it is characterized in that: described inspection client computer also comprises: be used to read the OCR reading device of the test result of written test scale, described OCR reading device is obtained the unit with described answer and is connected.
3. the device of the old mild cognitive impairment of computer-aided screening as claimed in claim 1 or 2 is characterized in that: draw the described first threshold and second threshold value according to sensitivity and specificity analyses.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105084062A CN101983613B (en) | 2010-10-15 | 2010-10-15 | Computer-aided device for screening mild cognitive impairment (MCI) of old people |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105084062A CN101983613B (en) | 2010-10-15 | 2010-10-15 | Computer-aided device for screening mild cognitive impairment (MCI) of old people |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101983613A true CN101983613A (en) | 2011-03-09 |
| CN101983613B CN101983613B (en) | 2012-07-04 |
Family
ID=43640775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105084062A Active CN101983613B (en) | 2010-10-15 | 2010-10-15 | Computer-aided device for screening mild cognitive impairment (MCI) of old people |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101983613B (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103815920A (en) * | 2014-02-27 | 2014-05-28 | 首都医科大学 | Domestic detector and detecting method of domestic detector |
| CN104143169A (en) * | 2014-08-18 | 2014-11-12 | 上海市精神卫生中心 | E-mental symptom fast screening and self-checking system for assisting diagnosis and treatment |
| CN104409074A (en) * | 2014-05-12 | 2015-03-11 | 湖北文理学院 | Auditory sense cognition impairment evaluating device |
| CN104657929A (en) * | 2015-02-25 | 2015-05-27 | 潘晓东 | Multimedia based cognitive mental health status parallel test method and system |
| CN104715157A (en) * | 2015-03-25 | 2015-06-17 | 成都信息工程学院 | Cognition impairment evaluating system and method based on clock drawing test |
| US9576593B2 (en) | 2012-03-15 | 2017-02-21 | Regents Of The University Of Minnesota | Automated verbal fluency assessment |
| CN107145739A (en) * | 2017-05-07 | 2017-09-08 | 黄石德龙自动化科技有限公司 | Method of discrimination based on Alzheimer disease under a variety of data |
| CN109841231A (en) * | 2018-12-29 | 2019-06-04 | 深圳先进技术研究院 | A kind of early stage AD speech auxiliary screening system for standard Chinese |
| CN110288986A (en) * | 2019-07-04 | 2019-09-27 | 上海市精神卫生中心（上海市心理咨询培训中心） | Online cognition self-appraisal voice system and its processing method |
| CN111816295A (en) * | 2020-07-23 | 2020-10-23 | 厦门市和家健脑智能科技有限公司 | System and method for internet-based cognitive disorder screening evaluation and rehabilitation training |
| CN113827191A (en) * | 2021-09-29 | 2021-12-24 | 上海市精神卫生中心（上海市心理咨询培训中心） | Method, device, processor and computer storage medium for realizing rapid screening of cognitive impairment of old people in hierarchical progressive mode |
| CN114096200A (en) * | 2019-07-26 | 2022-02-25 | 麦克赛尔株式会社 | System, computer program and method for TMT examination result display |
| CN114305457A (en) * | 2021-12-28 | 2022-04-12 | 上海仪器仪表研究所 | Senile dementia judging system |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050240086A1 (en) * | 2004-03-12 | 2005-10-27 | Metin Akay | Intelligent wearable monitor systems and methods |
| CN1839749A (en) * | 2005-04-01 | 2006-10-04 | 浙江工业大学 | Computer aided device for early identifying and predicting senile dementia |
| US20070027406A1 (en) * | 2004-02-13 | 2007-02-01 | Georgia Tech Research Corporation | Display enhanced testing for concussions and mild traumatic brain injury |
-
2010
- 2010-10-15 CN CN2010105084062A patent/CN101983613B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070027406A1 (en) * | 2004-02-13 | 2007-02-01 | Georgia Tech Research Corporation | Display enhanced testing for concussions and mild traumatic brain injury |
| US20050240086A1 (en) * | 2004-03-12 | 2005-10-27 | Metin Akay | Intelligent wearable monitor systems and methods |
| CN1839749A (en) * | 2005-04-01 | 2006-10-04 | 浙江工业大学 | Computer aided device for early identifying and predicting senile dementia |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9576593B2 (en) | 2012-03-15 | 2017-02-21 | Regents Of The University Of Minnesota | Automated verbal fluency assessment |
| CN103815920A (en) * | 2014-02-27 | 2014-05-28 | 首都医科大学 | Domestic detector and detecting method of domestic detector |
| CN103815920B (en) * | 2014-02-27 | 2015-09-09 | 首都医科大学 | A kind of detection method of utilizer detector |
| CN104409074A (en) * | 2014-05-12 | 2015-03-11 | 湖北文理学院 | Auditory sense cognition impairment evaluating device |
| CN104143169A (en) * | 2014-08-18 | 2014-11-12 | 上海市精神卫生中心 | E-mental symptom fast screening and self-checking system for assisting diagnosis and treatment |
| CN104657929A (en) * | 2015-02-25 | 2015-05-27 | 潘晓东 | Multimedia based cognitive mental health status parallel test method and system |
| CN104715157A (en) * | 2015-03-25 | 2015-06-17 | 成都信息工程学院 | Cognition impairment evaluating system and method based on clock drawing test |
| CN107145739A (en) * | 2017-05-07 | 2017-09-08 | 黄石德龙自动化科技有限公司 | Method of discrimination based on Alzheimer disease under a variety of data |
| CN109841231A (en) * | 2018-12-29 | 2019-06-04 | 深圳先进技术研究院 | A kind of early stage AD speech auxiliary screening system for standard Chinese |
| WO2020134647A1 (en) * | 2018-12-29 | 2020-07-02 | 深圳先进技术研究院 | Early-stage ad speech auxiliary screening system aiming at mandarin chinese |
| CN110288986A (en) * | 2019-07-04 | 2019-09-27 | 上海市精神卫生中心（上海市心理咨询培训中心） | Online cognition self-appraisal voice system and its processing method |
| CN114096200A (en) * | 2019-07-26 | 2022-02-25 | 麦克赛尔株式会社 | System, computer program and method for TMT examination result display |
| CN114096200B (en) * | 2019-07-26 | 2024-03-12 | 麦克赛尔株式会社 | System, computer program and method for TMT inspection result display |
| CN111816295A (en) * | 2020-07-23 | 2020-10-23 | 厦门市和家健脑智能科技有限公司 | System and method for internet-based cognitive disorder screening evaluation and rehabilitation training |
| CN111816295B (en) * | 2020-07-23 | 2022-08-05 | 厦门市和家健脑智能科技有限公司 | System and method for internet-based cognitive disorder screening evaluation and rehabilitation training |
| CN113827191A (en) * | 2021-09-29 | 2021-12-24 | 上海市精神卫生中心（上海市心理咨询培训中心） | Method, device, processor and computer storage medium for realizing rapid screening of cognitive impairment of old people in hierarchical progressive mode |
| CN113827191B (en) * | 2021-09-29 | 2024-01-23 | 上海市精神卫生中心（上海市心理咨询培训中心） | Method, device, processor and computer storage medium for realizing quick screening of cognitive impairment of old people by using layering progressive mode |
| CN114305457A (en) * | 2021-12-28 | 2022-04-12 | 上海仪器仪表研究所 | Senile dementia judging system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101983613B (en) | 2012-07-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101983613B (en) | Computer-aided device for screening mild cognitive impairment (MCI) of old people | |
| Akhmedov | Analysis of the Reliability of the Test form of Knowledge Control in Cluster Education | |
| Tarrant et al. | Impact of item‐writing flaws in multiple‐choice questions on student achievement in high‐stakes nursing assessments | |
| CN100360076C (en) | Computer aided device for early identifying and predicting senile dementia | |
| Elmore et al. | A model of statistics achievement using spatial ability, feminist attitudes and mathematics-related variables as predictors | |
| Barr | Methodologic issues in neuropsychological testing | |
| Smith et al. | Diagnostic Utility of the Bannatyne WISC–III Pattern | |
| Qiu et al. | Development and psychometric testing of the Research Competency Scale for Nursing Students: An instrument design study | |
| Warner | Clinicians' guide to evaluating diagnostic and screening tests in psychiatry | |
| Hayes et al. | Medical training and English language proficiency | |
| Benson et al. | Invariance of Woodcock-Johnson III scores for students with learning disorders and students without learning disorders. | |
| Canivez | Validity and diagnostic efficiency of the Kaufman Brief Intelligence Test in reevaluating students with learning disability | |
| Ryan et al. | Understanding test construction | |
| Cervetti et al. | Examining multiple dimensions of word knowledge for content vocabulary understanding | |
| CN115497621A (en) | Old person cognitive status evaluation system | |
| Rubenzer | Review of the inventory of legal knowledge | |
| Sari et al. | Effect of knowledge, attitude, role of health officers and family support on early detection of pregnancy signs with the quality of utilization of the MCH handbook in the Puskesma Region Kesamben Jombang Regency | |
| Steffan et al. | Effect of symptom information and intelligence in dissimulation: An examination of faking response styles by inmates on the Basic Personality Inventory | |
| Halpin et al. | Measuring Critical Education Processes and Outcomes: Illustration from a Cluster Randomized Trial in the Democratic Republic of the Congo. | |
| Reed et al. | Construct validity of the universal nonverbal intelligence test (UNIT) | |
| Maller et al. | WISC-III factor invariance across samples of children exhibiting appropriate and inappropriate test-session behaviors | |
| Rutledge | Sensitivity and specificity of lump detection in breast models | |
| Yin et al. | An investigation of difference scores for a grade-level testing program | |
| Song et al. | Does symptom severity moderate the relationship between body mass index and motor competence in children with autism spectrum disorders? An exploratory study | |
| Saleem et al. | Academic stress, psychological well-being and academic achievement among college students |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |