CN101982229B - Gravity driven microfluidic device for preparing monodispersed emulsion and method thereof - Google Patents
Gravity driven microfluidic device for preparing monodispersed emulsion and method thereof Download PDFInfo
- Publication number
- CN101982229B CN101982229B CN2010105032212A CN201010503221A CN101982229B CN 101982229 B CN101982229 B CN 101982229B CN 2010105032212 A CN2010105032212 A CN 2010105032212A CN 201010503221 A CN201010503221 A CN 201010503221A CN 101982229 B CN101982229 B CN 101982229B
- Authority
- CN
- China
- Prior art keywords
- sample
- continuous phase
- decentralized photo
- continuous
- sample introduction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Abstract
The invention relates to a gravity drive microfluidic device for preparing a monodispersed emulsion and a method thereof, which is characterized in that a microfluidic system is driven by utilizing the constant flow rate generated by means of the constant gravity action of fluid columns with different heights based on the microfluidic device; liquid drops with different and even volumes are formed by utilizing the action of a shearing force, the surface tension and the like of the continuous phase fluid to the dispersed phase fluid; and microspheres meeting the requirements on bioanalysis and carriers of proteins, genes, medicine screening and the like are formed by solidification, drying or ultraviolet irradiation polymerization. The device of the invention comprises a microfluidic control device support component, a constant sample introduction component, a fluid pipeline, a microfluidic control channel component and a continuous sample adding component, wherein the heights of two-phase liquid columns are automatically controlled by controlling a two-phase mechanical motor; the liquid columns with different heights drive the fluid to generate the constant speed; the continuous-phase fluid for driving the microfluidic control device is used for shearing the dispersed phase liquid to prepare the liquid drops with the different volumes; and the large-scale and continuous preparation of the liquid drops can be realized by the continuous sample adding component and the constant sample introduction component.
Description
Technical field
What the present invention relates to is a kind of weight-driven microfluidic device that can be used for the monodisperse emulsion preparation.Based on micro fluidic device; The constant flow rate that produces through the constant gravity effect by means of the fluid column of differing heights drives microfluidic system; Utilize continuous phase fluid to effects such as the shearing force of dispersed phase fluid, surface tension; Form drop of uniform size, again through solidifying dry or ultraviolet irradiation polymerization, form the microballoon of carrier requirements such as meeting bioanalysis and protein, gene, drug screening.
Background technology
Along with the continuous development of biomedical technology, be that the liquid phase flow chip technology of carrier has obtained increasing utilization with the microballoon in bioanalysis and protein, gene, drug screening.With respect to other forms of solid phase carrier, microballoon has significant advantage: the first, and the specific area of microballoon is big, can increase the effecting reaction surface to volume ratio, and the chemical reaction on surface is carried out in littler volume; The second, adopt microballoon can utilize some other supplementary means to realize a kind of reaction system between solid-liquid reaction and liquid-liquid reactions, thereby accelerate the reaction speed of system like stir, liquid washes away etc. as carrier; The 3rd, the molecule that microsphere surface combines can be separated from solution after reaction is accomplished easily; The 4th, along with the change of microsphere surface functionalization group, can expand the purposes of microballoon.
At present, preparation multi-functional, the high-performance polymer microballoon is a focus of studying both at home and abroad always, and has penetrated in the research of numerous related disciplines.Method for preparing polymer micro commonly used has emulsion polymerization, dispersion copolymerization method, seeding polymerization method, suspension polymerization and microsuspension polymerization method etc.; But the microspherulite diameter of this method preparation is in nanometer and sub-micrometer range, and the difficulty that certain particle is coated in the polymer is very big.And prepare hundreds of micron a method spray drying process and template etc. are arranged, but all have the inhomogeneous and making apparatus requirement height of particle diameter, problems such as cost of manufacture height to several millimeters particle diameter polymer microballoons.Microflow control technique is meant the employing Micrometer-Nanometer Processing Technology; On more than one square centimeters chip, produce the microchannel network structure; Be integrated in the laboratory main equipment on the as far as possible little operating platform, in order to accomplishing different experimentations, and the technology that can analyze product.It not only makes the consumption of reagent reduce, and speed of experiment is improved, and expense reduces, and has demonstrated fully the development trend of microminiaturized, the integrated and portability of current laboratory equipment.Therefore, exploitation will reduce experimental cost based on the micro fluidic device of weight-driven, simplify experimental procedure, dwindle experimental facilities, accurately control the result, realize the extensive of microballoon and preparation continuously.
Summary of the invention
Technical problem: the objective of the invention is to manufacture and design a kind of weight-driven microfluidic device and method that is used for the monodisperse emulsion preparation; This apparatus structure is simple, and design and manufacture cost is cheap, and is easy to operate; Can control the size of emulsion droplets more accurately; The good monodispersity of emulsion droplets polymerization of preparation can realize the mass preparation of emulsion droplets and preparation continuously, favorable repeatability.
Technical scheme: the weight-driven microfluidic device that is used for the monodisperse emulsion preparation of the present invention mainly comprises with the lower part:
The micro fluidic device support component: decentralized photo support column and continuous phase support column branch are solid to be supported on the base plate, and the decentralized photo geometrical clamp is fixed on the decentralized photo support column, and the continuous phase geometrical clamp is fixed on the continuous phase support column; Be respectively equipped with the decentralized photo height control motor and the continuous phase height control motor of highly automated Lift Part on decentralized photo support column and the continuous phase support column, the height of microfluidic device is regulated in the rotation of motor controller control motor respectively;
Constant sample introduction parts: decentralized photo sample introduction column jacket is fixed on the decentralized photo geometrical clamp; Decentralized photo sample introduction inner prop is positioned at decentralized photo sample introduction column jacket; It highly is lower than the height of decentralized photo sample introduction column jacket; The outlet of decentralized photo sample intake passage connects the bottom of decentralized photo sample introduction inner prop, and the decentralized photo overfall connects the bottom of decentralized photo sample introduction column jacket;
Continuous phase sample introduction column jacket is fixed on the continuous phase geometrical clamp; Continuous phase sample introduction inner prop is positioned at continuous phase sample introduction column jacket; It highly is lower than the height of continuous phase sample introduction column jacket, and the outlet of continuous phase sample intake passage connects the bottom of continuous phase sample introduction inner prop, and the continuous phase overfall connects the bottom of continuous phase sample introduction column jacket;
Fluid line and microfluidic channel parts: the decline decentralized photo inlet of Flow Control passage of the last termination decentralized photo sample intake passage outlet of decentralized photo microfluid pipeline, the micro-fluidic or coflow of T shape of following termination; The upper end of continuous phase microfluid pipeline connects continuous phase sample intake passage outlet, the decline continuous phase inlet of Flow Control passage of the micro-fluidic or coflow of T shape of following termination; The decline outlet of Flow Control passage of the micro-fluidic or coflow of T shape connects microfluid and flows out pipeline;
Continuous application of sample parts: the inlet side of decentralized photo liquid storage sample cell connects the decentralized photo overfall; Sample outlet end connects decentralized photo wriggling sample-adding pump; The sample outlet end of decentralized photo wriggling sample-adding pump is positioned at the top of the continuous addition pool of decentralized photo, and the bottom of the continuous addition pool of decentralized photo connects decentralized photo sample introduction inner prop;
The sample introduction termination continuous phase overfall of continuous phase liquid storage sample cell, sample outlet end connect continuous phase wriggling sample-adding pump, and the sample outlet end of continuous phase wriggling sample-adding pump is positioned at the top of the continuous addition pool of continuous phase, and the bottom of the continuous addition pool 25 of continuous phase connects continuous phase sample introduction inner prop;
The method of weight-driven microfluid that is used for the weight-driven microfluidic device of monodisperse emulsion preparation is: the drive force source of described micro fluidic device is in fluid column fluid gravity, and the weight-driven fluid produces constant speed, as the actuating speed of micro fluidic device; Through the height of control fluid column, the different constant speed drive micro fluidic device of generation makes emulsion or preceding aggressiveness solution in flowing phase, shear the single dispersant liquid drop that forms different sizes; Through controlling continuous application of sample parts, realize the continuous sample introduction of micro fluidic device, realize the extensive of single dispersant liquid drop and preparation continuously;
The liquid column of keeping micro fluidic device keeps constant altitude and constant basis liquid, and unnecessary liquid overflows two phase inner props, flows out from overfall; Through wriggling application of sample motor, constantly, keep continuous continuous sample introduction to constant sample introduction parts application of sample; Control two phase lift in height machinery motor, the height of the liquid column of control micro fluidic device through motor controller.
Beneficial effect:, utilize micro fluidic device to have the following advantages based on weight-driven according to the present invention:
System is simple, with low cost: only need make two height bracing frames, fluid flow control system and microfluidic channel systems based on the microfluidic system of weight-driven and get final product, and with low cost; Customer service Mechanical Driven expensive cost and the error brought.Simultaneously, as long as make the preparation that a microfluid system can be realized a series of microballoons.
The microballoon monodispersity is good: because the fluid weight-driven, the flow velocity of generation is more constant, receives ectocine stealthy littler, and the microballoon for preparing is more even, and monodispersity is good.
Preparation continuously: because system can use a large amount of fluids, can realize the continuous preparation of microballoon, as long as Fluid Volume enough can realize continuously preparing microballoon.
Mass preparation: because system can use quantity of liquid and realize preparation continuously, system can realize a large amount of preparations of microballoon.
Favorable repeatability: because the material behavior of the size of microballoon and device is irrelevant, so but as long as the identical just repeated experiments result of two phase liquid with previous experiments.
Through after the corresponding cured, the Stability Analysis of Structures of microballoon can satisfy the instructions for use as bio-carrier preferably.
Description of drawings
Fig. 1 is the micro fluidic device figure that the present invention is based on weight-driven, and the figure acceptance of the bid is marked with supports base plate 1, decentralized photo support column 2, decentralized photo geometrical clamp 3; Continuous phase support column 4, continuous phase geometrical clamp 5, decentralized photo sample introduction column jacket 6 highly is lower than the decentralized photo sample introduction inner prop 7 of the constant altitude of column jacket; Decentralized photo sample intake passage outlet 8, decentralized photo overfall 9, continuous phase sample introduction column jacket 10 highly is lower than the continuous phase sample introduction inner prop 11 of the constant altitude of column jacket; Continuous phase sample intake passage outlet 12, continuous phase overfall 13, decentralized photo microfluid pipeline 14, continuous phase microfluid pipeline 15; Microfluid flows out pipeline 16, microfluidic channel decentralized photo inlet 17, microfluidic channel continuous phase inlet 18, microfluidic channel outlet 19; Decentralized photo sample cell 20, decentralized photo wriggling sample-adding pump 21, the continuous addition pool 22 of decentralized photo, continuous phase sample cell 23; Continuous phase wriggling sample-adding pump 24, the continuous addition pool 25 of continuous phase, decentralized photo height control motor 26, continuous phase height control motor 27 and motor controller 28.
The specific embodiment
The present invention is through manufacturing and designing the micro fluidic device based on weight-driven; This device produces constant speed based on the fluid gravity of liquid column; Drive microfluidic system; Height through the control liquid column; The constant drive speed of the different sizes that produce are by the drop templates of continuous phase fluid to different sizes of effect preparation such as the shearing force of decentralized photo liquid, surface tension; Through controlling continuous application of sample parts, realize the extensive of drop and preparation continuously; Again through solidifying dry or ultraviolet polymerization, form the polymer microballoon of carrier requirements such as meeting bioanalysis and protein, gene, drug screening.
In the liquid column of constant altitude, produce constant flow velocity, based on fluid with actuating speed as the microfluidic channel system; Adopt the microfluidic channel system to make emulsion or preceding aggressiveness solution in flowing phase, form drop.Through controlling mechanical motor, the liquid column height of automatic regulating apparatus is to produce the constant drive speed of different sizes; Through continuous application of sample and constant sample introduction parts, continuous application of sample and the fluid total volume of control fluid constant to keep actuating speed invariable, realized the mass preparation of drop and preparation continuously, installs mainly to comprise with the lower part:
1) micro fluidic device support component: adopt Machining Technology to set up the micro fluidic device support component, these parts have three parts, are respectively and support base plate 1, decentralized photo support column 2, decentralized photo geometrical clamp 3, continuous phase support column 4 and continuous phase geometrical clamp 5;
2) constant sample introduction parts: adopt glass or plastics or metalworking technology to set up constant sample introduction parts, these parts comprise, decentralized photo sample introduction column jacket 6; Highly be lower than the decentralized photo sample introduction inner prop 7 of the constant altitude of column jacket; Decentralized photo sample intake passage outlet 8, decentralized photo overfall 9 and continuous phase sample introduction column jacket 10 highly are lower than the continuous phase sample introduction inner prop 11 of the constant altitude of column jacket; Continuous phase sample intake passage outlet 12, continuous phase overfall 13;
3) fluid line and microfluidic channel parts: adopt the circulation duct of Te Fulong as microfluid, pipeline mainly is divided into three parts, is respectively decentralized photo microfluid pipeline 14, continuous phase microfluid pipeline 15, and microfluid flows out pipeline 16; Adopt micro-processing technology to set up the microfluidic channel network, perhaps select syringe needle, polymer pipe, threeway to connect a T shape passage, this passage has 2 inlets, is respectively decentralized photo inlet 17 and continuous phase inlet 18, and 1 outlet 19 is arranged;
4) continuous application of sample parts: adopt Machining Technology, select the wriggling sample-adding pump, set up continuous application of sample parts; These parts are divided into six parts; Be respectively decentralized photo sample cell 20, and decentralized photo wriggling sample-adding pump (21, continuous addition pool 22 of decentralized photo and continuous phase sample cell 23; Continuous phase wriggling sample-adding pump 24, the continuous addition pool 25 of continuous phase;
5) highly automated Lift Part: adopt machining and electronics process technology; Selection can be controlled mechanical horse and reach, and sets up highly automated Lift Part, and these parts mainly comprise three parts; Be respectively decentralized photo height control motor 26, continuous phase height control motor 27 and motor controller 28;
The drive force source of described micro fluidic device is in fluid column fluid gravity, and the weight-driven fluid produces constant speed, as the actuating speed of micro fluidic device; Through the height of control fluid column, the different constant speed drive micro fluidic device of generation makes emulsion or preceding aggressiveness solution in flowing phase, shear the single dispersant liquid drop that forms different sizes; Through controlling continuous application of sample parts, realize the continuous sample introduction of micro fluidic device, realize the extensive of single dispersant liquid drop and preparation continuously;
Support component is that micro fluidic device provides height bracket, supports micro fluidic device to produce the fluid column of constant altitude; The liquid column of keeping micro fluidic device keeps constant altitude and constant basis liquid, and unnecessary liquid overflows two phase inner props, flows out from overfall; Through wriggling application of sample motor, constantly, keep continuous continuous sample introduction to constant sample introduction parts application of sample; Control two phase lift in height machinery motor through motor controller, control the height of the liquid column of micro fluidic device automatically.
Claims (2)
1. one kind is used for the weight-driven microfluidic device that monodisperse emulsion prepares, and it is characterized in that this device mainly comprises with the lower part:
The micro fluidic device support component: decentralized photo support column (2) and continuous phase support column (4) are solid respectively to be supported on the base plate (1), and decentralized photo geometrical clamp (3) is fixed on the decentralized photo support column (2), and continuous phase geometrical clamp (5) is fixed on the continuous phase support column (4); Be respectively equipped with the decentralized photo height control motor (26) and the continuous phase height control motor (27) of highly automated Lift Part on decentralized photo support column (2) and the continuous phase support column (4), the height of microfluidic device is regulated in the rotation of motor controller (28) control motor respectively;
Constant sample introduction parts: decentralized photo sample introduction column jacket (6) is fixed on the decentralized photo geometrical clamp (3); Decentralized photo sample introduction inner prop (7) is positioned at decentralized photo sample introduction column jacket (6); It highly is lower than the height of decentralized photo sample introduction column jacket (6); Decentralized photo sample intake passage outlet (8) connects the bottom of decentralized photo sample introduction inner prop (7), and decentralized photo overfall (9) connects the bottom of decentralized photo sample introduction column jacket (6);
Continuous phase sample introduction column jacket (10) is fixed on the continuous phase geometrical clamp (5); Continuous phase sample introduction inner prop (11) is positioned at continuous phase sample introduction column jacket (10); It highly is lower than the height of continuous phase sample introduction column jacket (10); Continuous phase sample intake passage outlet (12) connects the bottom of continuous phase sample introduction inner prop (11), and continuous phase overfall (13) connects the bottom of continuous phase sample introduction column jacket (10);
Fluid line and microfluidic channel parts: the decline decentralized photo inlet (17) of Flow Control passage of the last termination decentralized photo sample intake passage outlet (8) of decentralized photo microfluid pipeline (14), the micro-fluidic or coflow of T shape of following termination; The upper end of continuous phase microfluid pipeline (15) connects continuous phase sample intake passage outlet (12), the decline continuous phase inlet (18) of Flow Control passage of the micro-fluidic or coflow of T shape of following termination; The decline outlet (19) of Flow Control passage of the micro-fluidic or coflow of T shape connects microfluid and flows out pipeline (16);
Continuous application of sample parts: the sample introduction termination decentralized photo overfall (9) of decentralized photo liquid storage sample cell (20); Sample outlet end connects decentralized photo wriggling sample-adding pump (21); The sample outlet end of decentralized photo wriggling sample-adding pump (21) is positioned at the top of the continuous addition pool of decentralized photo (22), and the bottom of the continuous addition pool of decentralized photo (22) connects decentralized photo sample introduction inner prop (7);
The sample introduction termination continuous phase overfall (13) of continuous phase liquid storage sample cell (23); Sample outlet end connects continuous phase wriggling sample-adding pump (24); The sample outlet end of continuous phase wriggling sample-adding pump (24) is positioned at the top of the continuous addition pool of continuous phase (25), and the bottom of the continuous addition pool of continuous phase (25) connects continuous phase sample introduction inner prop (11).
2. the method for the weight-driven microfluid of a weight-driven microfluidic device that is used for monodisperse emulsion preparation as claimed in claim 1; The drive force source that it is characterized in that described micro fluidic device is in fluid column fluid gravity; The weight-driven fluid produces constant speed, as the actuating speed of micro fluidic device; Through the height of control fluid column, the different constant speed drive micro fluidic device of generation makes emulsion or preceding aggressiveness solution in flowing phase, shear the single dispersant liquid drop that forms different sizes; Through continuous application of sample parts, the continuous sample introduction of control micro fluidic device is realized the extensive of single dispersant liquid drop and preparation continuously;
The liquid column of keeping micro fluidic device keeps constant altitude and constant basis liquid, and unnecessary liquid overflows two phase inner props, flows out from overfall; Through wriggling application of sample motor, constantly, keep continuous continuous sample introduction to constant sample introduction parts application of sample; Control two phase lift in height machinery motor, the height of the liquid column of control micro fluidic device through motor controller.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105032212A CN101982229B (en) | 2010-10-12 | 2010-10-12 | Gravity driven microfluidic device for preparing monodispersed emulsion and method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105032212A CN101982229B (en) | 2010-10-12 | 2010-10-12 | Gravity driven microfluidic device for preparing monodispersed emulsion and method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101982229A CN101982229A (en) | 2011-03-02 |
| CN101982229B true CN101982229B (en) | 2012-08-15 |
Family
ID=43619151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105032212A Expired - Fee Related CN101982229B (en) | 2010-10-12 | 2010-10-12 | Gravity driven microfluidic device for preparing monodispersed emulsion and method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101982229B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109310975A (en) * | 2016-11-14 | 2019-02-05 | 创技公司 | Equipment for producing monodisperse biodegradable polymers base microballoon and biodegradable polymers base drug delivery system in batches designs and the optimization of process |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104148124B (en) * | 2014-07-30 | 2015-12-16 | 河北工业大学 | A kind of drop formation device for micro-fluidic chip |
| CN105921188A (en) * | 2016-06-07 | 2016-09-07 | 东南大学 | Microfluidic device capable of rapidly preparing emulsion in multiple dimensions |
| CN106249663B (en) * | 2016-09-18 | 2018-10-12 | 山东省科学院能源研究所 | A method of realization automatically continuously prepares microballoon |
| CN106975411B (en) * | 2017-05-05 | 2020-01-10 | 北京大学 | Micro-fluidic chip based on 3D prints and including emulsion generating device of this chip |
| CN110064451B (en) * | 2018-01-24 | 2023-08-15 | 思纳福(苏州)生命科技有限公司 | Fluid driving mechanism and fluid driving method |
| CN109364835B (en) * | 2018-09-27 | 2021-05-11 | 广东工业大学 | Phase-change microcapsule and preparation method and application thereof |
| CN115400808A (en) * | 2022-10-31 | 2022-11-29 | 杭州跃真生物科技有限公司 | Micro-fluidic chip flow accurate control device and method |
| CN116237095A (en) * | 2023-02-18 | 2023-06-09 | 四川大学 | Microfluidic method for controllably preparing monodisperse emulsion based on infiltration principle |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279232A (en) * | 2008-01-11 | 2008-10-08 | 东南大学 | Preparation of microballoons based on microfluid |
| CN101382538A (en) * | 2007-09-04 | 2009-03-11 | 财团法人工业技术研究院 | Auto-shunting microfluid apparatus |
| CN201823514U (en) * | 2010-10-12 | 2011-05-11 | 东南大学 | Gravity-driven microfluid device for preparing monodispersed emulsion |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5712212A (en) * | 1995-03-08 | 1998-01-27 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for the production of gel beads containing a biocatalyst |
| JP3081880B2 (en) * | 1998-03-30 | 2000-08-28 | 農林水産省食品総合研究所長 | Microsphere continuous manufacturing equipment |
| CN201333185Y (en) * | 2009-01-12 | 2009-10-28 | 高月荣 | Continuous preparation device for microsphere medicament |
-
2010
- 2010-10-12 CN CN2010105032212A patent/CN101982229B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101382538A (en) * | 2007-09-04 | 2009-03-11 | 财团法人工业技术研究院 | Auto-shunting microfluid apparatus |
| CN101279232A (en) * | 2008-01-11 | 2008-10-08 | 东南大学 | Preparation of microballoons based on microfluid |
| CN201823514U (en) * | 2010-10-12 | 2011-05-11 | 东南大学 | Gravity-driven microfluid device for preparing monodispersed emulsion |
Non-Patent Citations (3)
| Title |
|---|
| Engineering Chemistry Research》.ACS Publications,2010,第49卷(第9期),4162-4168. * |
| Zheng Zhai 等.Preparation of Monodispersed Uniform Silica Spheres with Large Pore Size for Fast Adsorption of Proteins.《Industrial & Engineering Chemistry Research》.ACS Publications,2010,第49卷(第9期),4162-4168. |
| Zheng Zhai 等.Preparation of Monodispersed Uniform Silica Spheres with Large Pore Size for Fast Adsorption of Proteins.《Industrial & * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109310975A (en) * | 2016-11-14 | 2019-02-05 | 创技公司 | Equipment for producing monodisperse biodegradable polymers base microballoon and biodegradable polymers base drug delivery system in batches designs and the optimization of process |
| CN109310975B (en) * | 2016-11-14 | 2022-04-01 | 创技公司 | Optimization method for equipment for large scale production of monodisperse microspheres and biodegradable polymer-based drug delivery systems |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101982229A (en) | 2011-03-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101982229B (en) | Gravity driven microfluidic device for preparing monodispersed emulsion and method thereof | |
| CN101279232B (en) | Preparation of microballoons based on microfluid | |
| Xu et al. | Controllable preparation of monodisperse O/W and W/O emulsions in the same microfluidic device | |
| CN106140340B (en) | Micro-fluidic chip based on flow focusing type microchannel synthesis micro emulsion drop | |
| Yao et al. | Review of the applications of microreactors | |
| Maenaka et al. | Continuous and size-dependent sorting of emulsion droplets using hydrodynamics in pinched microchannels | |
| Chen et al. | Gas-liquid-liquid multiphase flow in microfluidic systems–A review | |
| CN201823514U (en) | Gravity-driven microfluid device for preparing monodispersed emulsion | |
| US20060286015A1 (en) | Methods of operating surface reactors and reactors employing such methods | |
| Feng et al. | Leveraging 3D printing for the design of high-performance venturi microbubble generators | |
| CN112275336B (en) | Multi-channel integrated micro-fluidic chip and method for preparing monodisperse gel microspheres by using same in high throughput | |
| CN104324769A (en) | Micro-pipeline-based liquid droplet generation method | |
| Moloudi et al. | Inertial particle focusing dynamics in a trapezoidal straight microchannel: Application to particle filtration | |
| Al-Azzawi et al. | A review on the hydrodynamics of the liquid–liquid two-phase flow in the microchannels | |
| Lan et al. | A one-step microfluidic approach for controllable preparation of nanoparticle-coated patchy microparticles | |
| Mastiani et al. | High-throughput aqueous two-phase system droplet generation by oil-free passive microfluidics | |
| CN102757012B (en) | Method for preparing micro-solution storage and multi-phase heterogenous microparticles | |
| Du et al. | Liquid–liquid mass transfer enhancement in milliscale packed beds | |
| Hao et al. | Controlling factors on droplets uniformity in membrane emulsification: experiment and modeling analysis | |
| Xu et al. | High-throughput production of droplets using mini hydrodynamic focusing devices with recirculation | |
| Ma et al. | Effect of viscosity on liquid–liquid slug flow in a step T-junction microchannel | |
| CN210206901U (en) | Double-water-phase system for emulsification and liquid drop generation module thereof | |
| Lan et al. | Study on Liquid–Liquid Droplet Flow Separation in a T-Shaped Microseparator | |
| Zhou et al. | Controllable microdroplet splitting via additional lateral flow and its application in rapid synthesis of multi-scale microspheres | |
| Scheiff et al. | Solid particle handling in microreaction technology: Practical challenges and application of microfluid segments for particle-based processes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120815 Termination date: 20211012 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |