CN101942059A - Application of cyclo olefin copolymer in preparing biological and chemical container - Google Patents
Application of cyclo olefin copolymer in preparing biological and chemical container Download PDFInfo
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- CN101942059A CN101942059A CN 201010252750 CN201010252750A CN101942059A CN 101942059 A CN101942059 A CN 101942059A CN 201010252750 CN201010252750 CN 201010252750 CN 201010252750 A CN201010252750 A CN 201010252750A CN 101942059 A CN101942059 A CN 101942059A
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- olefin copolymer
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Abstract
The invention discloses application of a cyclo olefin copolymer in preparing a biological and chemical container. When the cyclo olefin copolymer is applied to prepare the biological and chemical container, the prepared biological and chemical container has the following advantages: the glass bottle is resistant to heat and transparent, has high gas barrier property and low moisture absorption, can carry out high temperature moist heat sterilization and has good chemical resistance; and other high polymer materials such as plastic bottles are not easy to break, have light weight and can carry out high-energy ray radiation and sterilization with ethylene oxide.
Description
Technical field
The present invention relates to the application of a kind of cyclic olefin copolymer in preparation biology and chemical vessel.
Background technology
Preparation both at home and abroad is biological at present mainly contains following three types with chemical vessel:
One, Glass Containers:
Advantage: transparent, high temperature resistant, endurance is good, can carry out moist heat sterilization (steam sterilizing), and the close property of gas (vapour) is good, low moisture absorption.
Shortcoming: simple glass can not carry out high-energy radiation sterilization, can not ethylene oxide sterilizing, and frangible, matter is heavy, makes the energy consumption height.
Two, layer high molecule material bottle: the bottle wall is the sandwich of layers structure, inside and outside wall material ability higher temperatures, and low moisture absorption, the close property of sandwich of layers gas (vapour) is good.
Advantage: moist heat sterilization can be carried out, the high-energy radiation sterilization can be carried out, the energy ethylene oxide sterilizing, the close property of gas (vapour) is good.
Shortcoming: the manufacturing process complexity, technical difficulty is big, and the cost height has certain water absorbability.
Three, individual layer macromolecular material bottle: as polyethylene terephthalate (PET) and polycarbonate (PC) bottle.
Advantage: transparent, light weight, manufacturing process is simple, can resistant to high energy radiation sterilization and ethylene oxide sterilizing.
Shortcoming: can not satisfy performances such as high pressure moist heat sterilization, low moisture absorption, the close property of gas (vapour) are good simultaneously.
Summary of the invention
Purpose of the present invention provides the application of a kind of cyclic olefin copolymer in preparation biology and chemical vessel in order to overcome the deficiencies in the prior art and defective.
Purpose of the present invention is achieved through the following technical solutions: the application of cyclic olefin copolymer in preparation biology and chemical vessel, described cyclic olefin copolymer is that the high-molecular copolymer that copolymerization obtains takes place under catalyst action for double-heptene monomer and vinyl monomer, and its general molecular formula is:
The X value is 4～10 in the formula
4The Y value is 4～10
4
As first kind of optimal way of the present invention, described biology and chemical vessel are bacteria culture bottle.
As second kind of optimal way of the present invention, described biology and chemical vessel are Tissue Culture Flask
As the third optimal way of the present invention, described biology and chemical vessel are drug packaging bottle.
As the 4th kind of optimal way of the present invention, described biology and chemical vessel are the biological products packing bottle.
As the 5th kind of optimal way of the present invention, described biology and chemical vessel are the daily cosmetics packing bottle.
As the 6th kind of optimal way of the present invention, described biology and chemical vessel are Prefilled syringe (bottle).
As the 7th kind of optimal way of the present invention, described biology and chemical vessel are the food drink packing bottle.
As the 8th kind of optimal way of the present invention, described biology and chemical vessel are the chemical reagent packing bottle.
As the 9th kind of optimal way of the present invention, described biology and chemical vessel are the packing bottle of experiment reagent and standard substance.
Above-mentioned X value is preferably 400～7000; The Y value is preferably 400～7000.
The present invention compared with prior art, have the following advantages and beneficial effect: when cyclic olefin copolymer is applied to the preparation biology with chemical vessel, the advantage that make biology and the chemical vessel of preparation not only have heat-resisting, transparent, gas (vapour) the height barrier of vial, to hang down moisture absorption, can carry out damp and hot high-temperature sterilization, endurance is good has difficult fragmentation, light weight such as other macromolecular materials such as Plastic Bottle again, can carry out the advantage of energetic ray radiation and eo sterilization.
Embodiment
Below in conjunction with embodiment, to the detailed description further of the present invention's do, but embodiments of the present invention are not limited thereto.
Embodiment 1:
The cyclic olefin copolymer that the present invention relates to is that the high-molecular copolymer that copolymerization obtains takes place under catalyst action for double-heptene monomer and vinyl monomer, and its general molecular formula is:
The X value is 400～7000 in the formula; The Y value is 400～7000.
When above-mentioned cyclic olefin copolymer is applied to prepare bacteria culture bottle, as blood or coelomic fluid bacteria culture bottle.Its preparation method is: more than 75% (wt/%), the cyclic olefin copolymer pellet of heat-drawn wire 〉=127 ℃ is injection molded into pipe, again pipe is blow molded into bottle with double-heptene content.
Can get by experiment, the bacteria culture bottle of employing cyclic olefin copolymer preparation and the contrast properties parameter of existing bacteria culture bottle are as shown in the table:
As can be known from the above table, with respect to existing bacteria culture bottle, the bacteria culture bottle resistance to air loss that adopts cyclic olefin copolymer to prepare is good, can be beneficial to the different methods sterilization of guaranteeing the quality, bottle is transparent, the bottle light weight, and cracky is not easy to transportation, the method that is easy to environmental protection and Biosafety after the use is handled clinical waste, and this culturing bottle comprises automatic culturing bottle (bottle end built-in optical sensing diaphragm) and artificial culture bottle.Splendid attire substratum (the single-phase or liquid solid two-phase of liquid) in the culturing bottle, the bacterium that is used for blood, cerebrospinal fluid, ascites pleural fluid etc. increases bacterium and cultivates.
Embodiment 2:
The difference of present embodiment and embodiment 1 only is above-mentioned cyclic olefin copolymer is applied to prepare Tissue Culture Flask, as the culturing bottle of human or animal tissues cell, insect, plant tissue cell.Its preparation method is: more than 75% (wt/%), the cyclic olefin copolymer pellet of heat-drawn wire 〉=127 ℃ is injection molded into pipe, again pipe is blow molded into bottle with double-heptene content.
Can get by experiment, the Tissue Culture Flask of employing cyclic olefin copolymer preparation and the contrast properties parameter of existing Tissue Culture Flask are as shown in the table:
As can be known from the above table, with respect to existing Tissue Culture Flask, the Tissue Culture Flask that adopts cyclic olefin copolymer to prepare can carry out the different methods sterilization, transparent being easy to of bottle observed, the cell colony of attached wall is easy to peel off, the bottle light weight, cracky is not easy to transportation, and the method that is easy to environmental protection and Biosafety after the use disposes waste liquid.
Embodiment 3:
The difference of present embodiment and embodiment 1 only is above-mentioned cyclic olefin copolymer is applied to prepare drug packaging bottle, as aqua, the bottling of injection cartridge bag.Its preparation method is: more than 75% (wt/%), the cyclic olefin copolymer pellet of heat-drawn wire 〉=127 ℃ is injection molded into pipe, again pipe is blow molded into bottle with double-heptene content.
Can get by experiment, the drug packaging bottle of employing cyclic olefin copolymer preparation and the contrast properties parameter of existing drug packaging bottle are as shown in the table:
As can be known from the above table, with respect to existing drug packaging bottle, the drug packaging bottle resistance to air loss that adopts cyclic olefin copolymer to prepare is good, can carry out the diverse ways sterilization, be beneficial to medicine and guarantee the quality, the bottle light weight, cracky is not easy to transportation, is easy to the environment protection method recycling after the use.
Embodiment 4:
The difference of present embodiment and embodiment 1 only is above-mentioned cyclic olefin copolymer is applied to prepare the biological products packing bottle, as human or animal's serum product bottle, vaccine bottle.Its preparation method is: more than 75% (wt/%), the cyclic olefin copolymer pellet of heat-drawn wire 〉=127 ℃ is injection molded into pipe, again pipe is blow molded into bottle with double-heptene content.
Can get by experiment, the biological products packing bottle of employing cyclic olefin copolymer preparation and the contrast properties parameter of prior biological goods packing bottle are as shown in the table:
As can be known from the above table, with respect to prior biological goods packing bottle, the close property of biological products packing bottle gas (vapour) that adopts cyclic olefin copolymer to prepare is good, can carry out the diverse ways sterilization, be beneficial to goods and guarantee the quality, packing bottle light weight, not cracky, be easy to transportation, use the back bottle to be easy to the environment protection method recycling.
Embodiment 5:
The difference of present embodiment and embodiment 1 only is above-mentioned cyclic olefin copolymer is applied to prepare the daily cosmetics packing bottle, as perfume, essence packing bottle.Its preparation method is: more than 75% (wt/%), the cyclic olefin copolymer pellet of heat-drawn wire 〉=127 ℃ is injection molded into pipe, again pipe is blow molded into bottle with double-heptene content.
Can get by experiment, the daily cosmetics packing bottle of employing cyclic olefin copolymer preparation and the contrast properties parameter of existing daily cosmetics packing bottle are as shown in the table:
As can be known from the above table, with respect to existing daily cosmetics packing bottle, the close property of daily cosmetics packing bottle gas (vapour) that adopts cyclic olefin copolymer to prepare is good, can prevent that fragrance ingredient scatters and disappears, be beneficial to goods and guarantee the quality, packing bottle light weight, not cracky, be easy to transportation and preserve, use the back bottle to be easy to the environment protection method recycling.
Embodiment 6:
The difference of present embodiment and embodiment 1 only is above-mentioned cyclic olefin copolymer is applied to prepare Prefilled injection packing bottle, as the disposable pre-filling injection of injected articles such as immune vaccine, Regular Insulin.Its preparation method is: with double-heptene content more than 75% (wt/%), the cyclic olefin copolymer pellet of heat-drawn wire 〉=127 ℃, injection moulding.
Can get by experiment, the Prefilled injection packing bottle of employing cyclic olefin copolymer preparation and the contrast properties parameter of existing Prefilled syringe are as shown in the table:
As can be known from the above table, with respect to existing Prefilled injection packing bottle, the Prefilled injection packing bottle that adopts cyclic olefin copolymer to prepare, the close property of gas (vapour) is good, can adopt to help the active any method sterilization of product biological, be beneficial to goods and guarantee the quality, not cracky, be easy to transportation and preserve, be easy to the environment protection method recycling after the use.
Embodiment 7:
The difference of present embodiment and embodiment 1 only is above-mentioned cyclic olefin copolymer is applied to prepare the food drink packing bottle, as beer, red wine, liquor, beverage packets bottling.Its preparation method is: more than 75% (wt/%), the cyclic olefin copolymer pellet of heat-drawn wire 〉=127 ℃ is injection molded into pipe, again pipe is blow molded into bottle with double-heptene content.
Can get by experiment, the food drink packing bottle of employing cyclic olefin copolymer preparation and the contrast properties parameter of existing food drink packing bottle are as shown in the table:
As can be known from the above table, with respect to existing food drink packing bottle, the close property of food drink packing bottle gas (vapour) that adopts cyclic olefin copolymer to prepare is good, can prevent that volatile component scatters and disappears is beneficial to product and guarantees the quality, Package Quality is light, cracky is not easy to transportation and preserves, and is easy to the environment protection method recycling after the use.
Embodiment 8:
The difference of present embodiment and embodiment 1 only is above-mentioned cyclic olefin copolymer is applied to prepare the chemical reagent packing bottle, as the packing bottle of easy volatile reagent, poisonous and harmful product, agricultural chemicals etc.Its preparation method is: more than 75% (wt/%), the cyclic olefin copolymer pellet of heat-drawn wire 〉=127 ℃ is injection molded into pipe, again pipe is blow molded into bottle with double-heptene content.
Can get by experiment, the chemical reagent packing bottle of employing cyclic olefin copolymer preparation and the contrast properties parameter of existing chemical reagent packing bottle are as shown in the table:
As can be known from the above table, with respect to existing chemical reagent packing bottle, the close property of chemical reagent packing bottle gas (vapour) that adopts cyclic olefin copolymer to prepare is good, chemical resistant properties is good, can prevent that toxic ingredient scatters and disappears, and is beneficial to the storage of hazardous substance, Package Quality is light, cracky is not easy to transportation and preserves, and is easy to the environment protection method recycling after the use.
Embodiment 9:
The difference of present embodiment and embodiment 1 only is above-mentioned cyclic olefin copolymer is applied to the packing bottle of preparation experiment reagent and standard substance, as the packing bottle of medical science, biology, agronomy experiment reagent and standard substance.Its preparation method is: more than 75% (wt/%), the cyclic olefin copolymer pellet of heat-drawn wire 〉=127 ℃ is injection molded into pipe, again pipe is blow molded into bottle with double-heptene content.
Can get by experiment, the contrast properties parameter of the packing bottle of the experiment reagent of employing cyclic olefin copolymer preparation and the packing bottle of standard substance and current experiments reagent and standard substance is as shown in the table:
As can be known from the above table, packing bottle with respect to current experiments reagent and standard substance, the experiment reagent that the employing cyclic olefin copolymer is prepared and the close property of packing bottle gas (vapour) of standard substance are good, chemical resistant properties is good, can prevent that toxic ingredient scatters and disappears, and is beneficial to the storage of hazardous substance, Package Quality is light, cracky is not easy to transportation and preserves, and is easy to the environment protection method recycling after the use.
As mentioned above, just can realize the present invention preferably.
Claims (10)
1. the application of cyclic olefin copolymer in preparation biology and chemical vessel, described cyclic olefin copolymer is that the high-molecular copolymer that copolymerization obtains takes place under catalyst action for double-heptene monomer and vinyl monomer, its general molecular formula is:
The X value is 4～10 in the formula
4The Y value is 4～10
4
2. the application of cyclic olefin copolymer according to claim 1 in preparation biology and chemical vessel is characterized in that described biology and chemical vessel are bacteria culture bottle or Tissue Culture Flask.
3. the application of cyclic olefin copolymer according to claim 1 in preparation biology and chemical vessel is characterized in that described biology and chemical vessel are drug packaging bottle.
4. the application of cyclic olefin copolymer according to claim 1 in preparation biology and chemical vessel is characterized in that described biology and chemical vessel are the biological products packing bottle.
5. the application of cyclic olefin copolymer according to claim 1 in preparation biology and chemical vessel is characterized in that described biology and chemical vessel are the daily cosmetics packing bottle.
6. the application of cyclic olefin copolymer according to claim 1 in preparation biology and chemical vessel is characterized in that described biology and chemical vessel are the Prefilled syringe packing bottle.
7. the application of cyclic olefin copolymer according to claim 1 in preparation biology and chemical vessel is characterized in that described biology and chemical vessel are the food drink packing bottle.
8. the application of cyclic olefin copolymer according to claim 1 in preparation biology and chemical vessel is characterized in that described biology and chemical vessel are the chemical reagent packing bottle.
9. the application of cyclic olefin copolymer according to claim 1 in preparation biology and chemical vessel is characterized in that described biology and chemical vessel are the packing bottle of experiment reagent and standard substance.
10. according to the application of each described cyclic olefin copolymer among the claim 1-9 in preparation biology and chemical vessel, it is characterized in that the X value is 400～7000; The Y value is 400～7000.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010252750 CN101942059A (en) | 2010-08-13 | 2010-08-13 | Application of cyclo olefin copolymer in preparing biological and chemical container |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010252750 CN101942059A (en) | 2010-08-13 | 2010-08-13 | Application of cyclo olefin copolymer in preparing biological and chemical container |
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| CN101942059A true CN101942059A (en) | 2011-01-12 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104086933A (en) * | 2014-07-29 | 2014-10-08 | 上海海昌医用塑胶厂 | COC bottle and preparation method thereof |
| CN104608453A (en) * | 2015-01-09 | 2015-05-13 | 山东大学 | Ultraviolet-resistant thin film for isolation clothes and preparation method thereof |
| CN107709381A (en) * | 2015-06-30 | 2018-02-16 | Sabic环球技术有限责任公司 | With highdensity ethene polymers |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0524802B1 (en) * | 1991-07-22 | 1996-11-27 | Daikyo Gomu Seiko Ltd. | A container for a sanitary article |
| CN101596334A (en) * | 2009-06-18 | 2009-12-09 | 李炜平 | A kind of spliced prefilled injector and using method thereof |
-
2010
- 2010-08-13 CN CN 201010252750 patent/CN101942059A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0524802B1 (en) * | 1991-07-22 | 1996-11-27 | Daikyo Gomu Seiko Ltd. | A container for a sanitary article |
| CN101596334A (en) * | 2009-06-18 | 2009-12-09 | 李炜平 | A kind of spliced prefilled injector and using method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 《化学进展》 20010131 赵健等 环烯烃聚合物的合成和应用研究进展 第48-55页 1-10 第13卷, 第1期 2 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104086933A (en) * | 2014-07-29 | 2014-10-08 | 上海海昌医用塑胶厂 | COC bottle and preparation method thereof |
| CN104608453A (en) * | 2015-01-09 | 2015-05-13 | 山东大学 | Ultraviolet-resistant thin film for isolation clothes and preparation method thereof |
| CN107709381A (en) * | 2015-06-30 | 2018-02-16 | Sabic环球技术有限责任公司 | With highdensity ethene polymers |
| CN107709381B (en) * | 2015-06-30 | 2021-02-09 | Sabic环球技术有限责任公司 | Ethylene polymers having high density |
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Application publication date: 20110112 |