CN101942039B - Parnaparin production method - Google Patents
Parnaparin production method Download PDFInfo
- Publication number
- CN101942039B CN101942039B CN2010102871329A CN201010287132A CN101942039B CN 101942039 B CN101942039 B CN 101942039B CN 2010102871329 A CN2010102871329 A CN 2010102871329A CN 201010287132 A CN201010287132 A CN 201010287132A CN 101942039 B CN101942039 B CN 101942039B
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- CN
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- concentration
- adjust
- dissolved
- heparin
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920000669 heparin Polymers 0.000 title claims abstract description 21
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims abstract description 17
- 238000004519 manufacturing process Methods 0.000 title abstract description 7
- 229960004762 parnaparin Drugs 0.000 title abstract 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229960002897 heparin Drugs 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 8
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims abstract description 4
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 claims abstract description 4
- 229960001008 heparin sodium Drugs 0.000 claims abstract description 4
- 235000017281 sodium acetate Nutrition 0.000 claims abstract description 4
- 239000001632 sodium acetate Substances 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 230000007935 neutral effect Effects 0.000 claims description 9
- 238000000151 deposition Methods 0.000 claims description 6
- 230000008021 deposition Effects 0.000 claims description 6
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 claims description 5
- 230000003647 oxidation Effects 0.000 claims description 4
- 238000007254 oxidation reaction Methods 0.000 claims description 4
- 239000011347 resin Substances 0.000 claims description 4
- 229920005989 resin Polymers 0.000 claims description 4
- YMHOBZXQZVXHBM-UHFFFAOYSA-N 2,5-dimethoxy-4-bromophenethylamine Chemical compound COC1=CC(CCN)=C(OC)C=C1Br YMHOBZXQZVXHBM-UHFFFAOYSA-N 0.000 claims description 3
- 241000545067 Venus Species 0.000 claims description 3
- 230000002378 acidificating effect Effects 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 239000013078 crystal Substances 0.000 claims description 3
- 230000018044 dehydration Effects 0.000 claims description 3
- 238000006297 dehydration reaction Methods 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 claims description 3
- 150000002500 ions Chemical class 0.000 claims description 3
- 238000005374 membrane filtration Methods 0.000 claims description 3
- 239000000088 plastic resin Substances 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- 238000004062 sedimentation Methods 0.000 claims description 3
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract description 4
- 238000006731 degradation reaction Methods 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 abstract description 2
- 239000011780 sodium chloride Substances 0.000 abstract description 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 150000002302 glucosamines Chemical class 0.000 abstract 1
- 229910001385 heavy metal Inorganic materials 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 150000002978 peroxides Chemical class 0.000 abstract 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 239000003055 low molecular weight heparin Substances 0.000 description 2
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
Images
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- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010102871329A CN101942039B (en) | 2010-09-16 | 2010-09-16 | Parnaparin production method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010102871329A CN101942039B (en) | 2010-09-16 | 2010-09-16 | Parnaparin production method |
Publications (2)
Publication Number | Publication Date |
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CN101942039A CN101942039A (en) | 2011-01-12 |
CN101942039B true CN101942039B (en) | 2012-11-28 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010102871329A Active CN101942039B (en) | 2010-09-16 | 2010-09-16 | Parnaparin production method |
Country Status (1)
Country | Link |
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CN (1) | CN101942039B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103421128B (en) * | 2013-07-31 | 2015-08-12 | 山东辰中生物制药有限公司 | A kind of preparation method of that heparin of high-quality low-molecular weight handkerchief |
CN104193848B (en) * | 2014-08-13 | 2016-10-05 | 南京健友生化制药股份有限公司 | A kind of remove the method for bacterial endotoxin in heparin sodium |
CN104403025B (en) * | 2014-12-24 | 2016-10-05 | 南京健友生化制药股份有限公司 | A kind of liquaemin removes color method |
CN105461830A (en) * | 2016-01-08 | 2016-04-06 | 东营天东制药有限公司 | Method for removing copper ions through poly-chelate resin |
CN109575156B (en) * | 2018-11-05 | 2021-02-23 | 上海宝维医药技术有限公司 | Purification method of low-molecular heparin |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4426289A (en) * | 1988-10-05 | 1990-05-01 | Nicola Diferrante | Methods for interfering with hiv multiplication and composition for the treatment of aids |
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2010
- 2010-09-16 CN CN2010102871329A patent/CN101942039B/en active Active
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CN101942039A (en) | 2011-01-12 |
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Owner name: DONGYING TIANDONG BIOCHEMICAL INDUSTRY CO., LTD. |
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Inventor after: Yang Xiaohong Inventor after: Zhang Zaizhong Inventor after: Guo Lin Inventor after: Li Rong Inventor after: Wang Chunmei Inventor after: Liu Wei Inventor after: Zhang Yanyan Inventor after: Yu Hexin Inventor before: Liu Wei Inventor before: Zhang Yanyan Inventor before: Yu Hexin |
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Free format text: CORRECT: INVENTOR; FROM: LIU WEI ZHANG YANYAN YU HEXIN TO: YANG XIAOHONG ZHANG ZAIZHONG GUO LIN LI RONG WANG CHUNMEI LIU WEI ZHANG YANYAN YU HEXIN |
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Effective date of registration: 20110927 Address after: 257000 Shandong District of Dongying city in Dongying Province North Road No. 726 in the building Applicant after: SHANDONG HI-TECH CHEMICAL GROUP Co.,Ltd. Co-applicant after: DONGYING TIANDONG BIOCHEMICAL INDUSTRY Co.,Ltd. Address before: 257000 Shandong District of Dongying city in Dongying Province North Road No. 726 in the building Applicant before: SHANDONG HI-TECH CHEMICAL GROUP Co.,Ltd. |
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Owner name: DONGYING TIANDONG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: DONGYING TIANDONG BIOCHEMICAL INDUSTRY CO., LTD. Effective date: 20120914 |
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CB03 | Change of inventor or designer information |
Inventor after: Guo Lin Inventor after: Li Rong Inventor after: Cui Huifei Inventor before: Yang Xiaohong Inventor before: Zhang Zaizhong Inventor before: Guo Lin Inventor before: Li Rong Inventor before: Wang Chunmei Inventor before: Liu Wei Inventor before: Zhang Yanyan Inventor before: Yu Hexin |
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Free format text: CORRECT: INVENTOR; FROM: YANG XIAOHONG ZHANG ZAIZHONG GUO LIN LI RONG WANG CHUNMEI LIU WEI ZHANG YANYAN YU HEXIN TO: GUO LIN LI RONG CUI HUIFEI |
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TA01 | Transfer of patent application right |
Effective date of registration: 20120914 Address after: 257000 Shandong District of Dongying city in Dongying Province North Road No. 726 in the building Applicant after: SHANDONG HI-TECH CHEMICAL GROUP Co.,Ltd. Applicant after: DONGYING TIANDONG PHARMACEUTICAL Co.,Ltd. Address before: 257000 Shandong District of Dongying city in Dongying Province North Road No. 726 in the building Applicant before: SHANDONG HI-TECH CHEMICAL GROUP Co.,Ltd. Applicant before: DONGYING TIANDONG BIOCHEMICAL INDUSTRY Co.,Ltd. |
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Address after: 257000 West of HaoChun Road, Dongying District, Dongying City, Shandong Province Co-patentee after: DONGYING TIANDONG PHARMACEUTICAL Co.,Ltd. Patentee after: Shandong Haike Chemical Co.,Ltd. Address before: 257000 Shandong District of Dongying city in Dongying Province North Road No. 726 in the building Co-patentee before: DONGYING TIANDONG PHARMACEUTICAL Co.,Ltd. Patentee before: SHANDONG HI-TECH CHEMICAL GROUP Co.,Ltd. |
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Effective date of registration: 20200506 Address after: 257000 No. two, 1236 South Road, Dongying District, Shandong, Dongying Patentee after: DONGYING TIANDONG PHARMACEUTICAL Co.,Ltd. Address before: 257000 West of HaoChun Road, Dongying District, Dongying City, Shandong Province Co-patentee before: DONGYING TIANDONG PHARMACEUTICAL Co.,Ltd. Patentee before: Shandong Haike Chemical Co.,Ltd. |