Summary of the invention
Therefore people better treat very demand of cerebral infarction sequela Chinese medicine preparation to curative effect, and the inventor has found the Chinese medicine preparation of the treatment cerebral infarction sequela of better efficacy finally through research repeatedly, has finished the present invention.The object of the invention provides little, the treating both the principal and secondary aspects of a disease of a kind of side effect, can more effectively treat the Chinese medicine preparation of cerebral infarction sequela.
The consumption that medicine of the present invention is formed part is that inventor's process gropes to sum up to get for a long time in a large number, and the each component consumption all has curative effect preferably in following weight parts: 1~5 part of Radix Astragali, 1~3 part of Radix Salviae Miltiorrhizae, 0.5~1.5 part of Radix Angelicae Sinensis, 0.5~1.5 part of Rhizoma Chuanxiong, 1~3 part in Rhizoma Gastrodiae, 0.5~1.5 part of Cornu Saigae Tataricae, 1~3 part of Pheretima, 1~3 part of Radix Cyathulae, 1~3 part of Radix Paeoniae Rubra, 0.5~1.5 part of Ramulus Mori, 0.5~1.5 part of Radix Saposhnikoviae, 1~3 part of Herba Lycopodii, 1~3 part of Caulis Spatholobi, 1~3 part of Bombyx Batryticatus, 0.5~1.5 part of Rhizoma Typhonii, 0.5~1.5 part of Scorpio, 0.5~1.5 part of Squama Manis, 1~3 part of the Cortex Eucommiae, 0.5~1.5 part of Agkistrodon, 1~3 part of Carapax et Plastrum Testudinis, 1~3 part of Fructus Lycii, 1~3 part of Fructus Alpiniae Oxyphyllae, 1~3 part of Carapax Trionycis, 0.5~1.5 part in Radix Glycyrrhizae.
Be preferably: 2~4 parts of Radix Astragali, 1.5~2 parts of Radix Salviae Miltiorrhizaes, 0.8~1.2 part of Radix Angelicae Sinensis, 0.8~1.2 part of Rhizoma Chuanxiong, 1.5~2 parts in Rhizoma Gastrodiae, 0.8~1.2 part of Cornu Saigae Tataricae, 1.5~2 parts of Pheretimas, 1.5~2 parts of Radix Cyathulaes, 1.5~2 parts of Radix Paeoniae Rubra, 0.8~1.2 part of Ramulus Mori, 0.8~1.2 part of Radix Saposhnikoviae, 1.5~2 parts of Herba Lycopodiis, 1.5~2 parts of Caulis Spatholobis, 1.5~2 parts of Bombyx Batryticatus, 0.8~1.2 part of Rhizoma Typhonii, 0.8~1.2 part of Scorpio, 0.8~1.2 part of Squama Manis, 1.5~2 parts of the Cortexs Eucommiae, 0.8~1.2 part of Agkistrodon, 1.5~2 parts of Carapax et Plastrum Testudiniss, 1.5~2 parts of Fructus Lycii, 1.5~2 parts of Fructus Alpiniae Oxyphyllaes, 1.5~2 parts of Carapax Trionycis, 0.8~1.2 part in Radix Glycyrrhizae.
More preferably: 3 parts of Radix Astragali, 2 parts of Radix Salviae Miltiorrhizaes, 1 part of Radix Angelicae Sinensis, 1 part of Rhizoma Chuanxiong, 2 parts in Rhizoma Gastrodiae, 1 part of Cornu Saigae Tataricae, 2 parts of Pheretimas, 2 parts of Radix Cyathulaes, 2 parts of Radix Paeoniae Rubra, 1 part of Ramulus Mori, 1 part of Radix Saposhnikoviae, 2 parts of Herba Lycopodiis, 2 parts of Caulis Spatholobis, 2 parts of Bombyx Batryticatus, 1 part of Rhizoma Typhonii, 1 part of Scorpio, 1 part of Squama Manis, 2 parts of the Cortexs Eucommiae, 1 part of Agkistrodon, 2 parts of Carapax et Plastrum Testudiniss, 2 parts of Fructus Lycii, 2 parts of Fructus Alpiniae Oxyphyllaes, 2 parts of Carapax Trionycis, 1 part in Radix Glycyrrhizae.
Improve the cerebral infarction sequela symptom, reduce the effective ways of high relapse rate, should be science diet and master, when passive recovery is taken exercise, by reliable Drug therapy, cerebral infarction inducement atheromatous plaque is formed, and the high basic pathological changes of blood viscosity is effectively treated, and prevents that the arteriosclerosis thrombosis from forming once more; Improve cerebral tissue blood supply oxygen-supplying amount, create a good interior environment for cerebral tissue, recover cerebral nervous system, make the motion by its control, the language nervous system signs improves.Medicine of the present invention is to select the medicine prescription to form on this basis.
Cerebral infarction claims cerebral infarction again, is meant that because brain blood supply obstacle the ischemic gathering of the limitation cerebral tissue that ischemia, anoxia cause etc. make that cerebral blood flow is proud to be reproduced; Side Zhi Xunhuan sets up, and the brain dysbolismus is recovered.Motherland's medical science is included into primary disease " apoplexy " category, empty within its cause of disease is at first blamed (hepatic and renal YIN deficiency is this), the empty reciprocal causation of the wind-fire expectorant stasis of blood and send out primary disease.Therefore in treatment, adopt enriching yin and nourishing kidney, dispelling pathogenic wind and eliminating phlegm, benefiting QI for activating blood circulation blood stasis dispelling treating both the principal and secondary aspects of a disease legislation prescription.The Radix Astragali, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, the blood stasis dispelling of Rhizoma Chuanxiong benefiting QI for activating blood circulation in the present invention, wherein Radix Astragali strongly invigorating primordial QI makes blood circulation depending on qi flow, and modern pharmacological research proves its slow down aging, and the expansion peripheral blood vessel participates in blood pressure regulating, improves the ischemic tissue of brain blood supply; Rhizoma Chuanxiong is the gas medicine in the blood, and the effective ingredient ligustrazine can see through the blood brain barrier expansion of cerebral vascular rapidly, improves cerebral circulation, anticoagulant, and antithrombotic forms; The Radix Salviae Miltiorrhizae stasis of blood of invigorating blood circulation, but anti-cerebral ischemia, antithrombotic, microcirculation improvement promotes tissue repair and regeneration, by the cerebrovascular treatment essential.Rhizoma Gastrodiae, Cornu Saigae Tataricae, Pheretima eliminating phlegm and calming wind, suppressing the hyperactive liver and subsiding YANG, wherein Rhizoma Gastrodiae has been proved to effects such as cranial nerve cell protection, vertigo, blood pressure lowering, convulsion, antiplatelet aggregation, antithrombotics; Cornu Saigae Tataricae, Pheretima have the merit of calm convulsion, antithrombotic.Carapax et Plastrum Testudinis, Carapax Trionycis salty in the mouth are cold in nature, return Liver Channel, and two medicines match and play the merit of nourishing YIN for suppressing the hyperactive YANG, the liver and the kidney tonifying altogether.Medicine of the present invention is used for the treatment of cerebral infarction sequela and meets the traditional Chinese medical science and modern pharmacological research theory, and it is evident in efficacy, is worthy of popularization.
The specific embodiment
Medicine of the present invention is made by following bulk drugs: 1~5 part of Radix Astragali, 1~3 part of Radix Salviae Miltiorrhizae, 0.5~1.5 part of Radix Angelicae Sinensis, 0.5~1.5 part of Rhizoma Chuanxiong, 1~3 part in Rhizoma Gastrodiae, 0.5~1.5 part of Cornu Saigae Tataricae, 1~3 part of Pheretima, 1~3 part of Radix Cyathulae, 1~3 part of Radix Paeoniae Rubra, 0.5~1.5 part of Ramulus Mori, 0.5~1.5 part of Radix Saposhnikoviae, 1~3 part of Herba Lycopodii, 1~3 part of Caulis Spatholobi, 1~3 part of Bombyx Batryticatus, 0.5~1.5 part of Rhizoma Typhonii, 0.5~1.5 part of Scorpio, 0.5~1.5 part of Squama Manis, 1~3 part of the Cortex Eucommiae, 0.5~1.5 part of Agkistrodon, 1~3 part of Carapax et Plastrum Testudinis, 1~3 part of Fructus Lycii, 1~3 part of Fructus Alpiniae Oxyphyllae, 1~3 part of Carapax Trionycis, 0.5~1.5 part in Radix Glycyrrhizae.
Be preferably: 2~4 parts of Radix Astragali, 1.5~2 parts of Radix Salviae Miltiorrhizaes, 0.8~1.2 part of Radix Angelicae Sinensis, 0.8~1.2 part of Rhizoma Chuanxiong, 1.5~2 parts in Rhizoma Gastrodiae, 0.8~1.2 part of Cornu Saigae Tataricae, 1.5~2 parts of Pheretimas, 1.5~2 parts of Radix Cyathulaes, 1.5~2 parts of Radix Paeoniae Rubra, 0.8~1.2 part of Ramulus Mori, 0.8~1.2 part of Radix Saposhnikoviae, 1.5~2 parts of Herba Lycopodiis, 1.5~2 parts of Caulis Spatholobis, 1.5~2 parts of Bombyx Batryticatus, 0.8~1.2 part of Rhizoma Typhonii, 0.8~1.2 part of Scorpio, 0.8~1.2 part of Squama Manis, 1.5~2 parts of the Cortexs Eucommiae, 0.8~1.2 part of Agkistrodon, 1.5~2 parts of Carapax et Plastrum Testudiniss, 1.5~2 parts of Fructus Lycii, 1.5~2 parts of Fructus Alpiniae Oxyphyllaes, 1.5~2 parts of Carapax Trionycis, 0.8~1.2 part in Radix Glycyrrhizae.
Said medicine is fine flour altogether, and processed with honey is ball, and is big as Semen Firmianae, and three times on the one, one time one ball.
The active component of medicine of the present invention can also add various conventional adjuvant required when preparing different dosage form, be prepared into any peroral dosage form commonly used as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, as: powder, tablet, capsule, oral agents etc.
Embodiment 1: medicine of the present invention is made by following bulk drugs: 1 part of Radix Astragali, 1 part of Radix Salviae Miltiorrhizae, 0.5 part of Radix Angelicae Sinensis, 0.5 part of Rhizoma Chuanxiong, 1 part in Rhizoma Gastrodiae, 0.5 part of Cornu Saigae Tataricae, 1 part of Pheretima, 1 part of Radix Cyathulae, 1 part of Radix Paeoniae Rubra, 0.5 part of Ramulus Mori, 0.5 part of Radix Saposhnikoviae, 1 part of Herba Lycopodii, 1 part of Caulis Spatholobi, 1 part of Bombyx Batryticatus, 0.5 part of Rhizoma Typhonii, 0.5 part of Scorpio, 0.5 part of Squama Manis, 1 part of the Cortex Eucommiae, 0.5 part of Agkistrodon, 1 part of Carapax et Plastrum Testudinis, 1 part of Fructus Lycii, 1 part of Fructus Alpiniae Oxyphyllae, 1 part of Carapax Trionycis, 0.5 part in Radix Glycyrrhizae.
Embodiment 2: medicine of the present invention is made by following bulk drugs: 3 parts of Radix Astragali, 2 parts of Radix Salviae Miltiorrhizaes, 1 part of Radix Angelicae Sinensis, 1 part of Rhizoma Chuanxiong, 2 parts in Rhizoma Gastrodiae, 1 part of Cornu Saigae Tataricae, 2 parts of Pheretimas, 2 parts of Radix Cyathulaes, 2 parts of Radix Paeoniae Rubra, 1 part of Ramulus Mori, 1 part of Radix Saposhnikoviae, 2 parts of Herba Lycopodiis, 2 parts of Caulis Spatholobis, 2 parts of Bombyx Batryticatus, 1 part of Rhizoma Typhonii, 1 part of Scorpio, 1 part of Squama Manis, 2 parts of the Cortexs Eucommiae, 1 part of Agkistrodon, 2 parts of Carapax et Plastrum Testudiniss, 2 parts of Fructus Lycii, 2 parts of Fructus Alpiniae Oxyphyllaes, 2 parts of Carapax Trionycis, 1 part in Radix Glycyrrhizae.
Embodiment 3: medicine of the present invention is made by following bulk drugs: 5 parts of Radix Astragali, 3 parts of Radix Salviae Miltiorrhizaes, 1.5 parts of Radix Angelicae Sinensis, 1.5 parts of Rhizoma Chuanxiongs, 3 parts in Rhizoma Gastrodiae, 1.5 parts of Cornu Saigae Tataricae, 3 parts of Pheretimas, 3 parts of Radix Cyathulaes, 3 parts of Radix Paeoniae Rubra, 1.5 parts of Ramulus Moris, 1.5 parts of Radix Saposhnikoviaes, 3 parts of Herba Lycopodiis, 3 parts of Caulis Spatholobis, 3 parts of Bombyx Batryticatus, 1.5 parts of Rhizoma Typhoniis, 1.5 parts of Scorpios, 1.5 parts of Squama Maniss, shut out 3 parts, 1.5 parts of Agkistrodons, 3 parts of Carapax et Plastrum Testudiniss, 3 parts of Fructus Lycii, 3 parts of Fructus Alpiniae Oxyphyllaes, 3 parts of Carapax Trionycis, 1.5 parts in Radix Glycyrrhizae.
Embodiment 4: medicine of the present invention is made by following bulk drugs: 4 parts of Radix Astragali, 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Radix Angelicae Sinensis, 0.8 part of Rhizoma Chuanxiong, 3 parts in Rhizoma Gastrodiae, 1 part of Cornu Saigae Tataricae, 1.5 parts of Pheretimas, 3 parts of Radix Cyathulaes, 1 part of Radix Paeoniae Rubra, 0.5 part of Ramulus Mori, 1.5 parts of Radix Saposhnikoviaes, 3 parts of Herba Lycopodiis, 2 parts of Caulis Spatholobis, 2 parts of Bombyx Batryticatus, 1.2 parts of Rhizoma Typhoniis, 0.8 part of Scorpio, 1.5 parts of Squama Maniss, 1.8 parts of the Cortexs Eucommiae, 0.9 part of Agkistrodon, 1 part of Carapax et Plastrum Testudinis, 3 parts of Fructus Lycii, 1.5 parts of Fructus Alpiniae Oxyphyllaes, 1 part of Carapax Trionycis, 0.5 part in Radix Glycyrrhizae.
Embodiment 5: medicine of the present invention is made by following bulk drugs: 5 parts of Radix Astragali, 2 parts of Radix Salviae Miltiorrhizaes, 2 parts of Radix Angelicae Sinensis, 1 part of Rhizoma Chuanxiong, 1 part in Rhizoma Gastrodiae, 1.5 parts of Cornu Saigae Tataricae, 2 parts of Pheretimas, 3 parts of Radix Cyathulaes, 3 parts of Radix Paeoniae Rubra, 0.8 part of Ramulus Mori, 1 part of Radix Saposhnikoviae, 2 parts of Herba Lycopodiis, 3 parts of Caulis Spatholobis, 3 parts of deadlocks, 1.5 parts of Rhizoma Typhoniis, 0.9 part of Scorpio, 0.7 part of Squama Manis, 1 part of the Cortex Eucommiae, 1 part of Agkistrodon, 1 part of Carapax et Plastrum Testudinis, 1.5 parts of Fructus Lycii, 2 parts of Fructus Alpiniae Oxyphyllaes, 2 parts of Carapax Trionycis, 1 part in Radix Glycyrrhizae.
Embodiment 6: medicine of the present invention is made by following bulk drugs: 5 parts of Radix Astragali, 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Radix Angelicae Sinensis, 1.5 parts of Rhizoma Chuanxiongs, 2 parts in Rhizoma Gastrodiae, 1.5 parts of Cornu Saigae Tataricae, 1 part of Pheretima, 1 part of Radix Cyathulae, 3 parts of Radix Paeoniae Rubra, 1.5 parts of Ramulus Moris, 0.5 part of Radix Saposhnikoviae, 2 parts of Herba Lycopodiis, 1.5 parts of Caulis Spatholobis, 1.5 parts of Bombyx Batryticatus, 0.8 part of Rhizoma Typhonii, 1 part of Scorpio, 1 part of Squama Manis, 2 parts of the Cortexs Eucommiae, 1.5 parts of Agkistrodons, 3 parts of Carapax et Plastrum Testudiniss, 3 parts of Fructus Lycii, 1 part of Fructus Alpiniae Oxyphyllae, 1 part of Carapax Trionycis, 0.5 part in Radix Glycyrrhizae.
Clinical observation material
(1) invention medicine major function and therapeutic domain
1, major function:
Enriching yin and nourishing kidney, dispelling pathogenic wind and eliminating phlegm, benefiting QI for activating blood circulation blood stasis dispelling.
2, therapeutic domain:
Be applicable to cerebral infarction, cerebral infarction sequela, apoplexy sequela.
(2) clinical observation of medicine of the present invention
Treatment group Drug therapy of the present invention, matched group hemiparalysis restoration pill for curing.Therapeutic outcome: treatment is organized in 171 examples, and 34 examples of fully recovering account for 19.9%; Marked improvement 39 examples account for 22.8%; Progressive 59 examples account for 34.5%; Invalid 39 examples account for 22.8%; Total effective rate is 77.2%.Recovery from illness 18 examples account for 11.0% in matched group 164 examples; Marked improvement 26 examples account for 15.9%; Progressive 43 examples account for 26.2%; Invalid 77 examples account for 47%; Total effective rate is 53%.Two groups of total effective rates compare P<0.01, and there were significant differences.
Table 1 liang group curative effect relatively
Group |
The example number |
Recovery from illness |
Produce effects |
Progressive |
Invalid |
Total effective rate |
Treatment group (medicine of the present invention) |
171 |
34 |
39 |
59 |
39 |
77.2% |
Matched group (PIANTAN FUYUAN WAN) |
164 |
18 |
26 |
43 |
77 |
53% |
The curative effect of treatment group as can be seen from Table 1 obviously is better than matched group (p<0.01).